Antimicrobial efficacy of extracts and constituents fractionated from <i>Rheum tanguticum</i> Maxim. ex Balf. rhizomes against phytopathogenic fungi and bacteria

Pham, Duong Quang,Ba, Duong Thi,Dao, Nga Thu,Choi, Gyung Ja,Vu, Thuy Thu,Kim, Jin-Cheol,Giang, Thi Phuong Ly,Vu, Hoang Dinh,Le Dang, Quang Elsevier 2017 INDUSTRIAL CROPS AND PRODUCTS Vol.108 No.-

<P><B>Abstract</B></P> <P>The antimicrobial efficacies of extracts and constituents fractionated from <I>Rheum tanguticum</I> rhizomes were evaluated by using <I>in vitro</I> and <I>in vivo</I> bioassay against seven phytopathogenic fungi and ten pathogenic bacteria, respectively. Dichloromethane and ethyl acetate soluble extracts derived from <I>R. tanguticum</I> rhizomes effectively controlled plant diseases caused by five fungi <I>Magnaporthe oryzae</I>, <I>Blumeria graminis</I> f. sp<I>. hordei, Colletotrichum coccodes, Phytophthora infestans,</I> and <I>Puccinia recondita</I> in <I>in vivo</I> whole plant bioassay. In addition, these extracts showed strong inhibitory activity against the bacterial growth of <I>Acidovorax avenae</I> subsp. <I>cattlyae</I> (Aac), <I>Clavibacter michiganensis</I> subsp. <I>michiganensis</I>, <I>Xanthomonas arboricola</I> pv. <I>pruni</I> (Xap), and <I>Pseudomonas syringae</I> pv. <I>actinidiae</I> (Psa), with MIC values ranging from 125 to 250μg/mL. The active extracts of <I>R. tanguticum</I> rhizomes were fractionated by using various and repeated chromatographic techniques to yield seven constituents that included three anthraquinones and four stilbenes. Notably, at concentrations ranging from 75 to 300μg/mL, physcion (<B>DH03</B>) and chrysophanol (<B>DH04</B>) were significantly effective in suppressing the development of barley powdery mildew (BPM) caused by <I>B. graminis</I> f. sp. <I>hordei,</I> with control values from 80 to 96.7%. Moreover, stilbenes rhapontigenin (<B>DH02</B>) and desoxyrhapontigenin (<B>DH05</B>) had a broad spectrum and potent activity against phytopathogenic bacteria; <B>DH05</B> effectively inhibited the bacterial growth of Aac, <I>Burkholderia glumae</I> and Psa at MICs ranging from 38 to 150μg/mL. In this paper, we report their antibacterial activity for the first time. The botanical materials containing anthraquinones and stilbenes were active against both phytopathogenic fungi and bacteria. These results suggested that <I>R. tanguticum</I> rhizomes could be used as a new source of antimicrobial substances for developing a botanical fungicide and bactericide to control plant diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>R. tanguticum</I> extracts exhibited activity against phytopathogenic fungi and bacteria. </LI> <LI> Seven anthraquinones and stilbenes from <I>R. tanguticum</I> were isolated and identified. </LI> <LI> <I>In vivo</I> antifungal activity of botanicals was evaluated by the whole plant bioassay. </LI> <LI> The isolated stilbenes effectively inhibited the growth of phytopathogenic bacteria. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Metabolic Syndrome and Insulin Resistance Syndrome among Infertile Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from Central Vietnam

Minh Tam Le,Vu Quoc Huy Nguyen,Quang Vinh Truong,Dinh Duong Le,Viet Nguyen Sa Le,Ngoc Thanh Cao 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.4

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). Theobjective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS. Methods: A cross-sectional study was conducted at a tertiary fertility centre at Hue University Hospital from June 2016 to November 2017. A total of 441 infertile women diagnosed with PCOS based on the revised 2003 Rotterdam consensus criteria were enrolled. MS and IRS were defined based on the National Heart, Lung, and Blood Institute/American Heart Association Adult Treatment Panel III 2005 and American College of Endocrinology IRS 2003 criteria, respectively. Complete clinical and biochemicalmeasurements of 318 women were available for analysis. Independent predictors of MS and IRS were identified using multivariatelogistic regression. Results: The overall prevalence of MS and IRS in women with PCOS was 10.4% and 27.0%, respectively. We identified older age(>30 years) and obesity as independent predictors of MS and IRS. Elevated anti-Müllerian hormone levels increased the risk of IRS,but not that of MS. Conclusion: MS and IRS are prevalent disorders among infertile Vietnamese women with PCOS. PCOS is not solely a reproductiveproblem. Screening and early intervention for MS and/or IRS based on anthropometric, metabolic, and reproductive hormone riskfactors should be an integral part of fertility care.

