소아에서 편도절제술 시행시 진통효과 : Tramadol과 Meperidine의 비교

소금영,식홍림,임시경,안태훈,임태승 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

Background: Pain is major problem regarding quality of life in children undergoing tonsillectomy. Preemptive analgesia by medicine given before commencement of surgery is a new recommended for relief of pain during and after operation. We compared intra-and postoperative analgesic and recovery characteristics of tramadol, meperidine given at induction of anesthesia in 40 ASA I or II children undergoing tonsillectomy with or without adenoidectomy. Materias and Methods: Fourty children aged 4-7 years undergoing tonsillectomy with or without adenoidectomy were randomly assigned to receive either tramadol 2 mg/kg (group 1) or meperidine 1 mg/kg (group 2) at induction of anesthesia. Thiopental sodium (5 mg/kg) and rocuronium (0.6 mg/kg) were used for the induction of anesthesia, and it was maintained with sevoflurane in N₂O/O₂50/50 via an endotracheal tube. Pain assessment was done by facial pain scale. Agitation scores, time to recovery of spontaneous respiration and the incidence of postoperative nausea and vomiting. Heart rate and mean arterial pressure was recorded at regular intervals. Results: Facial pain scale scores were increased in group 1 at 10 and 20 min in recovery room. There was no difference for agitation scores in the two groups. Intraoperative mean arterial pressure (15th min) were found to be higher in group 1. The time to recovery of spontaneous respiration was delayed with group 2 compared with group 1. The incidence of nausea and vomiting was not statistically differed between groups. Conclusions: Meperidine was more effective for pain relief than tramadol after tonsillectomy in children.

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Zhang, Lin-Lin,Sun, Liang,Zhu, Xiao-Quan,Xu, Yong,Yang, Kuo,Yang, Fan,Yang, Yi-Ge,Chen, Guo-Qiang,Fu, Ji-Cheng,Zheng, Chen-Guang,Li, Ying,Mu, Xiao-Qiu,Shi, Xiao-Hong,Zhao, Fan,Wang, Fei,Yang, Ze,Wang, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

Existence of Nonoscillatory Solution of Second Order Nonlinear Neutral Delay Equations

Lin, Shi-Zhong,Qu, Ying,Yu, Yuan-Hong Department of Mathematics 2006 Kyungpook mathematical journal Vol.46 No.2

In this paper, we study nonoscillatory solutions of a class of second order nonlinear neutral delay differential equations with positive and negative coefficients. Some sufficient conditions for existence of nonoscillatory solutions are obtained.

CpG methylated ribosomal RNA genes in relation to wing polymorphism in the rice pest Sogatella furcifera

Shi-Ke Liang,Zi-Qiang Liang,Xiao-Sui Zhou,Jia-Lin Chen,Guang-Hong Li,Fang-Hai Wang 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.3

Sogatella furcifera is amajor rice pest that exhibits wing dimorphism. The methylation-sensitive representational difference analysis (MS-RDA) is widely used in plants and some animals to identify methylation differences in genomic DNA regions. However the method has been applied to insects very less. The objective of the current research was tomonitor differential cytosine methylations at CCGG sequences inmacropterous and brachypterous adults of female S. furcifera to determine the association between gene methylation and wing phenotypes using MS-RDA. After the second subtractive hybridization, two differentially methylated DNA fragments were obtained. These DNA fragments were then cloned into the pGEM-T vector and sequenced. One fragment fromthe positive hybridization was 464 bp, and highly similar to the 18S ribosomal RNA (rRNA) genes from some animals. Another fragment from the reverse hybridization was 453 bp, and homologous to the 28S rRNA gene of S. furcifera with a similarity rate as high as 99%. These results provide potential evidence that DNA methylation of rRNA genes may be related to wing phenotype variations in S. furcifera, and will facilitate future studies on the epigenetic mechanisms of insect wing polymorphism.

Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii

Hong-Sheng Wang,Ling Sun,Yue-Hu Wang,Ya-Na Shi,Gui-Hua Tang,Fu-Wei Zhao,Hong-Mei Niu,Chun-Lin Long,Ling Li 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8

A new dihydroflavone, 5-carboxymethyl-7,4'-dihydroxyflavonone (1), and its glucoside 5-carboxymethyl-7,4'-dihydroxyflavonone-7-O-β-D-glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-β-D-glucopyranoside (3), were isolated from the whole plants of Selaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% (p < 0.01) by compound 2 at a concentration of 0.1 μM in the presence of insulin (1 nM).

Digital Image-based Identification Method for the Determination of the Particle Size Distribution of Dam Granular Material

Shi-lin Zhang,Gao-jian Wu,Xingguo Yang,Wan-hong Jiang,Jia-wen Zhou 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.8

The Particle Size Distribution (PSD) properties of dam granular material plays an important role in the construction process ofearth-rock dams, as it can affect the filling quality and structural safety. However, the conventional sieving method employed tocheck the PSD is labor-intensive, time-consuming and not highly accurate. In this study, a digital image-based identification methodis presented for the determination of the PSD of dam granular material, which mainly incorporates image acquisition technology, alarge database and a neural network. Digital Image Processing (DIP) technology is used to recognize the geometric size and gradingcurve of dam granular materials at a small scale, while statistical distribution models are used to determine the characteristicparameters of the grading curve and convert the graphical curve into mathematical variables. Furthermore, a large database and a BPneutral algorithm, which is improved using a genetic algorithm, are introduced as tools to reveal the implicit relationship between theDIP and sieving grading curves to correct the error of identification. A case study for the Changheba Hydropower Station is used toillustrate the implementation details of the presented method. The identification results demonstrate that the presented method canacquire and assess the gradation in spite of a degree of error, which can be decreased when more advanced DIP technologies areexplored, the amount of data in the database is increased, and a more optimized network algorithm is adopted.

