中心壓軸力을 받는 高强度 鐵筋콘크리트 기둥의 耐力과 延性에 關한 실험적 硏究

곽노현,이영호,김남주,이경종,정헌수 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

A study on the behavior of short reinforced concrete columns was experimently described. Twenty-four concrete columns, with 20cm square and 60cm height, containing 8 longitudinal steel bars and different the amount of ties, spacing and concrete strengths, were subjected to concentric load by failure. Test results indicated that 1) It is incompatible in high-strength concrete to arrange stirrups to the AIK code of D/2 throughout the example of 10cm stirrup spacing following AIK codes. 2) As the amount of stirrup increased, the strength and ductily of reinforced concrete column improved. 3) As the concrete strength is high, the effect of the was reduced. 4) If strength enhancement factors increased, strain at maximum load also does and ductility ratios does almost linearliary. 5) The rate of strength enhancement factor does well with the modified kent & Park's theory. 6) As to the result of calculating the effective confined area which is suggested in Sheikh & Uzumeri's theory, the middle vertical steel is effective, only if the stirrups are arranged with spacing of 3cm.

高强度 콘크리트를 사용한 R.C 보 部材의 付着割裂性狀에 관한 實驗的 硏究

곽노현,정헌수 중앙대학교 기술과학연구소 1993 기술과학연구소 논문집 Vol.23 No.-

In order to quantify the effect of transverse reinforcement on the bond splitting behavior of reinforcement monotonic loading tests of 6 slmply beams were carried out. The reinforcing details and material properties were so determined that the bond splitting failure proceded the shear and flexural gailure. A bond splitting strength derived from the experimental data and it accounts for folloeing paramenters : 1) Concrete Strength 2) Transverse reinforcement tatio and shape 3) Thickness of concrete cover

중심압축력을 받는 高强度 RC기둥의 띠철근 配筋形態에 關한 實驗的 硏究

이영인,이영호,곽노현,정헌수 중앙대학교 기술과학연구소 1998 기술과학연구소 논문집 Vol.28 No.-

An objective of this study is to experimentally investigate the strength and ductility of reinforced concrete columns under uniaxial load and several test variables. To do this, we have conducted tests on twelve 20×20×60cm specimens with 8 and 12 longitudinal steel bars subjected to monotonic uniaxial compression. The main variables considered in this test are the configuration of ties, the strength of concrete, and the space of ties. The results indicate that the strength and the ductility of reinforced concrete columns have been influenced on the configuration of ties, the space of ties, and the strength of concrete.

도시근린공원의 이미지와 이용만족도에 관한 연구

하영철,정수일,곽윤근,신현익,하헌정,김익환,김석만 金烏工科大學校 1999 論文集 Vol.20 No.-

This paper presents the future direction of the development and maintenance of the urban park of the Kumi city. The direction was obtained by analyzing the evaluation results on the satisfaction level of park use and the park image of the park users. The analysis results are as follows. 1) It turns out that the rest and accommodation facilities are the major facilities that uplifts the total image of the park. 2) Among the park images, the image on the pleasantness was the major image, related with the satisfaction on the park equipments. 3) The social class, who gave a bad score on the above equipments and images, is a low-aged class, who is a white class with high income as well. Therefore, it is suggested that the park maintenance plan, with emphasis on the class, is an important task.

구속된 고강도 콘크리트 기둥의 휨 거동에 관한 실험적 연구

양근혁,이영호,곽노현,정헌수 중앙대학교 기술과학연구소 1998 기술과학연구소 논문집 Vol.28 No.-

본 실험적 연구의 목적은 콘크리트 강도, 띠근 배근형태, 띠근 량, 축하중비가 축하증과 횡하증을 받는 구속된 콘크리트 기둥의 휨 내력과 연성에 미치는 영향을 팡가하기 위한 것이다. 구속된 기둥의 휨 거동을 시험하기 위하여 200×200×800mm 크기의 시험체 14개를 2축 하중하에서 실험하였다. 시험결과로서, 저축력에서 콘크리트 구속으로 인한 휨 강도의 증가는 비교적 작게 있지만, 고축력에서 콘크리트 구속으로 인한 휨 강도 증가는 크게 있다. 그리고, 고축력, 고강도 콘크리트에서 내부 cross-ties가 있으면 휨 연성의 증가가 보였으며, 구속된 콘크리트 기둥의 연성은 단순한 띠근 량보다는 구속지수에 관계되었다. The purpose of this experimental study was to investigate the effects of concrete strength, the configuration of lateral ties, the amount of lateral ties, and level of axial loads on flexural strength and ductility of confined of reinforced concrete columns subjected to combined axial and lateral loads. To simulate the flexural behavior of confined columns, fourteen reinforced concrete columns, 200×200×800mm, were tested under bi-axial loads. Test results indicate that for low axial load levels, the enhancement of the flexural strength due to concrete confinement is relatively small, but that for high axial load levels, the enhancement of the flexural strength due to concrete confinement can be very high. Considerable enhancement of ductility was observed in columns confined by cross-ties, even for high strength concrete columns and under high axial loads. Ductility of confined columns are found to be more related to confinement index (ρ??f??/??) than the amount of lateral ties(ρ??)

