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( Alejandra García-garcía ),( Luis A. Alvarez-sala-walther ),( Hae-young Lee ),( Cristina Sierra ),( Domingo Pascual-figal ),( Miguel Camafort ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.1
The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restriction, but without any clear evidence. We conducted a systematic review to analyse the degree of evidence for these dietary recommendations in HF. Only randomized controlled trials (RCT), and observational studies in humans were selected. Studies were considered eligible if they included participants with HF and sodium and/or fluid restriction. Publications in languages other than English or Spanish were excluded. We included 15 studies related to sodium or fluid restriction. Nine RCT and six observational studies showed some improvements in symptoms and quality of life and a degree of reduction in new hospitalizations, but the results are based on limited population groups, applying different methodologies, and with different restriction goals. We found a lack of clear evidence of the benefits of sodium/fluid restriction in chronic HF. The evidence is limited to few studies with conflicting results. Randomized clinical trials are needed to fill this gap in our knowledge.
First report of splenic myelolipoma in a Schnauzer in Colombia: case report
Valentina Rueda-García,Nicolas Carrillo-Godoy,Carlos Alberto Bonilla-Gutiérrez,Alejandra Valdivieso-Valencia,Iang Schroniltgen Rondón-Barragán 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.4
Splenic myelolipoma is a rare tumor in dogs with an unclear origin. A male 13-year-old Schnauzer dog was presented because of a bump on the left side of the abdomen. Clinical examination and abdominal ultrasound revealed a mass in the spleen. A total splenectomy was carried out, and histopathology revealed a splenic myelolipoma. Before surgery, the patient showed high serum alanine aminotransferase levels, which returned to normal eight months after the resection. Unfortunately, the postoperative follow-up showed increased serum cholesterol and triglyceride levels, suggesting liver compromise. This is the first report of a splenic myelolipoma in Colombia.
Alejandra Pérez-Nava,Josué D. Mota-Morales,Zaira Y. García-Carvajal,Sara E. Herrera-Rodríguez,Gerardo Arrevillaga-Boni,Cristy L. Azanza-Ricardo,Milton O. Vazquez-Lepe,J. Betzabe Gonzalez-Campos 한국섬유공학회 2018 Fibers and polymers Vol.19 No.1
Silver and gold nanoparticles were produced and embedded in poly(vinyl alcohol) (PVA) and chitosan (CTS) solutions by the photoreduction of metallic salt precursors triggered by direct sunlight irradiation, in which the polymers acted as reducing, dispersing and stabilizing agents. Sunlight photoreduction can be standardized using a constant UV index regardless of the season. This strategy was found to be an improvement over other common energy sources used to trigger the reduction of metal ions, including UV light irradiation and high-temperature reduction with mechanical stirring. The resulting PVA/metal nanoparticle and CTS/metal nanoparticle composite solutions were processed into thin films and nanofiber composites. In vitro testing of the cytotoxicity and biocompatibility demonstrates that the film composites are non-toxic andbiocompatible with the HT-29 human colon cancer cell line. Promotion of HT-29 cell growth using our hybrid composites was observed, in contrast to other studies in which colloidal NPs were tested. Therefore, a sustainable approach for the onestep preparation of biocompatible polymer/metallic nanoparticle composites is reported.
White spots on the mucosal surface of the duodenum in dogs with lymphocytic plasmacytic enteritis
Mercedes García-Sancho,Ángel Sainz,Alejandra Villaescusa,Antonio Rodríguez,Fernando Rodríguez-Franco 대한수의학회 2011 Journal of Veterinary Science Vol.12 No.2
Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia. In the present study, we evaluated the significance of white spots present in the duodenal mucosa of dogs with lymphocytic plasmacytic enteritis (LPE). Fifty dogs with LPE were included in this study, and white spots were detected in the duodenal mucosa in 22 dogs during endoscopy. Hypoproteinemia was more frequent in dogs with white spots than in dogs without spots (p = 0.02). Serum protein and albumin concentration were significantly lower in LPE dogs with white spots (p = 0.038) compared to LPE dogs without white spots (p = 0.039). There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481). These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia. Low serum protein and albumin concentrations together with lymphatic dilatation seem to be related to the presence of white spots in the duodenal mucosa of LPE dogs.
José Aurelio Sosa,José Ramón Laines,David Salvador García,Rafael Hernández,Mark Zappi,Alejandra E. Espinosa de los Monteros 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.3
The energy growing demand and the international environmental policies contribute to the use of renewable energy sources. Among these sources, biogas has acquired great relevance due to its energetic similarity to fuels such as liquefied petroleum gas (LPG) and natural gas (NG). However, biogas needs to be upgraded by removing CO2 and trace gases to obtain biomethane (>85% CH4). This review identifies and classifies seven techniques used in biogas upgrading, reported in academic and scientific publications. A 13-year review period (2008–2021) was considered. Lineal regression was used to analyze the publications number per year. Membranes use represents the largest proportion of publications (33%), while activated carbon (AC) reaches only 22%. However, the use and application of AC obtained the best trend as a publication topic, with a maximum value of R2 = 0.7882. This review documents publish works on obtaining and applying AC in biogas enrichment processes. It includes a review of the characteristics and generation rates of various residual lignocellulosic materials used in the synthesis of AC, the synthesis processes, the characterization techniques, and the final adsorption capacities.
