CURRENT SITUATION AND PROSPECT OF SHIPPING INDUSTRY IN VIETNAM

Le,Thanh Van,Kim,Sung-June 한국항해항만학회 2014 한국항해항만학회 학술대회논문집 Vol.2014 No.춘계

The report analyze the current situation of shipping industry in Viet Nam, including information about Viet Nam seaborne trade, shipping companies, sea-going fleets, seafarers, major seaports. Afterward it will be disclosed the policy of sea transport in Viet Nam. And finally, the author will give summary and conclusion about shipping industry in Viet Nam.

Geotextile Filter의 특수성능 분석

權武南,李相昊,金勝勳 慶北大學校 1992 論文集 Vol.52 No.-

In order to lock stability of geotextile filer to clogging or blocking, small scale laboratory tests were accomplished, considering to drainage conditions, on domestic and foreign nonwoven geotextile products used for filter, and permeable capacity of the geotextile filter was analyzed. The results obtained are as follows: 1. The permeable flow rate through the geotextile filter appears to be decrease remarkably in the initial stage of duration time but gradually afterward and is stabilized at 300 hours∼400 hours of duration time. 2. The increase ratio of permeable flow rate through the geotextile filter due to rising hydraulic head appears to be higher with protected soil having lower comparative content of fine particles, and the effect of rising hydraulic head finds to be higher with that protected soil. 3. The permeable flow rate through the geotextile filter appears to be higher with protected soil having lower content of fine particles and the increase of it trends to be considerable and to be decrease according to the elapse of time. From the fact, the flow rate finds to be more influenced by clogging or blocking with protected soil layer having lower content of fine particles. 4. It seems generally that the thicker the geotextile filter is, the higher the permeable flow rate is, but the decrease ratio of it in the initial stage finds to be lower in the case of thicker geotextile.

A Study on the Application of Standards for Clearance of Metal Waste Generated During the Decommissioning of NPP by Using the RESRAD-RECYCLE

Jong Soon Song,Dong Min Kim,Sang Heon Leε 한국방사성폐기물학회 2016 방사성폐기물학회지 Vol.14 No.4

원자력발전소 해체 시 발생하는 금속폐기물은 폐기물 중에서 많은 비중을 차지하고 있다. 본 연구에서는 국내 자체처분 규제 요건 및 국내 기관별 자체처분현황을 조사하였다. 실제 원자력발전소 해체 시 발생되는 금속폐기물의 자체처분을 위하여 RESRAD-RECYCLE 코드를 이용하였으며 26가지 시나리오에 대한 선량평가를 수행하였다. 평가결과는 원자력발전소 해체 시 자체처분 및 재활용에 관한 사전자료로서 활용가치가 있을 것으로 사료된다. 추후 자체처분을 통한 처분비용 저감효과 연구가 추가로 가능할 것으로 판단된다. The metal waste generated during nuclear power plant decommissioning constitutes a large proportion of the total radioactive waste. This study investigates the current status of domestic and international regulatory requirements for clearance and the clearance experience of domestic institutions. The RESRAD-RECYCLE code was used for analyzing the clearance of the metal wastes generated during actual nuclear power plant decommissioning, and assessment of the exposure dose of twenty-six scenarios was carried out. The evaluation results will be useful in preliminary analysis of clearance and recycling during nuclear power plant decommissioning. As a next step, the effects of reducing disposal costs by clearance can be studied.

Effects of Constituent Amino Acids of Glutathione and Ammonium Sulfate added to Hydroponic Solution on the Synthesis of Glutathione in Lettuce

Kim Ju-Sung,Seo Sang-Gyu,Kim Sun-Hyung,Usui Kenji,Shim Le-Sung The Korean Society of Plant Biotechnology 2005 Plant molecular biology and biotechnology research Vol.7 No.3

The effects of constituent amino acids of glutathione (GSH), glutamate (Glu), cysteine (Cys) and glycine (Gly), on GSH synthesis in lettuce seedlings were examined in this study. The GSH concentration of the seedlings was increased to 5.1-fold and 1.6-fold the concentration of the control in the first leaves and roots, respectively, by simultaneous application of these constituent amino acids (Glu+Cys+Gly) at 100 mg/l to the culture solution for two days. In the first leaves and roots of these seedlings, the concentration of GSH was 180.4 and 14.6 nmole/gFW, and non-essential amino acids including Glu, Cys and Gly occupied 93.2% and 84.0% of the total free amino acids, respectively. Application of Cys greatly increased the concentration of GSH in the roots, and application of 50 mg/l Cys increased it to 26.1-fold the concentration in the control. The activity of GSH synthetase was higher in the leaves than in the roots, whereas the activity of ${\gamma}$-glutamylcysteine synthetase was higher in the roots than in the leaves.

