Considerations of Intermaxillary Fixation Methods in the Management of Mandibular Fractures

( Kyung Ho Song ),( Seul Ki Lee ),( Jae An Chung ),( Jin Eob Shin ),( Jwa Young Kim ),( Sang Hoon Song ),( Byoung Eun Yang ),( Young Jun Choi ),( Seong Gon Kim ) 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.2S

Prognostic value of $^{18}F$-fluorodeoxyglucose positron emission tomography, computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with pathologically positive neck lymph node

Jwa, Eunjin,Lee, Sang-Wook,Kim, Jae-Seung,Park, Jin Hong,Kim, Su Ssan,Kim, Young Seok,Yoon, Sang Min,Song, Si Yeol,Kim, Jong Hoon,Choi, Eun Kyung,Ahn, Seung Do The Korean Society for Radiation Oncology 2012 Radiation Oncology Journal Vol.30 No.4

Purpose: To evaluate the prognostic value of preoperative neck lymph node (LN) assessment with $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET), computed tomography (CT), and magnetic resonance imaging (MRI) in oral cavity squamous cell carcinoma (OSCC) patients with pathologically positive LN. Materials and Methods: In total, 47 OSCC patients with pathologically positive LN were retrospectively reviewed with preoperative $^{18}F$-FDG PET and CT/MRI. All patients underwent surgical resection, neck dissection and postoperative adjuvant radiotherapy and/or chemotherapy between March 2002 and October 2010. Histologic correlation was performed for findings of $^{18}F$-FDG PET and CT/MRI. Results: Thirty-six (76.6%) of 47 cases were correctly diagnosed with neck LN metastasis by $^{18}F$-FDG PET and 32 (68.1%) of 47 cases were correctly diagnosed by CT/MRI. Follow-up ranged from 20 to 114 months (median, 56 months). Clinically negative nodal status evaluated by $^{18}F$-FDG PET or CT/MRI revealed a trend toward better clinical outcomes in terms of overall survival, disease-free survival, local recurrence-free survival, regional nodal recurrence-free survival, and distant metastasis-free survival rates even though the trends were not statistically significant. However, there was no impact of neck node standardized uptake value ($SUV_{max}$) on clinical outcomes. Notably, $SUV_{max}$ showed significant correlation with tumor size in LN (p < 0.01, $R^2$ = 0.62). PET and CT/MRI status of LN also had significant correlation with the size of intranodal tumor deposit (p < 0.05, $R^2$ = 0.37 and p < 0.01, $R^2$ = 0.48, respectively). Conclusion: $^{18}F$-FDG PET and CT/MRI at the neck LNs might improve risk stratification in OSCC patients with pathologically positive neck LN in this study, even without significant prognostic value of $SUV_{max}$.

Gamma-irradiation-killed <i>Streptococcus pneumoniae</i> potently induces the expression of IL-6 and IL-8 in human bronchial epithelial cells

Jwa, Min Yong,Ko, Eun Byeol,Kim, Hyun Young,Kim, Sun Kyung,Jeong, Soyoung,Seo, Ho Seong,Yun, Cheol-Heui,Han, Seung Hyun Elsevier 2018 Microbial pathogenesis Vol.124 No.-

<P><B>Abstract</B></P> <P> <I>Streptococcus pneumoniae</I> is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and cost-effective vaccines. Recently, an intranasal vaccine formulated with gamma-irradiated nonencapsulated <I>S. pneumoniae</I> whole cells has been developed and its immunogenicity is under investigation. Since innate immunity influences the subsequent adaptive immunity, in the present study, we investigated the immunostimulatory activity of gamma-irradiated <I>S. pneumoniae</I> (r-SP) in the human bronchial epithelial cell-line, BEAS-2B, by comparing with heat-inactivated <I>S. pneumoniae</I> (h-SP) and formalin-inactivated <I>S. pneumoniae</I> (f-SP). r-SP potently induced interleukin (IL)-6 and IL-8 at both mRNA and protein levels in a dose- and time-dependent manner, whereas h-SP and f-SP poorly induced them. Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 × 10<SUP>7</SUP> CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 × 10<SUP>7</SUP> CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP. The expression of IL-6 and IL-8 induced by r-SP was mediated through the activation of mitogen-activated protein kinases. Remarkably, when r-SP was further treated with heat or formalin, there was a decrease in the aforementioned activities. Taken together, we suggest that r-SP stimulates the human respiratory epithelial cells to produce the cytokines IL-6 and IL-8, which might influence the induction of adaptive immune responses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> r-SP induces IL-6 and IL-8 expression more potently than h-SP or f-SP in BEAS-2B cells. </LI> <LI> r-SP phosphorylates MAP kinases more potently than h-SP or f-SP in BEAS-2B cells. </LI> <LI> r-SP strongly activates TLR2 compared with h-SP or f-SP. </LI> <LI> Soluble components of r-SP are responsible for the potent immunostimulatory activity. </LI> </UL> </P>

