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4년생 우리나라 사시나무 클론의 수고유전력 (樹高遺傳力) 및 개량효과
노의래(Eui Rae Noh),이성규(Soung Kyu Lee),구영본(Yeong Bon Koo),변광옥(Kwang Ok Byun) 한국산림과학회 1994 한국산림과학회지 Vol.83 No.2
The broad sense heritability of height of clonal means was estimated from 18 clones out of 25 clones growing at four different sites, and it showed considerably high heritability of H²_(CM)=0.883. Therefore if we select the best one clone(5% selection), the genetic gain of 35.3% which is equal to 1.02m in height is expected to attain. If we select the best two clones(10% selection), the genetic gain will be 25.6 which is equal to 0.74m in height. Because the trees are only 4-year-old, it is expected to show higher genetic gain than the current gain when the trees reach to the age of final selection.
지의규(Eui Kyu Chie),김규보(Kyubo Kim),최진화(Jin-Hwa Choi),장나영(Na-Young Jang),한원식(Wonshik Han),노동영(Dong-Young Noh),임석아(Seock-Ah Im),김태유(Tae-You Kim),방영주(Yung-Jue Bang),하성환(Sung Whan Ha) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.3
목 적: 조기유방암의 치료에 있어 과거에는 유방 전적출술이 주된 치료였으나 현재는 유방보존술이 표준 치료방법 으로 정립되었다. 저자들은 서울대학교병원에서 유방보존수술 및 방사선치료를 받은 환자의 임상적 특성을 조사 하고 치료결과 및 예후인자를 분석하고자 하였다. 대상 및 방법: 1992년 2월부터 2002년 1월까지 침윤성 유방암으로 유방보존수술 및 수술 후 방사선치료를 받은 424명을 대상으로 후향적으로 분석하였다. 대부분의 환자는 사분절제술 및 액와림프절 청소술을 시행 받았다(396명, 93.4%). 302명이 T1이었고 122명은 T2 병기였으며, 림프절 전이는 107명에서 확인되었다. 방사선치료는 전체 유방에 28회에 걸쳐 50.4 Gy를 조사한 후 종양이 있었던 부위에 10 Gy의 추가조사를 실시하였다. 영역림프절 조사는 57명에서 시행되었다. 항암화학요법은 231명에서 시행되었으며, 그 중 170명이 cyclophosphamide, methotrexate 및 5-fluorouracil을 투여 받았다. 중앙추적기간은 64개월이었다. 결 과: 전체 환자의 5년 국소제어율은 95.6%이었다. 추적관찰 중 15명의 환자에서 국소재발이 확인되었다. 5년 생존율은 93.1%이었고, 병기에 따른 5년 생존율은 I기 94.8%, IIA기 95.0%, IIB기 91.1%, IIIA기 75.9%, IIIC기 57.1% 이었다. 5년 무병생존율은 88.7%이었고, 병기별로는 I기 93.1%, IIA기 89.4%, IIB기 82.8%, IIIA기 62.0%, IIIC기 28.6%이었다. 예후인자 분석에서는 N 병기(p=0.0483)가 생존율에, 연령(p=0.0284)과 N 병기(p=0.0001)가 무병생존율에 각각 유의한 영향을 보였다. 결 론: 조기유방암에서 유방보존수술 및 수술 후 방사선치료는 우수한 국소제어율 및 생존율을 기대할 수 있는 치료법임을 확인할 수 있었다. Purpose: We analyzed the treatment outcomes and prognostic factors of breast conserving surgery, followed by postoperative radiotherapy. Materials and Methods: A total of 424 breast cancer patients treated with breast conserving surgery and postoperative radiotherapy between February 1992 and January 2001 were retrospectively analyzed. A quadrantectomy and axillary lymph node dissection was performed in 396 patients. A total of 302 patients had T1 disease, and 122 patients had T2 disease. Lymph node involvement was confirmed in 107 patients. Whole breast irradiation was administered at up to 50.4 Gy in 28 fractions, followed by a 10 Gy boost in 5 fractions to the tumor bed. In addition, 57 patients underwent regional lymph node irradiation. Moreover, chemotherapy was administered in 231 patients. A regimen consisting of cyclophosphamide, methotrexate, and 5-fluorouracil was most frequently used with 170 patients. The median follow-up time was 64 months. Results: The 5-year local control rate was 95.6%. During the follow-up period, local tumor recurrence was observed in 15 patients. The 5-year overall and disease-free survival rates were 93.1% and 88.7%, respectively. The 5-year overall survival rates, by stage, were 94.8% for stage I, 95.0% for stage IIA, 91.1% for stage IIB, 75.9% for stage IIIA, and 57.1% for stage IIIC. As for disease-free survival, the corresponding figures, by stage (in the same order), were 93.1%, 89.4%, 82.8%, 62.0%, and 28.6%, respectively. The advanced N stage (p=0.0483) was found to be a significant prognostic factor in predicting poor overall survival, while the N stage (p=0.0284) and age at diagnosis (p=0.0001) were associated with disease-free survival. Conclusion: This study has shown that breast conserving surgery and postoperative radiotherapy for early breast cancer results was excellent for local control and survival.
