http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Xingyu Xie ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Zhiqi Huang,Xingyu Li,Tian Xie,Changjiang Gu,Kan Ni,Qingqing Yin,Xiaolei Cao,Chunhui Zhang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers—such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Materials and Methods We used immunohistochemistry, western blot and quantitative real-time polymerase chain reaction to evaluate the expression of RIOK1 in BC patients. Then, knockdown or overexpression of RIOK1 were used to evaluate the effect on BC cells in vitro and in vivo. Finally, we predicted miR-204-5p could be a potential regulator of RIOK1. Results We found that the expression levels of RIOK1 were significantly higher in hormone receptor (HR)–negative BC patients and was associated with tumor grades (p=0.010) and p53 expression (p=0.008) and survival duration (p=0.011). Kaplan-Meier analysis suggested a tendency for the poor prognosis. In vitro, knockdown of RIOK1 could inhibit proliferation, invasion, and induced apoptosis in HR-negative BC cells and inhibited tumorigenesis in vivo, while overexpression of RIOK1 promoted HR-positive tumor progression. MiR-204-5p could regulate RIOK1 expression and be involved in BC progression. Conclusion These findings indicate that RIOK1 expression could be a biomarker of HR-negative BC, and it may serve as an effective prognostic indicator and promote BC progression.
-
( Shuai Zhang ),( Xingyu Xie ),( Shanqing Wan ),( Xiaodai Jia ) 아시아스포츠융합과학회 2021 Asia Pacific Journal of Applied Sport Sciences Vol.2 No.1
PURPOSE This study uses the extended model of goal-oriented behavior to predict and test the behavioral intentions of Chinese public Taekwondo consumers. Based on the original MGB, the study adds five variables related to Taekwondo consumption characteristic to investigate the influencing factors of general Taekwondo consumers' consumption decision-making process. METHOD This study conducts an online survey of 417 students studying in the Chinese Taekwondo Gymnasium and uses IBM SPSS statistical software 26.0 and AMOS 23.0 to analyze the data. Then, the data analysis is divided into two stages. In the first stage, confirmatory factor analysis (CFA) is used to test the reliability and validity of the scale. In the second stage, a structural equation modeling (SEM) analysis is employed to test the proposed hypotheses. RESULT The CFA test shows that the data and the model have a good fit, and the model has high combined reliability and convergence validity. And through the modification of the model, a SEM is established. CONCLUSION The results show that desire has the most significant impact on consumers' behavioral preference, followed by past satisfaction and Taekwondo coach image. Past satisfaction significantly affects desire, which in turn affects consumersʼ behavioral preference. The two constructs of Taekwondo cognition and perspective form a positive and significant relationship. In addition, perspective has developed a considerable influence relationship with past satisfaction and Taekwondo coach image, which influences behavior preferences. Expected emotions significantly affect past satisfaction, which indirectly affects desire and consumer behavioral intentions.
-
Chen Chao,Lei Zhijun,Xiong Yaoxi,Ni Meng,He Biwei,Gao Jing,Zheng Panchan,Xie Xianjing,He Chengrong,Yang Xingyu,Cheng Weiwei 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-
Background In all studies conducted so far, there was no report about the correlation between excessive gestational weight gain (GWG) and the risk of preeclampsia (PE) in multiparas, especially considering that multiparity is a protective factor for both excessive GWG and PE. Thus, the aim of this retrospective cohort study was to determine whether GWG of multiparas is associated with the increased risk of PE. Methods This was a study with 15,541 multiparous women who delivered in a maternity hospital in Shanghai from 2017 to 2021, stratifed by early-pregnancy body mass index (BMI) category. Early-pregnancy body weight, height, week-specifc and total gestational weight gain as well as records of antenatal care were extracted using electronic medical records, and antenatal weight gain measurements were standardized into gestational age-specifc z scores. Results Among these 15,541 multiparous women, 534 (3.44%) developed preeclampsia. The odds of preeclampsia increased by 26% with every 1 z score increase in pregnancy weight gain among normal weight women and by 41% among overweight or obese women. For normal weight women, pregnant women with preeclampsia gained more weight than pregnant women without preeclampsia beginning at 25 weeks of gestation, while accelerated weight gain was more obvious in overweight or obese women after 25 weeks of gestation. Conclusions In conclusion, excessive GWG in normal weight and overweight or obese multiparas was strongly associated with the increased risk of preeclampsia. In parallel, the appropriate management and control of weight gain, especially in the second and third trimesters, may lower the risk of developing preeclampsia.
-
Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
