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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
Ming Xie,Jin-Long Liang,Han-Dong Huang,Mai-Jian Wang,Tao Zhang,Xue-Feng Yang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose Nonylphenol (NP) is an endocrine disruptor found in products such as cleaners, plastics, and detergents. It exerts actions similar to endogenous 17-estradiol (E2) and is reported to influence various cancers. However, its role in colon cancer remains elusive. Materials and Methods Colon cancer cell lines COLO 205 and SW480 were employed in our study. The cells were treated with NP or E2 followed by measurement of apoptosis and proliferation using flow cytometry and MTT assays, respectively. G protein–coupled estrogen receptor 30 (GPR30) expression was visualized using immunofluorescence and Western blot. To investigate the underlying mechanism, the expression levels of GPR30, p-protein kinase A (PKA), c-myc, cyclin D1, and ERK1/2 were analyzed using Western blot. Meanwhile, the GPR30 antagonist G15 was utilized to validate the role of GPR30 in colon cancer progression. Finally, the effect of a GPR30 inhibitor on tumor growth was determined in vivo using tumor xenograft mouse models. Results NP facilitated the proliferation of colon cancer cells and induced apoptosis failure in vitro. Western blot revealed increased GPR30 expression levels in response to NP treatment. Cyclin D1, p-PKA, c-myc, and proliferating cell nuclear antigen, proteins that regulate the cell cycle, were all upregulated by NP, and NP-mediated ERK1/2 activation and subsequent cell proliferation were abrogated by the GPR30 inhibitor G15. Moreover, colon cancer mice that received G15 administration demonstrated impaired tumor growth in vivo. Conclusion Low dose NP promotes the growth of colon tumors through GPR30-mediated activation of ERK1/2 signaling.
Ming Yang,Wei-feng SHI 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.11
In view of fault diagnosis of the ship generator , the paper proposes improved fault diagnosis method of ship generator ,which is Optimized Neural Network based on Multi-population Chaos Genetic Algorithm. The results prove that the method effectively solves low precision,slow constringency and local minimum of neural network and improves global search ability, optimizes the rate and precision of fault diagnosis. The method has a certain application prospect for the ship power system generator fault diagnosis.
Yang Gao,Ming-Guang Feng,Sheng-Hua Ying 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1
Oxalic acid is used as a functional molecule by most filamentous fungi, and produced via cytoplasmic pathwayand mitochondrial pathway. The cytoplasmic pathway of oxalate production from oxaloacetate is a one-stepreaction catalyzed by oxaloacetate hydrolase. The entomopathogenic fungus Beauveria bassiana contains a uniqueoxaloacetate hydrolase gene (BbOAH). The role of cytoplasmic pathway of oxalate production in B. bassianadevelopment and virulence was studied via construction of a targeted gene disruption mutant of BbOAH. Disruption of BbOAH resulted in a slight decrease (~30%) in oxalate production, but has no significant influenceon fungal growth. The mutant strain displayed a significant delay at early stage of conidial development, and asignificant defect in dimorphic transition. Additionally, bioassay using the greater waxmoth as host indicated aslight (~20%) decrease in mortality caused by the gene disruption strain. The phenotypic defects of the ΔBbOAHstrain could be restored by ectopic integration of BbOAH. Our findings indicate that BbOAH gene connects thecytoplasmic route of oxalate production to fungal development and virulence, although the cytoplasmic route isnot indispensable for oxalate production in B. bassiana.
Large eddy simulation of blockage effects in the assessment of wind effects on tall buildings
Yang Gao,Ming Gu,Yong Quan,Chengdong Feng 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.6
The blockage effect on the aerodynamic characteristics of tall buildings is a fundamental issue in wind tunnel test but has rarely been addressed. To evaluate the blockage effects on the aerodynamic forces on a square tall building and flow field peripherally, large eddy simulations (LES) were performed on a 3D square cylinder with an aspect ratio of 6:1 under the uniform smooth inflow and turbulent atmospheric boundary layer (ABL) inflow generated by the narrowband synthesis random flow generator (NSRFG). First, a basic case at a blockage ratio (BR) of 0.8% was conducted to validate the adopted numerical methodology. Subsequently, simulations were systematically performed at 6 different BRs. The simulation results were compared in detail to illustrate the differences induced by the blockage, and the mechanism of the blockage effects under turbulent inflow was emphatically analysed. The results reveal that the pressure coefficients, the aerodynamic forces, and the Strouhal number increase monotonically with BRs. Additionally, the increase of BR leads to more coherence of the turbulent structures and the higher intensity of the vortices in the vicinity of the building. Moreover, the blockage effects on the aerodynamic forces and flow field are more significant under smooth inflow than those under turbulent inflow.
