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Jung, Byeongjin,Huh, Hyungkyu,Lee, Eun-hee,Han, Mun,Park, Juyoung Elsevier 2019 Journal of controlled release Vol.315 No.-
<P><B>Abstract</B></P> <P>Despite the recent development of a focused ultrasound (FUS) technique for disrupting the blood-brain barrier (BBB) and enabling the delivery of drugs into the targeted brain region, different sonication protocols have not been fully explored. In this study, we suggest a simple and cost-effective protocol that improves the BBB permeability and drug delivery without damaging the tissue. In this protocol, called “FUS+BBBD protocol”, an additional FUS stimulation without microbubbles (“FUS protocol”; 0.5, 1.0, or 2.0MPa acoustic pressure, 10ms tone burst, 1Hz pulse repetition frequency, 120s total duration) is applied prior to the conventional BBB disruption with microbubbles (“BBBD protocol”; 0.6∼0.72MPa acoustic pressure, 10ms tone burst, 1Hz pulse repetition frequency, 120s total duration). With the “FUS+BBBD protocol”, the magnetic resonance signal intensity and doxorubicin delivery at the targeted brain region were increased by 1.59 and 1.75 times at an FUS intensity of 1.0MPa, respectively, compared to the conventional BBBD. Other conditions also increase the drug delivery, but the increase was smaller than that at 1.0MPa (1.15 times for 0.5MPa and 1.60 times for 2.0MPa). The H&E histopathological analysis of the sonicated brain region using the proposed “FUS+BBBD protocol” showed no significant brain tissue damage at a FUS intensity of 0.5 and 1.0MPa. However, region cavities due to the damage were observed after an FUS intensity of 2.0MPa. These results suggest that the 1.0MPa “FUS+BBBD protocol” increases the BBB permeability and enhances the drug delivery efficiency without noticeable brain tissue damage, compared with the conventional BBBD. Although further studies are needed to determine the underlying mechanism of this effect, drugs that have been reported to be effective in the treatment of brain disease but had limited use due to severe systemic side effects will benefit from the enhanced drug delivery of “FUS+BBBD protocol”. Furthermore, the suggested protocol may facilitate the development of new strategies in clinical trials to treat brain disorders with improved drug delivery and safety.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Byeongjin Jung,Sae Kwang KU,Ming Gao,KYUNG MIN KIM,한민수,Hyukjae Choi,Jong-Sup Bae 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
Diketopiperazine is a naturally occurring cyclicdipeptide found from diverse living organisms. The compoundsin this structure class have been known with abroad spectrum of bioactivities including anti-inflammatoryactivities. Transforming growth factor b-inducedprotein (TGFBIp) is an extracellular matrix protein whoseexpression in several cell types is greatly increased byTGF-b. TGFBIp is released by human umbilical veinendothelial cells and functions as a mediator of experimentalsepsis. Here, three (1–3) of diketopiperazines wereisolated from two strains of marine-derived bacteria and wehypothesized that 1–3 could reduce TGFBIp-mediatedsevere inflammatory responses in human endothelial cellsand mice. Here, we investigated the anti-septic effects andunderlying mechanisms of 1–3 against TGFBIp-mediatedseptic responses. 1–3 effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressedTGFBIp-mediated septic responses. In addition, 1–3 suppressedcecal ligation and puncture (CLP)-induced sepsislethality and pulmonary injury. In conclusion, 1–3 suppressedTGFBIp-mediated and CLP-induced septicresponses. Therefore, 1–3 could be a potential therapeuticagent for treatment of various severe vascular inflammatorydiseases via inhibition of the TGFBIp signalingpathway.
( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.
