수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향

김미경 ( Kim¸ Mikyung ),한혜숙 ( Han¸ Hyesook ) 한국수학교육학회 2021 수학교육논문집 Vol.35 No.3

본 연구는 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향을 파악하기 위하여 대학 연계 자유학기제 융합수학탐구 수업에 신청한 49명의 학생들을 대상으로 단일집단 사전-사후 검사 설계를 통해 한 학기동안 이루어졌다. 본 연구의 주요 결과는 다음과 같다. 첫째, 사전, 사후 수학적 모델링 능력 검사 결과에 의하면, 사전 검사에 비해서 사후 수학적 모델링 검사의 평균 점수가 향상되었고, 사전, 사후 검사 간에 통계적으로 유의미한 차이가 있는 것으로 나타나 본 연구에서 제공한 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력을 향상시키는데 긍정적인 영향을 준다는 것을 확인하였다. 둘째, 각 문항별 분석 결과에 의하면 STEAM 수업 경험은 학생들의 창의적 사고 및 열린 사고를 요구하는 개방성이 높은 수학적 모델링 문항의 해결에 더욱 효과적인 것으로 나타났다. 셋째, 하위문항별 학생 응답 내용 분석 결과에 의하면, STEAM 수업 경험이 특히 학생들의 수학적 모델 구성 및 결과에 대한 타당성 검토 과정을 더욱 활성화시킨 것으로 나타났다. This study was conducted for one semester through one group pretest-posttest design with 49 first-year middle school students to explore the effects of mathematics-centered STEAM class experiences on students’ mathematical modeling abilities. The main results of this study are as follows: First, the results of the pre and post-mathematical modeling ability tests showed that the average score of posttest was improved compared to the pretest, and that the experiences of mathematics-centered STEAM classes provided in this study had a positive effect on improving the mathematical modeling ability of first-year middle school students. Second, STEAM classes were more effective in solving mathematical modeling problems that require students’ creative and divergent thinking. Third, the content analysis of student responses for each subquestion showed that STEAM classes were especially more helpful in activating students' mathematical model construction and validating steps.

Effect of fermented porcine placenta on physical fatigue in mice

Kim, Hee-Yun,Han, Na-Ra,Kim, Na-Rae,Lee, Mikyung,Kim, Jongbae,Kim, Chang-Ju,Jeong, Hyun-Ja,Kim, Hyung-Min SAGE Publications 2016 Experimental biology and medicine Vol.241 No.17

<P>The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu. In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain. Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-kappa B, interleukin (IL)-6, IL-1, and IL-4 through blockade of caspase-1/nuclear factor-B pathway in stimulated splenocytes. In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue.</P>

A Profile of Serum Mineral Parameters in Korean CKD Patients on Maintenance Hemodialysis

( Gheunho Kim ),( Bumsoon Choi ),( Daeryong Cha ),( Eunah Hwang ),( Hyungwuk Kim ),( Jaehyun Chang ),( Joohak Lee ),( Joongkyung Kim ),( Kwonwook Joo ),( Mikyung Kim ),( Sangchoel Lee ),( Sangwoong Ha 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double‐blind randomized controlled trial ( INICOM study)

Lim, Soo,Han, Kyung Ah,Yu, JaeMyung,Chamnan, Parinya,Kim, Eun Sook,Yoon, Kun‐,Ho,Kwon, Sam,Moon, Min Kyong,Lee, Kwan Woo,Kim, Dong‐,Jun,Kim, Mikyung,Wongtanate, Manaj,Kim, Eun Young,Kim, S Blackwell Publishing Ltd 2017 Diabetes, obesity & metabolism Vol.19 No.1

<P><B>Background</B></P><P>Gemigliptin is a new dipeptidyl peptidase‐IV inhibitor. We investigated the efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes (T2D).</P><P><B>Methods</B></P><P>A total of 433 T2D patients with a glycosylated haemoglobin (HbA1c) level of 7.5% to 11.0% and a fasting plasma glucose (FPG) concentration <270 mg/dL were randomly assigned to 3 groups: (1) gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd (titrated individually), (2) gemigliptin 50 mg qd, or (3) metformin 1000 to 2000 mg qd. The primary end‐point was the change in HbA1c level after 24 weeks. Secondary end‐points were the changes in FPG, insulin, proinsulin and C‐peptide levels. The percentages of responders who achieved an HbA1c level <7% (or <6.5%) were compared between treatment groups.</P><P><B>Results</B></P><P>Baseline HbA1c levels were 8.7% in all groups. The mean changes in HbA1c level from baseline to week 24 were −2.06%, −1.24% and −1.47% in the combination, gemigliptin monotherapy and metformin monotherapy groups, respectively. The 95% confidence intervals for between‐group differences in HbA1c changes were −1.02 to −0.63 in the combination group vs the gemigliptin group and −0.82 to −0.41 vs the metformin group, which confirmed the superiority of combination therapy. A significantly higher percentage of patients in the combination therapy group reached the target HbA1c level <7% (or <6.5%) compared with the monotherapy groups. No severe side effects were observed.</P><P><B>Conclusions</B></P><P>In T2D patients, the initial combination of gemigliptin and metformin had superior efficacy without safety concerns compared with monotherapy with either drug.</P>