A Comparison Experiment on the Compressive Strength of the Sealant and the Micro-leakage according to the Light Source Enlighting

Eun-Kyoung Lee,Mi-Kyoung Jeong,Ji-Yonng Lee,Su-Kyung Jwa,Ja-Won Cho 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.4

Objective: The purpose of this study was to increase success rate of sealant targeting C Product/3M Espe, T Product/Kuraray, U Product/Ultradent, and H Product/Ivoclar Vivadent AG as the light-cured sealants with high use frequency in the clinical. Methods: It polymerized halogen curing unit ULTRA-LIRE 5 TUBO (ROLENCE ENTERRISE INC), plasma arc curing unit LIEXTN 685 (3M Espe, USA), and LED curing unit Elipar Freelight 2 (3M Espe, USA), evaluated the compressive strength and micro-leakage in each material according to light wave length, compared difference between each curing unit and material, and then carried out this experiment in order to be conducive to selecting proper material. Results: U Product showed the highest compressive strength in light-source Plasma arc and LED. U Product and C Product showed high compressive strength in Halogen (p<0.001). As for a result of measuring the micro-leakage according to light source in tooth surface depending on a kind of sealant, T Product and U Product showed low micro-leakage in Plasma arc (p<0.001). As for a result of measuring the micro-leakage in tooth surface of sealant according to light source, Plasma arc showed the lowest micro-leakage in C Product, T Product, and U Product. Plasma arc and Halogen showed low micro-leakage in H Product (p<0.001). Conclusion: In consequence of the above experiment, the patients with strong occlusal force in the clinical application of sealant are recommended to polymerize U Product with LED. The patients as children with high probability of micro-leakage are recommended to use T Product as Plasma arc.

Gamma-irradiation of Streptococcus pneumoniae for the use as an immunogenic whole cell vaccine

Jwa, Min Yong,Jeong, Soyoung,Ko, Eun Byeol,Kim, A Reum,Kim, Hyun Young,Kim, Sun Kyung,Seo, Ho Seong,Yun, Cheol-Heui,Han, Seung Hyun MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.8

The Relation between Fertilization Practices and Functional Metabolites of Crops

Jung-Eun Lim,Min-Ji Cho,Hye-Jin Yun,Sang-Keun Ha,Deog-Bae Lee,Jwa-Kyung Sung 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.2

Various researches on the effects of fertilization levels on functional metabolites in crop have been conducted. This review summarizes the previous studies on the relation between fertilization supply and accumulation of metabolites (phenolics, carotenoids, ascorbic acid and glucosinolates) which function as antioxidants in crop. The accumulation of phenolic compounds is related to the activation of phenylalanine ammonia lyase (PAL) in phenylpropanoid pathway. Most of the previous studies discuss that low nitrogen (N) supply activates PAL, thereby increasing the synthesis of phenolics. Similarly, high N supply leads to a decrease in ascorbic acid because of the shading effect derived from the accelerated vegetative growth under high N level. Unlike the phenolics and ascorbic acid, carotenoids are accumulated with increasing N supply. In this regard, the previous studies explain that N is a main element closely associated with formation of key enzyme for the synthesis of carotenoids. Glucosinolates are generally increased under decreasing N supply and increasing S supply. Although the previous studies show similar trends about the accumulation of metabolites by nutrient level, they also suggest that many other factors including crop types, cultivars, cultural environment (water, temperature, light, etc.) influence the accumulation of functional metabolites in crop.

