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Dental imaging characterization of micropigs
Lee, Hyeyeon,Choi, Mihyun,Chang, Jinhwa,Jung, Joohyun,Kim, Mieun,Lee, Namsoon,Kim, Junyoung,Choi, Mincheol The Korean Society of Veterinary Science 2010 大韓獸醫學會誌 Vol.50 No.4
Recently the micropig has been developed as human disease model. The dental and orofacial region of micropig is similar to that of humans, so it has been used for testing implant materials and techniques. The purpose of this study is on dental image at each age using radiography and computed tomography. Total twenty-two male micropigs, two or three animals of each 1, 3, 5, 7, 9, 12, 18 and 24 months old, were given radiographic examinations. After general anesthesia, extra- and intra-oral radiographic technique and computed tomographic scans were performed to assess the dental characterization of micropigs. The total deciduous dental formula comprised 28 teeth and was depicted as Di 3/3, Dc 1/1, Dp 3/3. The total permanent dental formula comprised 44 teeth and was depicted as I 3/3, C 1/1, P 4/4, M 3/3. Hypodontia of the first premolars was common in the micropig. The permanent teeth erupted from 3 to 24 month after birth. The sequence of eruption of the permanent teeth was M1, P1, I3, C, M2, I1 + P3 + P4, P2, I2, M3. Dental imaging enables visualization of the unerupted teeth and gives more information about the development of the teeth. The growth pattern of the teeth obtained through radiographic and computed tomographic examination provides basic data in the micropig as animal model for dental research.
( Hyeyeon Lee ),( Mihui Kim ),( Ocksim Kim ),( Sue Kim ),( Seongmi Choi ) 한국여성건강간호학회 2021 여성건강간호학회지 Vol.27 No.3
Purpose: The world saw a shift into a new society consequent to the coronavirus disease 2019 (COVID-19), which made home quarantine mandatory for a person in close contact with those who tested positive. For children, however, home quarantine was not limited only to themselves but parents, especially mothers were involved and required to quarantine. This qualitative study aims to explore and understand mothers’ experience and their related psychosocial issues while caring for their school-aged children in Korea, who had to home quarantine after coming in close contact with COVID-19 positive individuals. Methods: Data were collected from October 2020 to January 2021 via in-depth, semi-structured interviews with nine mothers of children who had to home quarantine. Interviews were conducted face-to-face in an independent space near the participant’s home or workplace (n=5) or via online platforms or telephone (n=4). The data were analyzed using thematic analysis through several iterative team meetings. Results: Thematic analysis revealed the following four themes: “Unable to be relieved due to uncertain situations surrounding me,” “Blame and hurt toward me, others, and one another,” “Pulling myself together for my children in my broken daily life,” and “Changes in the meaning of life amid COVID-19.” Conclusion: The narratives show that mothers experienced psychosocial difficulties while caring for their children during home quarantine. It is necessary to reduce the social stigma toward individuals in home quarantine and establish policies to ensure work-family compatibility for such mothers.