Christian Perspective and Education for Children from Different Cultures

Mikyung Kim CHONGSHIN UNIVERSITY 2010 CHONGSHIN REVIEW Vol.15 No.-

Rheological properties and thermal degradation behaviors of sonochemically treated polycarbonate/polysiloxanes blends

Mikyung Choi,Yubin Kim,Jihye Kim,Hyungsu Kim 한국유변학회 2008 Korea-Australia rheology journal Vol.20 No.4

Two polysiloxanes having different chemical structures were blended with polycarbonate (PC) under ultrasonic irradiation in solution. The polysiloxanes used were poly(methylphenyl siloxane) and vinylterminated poly(dimethyl siloxane). It was of primary interest to investigate the effect of polysiloxane structure on the rheological properties of PC/polysiloxane blends. It was found that a small amount (1.5 phr) of polysiloxanes greatly altered the melt viscosities and elasticity of PC. In particular, incorporation of poly(methylphenylsiloxane) led to a notable increase in elasticity with greater shear sensitivity of PC. The observed rheological behaviors of PC/polysiloxane blends were partly explained in conjunction with the tendencies found in ultrasonic degradation of polysiloxanes. Thermal stability and morphology in sonicated blends of PC/polysiloxane blends were also discussed.

The Protein Kinase 2 Inhibitor CX-4945 Induces Autophagy in Human Cancer Cell Lines

Kim, Jiyeon,Park, Mikyung,Ryu, Byung Jun,Kim, Seong Hwan Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

Autophagy is a self-digestion process in which intracellular structures are degraded in response to stress. Notably, prolonged autophagy leads to cell death. In this study, we investigated whether CX-4945, an orally available protein kinase 2 (CK2) inhibitor, induces autophagic cell death in human cervical cancer-derived HeLa cells and in human prostate cancer-derived LNCaP cells. CX-4945 treatment of both cell lines resulted in the formation of autophagosomes, in the conversion of microtubule-associated protein 1 light chain 3 (LC3), and in down-regulation of the Akt-mammalian target of rapamycin (mTOR)-p70 ribosomal protein S6 kinase (S6K) signaling cascade. Thus, pharmacologic inhibition of CK2 by CX-4945 induced autophagic cell death in human cancer cells by down-regulating Akt-mTOR-S6K. These results suggest that autophagy-inducing agents have potential as anti-cancer drugs.

Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2

Kim, Mikyung,Pena, June Bryan de la,Cheong, Jae Hoon,Kim, Hee Jin The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.

Revisiting the SINIS Junction via a Scattering Matrix Analysis

Mikyung Kim,문경순 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3

Based on the Bogoliubov de Gennes equations, we have studied the SINIS junction made of normal metal sandwiched between two superconductors. The thin insulating layers are deposited between superconductors and normal metal, forming a tunnelling barrier that can be modelled as a delta-function potential with variable height. We calculate the energy spectrum of the multiple Andreev reflected bound states by using the scattering matrix approach, and the role of branch-crossing scattering is investigated.

Effects of Abdominal Isolation and 20-Hydroxyecdysone During Development of Bombyx mori Ventral Nerve Cord

KIM, Mikyung,YUN, Chi-Young,KIM, Hak-Ryul 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

누에나방(Bombyx mori)의 각 신경절에 존재하는 신경세포의 분포를 toludine blue 염색법과 hematoxylin-eosin 염색법을 이용하여 확인하였다. 또한 신경계 발달과정에서각 복부 신경절에 존재하는 신경세포수의 변화를 조사해 본 결과, 유충에서 번데기로 전환되는 시기와 번데기 말기에서 성충으로 전환되는 시기에 뚜렷한 신경세포 소실시기가 관찰되었다. 이러한 신경세포 소실이 흉부 또는 뇌에서 기인되는 인자에 의해 조절되는가를 조사하기 위해 복부결절을 시행한 결과 신경세포소실이 현저히 억제된 것을 알수 있었다. 또한 신경세포 소실에서 steoid hormone의 효과를 조사하기 위해 B. mori의 흉부 측면에 주사한 결과 신경세포소실이 억제되었다. Total numbers of neuron from last instar larvae to adults in Bombyx mori abdominal ganglion were investigated to elucidate patterns of neuronal fluctuation during life cycle. Two periods in reduction of neuronal numbers were present; the larval- pupal transition and the pupal-adult transition. To eliminate the factor originating from thorax and head, abdominal isolation was conducted. Neuronal cell death on abdominal ganglion (A₃) was significantly delayed. To study the interaction between cell death and 20- hydroxyecdysone (20-HE), 20-HE was injected into lateral part of thorax every 12 hours for three days. Neuronal cell death was significantly delayed by 20-HE injection.