Factors Affecting FDI Intentions of Investors: Empirical Evidence from Provincial-Level Data in Vietnam

Van Loi TA,Anh Duc DO,To Uyen PHAN,Quang Huy NGUYEN,Thi Thuy Hong NGUYEN,Thuy Duong LE,Thanh Phong NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.4

This study aimed to explore the factors affecting the foreign direct investment (FDI) intentions of investors into Quang Ninh province, located in the north-eastern of Viet Nam. Researchers used two main methods, namely, Exploratory Factors Analysis (EFA) and the Structural Equation Model (SEM) based on partial least squares structural equation modeling (PLS SEM) to explore and measure the impact of factors affecting the investors’ FDI intentions into Quang Ninh province. The empirical analysis used data from the survey of 206 domestic and foreign investors into Quang Ninh province, including representatives of the Board of Directors, members, and management representatives at the department level, with reliable tools (SPSS 26 and SmartPLS 3.0 software). The research results identified the following factors affecting investment into Quang Ninh: FDI attraction policies have the strongest impact on the investors’ FDI intentions; it is followed by infrastructure, public services and human capital with strong effects on intentions of investors’ FDI; and finally the standards of living that affects the investors’ FDI intentions. There is also a positive relationship between all the factors and the investors’ FDI intentions. Several recommendations are further suggested to enhance attraction of foreign direct investment into Quang Ninh province.

Tetradiazo(o-carboxy)phenylcalix[4]arene for Determination of Pb2+ Ion

Le Van Tan,Duong Tuan Quang,이민희,김태현,김하석,Jong Seung Kim* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.5

A new azocalix[4]arene, 5,14,17,23-tetra[(2-benzoic acid)(azo)phenyl] calix[4]arene (2), has been prepared by hydrolysis of its ester derivative and characterized by 1H NMR, IR, UV-Vis spectroscopy and elemental analysis. Based on UV spectral changes, we found that 2 exhibits Pb2+ ion selectivity. In basic media, Pb2+ forms a 1:1 complex with the ligand. Beers law is obeyed in the range of 2.0 10-6 2.4 10-5 mol L-1 of Pb2+. The molar absorptivity (e ) of 2-Pb2+ complex is 1.89 104 L mol-1 cm-1 at 440 nm, and the detection limit is 1.6 10-6 mol L-1.

A two-stage approach of multiplicative dimensional reduction and polynomial chaos for global sensitivity analysis and uncertainty quantification with a large number of process uncertainties

Minh, Le Quang,Duong, Pham Luu Trung,Goncalves, Jorge,Kwok, Ezra,Lee, Moonyong Elsevier 2017 Journal of the Taiwan Institute of Chemical Engine Vol.78 No.-

<P><B>Abstract</B></P> <P>Uncertainties associated with estimates of model parameters are inevitable when simulating and modeling chemical processes and significantly affect safety, consistency, and decision making. Quantifying those uncertainties is essential for emulating the actual system behaviors because they can change the management recommendations that are drawn from the model. The use of conventional approaches for uncertainty quantification (<I>e.g</I>., Monte-Carlo and standard polynomial chaos methods) is computationally expensive for complex systems with a large/moderate number of uncertainties. This paper develops a two-stage approach to quantify the uncertainty of complex chemical processes with a moderate/large number of uncertainties (greater than 5). The first stage applies a multiplicative dimensional reduction method to approximate the variance-based global sensitivity measures (Sobol's method), and to simplify the model for the uncertainty quantification stage. The second stage uses the generalized polynomial chaos approach to quantify uncertainty of the simplified model from the first stage. A rigorous simulation illustrates the proposed approach using an interface between MATLAB and HYSYS for three complex chemical processes. The proposed method was compared with conventional approaches, such as the Quasi Monte-Carlo sampling-based method and standard polynomial chaos-based method. The results revealed the clear advantage of the proposed approach in terms of the computational efforts.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A two-stage approach of M-DRM and gPC proposed to UQ and SA. </LI> <LI> Sobol's indices detect non-influential inputs with little computational burden. </LI> <LI> The proposed method was compared with conventional gPC/QMC/MC methods. </LI> <LI> The computational cost was reduced by 10–100 times in comparison with the QMC method. </LI> <LI> The proposed method addresses global SA with UQ with large number of uncertain parameters. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Global Sensitivity Analysis and Uncertainty Quantification of Crude Distillation Unit Using Surrogate Model Based on Gaussian Process Regression

