http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, So-Hyun,Park, Chan-Sung,Kim, Young-Il,Nam-Goong, Il-Seong,Kim, Yon-Seon,Lee, Jong-Cheol,Choi, Jung-Il,Park, Jeong-Woo,Kim, Eun-Sook Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Background: Human papillary thyroid carcinoma (PTC) is often associated with Hashimoto's thyroiditis (HT); their coexistence improves PTC prognosis. Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies. Osteopontin overexpression correlates with aggressive clinicopathological features in PTC. Lymph node metastases and large tumor size positively correlate with osteopontin positivity. This study aimed to: (1) confirm osteopontin overexpression in human PTC samples; (2) compare osteopontin expression levels in PTC cases with and without HT; and (3) identify correlations between tumor aggressiveness and osteopontin expression levels. Materials and Methods: Plasma osteopontin was assessed in 45 patients with PTC, 22 patients with PTC and HT, and 24 healthy controls by enzyme-linked immunosorbent assay. Thyroid tissue osteopontin mRNA and protein levels were analyzed by reverse transcription-polymerase chain reaction and Western blotting, respectively. Results: Plasma osteopontin levels were significantly higher in PTC patients than in healthy controls. Plasma osteopontin, tissue osteopontin mRNA, and tissue osteopontin protein levels were significantly lower in patients with PTC and HT than in those with PTC alone. In advanced disease stage cases, osteopontin mRNA and protein expression levels were lower in patients with PTC and HT than in those with PTC alone. However, the osteopontin expression level was not significantly associated with the TNM stage. Conclusions: Plasma osteopontin, tissue osteopontin mRNA, and tissue osteopontin protein levels were significantly lower in patients with PTC and HT than in those with PTC alone, suggesting that HT attenuates PTC aggressiveness through negative regulation of osteopontin expression.
Park Ji In,Baek Hyunjeong,Kim Sang-Wook,Jeong Ji Yun,Song Kee-Ho,Yu Ji Hee,Nam-Goong Il Sung,Cho Eun-Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.26
Background: The incidence of early-onset diabetes is increasing among young adults. However, there are limited data on the characteristics and management of young Korean adults with diabetes. This study assessed the clinical and demographic characteristics, health behaviors, and mental health among young Korean adults with diabetes mellitus. Methods: This cross-sectional study included young Korean adults with diabetes (n = 225) with an onset age of 20–39 years from four university hospitals. Demographic characteristics, management of diabetes, and mental health were assessed using a questionnaire survey. Results: Type 2 diabetes was the most common type (73.3%), and 13.8% of participants were classified as other types or unknown. Approximately, 64.7% of participants had a strong family history of diabetes, and 76% had treatment within three months of diagnosis. Approximately, 11.1% of participants had diabetic complications; 39.1% of participants received insulin injections, including oral anti-diabetic medications. Additionally, 30.4% were smokers, and only 28% had active physical activity; 26.5% of participants had >3 hours of screen time. One third of participants never had breakfast, and 60.5% went out to eat at least three times a week. Half of the participants showed moderate to severe stress perception, and 21.4% of patients had moderate to severe levels of depression based on the Korean version of Beck Depression Inventory score. Conclusion: Early-onset diabetes was associated with a strong family history and early insulin treatment. Young adults with diabetes had poor health behaviors and frequent mental depression. These findings suggest the necessity of health policies for improving health behaviors and mental distress.
고명관,박찬성,변성수,홍정민,이무열,김경훈,나양원,최혜정,Il Sung Nam-Goong,김영일,김은숙 대한의학회 2013 Journal of Korean medical science Vol.28 No.3
In patients with primary aldosteronism who have bilateral adrenal incidentalomas, it is important to identify which adrenal gland is secreting excess aldosterone. Traditionally,adrenal vein sampling (AVS) has been performed for lateralization despite its invasiveness. Here we report a case of bilateral adrenal incidentaloma in which 18-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) was used to identify the functional adrenal mass. A 53-yr-old man was referred to our clinic due to bilateral adrenal incidentalomas (right: 1 cm, left: 2.5 cm) on computed tomography (CT). Given his history of colon cancer, FDG-PET/CT scanning was used to rule out metastasis. Although there was focal hot uptake lesion in the right adrenal gland, the patient was suspected primary aldosteronism clinically more than metastasis because of the patient’s underlying hypertension with hypokalemia. It was consistent with the results of AVS. Based on these findings, we propose that FDG-PET/CT can be used instead of AVS to identify the source of primary aldosteronism between two bilateral adrenal incidentalomas.
Contact system activation and high thrombin generation in hyperthyroidism
Kim, Namhee,Gu, Ja-Yoon,Yoo, Hyun Ju,Han, Se Eun,Kim, Young Il,Nam-Goong, Il Sung,Kim, Eun Sook,Kim, Hyun Kyung BioScientifica Ltd. 2017 European journal of endocrinology Vol.176 No.5
<P>Conclusion: This study demonstrated that contact system activation and abundant NET formation occurred in the high thrombin generation state in hyperthyroidism and were correlated with free T4 level.</P>
( Yun Im Lee ),( So Hyun Park ),( Mi Ae Bae ),( Yong Tae Park ),( Chan Ho Park ),( Hwa Sik Jung ),( Yun Sun Kim ),( Young Hwa Ko ),( Hee Jung Cha ),( Young Il Kim ),( Il Sung Nam Goong ),( Eun Sook Ki 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Radioactive iodine and surgery are options in the treatment of patients presenting with antithyroid drug-resistant hyperthyroidism. It is necessary to normalize thyroid function prior to any procedure in order to reduce complications. Cholestyramine is effective as a short-term adjunctive agent in the treatment of thyrotoxic patients who are resistant to conventional therapy. A 22-year-old woman with severe Graves` disease was referred from a local clinic because of her refractory hyperthyroidism. She presented with exophthalmos, diffuse goiter, and tachycardia. She was treated with a maximal dose of methimazole and a beta-blocker for 2 months. However, her thyroid function test(TFT) did not improve. TFT showed a free T4 level of 74.7 ng/dL (normal range: 0.93.1.7 ng/dL) and a thyroid stimulating hormone (TSH) level of 0.007 μIU/mL (normal range: 0.4.4.0 μIU/mL). She was then administered cholestyramine (4 g thrice daily), hydrocortisone (300 mg/day) and methimazole (100 mg/day) which prepared the patient for surgery by reducing the free T4 level (4.7 ng/dL). The patient underwent a total thyroidectomy without experiencing thyrotoxic crisis. This case describes the use of cholestyramine for the first time in Korea in treating Graves` disease and provides limited evidence that cholestyramine can be an effective option.