Dysregulated Fatty Acid Metabolism in Hepatocellular Carcinoma
( Ming-da Wang ),( Jun Han ),( Hao Xing ),( Han Zhang ),( Zheng Wang ),( Zhen-li Li ),( Liang Lei ),( Chao Li ),( Feng Shen ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Studies are urgently needed on it molecular pathogenesis and biological characteristics of hepatocellular carcinoma (HCC). Dysregulation of fatty acid (FA) metabolism, in which aberrant activation of oncogenic signaling pathways alters the expression and activity of lipid-metabolizing enzymes, is an emerging hallmark of cancer cells, and it may be involved in HCC development and progression. Methods: We summarize the characteristics of FA metabolism in HCC, focusing on the pathways of FA synthesis, oxidation, uptake and transport. We also provide a brief review of the relationship between NAFLD and HCC development. Results: The current review summarizes the dysregulated FA metabolism in HCC and pathways through which this dysregulation may regulate HCC survival and growth. Aberrant activation of oncogenic signaling pathways regulates the expression and activity of lipid-metabolizing enzymes, thus reprogramming FA metabolism to promote HCC development and progression. Intracellular FAs are required for biosynthesis of most biological membrane lipids and signaling molecules, and are also used to provide energy to support HCCs survival and proliferation, when necessary, through β-oxidation process. HCC cells can employ appropriate metabolic pathways as different situation demands. Intrahepatic cholangiocarcinoma (ICC) and HCC exhibits differential requirement for de novo lipogenesis and distinct response to therapeutic approaches focusing on inhibition of exogenous FA uptake. Non-alcoholic fatty liver disease related obesity and diabetes have increasingly emerged as two major factors responsible for the rise in prevalent of HCC. Conclusions: Our understanding of dysregulated FA metabolism and associated signaling pathways may contribute to the development of novel and efficient anti-tumor approaches for patients with HCC.
Feng, Chao,Song, Ruixi,Sun, Guohui,Kong, Ming,Bao, Zixian,Li, Yang,Cheng, Xiaojie,Cha, Dongsu,Park, Hyunjin,Chen, Xiguang American Chemical Society 2014 Biomacromolecules Vol.15 No.3
<P>We have designed and evaluated coacervate microcapsules-immobilized multilayer sodium alginate beads (CMs-M-ALG-Beads) for oral drug delivery. The CMs-M-ALG-Beads were prepared by immobilization of doxorubicin hydrochloride (DOX) loaded chitosan/carboxymethyl coacervate microcapsules (DOX:CS/CMCS-CMs) in the core and layers of the multilayer sodium alginate beads. The obtained CMs-M-ALG-beads exhibited layer-by-layer structure and rough surface with many nanoscale particles. The swelling characteristic and drug release results indicated that 4-layer CMs-M-ALG-Beads possessed favorable gastric acid tolerance (the swelling rate <5%, the cumulative drug release rate <3.8%). In small intestine, the intact DOX:CS/CMCS-CMs were able to rapidly release from CMs-M-ALG-Beads with the dissolution of ALG matrix. Ex vivo intestinal mucoadhesive and permeation showed that CMs-M-ALG-Beads exhibited continued growth for <I>P</I><SUB>app</SUB> values of DOX, which was 1.07–1.15 folds and 1.28–1.38 folds higher than DOX:CS:CMCS-CMs in rat jejunum and ileum, respectively, demonstrating that CMs-M-ALG-Beads were able to enhance the absorption of DOX by controlled releasing DOX:CS/CMCS-CMs and prolonging the contact time between the DOX:CS/CMCS-CMs and small intestinal mucosa.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2014/bomaf6.2014.15.issue-3/bm401890x/production/images/medium/bm-2013-01890x_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm401890x'>ACS Electronic Supporting Info</A></P>