응급실로 내원한 자살 시도자의 혈청 콜레스테롤 농도와 자살 심각도의 상관성

김용구,이헌정,이민수,곽동일 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 혈청 콜레스테롤 농도의 저하 혹은 이의 치료가 자살, 폭력적 행동, 그리고 우울증과 관련이 있다는 역학적, 임상적 보고들이 대두되었다. 본 연구에서는 첫째, 자살시도후 응급실로 내원한 정신과 환자의 혈중 콜레스테롤 농도가 자살시도가 없었던 정신과 입원환자 혹은 정상대조군에 비하여 감소되어 있는지, 둘째, 진단별로 분류하였을 때 우울증, 정신분열증, 인격장애 환자사이에 유의한 차이가 있는지, 셋째, 자살 심각도와 혈청 콜레스테롤 농도간에 유의한 상관관계가 있는지를 알아보았다. 연구방법 : 1994년 1월부터 1997년 7월까지 자살시도후 응급실로 내원한 정신과 환자 102명을 연구대상군으로 하였으며, 동 기간에 본원 정신과에서 입원 치료를 받은 자살시도가 없었던 환자 중 대상군과 나이, 성별, 진단을 일치시킨 102명의 환자대조군과 무작위로 102명의 정상 대조군을 선택하였다. 자살시도자는 자살의 심각도에 따라 5단계군으로 분류하였다. 혈청 콜레스테롤 농도는 효소법에 의한 자동분석기로 측정되었다. 연구결과 : 자살시도 환자군이 자살시도가 없었던 환자군과 정상대조군에 비해 콜레스테롤 농도의 유의한 감소를 나타내었다. 진단적으로 구분해서 살펴보면, 우울증에서는 이런한 차이가 유의하였으나, 정신분열병과 인격장애에서는 유의한 차이가 없었다. 낮은 콜레스테롤 농도는 자살시도의 심각도와 유의한 상관관계를 나타내었다. 결 론 : 본 연구의 결과는 콜레스테롤 농도의 저하가 자살시도의 위험을 증가시킨다는 이전의 주장들을 지지 해주는 결과로 사료된다. 이러한 관련성이 정신분열병이나 인격장애에서는 없었으나, 우울증에서만 있었다. 이는 낮은 콜레스테롤 농도와 자살행동사이의 연관성이 우울증에서 보이는 생물학적 기전과 관련이 있을 가능성을 제기하고 있다. 우울증에서 콜레스테롤 농도의 저하는 세로토닌, 인터루킨-2 그리고 멜라토닌 대사와 관련될 수 있다. Objectives : Epidemiological and clinical studies have suggested that low cholesterol levels or clinical trials to reduce cholesterol concentrations may be associated with suicide, violent behavior or depression. The aim of the present study was to determined ⅰ) whether suicidal psychiatric patients is characterized by decreased serum cholesterol concentration ;ⅱ) whether significant difference of cholesterol levels might be present according to the psychiatric diagnosis, and ⅲ) whether significant association between suicide severity and cholesterol levels might be present. Method : The subjects were 102 psychiatric patients who were admitted to emergency ward following an attempted suicide during the period from January 1994 to July 1997 and 102 age, and sex matched psychiatric controls who were consecutively admitted to a psychiatric ward during the same period, and 102 age, sex matched healthy normal controls. The suicide attempters were divided into 5 grades according to the suicide severity. Serum cholesterol concentrations were measured by a enzymatic method. Results : The serum cholesterol level in suicidal attempters were found to be significantly lower compared with both psychiatric and normal controls. This significant relationship between suicidal attempt and low cholesterol level was observed only in depressive patients, but not in schizophrenics or personality disorder patients. Low cholesterol was significantly associated with the severity of the suicide. Conclusions : These results support the previous finding that low cholesterol level might be associated with an increased risk of suicide. The fact that the significant relationship was observed only in depressive disorder, but not in schizophrenia or personality disorder raises the possibility that the association between low serum cholesterol and suicidal behavior may have relevance to biological mechanisms in depression. It is hypothesized that low cholesterol levels would be associated with depression by modifying the serotonin, the production of interleukin-2 and melatonin metabolism.

A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans

Kwak, Soo Heon,Park, Young Joo,Go, Min Jin,Lee, Kyu Eun,Kim, Su-jin,Choi, Hoon Sung,Kim, Tae Hyuk,Choi, Sung Hee,Lim, Soo,Kim, Ki Woong,Park, Do Joon,Kim, Sung Soo,Lee, Jong-Young,Park, Kyong Soo,Jang IRL Press 2014 Human molecular genetics Vol.23 No.16

