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위암종과 Epstein-Barr 바이러스와의 연관성에 대한 연구
심광용,김호영,김효열,백순구,권상옥,조미연,이창훈,이종인 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Objectives: Epstein-Barr virus (EBV) has been known to be linked to a spectrum of neoplastic conditions, including nasopharyngeal carcinoma, Burkitt's lymphoma, peripheral T-cell lymphoma and Hodgkin's disease. This study aims to investigate the association of EBV with gastric carcinoma in Korea. Methods: Fifty-three cases of gastric adenocarcinoma were studied for evidence of EBV infection by EBV-encoded small RNA (EBER) in situ hybridization (ISH) on the paraffin sections and amplifying the EBV genome encoding envelop glycoprotein (gp220) with polymerase chain reaction (PCR) in fresh gastric cancer specimens. Results: EBER was detected in 7 (13.2%) of 53 gastric carcinomas and all cases were male. In 6 (85.7%) of 7 EBER-positive cases, the tumors were located in the upper and middle part of the stomach. EBER ISH study showed strong positivity in all the tumor cells, but negativity in surrouning lymphocytes, stromal cells and normal gastric mucosa. DNA PCR was positive in 23 (43.4%) of 53 gastric carcinomas, including all of 7 EBER-positive cases. Conclusion: We could observe some association of EBV with gastric carcinoma, and our findings about the charateristics of EBV-positive gastric cancers involving sex, site and histological type are similar to those in Japan. However, EBV-positive rate of gastric cancer is higher than in Japan and lower than in Western countries. Further studies to elucidate oncogenic mechanism of EBV in gastric cancer should be performed.
Relationship of Hemodynamic Indices and Prognosis in Patients with Liver Cirrhosis
( Soon Koo Baik ),( Myeong Gwan Jee ),( Phil Ho Jeong ),( Jae Woo Kim ),( Sang Won Ji ),( Hyun Soo Kim ),( Dong Ki Lee ),( Sang Ok Kwon ),( Young Ju Kim ),( Joong Wha Park ),( Sei Jin Chang ) 대한내과학회 2004 The Korean Journal of Internal Medicine Vol.19 No.3
백순구 ( Soon Koo Baik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.2
Currently, the most effective treatment for end-stage liver fibrosis is liver transplantation; however, transplantation is limited by a shortage of donor organs, surgical complications, immunological rejection and high medical costs. Hence, stem cell transplantation has been suggested as an effective alternate therapy for hepatic disease. Hematopoietic stem cell, mesenchymal stem cell (MSC), umbilical cord blood cells, fetal liver progenitor cells, adult liver progenitor cells, and mature hepatocytes have been reported to be capable of self-renewal, giving rise to daughter hepatocytes both in vivo and in vitro. Bone marrow comprises two main populations of stem cells, hematopoietic stem cells and MSC, of which the latter have been considered as alternative cell sources for liver or hepatocyte transplantation because of their high capability for self-renewal and differentiation without ethical or tumorigenic problems. Indeed, stem cell therapies have shown promising benefits for hepatic fibrosis in experimental and clinical studies. In liver damage, MSC are able to differentiate into hepatocytes, stimulate the regeneration of endogenous parenchymal cells, migrate to damaged sites, and enhance fibrous matrix degradation indicating antifibrotic effect. Furthermore, several clinical studies have demonstrated favorable effects such as MSC improving the liver function and histological grading of fibrosis in patients with cirrhosis. Recently, multicenter randomized clinical trial conducted in Korea shows clinical efficacy and safety of MSC application, indicating that it has a potential to be a new strategy for chronic liver disease such as cirrhosis. Therefore, further clinical trials are required to validate and support the results for objective confirmation of clinical advantages of MSC therapy.
간경변증에 동반된 특발성 세균성 복막염의 재발빈도 및 예견인자
백순구(Soon Koo Baik),권상옥(Sang Ok Kwon),박의련(Eui Ryun Park),김준명(Jun Myeong Kim),이용규(Yong Gyu Lee),최윤종(Yeun Jong Choi),김일희(Il Hoi Kim),이동기(Dong Ki Lee) 대한내과학회 1998 대한내과학회지 Vol.54 No.6
N/A Objectives: Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication of cirrhosis. In the most recently published studies, the prevalence of SBP among hospitalized cirrhotics with ascites has been estimated to be around 10-15%, the mortality rate related to this complication being more than 50%. SBP is thought to appear as a consequence of the impaired defensive mechanisms against infection present in cirrhotic patients, such as depressed reticuloendothelial system phagocytic activity, impaired leukocyte function, reduced serum compliment levels, and low antibacterial activity of ascitic fluid. It has proposed that ascitic fluid opsonin capacity is directly correlated to ascitic protein concentration and that this explains an observed predisposition to infection in patients with low ascitic fluid protein concentration. This present study aims to investigate the frequency of the recurrence of SBP in u large series of cirrhotic patient who recovered from the first episode of SBP and to identify any possible predictors of recurrent SBP. Method: We reviewed records of chart in 312 consecutive cirrhotics with ascites patients treated in our hospital between January, 1988 and August, 1995. Results: The incidence of SRP was 21.8% (68 cases) and showed 80.9% in male, 19.1% in female. Seven- teen (25%) of the 68 patients included in the study after the resolution of their first episode of SBP developed one or more episodes of SBP during follow-up. SBP recurred once in 16 of these patients, twice in 1 patients. The cumulative probability of SBP recurrence was 47.1% at 6 months, 64.7% at 12 months, and 82% at 18 months of follow-up. This study reveals that neither ascitic fluid total protein nor the severity of liver disease(Child's class) predicts the occurence of recurrant SBP. Conclusion: We conclude that the occurrence of recurrent SBP is unrelated to the type of liver disease, and severity of liver disease did not predict the presence of recurrent SBP. Also, ascitic fluid total protein ≤1.0 g/dl, prothrombin time 45% may not be a sensitive predictor of recurrent SBP.
문맥압 항진증의 약물 치료 -국내 자료와 경험을 중심으로-
백순구 ( Soon Koo Baik ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Portal hypertension as a consequence of liver cirrhosis is responsible for serious complications such as variceal bleeding, ascites and hepatic encephalopathy. Successful pharmacological treatment of portal hypertension can prevent the risk of the varicea