Screening of Recurrence Related MicroRNA in Ductal Carcinoma In Situ and Functional Study of MicroRNA-654-5p

Shi Li,Tianjie Pu,Lin Xiao,Hongwei Gao,Li Li,Feng Ye,Yueping Liu,Hong Bu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1

Purpose: Ductal carcinoma in situ (DCIS) contributes to 20%–30% of newly diagnosed cases of breast cancer in China. Although the breast cancer-specific mortality of DCIS is extremely low, a small proportion of DCIS patients still show relapse or metastasis, leading to poor prognosis. Little is known about the molecular mechanism for DCIS metastasis, partly due to the limited number of poor prognosis patients. This study analyzed the clinicopathological features and screened key microRNAs (miRNAs) contributing to local or distant recurrence. Methods: The clinicopathological features of DCIS were evaluated and survival analysis were performed to clarify risk factors associated with poor prognosis. Using miRNA arrays and real-time quantitative polymerase chain reaction (RT-qPCR) on DCIS formalin-fixed and paraffin-embedded samples with or without microinvasion with different clinical outcomes, potential DCIS metastasis-related miRNAs were screened out and further validated. The influence of one identified miRNA, miRNA-654-5p, on DCIS progression was analyzed. Results: Poor prognosis was significantly associated with larger tumor size and higher lymph node metastasis rate (both p < 0.05). Both were independent prognostic factors for DCIS. According to RT-qPCR results, distinct miRNA expression profiles were identified between DCIS and DCIS with microinvasion (DCIS-Mi) patients. In the DCIS panel, miRNA-654-5p was significantly upregulated in the patients with poor prognosis. In vitro, miRNA-654-5p promoted MDA-MB-231 cell mobility in healing tests and metastasis in the Transwell study. Conclusion: The panel of high-risk miRNAs in DCIS and DCIS-Mi differs markedly. miRNA-654-5p is significantly upregulated DCIS patients having poor prognosis and may be essential for local and distant recurrence in DCIS.

On the Possibility of Seasonal Prediction of Typhoon Activity using modified FDDA

Joo-Hong Kim,Chang-Hoi Ho,Chung-Hisung Sui,Wen-shi Lin 한국기상학회 2004 한국기상학회 학술대회 논문집 Vol.2004 No.-

Genetic Diversity and Phylogenetic Relationships between Chinese Cabbages [B. campestris (syn. rapa) L.] and Cabbages (B. oleracea L.) in Korea

Yan-Lin Sun,Shi-Lin Zheng,Kyong-Cheul Park,Ki-Young Choi,Ho-Min Kang,Soon-Kwan Hong 한국원예학회 2016 원예과학기술지 Vol.34 No.2

Members of the genus Brassica, which are known as oil crops or cruciferous vegetables, are widely cultivated in Canada, Australia, Asian and Europe. Because Brassica species have high yields, are well adapted to their environments, and are self-incompatible, the germplasm is abundant. Previous studies have reported abundant genetic diversity even within Brassica subspecies. In Korea, fresh cabbage leaves are eaten with roast meat, and to meet the current popular demand, new varieties are being increasingly bred. To determine the genetic diversity and relationships among the cabbage vegetables in Korea, we evaluated the genetic variation of 18 accessions based on 5S and 18S ribosomal RNA (rRNA) gene sequences. We detected many variable nucleotide sites, especially in the 5S rRNA gene sequences. Because the length of the 18S rRNA gene might influence the dissimilarity rate statistics, we used both the 5S and 18S sequences to analyze the phylogenetic relationships. S7 (B. oleracea) showed the most distant phylogenetic relationship with the other Brassica species. Interestingly, B2 (B. oleracea), B15, and B18 (B. campestris) have three different types of leaf profiles, and were divided into one group, and the other Brassica species formed another group. Statistical analysis of interspecies and intraspecies genetic distances revealed that B. campestris L. showed higher genetic diversity than B. oleracea L. This work provides additional data that facilitates the evaluation of the genetic variation and relationships among Brassica species. The results could be used in functional plant breeding programs to improve Brassica crops.

Recent progress (2015e2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb₁, a main active ingredient in Panax ginseng Meyer

Zuan Lin,Rongfang Xie,Chenhui Zhong,Jianyong Huang,Peiying Shi,Hong Yao 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1

Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb1 against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effects of Rb1 on these diseases are referring to HMGB1, GLUT4, 11b-HSD1, ERK, Akt, Notch, NF-kB, MAPK, PPAR-g, TGF-b1/Smad pathway, PI3K/mTOR pathway, Nrf2/HO-1 pathway, Nrf2/ARE pathway, and MAPK/NF-kB pathway. The potential effects of Rb1 and its possible mechanisms against diseases were further predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and disease ontology semantic and enrichment (DOSE) analyses with the reported targets. This study provides insights into the therapeutic effects of Rb1 and its mechanisms against diseases, which is expected to help in promoting the drug development of Rb1 and its clinical applications.