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경량 고강도 Mg-Zn계합금의 조직과 내식성에 관한 연구
안효준,남태현,임수근,안인섭,허보영,김기원 慶尙大學校 1995 論文集 Vol.34 No.1
The purpose in this study is to develope of high strength and corrosion reistant Mg-Zn system alloys by controlling microstructures and by adding of Cu elements. To produce optimum tesile strength,it is imperative to obtain effective grain refinment during casting. Optimal condition for grain size refining effect was obtained at the minmum composotion of 2wt% Cu or 1.5wt%So addition to Mg-6wt%Zn alloy.Age hardening behavior was experimented at the optimal compositions of the Mg-6wt%Zn, Mg-6wt%Zn-2wt%Cu and Mg-6wt%Zn-1.5wt%Si. The hardeness increment due to age hardening was at the Mg-Zn-Si alloy system. The improvement of corrosion resistanece by the addition with Cu is related to and increasing Zn/Cu ration in the intermatallic particles in the Mg-Zn system.Further improvements obtained by T6 treatment are related to the properties of the Mg-Zn phase,whih acts as a corrosion barrier by precipitating along the grainboundaries.Filiform corrosion observed soon after pit initiation and cellular form of pit propagation later in chloride media are explained in terms of solid solution matrix structure and the properties of air formed oxide.The information obtained from the fundamental research work is utilized in suggesting ways of improving the corrosion resistance of commercial AZ91.
Lim, Jae Hoon,Kim, Min Ju,Chiang, Liu Wei,Lim, Hyo Keun,Park, Cheol Keun,Paik, Seung Woon,Joh, Jae Won,Koh, Kwang Cheol 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2
Objective: The objective of this study was evaluate the diagnostic efficacy of three-phase helical dynamic CT in the detection of hepatocellular carcinomas in patients with advanced liver cirrhosis. Materials and Methods: Three-phase helical dynamic CT in 77 patients with advanced liver cirrhosis was evaluated prospectively before orthotopic liver transplantation. The histopathologically confirmed hepatocellular carcinomas in the explanted livers were compared with pretransplantation CT results by one-to-one correlation. Results: Histopathologic examination of the explanted livers revealed 72 hepatocellular carcinomas in 41 patients. The size of the hepatocellular carcinomas was 0.5-14.0 cm (mean, 1.6 cm). The use of helical dynamic CT enabled the detection of 38 of 72 hepatocellular carcinomas (sensitivity, 53%). Fifteen of 35 (43%) hepatocellular carcinomas smaller than 2 cm and 23 of 37 (62%), hepatocellular carcinomas ranging from 2.0 cm to 14.0 cm were detected. Patient sensitivity and specificity in the detection of hepatocellular carcinoma were 81% (33/41) and 94% (34/36), respectively. Conclusions: Three-phase helical dynamic CT is insensitive for detection of hepatocellular carcinomas in patients with advanced liver cirrhosis, especially for hepatocellular carcinomas smaller than 2 cm.(Korean J Hepatol 2002;8:201-208)
Radiofrequency Thermal Ablation of Hepatocellular Carcinomas
Hyo Keun Lim The Korean Society of Radiology 2000 Korean Journal of Radiology Vol.1 No.4
Although surgical resection remains the best option as potentially curative therapy for hepatocellular carcinoma, radiofrequency thermal ablation has begun to receive much attention as an effective minimally invasive technique for the local control of unresectable malignant hepatic tumors. Most recent radiofrequency devices equipped with a powerful generator and larger needle electrode permit larger thermal lesions, up to 5 cm in diameter, with a single ablation. In this article, the author reviews the technical developments and early clinical results obtained with radiofrequency ablation techniques.
Paget disease of the breast: mammographic, US, and MR imaging findings with pathologic correlation.