<P>Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT<SUB>4</SUB>) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Stage 1 genome scan, 3396 participants from the Ansung cohort were investigated using 1.42 million genotyped or imputed markers. In the Stage 2 follow-up, 10 markers were genotyped in 842 participants from the Korean Longitudinal Study on Health and Aging cohort. An intronic variant in <I>VAV3,</I> rs12126655, which has been reported in Europeans, was significantly associated with plasma TSH concentration in the joint Stages 1 and 2 analyses (<I>P</I> = 2.2 × 10<SUP>−8</SUP>). We observed that a novel variant, rs2071403, located 75 bp proximal to the translational start site of <I>TPO</I> was significantly associated with plasma anti-TPO antibody positivity in the joint Stages 1 and 2 analyses (<I>P</I> = 1.3 × 10<SUP>−10</SUP>). This variant had a marginal sex-specific effect, and its association was more significant in females. Subjects possessing the rs2071403A allele, associated with an absence of the anti-TPO antibody, had decreased TPO mRNA expression in their thyroid tissue. Another intronic variant of <I>HLA-DPB2</I>, rs733208, had a suggestive association with anti-TPO antibody positivity (<I>P</I> = 4.2 × 10<SUP>−7</SUP>). In conclusion, we have identified genetic variants that are strongly associated with TSH level and anti-TPO antibody positivity in Koreans. Further replications and meta-analysis are required to confirm these findings.</P>

Nonsynonymous Variants in <i>PAX4</i> and <i>GLP1R</i> Are Associated With Type 2 Diabetes in an East Asian Population

Kwak, Soo Heon,Chae, Jeesoo,Lee, Seungbok,Choi, Sungkyoung,Koo, Bo Kyung,Yoon, Ji Won,Park, Jin-Ho,Cho, Belong,Moon, Min Kyong,Lim, Soo,Cho, Young Min,Moon, Sanghoon,Kim, Young Jin,Han, Sohee,Hwang, M American Diabetes Association 2018 Diabetes Vol.67 No.9

<P>We investigated ethnicity-specific exonic variants of type 2 diabetes (T2D) and its related clinical phenotypes in an East Asian population. We performed whole-exome sequencing in 917 T2D case and control subjects, and the findings were validated by exome array genotyping in 3,026 participants. In silico replication was conducted for seven nonsynonymous variants in an additional 13,122 participants. Single-variant and gene-based association tests for T2D were analyzed. A total of 728,838 variants were identified by whole-exome sequencing. Among nonsynonymous variants, PAX4 Arg192His increased risk of T2D and GLP1R Arg131Gln decreased risk of T2D in genome-wide significance (odds ratio [OR] 1.48, P = 4.47 x 10(-16) and OR 0.84, P = 3.55 x 10(-8), respectively). Another variant at PAX4 192 codon Arg192Ser was nominally associated with T2D (OR 1.62, P = 5.18 x 10(-4)). In T2D patients, PAX4 Arg192His was associated with earlier age at diagnosis, and GLP1R Arg131Gln was associated with decreased risk of cardiovascular disease. In control subjects without diabetes, the PAX4 Arg192His was associated with higher fasting glucose and GLP1R Arg131Gln was associated with lower fasting glucose and HbA(1c) level. Gene-based analysis revealed that SLC30A8 was most significantly associated with decreased risk of T2D (P = 1.0 x 10(-4)). In summary, we have identified nonsynonymous variants associated with risk of T2D and related phenotypes in Koreans.</P>

Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score

Kwak, Soo Heon,Choi, Sung Hee,Kim, Kyunga,Jung, Hye Seung,Cho, Young Min,Lim, Soo,Cho, Nam H.,Kim, Seong Yeon,Park, Kyong Soo,Jang, Hak C. Springer-Verlag 2013 Diabetologia Vol.56 No.12

Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity.

Kwak, Soo Heon,Park, Byoung Lae,Kim, Hail,German, Michael S,Go, Min Jin,Jung, Hye Seung,Koo, Bo Kyong,Cho, Young Min,Choi, Sung Hee,Cho, Yoon Shin,Shin, Hyoung Doo,Jang, Hak C,Park, Kyong Soo NAASO, the Obesity Society 2012 Obesity Vol.20 No.1

<P>Serotonin is involved in appetite regulation and energy homeostasis. Recently, it has been reported that 5-hydroxytryptamine receptor 2B (Htr2b) and tryptophan hydroxylase 1 (Tph1) play major role in β-cell proliferation in mouse during pregnancy. We investigated the genetic association of HTR2B and TPH1 with risk of gestational diabetes mellitus (GDM) and measures of obesity, in 869 Korean GDM women and carefully selected 632 nondiabetic control subjects. Six single-nucleotide polymorphisms (SNPs) in HTR2B and ten SNPs in TPH1 were selected for genotyping according to their tagging status. Genetic variants in HTR2B and TPH1 were not associated with the risk of GDM. In GDM women, SNPs of TPH1 were significantly associated with weight gain during pregnancy. In nondiabetic controls, SNPs of TPH1 were associated with waist circumference and BMI. We also found that a variant of TPH1 (rs623580) was associated with BMI in a genome-wide association study comprised of 8,842 subjects. Although genetic variants in HTR2B and TPH1 were not associated with risk of GDM, we found significant association of these variants with measures of obesity. However, further replication studies in a different population are required to confirm our findings.</P>