Homozygous LPL p.Gly188Glu Mutation in a Mexican Girl With Lipoprotein Lipase Deficiency
Ana Gabriela Colima Fausto,Juan Ramón González García,Teresita De Jesús Hernández Flores,Norma Alejandra Vázquez Cárdenas,Nery Eduardo Solís Perales,María Teresa Magaña Torres 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.4
Dear Editor, Lipoprotein lipase (LPL) deficiency is a rare disease characterized by severe hypertriglyceridemia due to mutations in the LPL gene. It shows an autosomal recessive inheritance pattern and has a general prevalence of 1:1,000,000 [1]. Patients typically present abdominal pain, hemorrhage, failure to thrive, jaundice, eruptive xanthomas, lipemia retinalis, neurological complications, hepatosplenomegaly, and life-threatening pancreatitis [2]. The LPL gene is located on chromosomal band 8p22, contains 10 exons, and codes for a 475-amino acid protein that is active only in its dimeric form. The LPL protein has two functions in lipid metabolism: it hydrolyzes triglycerides and functions as a ligand [3]. The aim of this work is to describe the biochemical, clinical, and molecular features of a Mexican girl with LPL deficiency.
Alejandro La Greca,Claudia Solari,Veronica Furmento,Antonella Lombardi,Maria Celeste Biani,Cyntia Aban,Lucia Moro,Marcela García,Alejandra Sonia Guberman,Gustavo Emilio Sevlever,Santiago Gabriel Miriu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Mesenchymal stem/stromal cells (MSCs) obtained from pluripotent stem cells (PSCs) constitute an interesting alternative to classical MSCs in regenerative medicine. Among their many mechanisms of action, MSC extracellular vesicles (EVs) are a potential suitable substitute for MSCs in future cell-free-based therapeutic approaches. Unlike cells, EVs do not elicit acute immune rejection, and they can be produced in large quantities and stored until ready to use. Although the therapeutic potential of MSC EVs has already been proven, a thorough characterization of MSC EVs is lacking. In this work, we used a label-free liquid chromatography tandem mass spectrometry proteomic approach to identify the most abundant proteins in EVs that are secreted from MSCs derived from PSCs (PD-MSCs) and from their parental induced PSCs (iPSCs). Next, we compared both datasets and found that while iPSC EVs enclose proteins that modulate RNA and microRNA stability and protein sorting, PD-MSC EVs are rich in proteins that organize extracellular matrix, regulate locomotion, and influence cell–substrate adhesion. Moreover, compared to their respective cells, iPSCs and iPSC EVs share a greater proportion of proteins, while the PD-MSC proteome appears to be more specific. Correlation and principal component analysis consistently aggregate iPSCs and iPSC EVs but segregate PD-MSC and their EVs. Altogether, these findings suggest that during differentiation, compared with their parental iPSC EVs, PDMSC EVs acquire a more specific set of proteins; arguably, this difference might confer their therapeutic properties.
José Luis Muñoz-Carrillo,José Luis Muñoz-López,José Jesús Muñoz-Escobedo,Claudia Maldonado-Tapia,Oscar Gutiérrez-Coronado,Juan Francisco Contreras-Cordero,María Alejandra Moreno-García 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.
Fernando Gonzá,lez-Magañ,a,Hé,ctor Omar Malagó,n-Hidalgo,Eugenio Garcí,a-Cano,Roberto Vilchis-Ló,pez,Adriana Fentanes-Vera,Fernan-Alejandra Ayala-Ugalde 대한구강악안면외과학회 2018 대한구강악안면외과학회지 Vol.44 No.1
Objectives: Airway management in patients with panfacial trauma is complicated. In addition to involving facial lesions, such trauma compromises the airway, and the use of intermaxillary fixation makes it difficult to secure ventilation by usual approaches (nasotracheal or endotracheal intubation). Submental airway derivation is an alternative to tracheostomy and nasotracheal intubation, allowing a permeable airway with minimal complications in complex patients. Materials and Methods: This is a descriptive, retrospective study based on a review of medical records of all patients with facial trauma from January 2003 to May 2015. In total, 31 patients with complex factures requiring submental airway derivation were included. No complications such as bleeding, infection, vascular, glandular, or nervous lesions were presented in any of the patients. Results: The use of submental airway derivation is a simple, safe, and easy method to ensure airway management. Moreover, it allows an easier reconstruction. Conclusion: Based on these results, we concluded that, if the relevant steps are followed, the use of submental intubation in the treatment of patients with complex facial trauma is a safe and effective option.