BMB Reports : Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses
( Byeongjin Jung ),( Hyejin Kang ),( Wonhwa Lee ),( Hyun Jin Noh ),( You Sun Kim ),( Min Su Han ),( Moon Chang Baek ),( Jaehong Kim ),( Jong Sup Bae ) 생화학분자생물학회 2016 BMB Reports Vol.49 No.4
A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strategy in the administration of severe sepsis or septic shock. Here, we examined the effects of dabrafenib (DAB) on the modulation of HMGB1-mediated septic responses. DAB inhibited the release of HMGB1 and downregulated HMGB1-dependent inflammatory responses by enhancing the expressions of cell adhesion molecules (CAMs) in human endothelial cells. In addition, treatment with DAB inhibited the HMGB1 secretion by CLP and sepsis-related mortality and pulmonary injury. This study demonstrated that DAB could be alternative therapeutic options for sepsis or septic shock via the inhibition of the HMGB1 signaling pathway. [BMB Reports 2016; 49(4): 214-219]
Junwoo Jung,Hyunhee Won,Sungyeol Park,Haengik Kang,Seungbok Kwon,Byeongjin Yu,Seungwoo Seo 사단법인 항법시스템학회 2023 Journal of Positioning, Navigation, and Timing Vol.12 No.2
Many spoofing detection studies have been conducted to cope with the most difficult types of deception among various disturbances of GPS, such as jamming, spoofing, and meaconing. In this paper, we propose a spoofing detection scheme based on elevation masked-relative received power between GPS L1 and L2 signals in a system using a multi-band array antenna. The proposed scheme focuses on enabling spoofing to be normally detected and minimizes the possibility of false detection in an environment where false alarms may occur due to pattern distortion among elements of an array antenna. The pattern distortion weakens the GPS signal strength at low elevation. It becomes confusing to detect a spoofing signal based on the relative power difference between GPS L1 and L2, especially when GPS L2 has weak signal strength. We propose design parameters for the relative power threshold including beamforming gain, the minimum received power difference between L1 and L2, and the patch antenna gain difference between L1 and L2. In addition, in order to eliminate the weak signal strength of GPS L2 in the spoofing detection process, we propose a rotation matrix that sets the elevation mask based on platform coordinates. Array antennas generally do not have high usefulness in commercial areas where receivers are operated alone, but are considered essential in military areas where GPS receivers are used together with signal processing for beamforming in the direction of GPS satellites. Through laboratory and live sky tests using the device under test, the proposed scheme with an elevation mask detects spoofing signals well and reduces the probability of false detection relative to that without the elevation mask.
Taejun Yoo,Byeongjin Ye,Jung-Il Kim,Siwoo Park 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Objective: The present study analyzed relationship of workplace violence and perpetrators of violence on sleep disturbance among wage workers in Korea. Methods: The present study used data from the 4th Korean Working Conditions Survey (KWCS) of 2014 in selecting a total of 25,138wage workers as the study population, which excluded those who failed or refused to respond to questions required for the present study. The workplace violence experience group included people who satisfied at least one of six relevant criteria (verbal abuse, unwanted sexual attention, threatening or humiliating behavior, physical violence, bullying/harassment, and sexual harassment) and the group was divided according to whether the perpetrator of violence was a client or colleague. Presence of sleep disturbance was determined based on subjective symptoms felt within the past 12 months by each individual. A multiple logistic regression analysis was performed to identify the effects on sleep distance according to general, occupational, and psychosocial characteristics, as well as the types of workplace violence and perpetrators of violence. Results: Workplace violence was found as a factor affecting sleep disturbance (OR = 3.773, 95 % CI = 3.058–4.655), and with respect to perpetrators of violence, complaint of sleep disturbance symptoms was higher when the perpetrator was a colleague or boss (OR = 5.688, 95 % CI 4.189–7.723) than a client (OR = 2.992, 95 % CI 2.301–3.890). Conclusion: Workplace violence had an effect on occurrence of sleep disturbance and when the perpetrators of violence was a boss or colleague at work, the risk for symptoms such as sleep disturbance increased, which indicated the need for appropriate intervention from a workplace healthcare perspective, including preventive education of workplace violence among employees.