http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica
Ming Shan Zheng,Jong Keun Son,Gao Li,Ying Li,서창섭,Yeun-Kyung Lee,Jun-Sub Jung,송동근,Hong-Beom Bae,Sang-Hyun Kwak,Hyun-Wook Chang,김재룡 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
Zheng, Ming-Shan,Lee, Yeun-Kyung,Li, Ying,HwangBo, Kyoung,Lee, Chong-Soon,Kim, Jae-Ryong,Lee, Sunny Kyung-Seon,Chang, Hyun-Wook,Son, Jong-Keun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9
Twenty five compounds including ten triterpenes (1-3, 5-11), six flavonoids (12-15, 24, 25), five lignans (17, 18, 21-23), two butenyl clohexnone glycosides (19-20), one fructofuranoside (16) and one fatty acid (4) were isolated from the roots of Ulmus davidiana var. japonica. The structures of those compounds were identified by comparing their physicochemical and spectral data with those of published in literatures. All the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 4 and 19 showed more potent inhibitory acitivities ($IC_{50}$: 39 and 19 ${\mu}M$, respectively) than camptothecin, as the positive control ($IC_{50}$: 46 ${\mu}M$) against topoisomerase I. Compounds, 4, 10, 12, 19, 24 and 25 showed strong inhibitory activities toward DNA topoisomerase II ($IC_{50}$: 0.1, 0.52, 0.47, 0.42, 0.17 ${\mu}M$ and 17 nM, respectively), which were more potent than that of etoposide as positive control ($IC_{50}$: 20 ${\mu}M$). In A549 cell line, 5 and 6 showed cytotoxicities ($IC_{50}$: 4 ${\mu}M$ and 3 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin as positive control: 10.3 ${\mu}M$). In the HepG2 cell line, 3, 5 and 7 showed cytotoxicity ($IC_{50}$: 4, 3 and 4 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 0.3 ${\mu}M$). Compounds 6, 12 and 23 showed cytotoxicities in the HT-29 cell line ($IC_{50}$: 19, 19 and 15 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 2 ${\mu}M$).
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Zheng, Ming Shan,Hwang, Nam-Kyung,Kim, Do-Hoon,Moon, Tae-Chul,Son, Jong-Keun,Chag, Hyeun-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, ${\alpha}-spinaterol$ (1), ursolic acid (2), ergosterol peroxide (3), ${\alpha}-spinaterol$ glucoside (4), 2-methoxy-9-${\beta}$-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with $IC_{50}$ values of 21.04 ${\mu}M$, 42.30 ${\mu}M$, 32.82 ${\mu}M$, and 17.18 ${\mu}M$, respectively.
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Ming Shan Zheng,Do Hoon Kim,Nam Kyung Hwang,Tae Chul Moon,Jong Keun Son,장현욱 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, α-spinaterol (1), ursolic acid (2), ergosterol peroxide (3), α- spinaterol glucoside (4), 2-methoxy-9-β-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5- LOX activity with IC50 values of 21.04 µM, 42.30 µM, 32.82 µM, and 17.18 µM, respectively.
A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.
Ming-Lu Xu,Ming Shan Zheng,Yeon-Kyong Lee,문동철,Chong-Soon Lee,우미희,정병선,Eung Seok Lee,장영동,장현욱,이승호,손종근 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Phenolic constituents from Parakmeria yunnanensis and their anti-HIV-1 activity
Shan-Zhai Shang,Huan Chen,Cheng-Qin Liang,Zhong-Hua Gao,Xue Du,Rui-Rui Wang,Yi-Ming Shi,Yong-Tang Zheng,Wei-Lie Xiao,Han Dong Sun 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10
Three new phenolic compounds, yunnanensinsA–C (1–3), together with fourteen known ones (4–17),were isolated from the leaves and stems of Parakmeriayunnanensis. The structures of new compounds wereestablished on the basis of extensive spectroscopic analyses. Several compounds showed weak anti-HIV-1 activity.
연구논문(硏究論文)(재록(再錄)) : 의약화학 ; 하수오로부터 신규 Stilbene Glucoside의 분리 및 구조결정
허명록 ( Ming Lu Xu ),정명선 ( Ming Shan Zheng ),이연경 ( Yeon Kyong Lee ),문동철 ( Dong Cheol Moon ),이종순 ( Chong Soon Lee ),우미희 ( Mi Hee Woo ),장영동 ( Yurng Dong Jahng ),장현욱 ( Hyeun Wook Chang ),이승호 ( Seung Ho Lee 영남대학교 약품개발연구소 2007 영남대학교 약품개발연구소 연구업적집 Vol.17 No.-
A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.
Xu, Ming-Lu,Zheng, Ming Shan,Lee, Yeon-Kyong,Moon, Dong-Cheol,Lee, Chong-Soon,Woo, Mi-Hee,Jeong, Byeong-Seon,Lee, Eung-Seok,Jahng, Yurng-Dong,Chang, Hyeun-Wook,Lee, Seung-Ho,Son, Jong-Keun The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.11
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Song, Ming-Xia,Deng, Xian-Qing,Wei, Zhi-Yu,Zheng, Chang-Ji,Wu, Yan,An, Chang-Shan,Piao, Hu-Ri Shaheed Beheshti University of Medical Sciences 2015 Iranian journal of pharmaceutical research Vol.14 No.1
<P>The microbial resistance has become a global hazard with the irrational use of antibiotics. Infection of drug-resistant bacteria seriously threatens human health. Currently, there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (<I>S</I><I>,Z</I>)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)pentanoic acids via a Knoevenagel condensation were synthesized and evaluated for their antibacterial activity <I>in</I><I>-</I><I>vitro</I>. The synthesized compounds were characterized by IR, <SUP>1</SUP>H NMR and MS. The antibacterial test<I> in</I><I>-</I><I>vitro</I> showed that all of the synthesized compounds had good antibacterial activity against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with minimum inhibitory concentration (MIC) values in the range of 2–4 µg/mL. Especially compounds 4c, 4d, 4e and 4f were the most potent, with MIC values of 2 µg/mL against four multidrug-resistant Gram-positive bacterial strains.</P>