miR-526b targets 3′ UTR of <i>MMP1</i> mRNA
Kim, Kyu-Han,Jung, Ji-Yong,Son, Eui Dong,Shin, Dong Wook,Noh, Minsoo,Lee, Tae Ryong Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.8
<P>Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of <I>MMP1</I> mRNA is downregulated by the overexpression of miR-526b which is a member of chromosome 19 microRNA cluster (C19MC). Our analysis using reporter constructs containing the 3′ untranslated region (3′ UTR) of <I>MMP1</I> and its mutant form showed that the region from 377–383 in the 3′ UTR of <I>MMP1</I> is critical for targeting by miR-526b. In addition, the expression pattern of miR-526b and <I>MMP1</I> mRNA showed reverse relation between adult dermal and neonatal fibroblasts. We show for the first time that miR-526b, an miRNA belonging to C19MC, can target the 377–383 region of the <I>MMP1</I> 3′ UTR.</P>
Study of the proton-beam irradiation effects on TlH<sub>2</sub>PO<sub>4</sub>
Kim, Se Hun,Lee, Kyu Won,Jang, Jae Won,Lee, Cheol Eui,Lee, K-S.,Noh, S.J. Elsevier 2006 CURRENT APPLIED PHYSICS Vol.6 No.2
<P><B>Abstract</B></P><P>The H<SUP>+</SUP>-ion treatment effect on TlH<SUB>2</SUB>PO<SUB>4</SUB>, a KH<SUB>2</SUB>PO<SUB>4</SUB> (KDP)-type ferroelectrics, was studied by nuclear magnetic resonance (NMR) and AC dielectric constant measurements. A sample of TlH<SUB>2</SUB>PO<SUB>4</SUB> was irradiated by 1-MeV H<SUP>+</SUP> ion beams to a dose of 10<SUP>15</SUP>ions/cm<SUP>2</SUP>. The change in the NMR relaxation behaviors after the irradiation was attributed that in the hydrogen-bond geometry, presumably affecting the order–disorder proton dynamics. A prominent decrease in the dielectric constant was also observed after the irradiation. The macroscopic and microscopic changes due to the irradiation are discussed in the light of the proton dynamics.</P>
Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells
Heo, Sook-Kyoung,Noh, Eui-Kyu,Kim, Jeong Yi,Jegal, SungHoo,Jeong, Yookyung,Cheon, Jaekyung,Koh, SuJin,Baek, Jin Ho,Min, Young Joo,Choi, Yunsuk,Jo, Jae-Cheol Elsevier 2018 Phytomedicine Vol.49 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid), a natural anthraquinone derivative, is a traditional Chinese herb that has been used as a medication in many Asian countries. It has been used as a laxative and stomach drug for a long time in both China and Korea. It is well-known to have many pharmacological activities, such as anti-cancer, anti-bacterial, anti-fungal, anti-oxidant, anti-atherogenic, anti-angiogenic, anti-fibrosis, anti-inflammatory, hepatoprotective, and nephroprotective properties. However, little is known about how rhein may affect the differentiation activities in acute promyelocytic leukemia (APL) cells.</P> <P><B>Purpose</B></P> <P>The present study was designed to examine the anti-leukemic effects of rhein against APL cells and to explore the underlying mechanism.</P> <P><B>Methods</B></P> <P>Cell viability was investigated by MTS assay. To examine the differentiation activities in APL cells, the cell surface molecules (CD11b, CD14, CCR1 and CCR2), phagocytosis, reactive oxygen species (ROS) were determined by flow cytometry. Also, induction of caspase-3 activity and reduction of mitochondrial membrane potential (MMP) were determined by flow cytometry. RNA and protein expressions were determined by qRT-PCR and western blotting, respectively.</P> <P><B>Results</B></P> <P>In this study we assessed the role of rhein in treating APL. Interestingly, rhein potentiated all-trans retinoic acid (ATRA)-induced macrophage differentiation in NB4 cells by inducing changes in morphology, expression of the differentiation markers CD11b and CD14, ROS production, phagocytic activity, and expression of CCR1 and CCR2. Signaling through CD11b was found to be dependent on ERK activation. Additionally, rhein induced APL cell death by activating apoptosis and suppressing the mTOR pathway.</P> <P><B>Conclusion</B></P> <P>Therefore, we suggest that a combination of rhein and ATRA carries strong therapeutic potential through the beneficial differentiation of APL cells. Moreover, rhein causes cell death via the activation of apoptosis and suppression of survival signals in APL cells. In combination with the ability of rhein to promote functional macrophage differentiation in APL, these properties suggest that a combined treatment of rhein and ATRA has great potential as an anti-leukemic therapy for APL.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>