Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis.

Cho, Bon-A,Sim, Ji Hyun,Park, Ji Ah,Kim, Hye Won,Yoo, Wan-Hee,Lee, Seung-Hyun,Lee, Dong-Sup,Kang, Jae Seung,Hwang, Young-Il,Lee, Wang Jae,Kang, Insoo,Lee, Eun Bong,Kim, Hang-Rae Springer 2012 Journal of clinical immunology Vol.32 No.4

<P>Little is known about the cellular characteristics of CD8(+) T cells in rheumatoid arthritis (RA). We addressed this by investigating whether the frequency of the CD8(+) T cell subsets and their phenotypic characteristics are altered in the peripheral blood and synovial fluid (SF) from patients with RA. In this study, CD8(+) T cells, mainly CD45RA(-) effector memory (EM) CD8(+) T cells, were increased significantly in the SF, but not in the peripheral blood from RA patients, compared with healthy controls. The synovial EM CD8(+) T cells were activated phenotypes with high levels of CD80, CD86, and PD-1, and had a proliferating signature in vivo upon Ki-67 staining, whereas the Fas-positive cells were prone to apoptosis. In addition, EM CD8(+) T cells in the SF were less cytotoxic, as they expressed less perforin and granzyme B. In particular, the proportions of synovial fluid mononuclear cells that were CCR4(+)CD8(+) T cells and IL-4-producing CD8(+) T cells (i.e., Tc2 cells) were significantly higher than those in peripheral blood mononuclear cells of patients with RA and healthy controls. In addition, the number of IL-10-producing CD8(+) suppressor T (Ts) cells increased significantly in the SF of RA patients. Especially, CD8(+) T cells were inversely correlated with disease activity. These findings strongly suggest that EM CD8(+) T cells in the SF are increased, likely because of inflammation, and they may be involved in modulating inflammation, thereby affecting the development and progression of RA.</P>

지구 비대칭 중력장과 대기모델에 따른 위성체의 수명 예측

조겸래,이일준,이대우 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

위성의 수명 및 소멸율은 섭동의 영향을 받고있는 위성의 궤도요소의 변화를 통해 결정되어질 수 있다. 섭동의 원인으로는 지구 비대칭 중력장, 대기저항, 태양과 달의 영향, 태양풍의 영향을 고려하였으며, 수치적분은 특수섭동법의 코웰의 방법을 이용하였다. 저궤도에서 운행되는 다복적 실용위성에 많은 영향을 줄수 있는 지구 비대칭 중력장과 대기저항에 대해 여러 가지 모델을 이용해서 위성에 미치는 영향을 연구하였다. 마지막에는 대기저항의 영향에 의한 수치적인 계산을 통해 위성이 가지는 수명과 소멸율에 대해서도 연구하였다. Life time and decay rate of a satellite can be determined through the variation of trajectory elements which are effected by perturbing disturbances. For the cause of the perturbind disturbances, non-symmetric gravity, force between sun and earth, atmospheric drag, and solar flux could be considered. Cowell's method is used for numerical integration. Various models, U.S.76, MSIS, and CIRA are utilized to investigate the effects due to non-symmetric gravity, atmospheric drag, and solar flux. Finally, life time and decay rate are studied through numerical computations due to the atmospheric drag.

대퇴 전자간 골절에서 금속정 고정술 시행결과 : 감미정과 근위 대퇴정의 비교 Comparision Gamma Nail and proximal Femoral Nail