Lim, Hyo Soon,Jeong, Su Jin,Lee, Ji Shin,Park, Min Ho,Kim, Jin Woong,Shin, Sang Soo,Park, Jin Gyoon,Kang, Heoung Keun The Society 2011 Radiographics Vol.31 No.7
<P>Paget disease is a rare malignancy of the breast characterized by infiltration of the nipple epidermis by adenocarcinoma cells. The clinical features of Paget disease are characteristic and should increase the likelihood of the diagnosis being made. An important point is that more than 90% of cases of Paget disease are associated with an additional underlying breast malignancy. Paget disease is frequently associated with ductal carcinoma in situ (DCIS) in the underlying lactiferous ducts of the nipple-areolar complex; it may even be associated with DCIS or invasive breast cancer elsewhere in the breast, at least 2 cm from the nipple-areolar complex. Nevertheless, mammographic findings may be negative in up to 50% of cases. Magnetic resonance (MR) imaging can be useful in patients with Paget disease for evaluation of the nipple-areolar complex and identification of an additional underlying malignancy in the breast. The appropriate surgical treatment must be carefully selected and individualized on the basis of radiologic findings, especially those obtained with breast MR imaging.</P>
ABCB1 c.2677G>T/c.3435C>T diplotype increases the early‑phase oral absorption of losartan
Hyo‑Bin Shin,Eui Hyun Jung,Pureum Kang,Chang Woo Lim,Kyung‑Yul Oh,Chang‑Keun Cho,Yun Jeong Lee,Chang‑Ik Choi,Choon‑Gon Jang,Seok‑Yong Lee,Jung‑Woo Bae 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.11
Losartan has been shown to be a substrate of thedrug-efflux transporter MDR1, encoded by the ABCB1 gene. ABCB1 c.2677G>T and c.3435C>T variants are knownto be associated with reduced expression and function ofP-glycoprotein (P-gp). We investigated the effects of ABCB1diplotype on the pharmacokinetics of losartan. Thirty-eighthealthy Korean volunteers with different ABCB1 diplotypes[c.2677G> T and c.3435C>T; carriers of GG/CC(n = 13), GT/CT (n = 12) and TT/TT (n = 13) diplotype]were recruited and administered a single 50 mg oral doseof losartan potassium. Losartan and its active metaboliteE-3174 samples in plasma and urine were collected up to10 and 8 h after drug administration, respectively, and theconcentrations of both samples were determined by HPLCmethod. Significant differences were observed in Cmax oflosartan and losartan plus E-3174 (Lo + E) among the threediplotype groups (both P < 0.01). However, the power ofthe performed test is less than the desired power (0.800). The tmax of losartan and E-3174 in three diplotype groups were also significantly different (both P < 0.01). The AUCvalues of Lo + E were significantly different among thethree diplotype groups until 6 h after losartan administration(P < 0.01). On the contrary, AUC at the periods of 8–10 hand 10 h-infinity of Lo + E were significantly lower in theTT/TT group than in the GG/CC group. Urinary excretionof losartan until 4 h after losartan administration in the TT/TT group was higher than that of the GG/CC group. Theseresults suggest that c.2677G>T/c.3435C>T diplotypes ofABCB1 may significantly increase the early-phase absorptionof losartan, but not the total absorption.
( Hyo Jin Yun ),( Eun Jung Cha ),( Hee Kwan Won ),( Keun Young Park ),( Jong Hyun Kim ),( Moon Hyang Park ),( Dong Mee Lim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Thyroid stimulating hormone (TSH)-secreting pituitary adenomas (TSH-omas) are rare (less than 2% of all pituitary tumors) and manifest as hyperthyroidism with elevated TSH levels. An elevated a-subunit/TSH molar ratio can be detected in TSH-omas. Surgical resection of the tumor can be curative, but incomplete resection is common. Therefore, approximately one out of three patients requires medical therapy. Therapeutic trials with somatostatin analogs or dopamine agonists have been reported to control hyperthyroidism and tumor growth. We present an unusual case with pituitary adenoma secreting TSH treated with transsphenoidal adenomectomy (TSA) and postoperative bromocriptine. A 23-year-old female presented with both hand tremors and palpitation for three months. She had been diagnosed with TSH-oma three years ago, and TSA had been tried twice in other hospitals but resulted in failure. On physical examination, the heart rate was 105 beats/minute, and goiter, exophthalmoses and visual fi eld defects were not noted. A thyroid function test (TFT) disclosed the following: TSH 4.46 IU/L, fT4 32.84 pM, T3 163.57 ng/dl. Magnetic resonance imaging of the sella (MRI sella) showed a pituitary adenoma about 1X1.2X1 cm in size. The calculated a-subunit/TSH molar ratio was 1.7. TSA was performed, and immunohistochemistry revealed growth hormone, prolactin and TSH-immunoreactivity in adenoma cells. Since both hand tremors remained at the postoperative follow-up visit, we decided to treat her with bromocriptine. Because she had side effects of octreotide therapy, such as severe nausea and vomiting, we could not prescribe somatostatin analogs. After taking bromocriptine, her clinical symptoms were improved. Now, she visits our hospital for routine follow-up visit with TFT checks.