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Lee, Moon Hee,Cha, Hee-Jae,Choi, Eun Ok,Han, Min Ho,Kim, Sung Ok,Kim, Gi-Young,Hong, Su Hyun,Park, Cheol,Moon, Sung-Kwon,Jeong, Soon-Jeong,Jeong, Moon-Jin,Kim, Wun-Jae,Choi, Yung Hyun Spandidos Publications 2017 International journal of molecular medicine Vol.39 No.3
<P>Natural phytochemicals of plant origin, including flavonoids, have been found to be potent antioxidants providing beneficial effects against oxidative stress-related diseases. The present study was carried out to investigate the antioxidant properties of morin, a flavonoid originally isolated from the flowering plants of the Moraceae family. Superoxide dismutase (SOD)-like activity and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging activity were determined. We also investigated the cytoprotective effects of morin against hydrogen peroxide (H2O2)-induced DNA damage and apoptosis in V79-4 Chinese hamster lung fibroblasts. Our results demonstrated that morin had strong scavenging effects against ABTS' radicals with enhanced SOD activity, which varied in a dose-dependent manner. Morin was found to reduce H2O2-induced intracellular reactive oxygen species generation and nuclear DNA damage, and it recovered cell viability damaged by H2O2 via inhibition of mitochondrial dysfunction-mediated apoptosis. Notably, the treatment of V79-4 cells with morin markedly enhanced the expression of heme oxygenase-1 (HO-1) but not quinone oxidoreductase-1, which was associated with the increased expression and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the downregulation of Kelch-like ECH-associated protein 1 expression. Based on our findings, we conclude that morin effectively ameliorated oxidative stress-induced DNA damage through intrinsic free radical scavenging activity and activation of the Nrf2/HO-1 pathway.</P>
Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2
<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>
차재호,최인철 서울大學校 社會科學大學 心理科學硏究所 1992 心理科學 Vol.1 No.-
1992년 여름에 서울지역 대학생들 (무선표본 n=150)의 外國人에 대한 能度調査 결과를 보고하였다. 모든 태도대상(나라 사람 범주)은 1988년의 전국 조사(차재호, 1992)와 동일했다. 1988년 이래 일본, 미국, 북한 및 러시아에 대한 태도가 호전된 것으로 나타났다. 1992년 봄의 LA지역에 있었던 흑인폭동에도 불구하고 미국 흑인에 대한 태도의 악화정도는 미약했고 오히려 흑인에 대한 태도는 악화됐다. 미국 흑인 외에 사우디 아라비아와 이스라엘에 대한 태도도 악화된 것으로 드러났다. 固定槪念의 시대간 변화 내용 속에서 가치차원의 변화가 드러난다는 증거를 제시했다. 그밖에 고정관념에서의 '原型的 特性'이라는 개념이 갖는 의미를 고찰했다. college student's attitude toward foreigners was assessed using a random sample of 150 students representing schools in the Seoul area. The data considered of rankings, scale values based on the rankings, like-dislike responses, and open-ended descriptions of traits. The results showed that the students' attitudes toward Americans, Japanese, North Korean, and Russians improved since 1988(Cha, 1992) while those toward Saudi Arabians, Israelis, and blacks took a downtown. The downward change for "American" blacks was modest despite the recent black riots in the LA area in which ethnic Koreans bore the brunt of the rampage. Evidence was presented showing that a set of values underlay the stereotypes and that such values had undergone change since early 60's. The notion of "prototypic traits" of stereotypes was introduced and its implications discussed.
차재호 서울大學校 社會科學大學 心理科學硏究所 1994 心理科學 Vol.3 No.1
구한말(1860년경)이래 70년대까지의 한국인에 관한 외국인 견문록들과 60년대 이래의 가치관 조사 연구들을 토대로 80년대까지의 약 100년간에 걸친 한국사회의 가치관 변화를 개관하고 이를 토대로 가치의 성질, 가치의 생성과 변화, 그리고 한국사회에서의 가치연구방법에 관한 27개의 명제를 제시했다. The paper summarized the value changes that occurred within the Korean society in about 100 years from 1860's through 1980's as determined through an analysis of foreigner's travelogues and empirical studies of values. Based on the findings, a set of 27 hypotheses were proposed relating to the nature and functions of value, generation and change of value, method of investigation, and value changes specific to Korea.