고상봉,조명래,김태훈,장일웅 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 대퇴 전자간 골절 환자에서 감마정과 근위 대퇴정으로 내고정을 시행하고 방사선학적, 임상적 결과 및 합병증을 비교하여 각각의 장단점을 분석하고자 하였다. 대상 및 방법: 1999년 1월부터 2002년 2월까지 대퇴 전자간 골절로 감마정과 근위 대퇴정을 이용하여 고정한 환자 중 방사선학적 및 임상적으로 6개월 이상 추시가 가능하였던 63예를 대상으로 하였으며 감마정군이 31예, 근위 대퇴정군이 32예이었다. 연령, 골절의 형태와 안정성에 따른 분류, 동반 질환, 골다공증의 정도, 환자의 활동 능력 등이 양 군에서 차이가 없었다. 평가방법으로는 두 군 사이의 수술시간, 출혈량, 안정정복 획득의 감입 정도 등을 비교하였다. 결과: 수술시간은 감마정군은 평균 103±40분, 근위 대퇴정군에서 101±28분으로 통계적인의미는 없었으며 (p=0.801), 수술 중 출혈량은 근위 대퇴정군에서 적은 경향을 보였으나 통계적인 의미는 없었다(p=0.601). 술 후 골절의 안정성 획득 여부는 감마정군 30%, 근위 대퇴정군 31%에서 안정 정복을 얻어 사용기구에 따른 고정의 안정성 획득에는 유의한 차이가 없었으며(p=0.934), 술 후 내반 고정의 빈도와 골절부위의 1.28단계의 보행능력 감소를, 근위 대퇴정군에서 평균 0.86단계의 보행능력 감소를 보여 역시 통계적으로 의미있는 차이는 없었다(p=0.383). 결론: 대퇴 전자간 골절치료에 있어서 임상적 및 방사선학적인 결과에서는 의미있는 차이는 없었으나, 근위 대퇴 골수정이 수술시간, 출혈량 등의 수술 수기의 측면에서 조금 더 우수한 경향을 보였다. Purpose: To evaluate the clinical and radiologic results of the fracture using the Proximal Femoral Nail(PFN) or Gamma nail in patient with the intertrochanteric fracture. Materials and Methods: From January 1999 to February 2002, we reviewed 63 patients of intertrochanteric fractures including 31 patients managed with Gamma nail and 32 patients with PFN. In variate analysis of age, the pattern and stability of fracture, bone density(Singh index), preoperative patient activity, there was no difference between two groups. We evaluated the operation time, blood loss, stable reduction rate and varus reduction rate as operation-related factors, and radiologically investigated union, time, the frequency of delayed union and nonunion, failure of fixation, status of the fracture line and complications. Functional results were evaluated by the possibility of early ambulation, ambulation ability at last follow up, and the pre and postoperative difference of ambulatory ability. Results: Mean operation time was 103±40 minutes in Gamma nail group 101±28 minutes in PFN group. It was not statistically significant(p=0.801). Even though intraoperative blood loss was less in PFN group, it was significant(p=0.601). Postoperative stable reduction rate was 31% in Gamma nail group and 30% in PFN group(p=0.934), suggesting not significant. Postoperative varus reduction and impacted amount of the fracture ling was not significant. Delayed union developed in one case of Gamma nail group and 2 cases of PFN group. Mean loss of ambulation ability was 1.28 grade in Gamma nail group and 0.86 grade in PFN(p=0.383). Statistical analysis was performed with the use of Student T test and Chi-square test. Analyses resulting in a p value of <0.05 were considered to show significance. Conclusion: Generally, the radiologic and clinical results of intertrochanteric fractures were comparable for the PFN group and Gamma nail group. Even though it was not statistically significant, PFN group had superior results in operation time blood than Gamma nail group for the fixation of the patients with interchanteric fracture.

2-Deoxy-D-Glucose에 의한 대사성 쇼크가 무우스의 면역 반응에 미치는 영향

김양숙,장선일,박래길,조성경,정헌택 최신의학사 1991 最新醫學 Vol.34 No.2

필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.

후복막강내 발생한 Castleman병 1례

남성진,이동욱,박찬규,정시욱,김추성,조성래,구본천,양사규,이일웅,박정자 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

Castleman' s disease is a rare, reactive lymphoid proliferation of unknown cause and pathogenesis. Depending on histololgic findings, it has been divided into two distinct histologic subtypes that include hyaline-vascular type(90%) and plasmacell type(10%). This disease occurs most commonly in mediastinal lymph nodes and cervical lymph nodes, inguinal lymph nodes respectively. But occurs rarely in retroperitoneum. We report a case of hyaline-vascular type asymptomatic Castleman' s disease of the retroperitoneum in a 47-year-old man.