Minh, Le Quang,Duong, Pham Luu Trung,Lee, Moonyong American Chemical Society 2018 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.57 No.14

<P>This study presents a global sensitivity analysis to simplify a surrogate-model-based uncertainty quantification of a crude distillation unit with a large number of uncertainties. To overcome the computational limitation of a conventional surrogate model-based approach where the number of simulations required grows exponentially as the input dimension increases, a novel two-stage approach was proposed in this study: in the first stage, a multiplicative dimensional reduction method is applied to identify factors that exert the highest influence on the model outputs. In the second stage, the Gaussian process regression is exploited for uncertainty quantification from the simplified model derived in the first stage. As a result, the computational efforts for uncertainty quantification were significantly reduced (approximately more than 95%) compared to the conventional Quasi Monte Carlo, while the predicted density functions by the proposed method closely matched with those from the Quasi Monte Carlo. The proposed two-stage approach was executed for sensitivity analysis and uncertainty quantification of a crude distillation unit by an interface between MATLAB and HYSYS. The economic revenue and the operating cost per unit of crude oil processed were selected as the output of interests for the crude distillation unit. The global sensitivity analysis result showed that the flow rates of crude oil and naphtha products are critical for both the economic revenue and the operating cost.</P> [FIG OMISSION]</BR>

Global Sensitivity Analysis and Uncertainty Quantification of Crude Distillation Unit Using Surrogate Model Based on Gaussian Process Regression

Minh, Le Quang,Duong, Pham Luu Trung,Lee, Moonyong ACS AMERICAN CHEMICAL SOCIETY 2018 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.57 No.14

Tetradiazo(o-carboxy)phenylcalix[4]arene for Determination of Pb²⁺ Ion

Tan, Le Van,Quang, Duong Tuan,Lee, Min-Hee,Kim, Tae-Hyun,Kim, Ha-Suck,Kim, Jong-Seung Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.5

A new azocalix[4]arene, 5,14,17,23-tetra[(2-benzoic acid)(azo)phenyl] calix[4]arene (2), has been prepared by hydrolysis of its ester derivative and characterized by 1H NMR, IR, UV-Vis spectroscopy and elemental analysis. Based on UV spectral changes, we found that 2 exhibits Pb2+ ion selectivity. In basic media, Pb2+ forms a 1:1 complex with the ligand. Beer's law is obeyed in the range of 2.0 × 10?6 ? 2.4 × 10?5 mol L?1 of Pb2+. The molar absorptivity (ε ) of 2-Pb2+ complex is 1.89 × 104 L mol?1 cm?1 at 440 nm, and the detection limit is 1.6 × 10?6 mol L?1.

Robust Static Output Feedback Controller Design via Chance Constrained Approach

Pham Luu Trung Duong,Le Minh Quang,Yuli Amalia Husnil,Riezqua Andika,Bong Gu Choi,Moonyong Lee 제어로봇시스템학회 2014 제어로봇시스템학회 국내학술대회 논문집 Vol.2014 No.5

Uncovering the Antibacterial Potential of a Peptide-Rich Extract of Edible Bird’s Nest against Staphylococcus aureus

Nguyen Thi-Phuong,Duong Tang Van,Le Thai Quang,Nguyen Khoa Thi 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.8

The diverse pharmacological properties of edible bird’s nest (EBN) have been elucidated in recent years; however, investigations into its antibacterial effects are still limited. In the present study, we explored the antibacterial activity of a peptide-rich extract of EBN against Staphylococcus aureus, a notorious pathogen. The EBN extract (EEE) was prepared by soaking EBN in 80% ethanol for 2 days at 60°C. Biochemical analyses showed that peptides at the molecular weight range of 1.7-10 kDa were the major biochemical compounds in the EEE. The extract exhibited strong inhibition against S. aureus at a minimum inhibitory concentration (MIC) of 125 μg/ml and a minimum bactericidal concentration (MBC) of 250 μg/ml. This activity could be attributed to the impact of the extract on cell membrane integrity and potential, biofilm formation, and reactive oxidative species (ROS) production. Notably, the expression of biofilm- and ROS-associated genes, including intercellular adhesion A (icaA), icaB, icaC, icaD, and superoxide dismutase A (sodA), were deregulated in S. aureus upon the extract treatment. Our findings indicate a noteworthy pharmacological activity of EBN that could have potential application in the control of S. aureus.