Pharmacokinetic study comparing pure desoxo-narchinol A and nardosinonediol with extracts from <i>Nardostachys jatamansi</i>

Le, Vu Ngoc Han,Zhao, Yan,Cho, Chong Woon,Na, MinKyun,Quan, Khong Trong,Kim, Jang Hoon,Hwang, Sung Yeoun,Kim, Sang Wook,Kim, Kyung Tae,Kang, Jong Seong Elsevier 2018 Journal of chromatography. B, Analytical technolog Vol.1102 No.-

<P><B>Abstract</B></P> <P>Nardostachyos Radix et Rhizoma (NR) is a valuable medicinal herb widely used in Korea, India, and China for the treatment of many diseases. Desoxo-narchinol A (DA) and nardosinonediol (ND) are the two main bioactive compounds belonging to the sesquiterpene group. Desoxo-narchinol A possesses anti-inflammatory activity while ND exhibits anti-depressant and cardioprotective activities. A pharmacokinetic study is important to decide whether the isolated compounds or the NR extract have better pharmacological activity. Hence, we developed an analytical method for studying the pharmacokinetics of DA and ND after oral administration of the pure compounds and herbal extract. An optimized liquid chromatography-mass spectrometry method (LC-MS/MS) with solid-phase extraction (SPE) for sample preparation was developed. A ZORBAX Extend C18 column (2.1 × 50 mm, 3.5 μm) was used under gradient elution with acetonitrile and 0.1% formic acid in water as the mobile phase. Validation experiments assessing accuracy, precision, and stability were satisfactory; the lower limit of quantification was 5 ng/mL. For the pharmacokinetic study, three groups of rats were administrated pure DA, pure ND, or NR extract orally. Concentrations of DA and ND in their plasma were determined by the developed method. Pharmacokinetic parameters, including the time to achieve maximum plasma concentration (<I>T</I> <SUB> <I>max</I> </SUB>) and the area under the plasma concentration curve from time zero to infinity (<I>AUC</I> <SUB>0–∞</SUB>), were compared for the herbal extract and pure compounds. The <I>T</I> <SUB> <I>max</I> </SUB> of the pure compound and the NR extract for DA was 7.50 and 8.33 min, respectively, compared to 5.00 and 5.83 min for the pure compound and the NR extract for ND, respectively. The <I>AUC</I> <SUB>0–∞</SUB> of the pure compound and the NR extract for DA was 156.34 and 133.90 μg min/mL, respectively, and that for the NR extract for ND was 6.42 and 4.15 μg min/mL, respectively. LC-MS/MS was used to determine DA and ND in rat plasma. The pharmacokinetic profile of each pure compound and those in the extract were characterized and compared.</P>

Evaluation of a mitochondrial voltage sensor, (18F-fluoropentyl)triphenylphosphonium cation, in a rat myocardial infarction model.

Kim, Dong-Yeon,Kim, Hyeon-Sik,Le, Uyenchi Nguyen,Jiang, Sheng Nan,Kim, Hee-Jung,Lee, Kyo-Chul,Woo, Sang-Keun,Chung, Jihwa,Kim, Hyung-Seok,Bom, Hee-Seung,Yu, Kook-Hyun,Min, Jung-Joon Society of Nuclear Medicine 2012 The Journal of nuclear medicine Vol.53 No.11

<P>Radiolabeled lipophilic cationic compounds, such as (18)F-labeled phosphonium salt, accumulate in the mitochondria through a negative inner transmembrane potential. The purpose of this study was to develop and evaluate ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) as a myocardial PET agent.</P>

Single and 28-day Repeated Dose Toxicity Studies of Coumarin in the Minipig

Sang-Koo Le,Youn-Sang Kweon,Chester D Solis,Shin-Joung Rho,Tae-Ho Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3

The minipig is becoming increasingly used as a test animal both in pharmacological and toxicological studies of new drugs. Coumarin is a natural product which presents in foodstuffs and use in clinical medicine. However, coumarin shows marked toxicity in some species of animals and species differences in toxicity depend on metabolic activation of coumarin. Enzymatic process of coumarin metabolism in minipig is similar to that of human. This study was conducted to compare the toxicity data of coumarin in the minipig with other animal species and to confirm the usefulness of minipig in the regulatory toxicity studies. Single and 28 day repeated-dose toxicity studies of coumarin were conducted using minipigs. In the single dose toxicity study, maximum tolerated dose (MTD) value of coumarin was determined to be a 200 ㎎/㎏/day and liver was decided as a target organ. Based on the single dose toxicity study, twenty-eight day repeated dose study was conducted at dose levels of 0, 50, 100, and 200 ㎎/㎏/day. Middle and high dose minipigs showed clinical signs and pathological lesions in the liver and kidneys. Low dose group minipigs did not display any clinical signs and functional abnormalities considered to have relation with coumarin treatment, but showed significant increase of liver weight. From the above findings, no observable effect level (NOEL) of minipig was determined to be below 50 ㎎/㎏/day.

