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열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria
Son, Jee Hee,Chung, Bo Young,Kim, Hye One,Park, Chun Wook 대한피부과학회 2018 Annals of Dermatology Vol.30 No.2
<P><B>Background</B></P><P>In adult patients with chronic urticaria (CU), the prevalence of food allergy is low compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance.</P><P><B>Objective</B></P><P>The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of a histamine-free diet in adult patients with CU.</P><P><B>Methods</B></P><P>Twenty-two adult patients with CU were enrolled. Foods with high amounts of histamine were prohibited to all patients for four weeks. The degree of severity of the urticaria was evaluated using the urticaria severity score (USS) and urticaria activity score (UAS). Plasma histamine levels and diamine oxidase (DAO) activity were determined and compared before (baseline) and after the histamine-free diet.</P><P><B>Results</B></P><P>Twenty-two adult patients were recruited and completed four weeks of histamine-free diet. The USS and UAS scores each showed significant differences before and after the histamine-free diet (<I>p</I>=0.010, <I>p</I>=0.006). There was a significant reduction in plasma histamine level after the histamine free-diet, compared with baseline (<I>p</I>=0.010). However, DAO activity did not change after the histamine-free diet (<I>p</I>=0.165).</P><P><B>Conclusion</B></P><P>Our study suggested that ingested histamine might be related to CU severity and that a histamine-free diet is helpful for treatment of adult patients with CU.</P>
( Jee Hee Son ),( Sook Young Park ),( Yong Se Cho ),( Yun Sun Byun ),( Yoon Seok Yang ),( Bo Young Chung ),( Hee Jin Cho ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Aryl hydrocarbon receptor (AhR) is a ligand-inducible transcription factor responding to halogenated aromatic hydrocarbons. AhR regulates nuclear factor-erythroid 2- related factor-2 (Nrf2), a key molecule for cell protection. Itraconazole (ICZ) and tacrolimus exhibit anti-inflammatory effects, but underlying molecular mechanism remains unclear, especially on AhR-Nrf2 pathway. Objectives: To evaluate the influence of ICZ and tacrolimus on AhR pathway, especially AhR-Nrf2 pathway. Methods: Normal human epidermal keratinocytes (NHEK) were treated with 2,3,7,8-tetrachlrodibenzo-p-dioxin TCDD), 6-Formylindolo[3,2-b]carbazole (FICZ), Indirubin, ICZ and tacrolimus. Then, RT-PCR and Western blot analysis were performed. Results: The expression levels of the AhR, Arylhydrocarbon receptor nuclear translocator (ARNT), Cytochrome P450 1A1 (CYP1A1) and NADPH quinine oxidoreductase 1 (NQO1) mRNA were higher when treated with TCDD, FICZ, and Indirubin, especially in 12 hours. However, with ICZ and tacrolimus, there was no significant difference from control. When analyzing protein expressions of NHEKs with Western blot, the levels of AhR, CYP1A1, and NQO1 were higher after treatment with TCDD, FICZ, and Indirubin. With ICZ and tacrolilmus, there was no significant difference Conclusion: ICZ and tacrolimus did not effect on mRNA and protein levels of AhR-related factors. This suggests ICZ and tacrolimus exhibit different pathway from AhR.
( Jee Hee Son ),( Bo Young Chung ),( Min Je Jung ),( Yong Won Choi ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.6
Background: Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries. Objective: To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the use of antihypertensive and antihyperlipidemic drugs in Korea. Methods: A five-year retrospective study, using hospital database, was conducted in five medical centers for five years. Totally 1,399,528 patients were evaluated. Results: The overall frequency for diagnosed rosacea was 0.18% over five years (2,536 rosacea patients). Patients with diabetes and patients with dyslipidemia were more likely to have rosacea (odd ratio [OR] 2.724, 95% confidence interval [CI] 1.295∼5.730, p=0.016; OR 1.788, 95% CI 1.445∼ 2.212, p<0.001). Patients with CVD were less likely to have rosacea (OR 0.431, 95% CI 0.244∼0.760, p=0.003). Patients with α-blocker prescriptions and patients with β-blocker prescriptions showed a tendency diagnosed with rosacea frequently (OR 1.963, 95% CI 1.200∼3.212, p=0.006; OR 3.939, 95% CI 3.512∼4.419, p<0.001). Patients with [beta]-hydroxy-[beta]-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and those with fibrate, were prone to have rosacea (OR 1.599, 95% CI 1.390∼1.839, p<0.001; OR 1.660, 95% CI 1.056∼2.609, p=0.026). As adjusted results, among the patients who took HMG-CoA reductase inhibitor without dyslipidemia, rosacea was less likely to be diagnosed (OR 0.780, 95% CI 0.620∼0.982, p=0.034). Conclusion: Rosacea is associated with chronic diseases and drugs. (Ann Dermatol 30(6) 676∼687, 2018)
( Jee Hee Son ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Coricosteroids are potent anti-inflammatory and antiallergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are especially considered frequent therapy for many skin diseases. Allergic reactions caused by corticosteroids, however, have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year old woman with triamcinolone induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She had atopic dermatitis (AD) since 3 years ago. She had used systemic steroid, cyclosporine and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injecting triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk and both hands. After intravenous injecting dexamethasone, her symptoms got worse. After treated with epinephrine, all symptoms resolved within two hours. We performed provocation test, skin prick test and patch test. She had a positive result only in prick test with triamcinolone and all other steroids showed negative in provocation test and patch test. Oral provocation test will be planned. Dermatologist should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.
[P326] A case of eccrine spiradenoma on the arm
( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Bo Young Chung ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Eccrine spiradenoma (ES) is a rare benign soft tissue tumor. It occur at any age, but typically affects young adults aged 15-35 years, with no sexual predilection. It presents as a solitary mass localized in the skin and subcutaneous tissue, smaller than 1 cm in size. Paroxysmal pain and tenderness may be present. It tends to arise on the upper part of the body. Rarely, it may be located on the upper and lower extremities. A 40-year-old man presented with a nodule on the extensor surface of his left forearm. He couldn`t remember when it formed. Initially, it showed no symptoms but with time, became painful. Physical examination revealed a slightly bluish to skin colored, hard mobile nodule on the left forearm measuring 1×1 cm in size. The initial clinical suspicion was epidermal cyst, trichilemmal cyst, or lipoma; thus, ultrasonography (US) was done. US results indicated a 10×7×10-mm well-defined oval isoechoic mass in the subcutaneous fat layer, with moderate hyperemia. A complicated epidermoid cyst, or other hypervascular mass, such as vascularized leiomyoma or a sarcoma (e.g., malignant fibrous histiocytoma) was suspected. Excisional biopsy was performed. Microscopic examination showed a deep, well-defined tumor with basophilic lobules, encapsulated by thick connective tissue in the dermis and subcutaneous layer. A trabecular arrangement of basophilic cells was present. Two types of cells were seen and he was diagnosed as ES.