Adoptive transfer of all-trans-retinal-induced regulatory T cells ameliorates experimental autoimmune arthritis in an interferon-gamma knockout model

Jeon, Eun-Joo,Yoon, Bo-Young,Lim, Jung-Yeon,Oh, Hye-Jwa,Park, Hyun-Sil,Park, Min-Jung,Lim, Mi-Ae,Park, Mi-Kyung,Kim, Kyung-Woon,Cho, Mi-La,Cho, Seok-Goo Informa Healthcare 2012 Autoimmunity Vol.45 No.6

<P>Maintaining an appropriate balance between subsets of CD4<SUP>+</SUP> helper T cells and T regulatory cells (Tregs) is a critical process in immune homeostasis and a protective mechanism against autoimmunity and inflammation. To identify the role of vitamin A-related compounds, we investigated the regulation of interleukin (IL)-17-producing helper T cells (Th17 cells) and Tregs treated with all-trans-retinal (retinal). CD4<SUP>+</SUP>T cells or total cells from the spleens of C57BL/6 mice were stimulated under Treg-polarizing (anti-CD3/CD28 and TGF-β) or Th17-polarizing (anti-CD3/CD28, TGF-β, and IL-6) conditions in the presence or absence of retinal. To analyze their suppressive abilities, retinal-induced Tregs or TGF-β-induced Tregs were co-cultured with responder T cells. Collagen-induced arthritis (CIA) was established in interferon (IFN)-γ knockout mice. On day 13, retinal-induced Tregs were adoptively transferred to mice with established CIA after second immunizations. Compared with TGF-β-induced Treg cells, retinal-induced Tregs showed increased Foxp3 expression and mediated stronger suppressive activity. Under Th17-polarizing conditions, retinal inhibited the production of IL-17 and increased the expression of Foxp3.Retinal-induced Tregs showed therapeutic effects in IFN-γ knockout CIA mice. Thus, we demonstrated that retinal reciprocally regulates Foxp3<SUP>+</SUP> Tregs and Th17 cells. These findings suggest that retinal, a vitamin A metabolite, can regulate the balance between pro- and anti-inflammatory immunity. A better understanding of the manipulation of Foxp3 and Tregs may enable the application of this tremendous therapeutic potential in various autoimmune diseases.</P>

스마트폰 이용자의 모바일광고 이용동기와 만족에 관한 연구

한은경(Eun Kyung Han),김좌중(Jwa Joong Kim) 사이버커뮤니케이션학회 2011 사이버 커뮤니케이션 학보 Vol.28 No.1

본 연구는 스마트폰을 이용하는 모바일 이용자들이 어떠한 동기 요인으로 모바일광고를 이용하는지 알아보고, 각 동기 요인이 모바일광고에 대한 태도와 만족도에 어떠한 영향을 미치는지 알아보기 위한 연구이다. 이를 위해 스마트폰 이용자들만을 대상으로 모바일광고의 이용동기, 모바일광고에 대한 태도와 모바일광고에 대한 만족도 등을 조사하였다. 이번 연구의 조사 결과 스마트폰 이용자들은 다양한 동기로 모바일광고를 이용하고 있다는 사실을 알 수 있었다. 모바일광고이용 동기요인은 이용자들이 모바일광고를 제품에 대한 정보를 획득 할 수 있기 때문에 이용하는 ‘제품정보획득’의 동기요인, 경제적 이익을 얻을 수 있기 때문에 이용하는 ‘경제적’ 요인, 다른 사람들과의 관계를 위한 ‘사회적’ 동기 요인, 그리고 재미와 호기심으로 이용하는 ‘흥미’ 요인으로 총 4개의 요인이 추출되었다. 각 요인이 모바일광고에 대한 태도에 미치는 영향에서는 제품정보획득, 경제, 흥미 요인이 유의미한 영향을 미치는 것으로 조사되었다. 모바일광고에 대한 만족도는 제품정보획득, 흥미 요인이 유의미한 영향을 미치는 것으로 나타났다. 마지막으로 기존의 광고에 대한 태도가 만족도에 대해 유의미한 영향을 미친다는 사실을 스마트폰에서의 모바일광고에서도 적용되는지를 파악해 보았다. 분석 결과 기존의 연구에서 검증되었듯이 모바일광고 역시 광고에 대한 태도가 만족도에 유의미한 영향을 미치는 것으로 나타났다. 스마트폰 이용자들의 모바일광고에 대한 태도와 만족도에 대한 결과를 종합적으로 정리해 보면, 스마트폰 이용자들의 모바일광고에 대한 태도와 만족도 모두 영향을 미치는 요인으로 제품정보획득과 흥미요인으로 나타났다. 경제 요인은 모바일광고에 대한 태도에는 영향을 미치는 것으로 나타났으나 만족에 대해서는 유의미한 영향을 미치지 못하는 것으로 나타났다. 이에 반해 사회 요인은 모바일광고에 대한 태도와 만족도 모두 영향을 미치지못한 것으로 조사되었다. This study is to see which motive factor mobile smartphone users use mobile advertisements with, and find what effect each motive factor has on users’ attitude and satisfaction toward mobile advertisements. To achieve this, users’ motives to use mobile advertisements, users’ attitudes and satisfactions toward mobile advertisements were researched from only smartphone users. The result of this research shows that smartphone users use mobile advertisements with various motives. Total 4 motive factors to use mobile advertisements were obtained including the motive factor ‘to obtain product information’ since users can obtain information about products from using mobile advertisements, ‘economic’ factor for obtaining economic benefits, ‘social’ motive factor for the relationship with other people and ‘interest’ factor for fun and curiosity. And the study shows that the motive factor ‘to obtain product information’, ‘economic’ factor and ‘interest’ factor give a meaningful effect on users’ attitude toward mobile advertisements. And, the study also shows that the motive factor ‘to obtain product information’ and ‘interest’ factor give a meaningful effect on users’ satisfaction toward mobile advertisements. Lastly, the analysis was conducted on whether the fact that users’ attitude toward previous advertisements give a meaningful effect on their satisfaction could be applied to mobile advertisements in smartphones.