Hexagonal Lattice Co/Pd Multilayer Nanodot Arrays Fabricated by Self-assembled Nanosphere Lithography

Le Van Phong,Vo Thanh Son,Sarah Kim,Seung-Man Yang,Sang-Hyun Kim,Sung-Chun Shin,CheolGi Kim,Jong-Ryul Jeong 한국자기학회 2009 한국자기학회 학술연구발표회 논문개요집 Vol.2009 No.5

Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling

Kim, Hyoung Kyu,Jeon, Jouhyun,Song, In-Sung,Heo, Hae Jin,Jeong, Seung Hun,Long, Le Thanh,Thu, Vu Thi,Ko, Tae Hee,Kim, Min,Kim, Nari,Lee, Sung Ryul,Yang, Jae-Seong,Kang, Mi Seon,Ahn, Jung-Mo,Cho, Je-Yo Elsevier 2019 Biochimica et biophysica acta Vol.1865 No.11

<P><B>Abstract</B></P> <P>Tetrahydrobiopterin (BH4) shows therapeutic potential as an endogenous target in cardiovascular diseases. Although it is involved in cardiovascular metabolism and mitochondrial biology, its mechanisms of action are unclear. We investigated how BH4 regulates cardiovascular metabolism using an unbiased multiple proteomics approach with a sepiapterin reductase knock-out (<I>Spr</I> <SUP>−/−</SUP>) mouse as a model of BH4 deficiency. <I>Spr</I> <SUP>−/−</SUP> mice exhibited a shortened life span, cardiac contractile dysfunction, and morphological changes. Multiple proteomics and systems-based data-integrative analyses showed that BH4 deficiency altered cardiac mitochondrial oxidative phosphorylation. Along with decreased transcription of major mitochondrial biogenesis regulatory genes, including <I>Ppargc1a</I>, <I>Ppara</I>, <I>Esrra</I>, and <I>Tfam</I>, <I>Spr</I> <SUP>−/−</SUP> mice exhibited lower mitochondrial mass and severe oxidative phosphorylation defects. Exogenous BH4 supplementation, but not nitric oxide supplementation or inhibition, rescued these cardiac and mitochondrial defects. BH4 supplementation also recovered mRNA and protein levels of PGC1α and its target proteins involved in mitochondrial biogenesis (mtTFA and ERRα), antioxidation (Prx3 and SOD2), and fatty acid utilization (CD36 and CPTI-M) in <I>Spr</I> <SUP>−/−</SUP> hearts. These results indicate that BH4-activated transcription of PGC1α regulates cardiac energy metabolism independently of nitric oxide and suggests that BH4 has therapeutic potential for cardiovascular diseases involving mitochondrial dysfunction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> BH4 deficiency impairs mitochondrial and cardiac function. </LI> <LI> BH4 regulates PGC1α, ERRα, and mtTFA transcription. </LI> <LI> BH4 regulates proteins related to mitochondrial antioxidation and fatty acid utilization. </LI> <LI> BH4 is essential for mitochondrial biogenesis and oxidative phosphorylation. </LI> <LI> BH4 has therapeutic potential for cardiovascular diseases involving mitochondrial dysfunction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Coaxial Fiber Supercapacitor Using All-Carbon Material Electrodes

Le, Viet Thong,Kim, Heetae,Ghosh, Arunabha,Kim, Jaesu,Chang, Jian,Vu, Quoc An,Pham, Duy Tho,Lee, Ju-Hyuck,Kim, Sang-Woo,Lee, Young Hee American Chemical Society 2013 ACS NANO Vol.7 No.7

<P>We report a coaxial fiber supercapacitor, which consists of carbon microfiber bundles coated with multiwalled carbon nanotubes as a core electrode and carbon nanofiber paper as an outer electrode. The ratio of electrode volumes was determined by a half-cell test of each electrode. The capacitance reached 6.3 mF cm<SUP>–1</SUP> (86.8 mF cm<SUP>–2</SUP>) at a core electrode diameter of 230 μm and the measured energy density was 0.7 μWh cm<SUP>–1</SUP> (9.8 μWh cm<SUP>–2</SUP>) at a power density of 13.7 μW cm<SUP>–1</SUP> (189.4 μW cm<SUP>–2</SUP>), which were much higher than the previous reports. The change in the cyclic voltammetry characteristics was negligible at 180° bending, with excellent cycling performance. The high capacitance, high energy density, and power density of the coaxial fiber supercapacitor are attributed to not only high effective surface area due to its coaxial structure and bundle of the core electrode, but also all-carbon materials electrodes which have high conductivity. Our coaxial fiber supercapacitor can promote the development of textile electronics in near future.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-7/nn4016345/production/images/medium/nn-2013-016345_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn4016345'>ACS Electronic Supporting Info</A></P>