Outcome of Gamma Knife Thalamotomy in Patients with an Intractable Tremor

Cho, Kyung Rae,Kim, Hong Rye,Im, Yong Seok,Youn, Jinyoung,Cho, Jin Whan,Lee, Jung-Il The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.3

Objective : Tremor is a common movement disorder that interferes with daily living. Since the medication for tremor has some limitations, surgical intervention is needed in many patients. In certain patients who cannot undergo aggressive surgical intervention, Gamma Knife thalamotomy (GKT) is a safe and effective alternative. Methods : From June 2012 to August 2013, 7 patients with an intractable tremor underwent GKT. Four of these 7 patients had medical comorbidities, and 3 patients refused to undergo traditional surgery. Each patient was evaluated with the modified Fahn-Tolosa-Marin tremor rating scale (TRS) along with analysis of handwriting samples. All of the patients underwent GKT with a maximal dose of 130 Gy to the left ventralis intermedius (VIM) nucleus of the thalamus. Follow-up brain MRI was performed after 3 to 8 months of GKT, and evaluation with the TRS was also performed. Results : Six patients showed objective improvement in the TRS score. Excluding one patient who demonstrated tremor progression, there was 28.9% improvement in the TRS score. However, five patients showed subjective improvement in their symptoms. On comparing the TRS scores between follow-up periods of more and less than 4 months, the follow-up TRS score at more than 4 months of GKT was significantly improved compared to that at less than 4 months of GKT. Follow-up MRI showed radiosurgical changes in 5 patients. Conclusion : GKT with a maximal dose of 130 Gy to the VIM is a safe procedure that can replace other surgical procedures.

Host and Microbe Interaction(Virology) : Reovirus infection induces degradation of HIF-1α independent of VHL and p53

( Il Rae Cho ),( Hye Jin Min ),( Eun Hee Park ),( Srisuttee Ratakorn ),( Young Hwa Chung ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

Assessment of Soil Compaction Related to the Bulk Density with Land use Types on Arable Land

Cho, Hee-Rae,Jung, Kang-Ho,Zhang, Yong-Seon,Han, Kyung-Hwa,Roh, Ahn-Sung,Cho, Kwang-Rae,Lim, Soo-Jeong,Choi, Seung-Chul,Lee, Jin-Il,Yun, Yeo-Uk,Ahn, Byoung-Gu,Kim, Byeong-Ho,Park, Jun-Hong,Kim, Chan-Y 한국토양비료학회 2013 한국토양비료학회지 Vol.46 No.5

Soil compaction is affected by soil texture, organic matter (OM), strength (ST) and soil moisture, which is difficult to understand the degree and effects of related factors. The purpose of the study is to assess the impact of them on the compaction with bulk density (BD). The analysis was conducted with data collected from national-wide monitoring sites including 105 upland soils, 246 orchard soils, and 408 paddy soils between 2009 and 2012. The distributions of soil physical properties were measured. The correlation and multi linear regression analysis were performed between soil physical properties using SAS. The regression equation of BD(y) includes ST, gravitational water contents (GWC), and OM as variables commonly, having additional factors, clay content and sand content in paddy soil and upland soil for only subsoil (p<0.001). Our results show that the BD could be explained about 40~50% by various physical properties. The regression was mainly determined by ST in orchard and upland soil and by the GWC in paddy soil. To mitigate soil compaction, it is important to maintain the proper level of OM in upland soil and to consider the moisture condition with soil texture in paddy soil when making work plan. Furthermore, it would be recommended the management criteria classified by soil texture for the paddy soils.

Poster Session : Alternative activation of NF-kappaB by STP-A11, an oncoprotein of Herepesvirus saimiri

( Il Rae Cho ),( Su Nam Jeong ),( Young Hwa Chung ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-