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Yuk, Heung Joo,Curtis-Long, Marcus J.,Ryu, Hyung Won,Jang, Ki Chang,Seo, Woo Duck,Kim, Jun Young,Kang, Kyu Young,Park, Ki Hun American Chemical Society 2011 Journal of agricultural and food chemistry Vol.59 No.23
<P>Soybean leaves are eaten as seasonal edible greens in Korea. Analysis of the ethyl acetate extract of these leaves showed that it exhibited potent and selective neuraminidase inhibition, which began at the R3 stage and peaked at R7. Ten pterocarpans, including the new 6a-hydroxypterocarpan <B>10</B>, were isolated from soybean leaves and their inhibition activities tested against a range of glycosidases. The relationship between structure and enzyme inhibition was investigated: 6a-hydroxypterocarpans exhibited much higher inhibition against neuraminidase (IC<SUB>50</SUB> = 2.4–89.4 μM) than α-glucosidase (IC<SUB>50</SUB> = 90.4– >100 μM). Glyceollin VII (<B>7</B>) displayed 40-fold greater activity (IC<SUB>50</SUB> = 2.4 μM) against neuraminidase than α-glucosidase (IC<SUB>50</SUB> = 90.4 μM). On the other hand, coumestanes (<B>1</B>–<B>3</B>) were good α-glucosidase inhibitors (IC<SUB>50</SUB> = 6.0–42.6 μM). In kinetic analysis, the most potent neuraminidase inhibitors (<B>5</B>–<B>10</B>) were noncompetitive. HPLC analysis indicated that most pterocarpan synthesis began from the R3 stage, and a rapid change of pterocarpan concentrations was observed between the R4 and R7 stages.</P>
한의학적 치료법으로 호전된 요추 추간판 탈출증 환자의 영상의학적 변화
김우영,한상엽,김기역,공덕현,이현종,김창연,남항우,Kim, Wu-Young,Han, Sang-Yup,Kim, Ki-Yuk,Kong, Duck-Hyun,Lee, Hyun-Jong,Kim, Chang-Youn,Nam, Hang-Woo 척추신경추나의학회 2009 척추신경추나의학회지 Vol.4 No.1
Objectives: The aim of this study was to evaluate the evolution of lumbar disc herniation in patients treated with oriental medicine. Methods: 14patients(15 cases) with lumbar disc herniation proved at MRI(Magnetic resonance imaging) underwent a follow-up MRI study. Follow-up MRI was performed $4{\sim}14$months(mean 7 months) after initial MRI. Results & Conclusions: 1. 13 cases(87%) had reduction of disc herniation. 1 showed no change in amount of disc herniation. 1 had an increase in disc herniation. 2. Comparison initial MRI with follow-up MRI showed that 2 of the herniations decreased between 0% and 25%, 3 decreased between 25% and 50%, 5 decreased between 50% and 75%, 3 decreased between 75% and 100%. The size of the herniation decreased on average by 49% in 14patients(15 cases). 3. On axial images, the proportion of the cross-sectional area of the spinal canal occupied by the herniated disc was 54.41% on the average on the initial scan, 29.65% on the follow-up scan.
Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates
Chang, Yuk-Jae,Lee, Won-Ki,Kim, Hyung-Gun The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.3
There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases. Pregnant female rats were injected intraperitoneally with deoxycorticosterone acetate (DOCA) and given 0.9% saline as drinking water during their pregnancy. We assessed plasma $F_2-isoprostane(8-iso-PGF_{2{\alpha})$ and malondialdehyde (MDA) in a rat model, and the same markers in the plasma of maternal blood and fetal cord blood in pregnant women with preclampsia. Blood samples from the umbilical arteries and veins were collected separately. The concentrations of MDA were increased in the preeclampsia groups of animal and humans, compared with the control group; it was significantly increased in the umbilical artery and vein of the preeclampsia group. The concentrations of $F_2-isoprostane$ were elevated in the preeclampsia groups of animal and humans, compared with the control group, and the increase in $F_2-isoprostane$ concentration was prominent in the umbilical vein than umbilical artery of the preeclampsia group. Therefore, it appears that the placenta has an important role in the pathophysiology of preeclampsia, and the $F_2-isoprostane$ of the umbilical vein may serve as a relatively reliable marker for ischemic/hypoxic injury to the fetus during the perinatal period.
Regulation of the Manganese-containing Superoxide Dismutase Gene from Fission Yeast
Haeng-Im Jung,Yuk-Young Lee,Hye-Won Lim,Ki-Sup Ahn,박은희,Chang-Jin Lim 한국분자세포생물학회 2002 Molecules and cells Vol.14 No.2
The manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates a potentially toxic superoxide radical into hydrogen peroxide and dioxygen. To study the regulation of the Schizosac-charomyces pombe MnSOD gene, the 943 bp upstream region was fused into the promoterless b-galactosidase gene of the shuttle vector YEp357, which resulted in the fusion plasmid pMS14. Restriction mapping and nucleotide sequencing confirmed its construction. The synthesis of b-galactosidase from the fusion plasmid was induced by aluminum chloride, menadione, cad-mium chloride, manganese chloride, and hydrogen peroxide. It was also induced by NO-generating S-nitroso-N-acetylpenicillamine (SNAP). However, cu-pric chloride and zinc chloride did not affect the syn-thesis of b-galactosidase from the fusion plasmid. The b-galactosidase synthesis appeared to be independent of the Pap1 protein. These results suggest that some metals, oxidative stress, and nitric oxide regulate the S. pombe MnSOD gene.
Seo, Woo Duck,Yuk, Heung Joo,Curtis-Long, Marcus J.,Jang, Ki Chang,Lee, Jin Hwan,Han, Sang-Ik,Kang, Hang Won,Nam, Min Hee,Lee, Sung-Joon,Lee, Ji Hae,Park, Ki Hun American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.5
<P>Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an intracellular sensor that can regulate glucose levels within the cell. For this reason, it is well-known to be a target for drugs against diabetes and obesity. AMPK was activated significantly by the hexane extract of barley sprouts. This AMPK activation emerges across the growth stages of the sprout, becoming most significant (3 times above the initial stages) 10 days after sprouting. After this time, the activation decreased between 13 and 20 days post-sprouting. Analysis of the hexane extracts by gas chromatography–mass spectrometry showed that the amounts of policosanols (PCs, which are linear, primary aliphatic alcohols with 20–30 carbons) in the plant dramatically increased between 5 days (109.7 mg/100 g) and 10 days (343.7 mg/100 g) post-sprouting and then levels fell back down, reaching 76.4 mg/100 g at 20 days post-sprouting. This trend is consistent with PCs being the active ingredient in the barley plants. We validate this by showing that hexacosanol is an activator of AMPK. The richest cultivar for PCs was found to be the Daejin cultivar. Cultivars had a significant effect on the total PC content (113.2–183.5 mg/100 g) within the plant up to 5 days post-sprouting. However this dependence upon the cultivar was not so apparent at peak stages of PC production (10 days post-sprouting). The most abundant PC in barley sprout, hexacosanol, contributed 62–80% of the total PC content at every stage. These results are valuable to determine the optimal times of harvest to obtain the highest yield of PCs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-5/jf3041879/production/images/medium/jf-2012-041879_0004.gif'></P>