Lee, Hyebin,Kim, Kwangsoo,Woo, Jongmin,Park, Joonho,Kim, Hyeyoon,Lee, Kyung Eun,Kim, Hyeyeon,Kim, Youngsoo,Moon, Kyung Chul,Kim, Ji Young,Park, In Ae,Shim, Bo Bae,Moon, Ji Hye,Han, Dohyun,Ryu, Han Suk American Society for Biochemistry and Molecular Bi 2018 Molecular and Cellular Proteomics Vol.17 No.9
<P>Cytological examination of urine is the most widely used noninvasive pathologic screen for bladder urothelial carcinoma (BLCA); however, inadequate diagnostic accuracy remains a major challenge. We performed mass spectrometry-based proteomic analysis of urine samples of ten patients with BLCA and ten paired patients with benign urothelial lesion (BUL) to identify ancillary proteomic markers for use in liquid-based cytology (LBC). A total of 4,839 proteins were identified and 112 proteins were confirmed as expressed at significantly different levels between the two groups. We also performed an independent proteomic profiling of tumor tissue samples where we identified 7,916 proteins of which 758 were differentially expressed. Cross-platform comparisons of these data with comparative mRNA expression profiles from The Cancer Genome Atlas identified four putative candidate proteins, AHNAK, EPPK1, MYH14 and OLFM4. To determine their immunocytochemical expression levels in LBC, we examined protein expression data from The Human Protein Atlas and in-house FFPE samples. We further investigated the expression of the four candidate proteins in urine cytology samples from two independent validation cohorts. These analyses revealed AHNAK as a unique intracellular protein differing in immunohistochemical expression and subcellular localization between tumor and non-tumor cells. In conclusion, this study identified a new biomarker, AHNAK, applicable to discrimination between BLCA and BUL by LBC. To our knowledge, the present study provides the first identification of a clinical biomarker for LBC based on in-depth proteomics.</P>
Theoretical Evaluation: Theory of Care-Seeking Behavior
Hyeyeon Lee,Minji Kim,Gahui Hwang 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim: To prevent the spread of Coronavirus (COVID-19), getting a screening test promptly is an important strategy, as well as keeping the COVID-19 Guidelines for distancing in daily life. For an effective screening test, a deep exploration of secondary preventive behavior is necessary. In this study, we aim to enhance understanding of secondary preventive behavior by evaluating the Theory of care-seeking behavior(TCSB). Methods: TCSB was comprehensively evaluated based on 7 criteria that combined 6 criteria of Fawcett & DeSanto-Madeya (2013) and 1 criteria (generality) of Chinn & Kramer (2015). For evaluation, literature was searched in the PubMed, Web of Science, CINAHL, and RISS databases. Total 11 literatures were reviewed. Results: TCSB was confirmed to be a mid-range theory in that it specifies two metaparadigms; environment and nursing, the target population is not limited, and hypotheses can be derived through a certain number of main concepts. Also, in terms of secondary preventive behavior, it has theoretical/social significance, semantic/structural internal consistency, and parsimony. However, the testability was low due to the lack of proper empirical indicators and tools to measure main concepts. For this reason, it showed controversial empirical results and led to low empirical adequacy. Lastly, it was considered to have partial pragmatic adequacy and generality because they can be applied to various groups and diseases. Conclusion: TCSB has been continuously evolving. Therefore, it was confirmed that it is a suitable theory to explain secondary preventive behavior such as screening tests and establish strategies for health crisis situations such as the current COVID-19 pandemic. In addition, TCSB has simplicity to use in aspects of nursing theory, practice, and education, therefore it is needed to test for worth being more tested for various health problems and population through refining concepts and propositions and developing measuring tools
Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium
Lee, Jesun,Jung, Jooyoung,Tak, Min Ho,Wee, Jungwon,Lee, Byeongjoon,Jang, Yongwoo,Chun, Hyeyeon,Yang, Dong-Jin,Yang, Young Duk,Park, Sang Ho,Han, Byung Woo,Hyun, Soonsil,Yu, Jaehoon,Cho, Hawon,Hartzell Springer Berlin Heidelberg 2015 Pfl ugers Arch Vol.467 No.8
<P>Anoctamin 1 (ANO1)/TMEM16A is a Cl<SUP>−</SUP> channel activated by intracellular Ca<SUP>2+</SUP> mediating numerous physiological functions. However, little is known of the ANO1 activation mechanism by Ca<SUP>2+</SUP>. Here, we demonstrate that two helices, “reference” and “Ca<SUP>2+</SUP> sensor” helices in the third intracellular loop face each other with opposite charges. The two helices interact directly in a Ca<SUP>2+</SUP>-dependent manner. Positively and negatively charged residues in the two helices are essential for Ca<SUP>2+</SUP>-dependent activation because neutralization of these charges change the Ca<SUP>2+</SUP> sensitivity. We now predict that the Ca<SUP>2+</SUP> sensor helix attaches to the reference helix in the resting state, and as intracellular Ca<SUP>2+</SUP> rises, Ca<SUP>2+</SUP> acts on the sensor helix, which repels it from the reference helix. This Ca<SUP>2+</SUP>-dependent push-pull conformational change would be a key electromechanical movement for gating the ANO1 channel. Because chemical activation of ANO1 is viewed as an alternative means of rescuing cystic fibrosis, understanding its gating mechanism would be useful in developing novel treatments for cystic fibrosis.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00424-014-1603-2) contains supplementary material, which is available to authorized users.</P>