토론회를 활용한 의료윤리 교육: 서울의대의 경험

박은경 ( Eun Kyung Park ),신좌섭 ( Jwa Seop Shin ),안규리 ( Cu Rie Ahn ),성명훈 ( Myung Whun Sung ),권복규 ( Ivo Kwon ) 한국의료윤리학회 2002 한국의료윤리학회지 Vol.5 No.2

Prognostic value of 18F-fluorodeoxyglucose positron emission tomography, computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with pathologically positive neck lymph node

Eunjin Jwa,Sang-Wook Lee,Jae-Seung Kim,Jin Hong Park,Su Ssan Kim,Young Seok Kim,Sang Min Yoon,Si Yeol Song,Jong Hoon Kim,Eun Kyung Choi,Seung Do Ahn 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.3

Purpose: To evaluate the prognostic value of preoperative neck lymph node (LN) assessment with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), computed tomography (CT), and magnetic resonance imaging (MRI) in oral cavity squamous cell carcinoma (OSCC) patients with pathologically positive LN. Materials and Methods: In total, 47 OSCC patients with pathologically positive LN were retrospectively reviewed with preoperative 18F-FDG PET and CT/MRI. All patients underwent surgical resection, neck dissection and postoperative adjuvant radiotherapy and/or chemotherapy between March 2002 and October 2010. Histologic correlation was performed for findings of 18F-FDG PET and CT/MRI. Results: Thirty-six (76.6%) of 47 cases were correctly diagnosed with neck LN metastasis by 18F-FDG PET and 32 (68.1%) of 47 cases were correctly diagnosed by CT/MRI. Follow-up ranged from 20 to 114 months (median, 56 months). Clinically negative nodal status evaluated by 18F-FDG PET or CT/MRI revealed a trend toward better clinical outcomes in terms of overall survival, disease-free survival, local recurrence-free survival, regional nodal recurrence-free survival, and distant metastasis-free survival rates even though the trends were not statistically significant. However, there was no impact of neck node standardized uptake value (SUVmax) on clinical outcomes. Notably, SUVmax showed significant correlation with tumor size in LN (p < 0.01, R2 = 0.62). PET and CT/MRI status of LN also had significant correlation with the size of intranodal tumor deposit (p < 0.05, R2 = 0.37 and p < 0.01, R2 = 0.48, respectively). Conclusion: 18F-FDG PET and CT/MRI at the neck LNs might improve risk stratification in OSCC patients with pathologically positive neck LN in this study, even without significant prognostic value of SUVmax.