수리모형을 활용한 화력 무기체계 개발 우선순위 도출

고현송,이윤호,이시연,정진규,진인탁 한국산업경영시스템학회 2019 한국산업경영시스템학회 학술대회 Vol.2019 No.추계

흉수부에 발생한 희돌기 교세포종(Oligodendroglioma) 1예 : 증례보고 Case Report

고현송,송시헌,김관태,김성호,김윤 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.5

Primary oligodendroglioma of the spinal cord is a very rare tumor. On searching through the literature from 1931. we could find only about 46 cases, and tumor is almost absent in Korea on the review of the literature. The authors present a case of 8-year-old female patient with the symptoms of paraparesis, urination difficulty. diffuse back pain and hypesthesia in both lower extremities. Spine MRI revealed the mass at the level of T(3)-T-(12), with combined nature of cystic and solid portion. Decompressive laminectomy and partial mass removal was performed, and then adjunctive radiotherapy and chemotherapy was done. The patient was improved after operation with radiotherapy and chemotherapy. so he walks alone and has no voiding difficulty at present (postoperative about 20months),

자발성 뇌실질내 출혈과 간기능 장애의 상관관계에 대한 임상 연구

고현송 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

A study of hemostatic systems was made in 61 patients with ICH. To compare ICH with other neulological disease, data from 76 patients with subarachnoid hemorrhage(SAH) and 49 other with brain tumor were reviewed. The purpose of this study was to investigate the relationship between liver dysfunction and spontaneous intracerebral hemorrhage(ICH) from the hemostatic standpoint, At admission, the medical histories of the patients, including information about previous alcohol consumption and smoking, was taken, and retrospective study of the hemostatic parameters : RBC, WBC, platelet count, prothrombin time, activated partial thromboplastin time, bleeding time, and lever function test were performed. The incidence of liver dysfunction and alcohol consumption in patients with ICH was significantly higher than in patients with SAH and those with brain tumor. Hematoma volume, mortality rate, and past alcohol consumption in patients with ICH significantly worsening severity of liver dysfunction. Although almost all hemostatic parameters became worse with increasing severity of liver dysfunction. In conclusion, liver dysfunction associated with alcohol consumption appears to be an important factor in the deterioration of the clinical status of patients with ICH and may be one of may be partially responsible for these abverse effects of liver dysfunction on ICH , it seems probable that nonhemostatic mechanisms are attributed to the effects.

자발성 소뇌 출혈에 대한 임상 분석

고현송 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

The author analysed 31 patients with spontaneous intracerebellar hemorrhage diagnosed by brain CT and MRI scan from July 1994 to December 1997 and assessed the correlation between the mental status at admission, outcome and clinical parameters. The purpose of this study was to analyse and evaluate the clinical and prognostic factors of the patients of spontaneous intracerebellar hemorrhage. The location of hematoma, volume of hematoma, the grade of quadrigeminal cistern obliteration, intraventricular hemorrhage and hydrocephalus were correlated to the mental status assessed by GCS(Glasgow coma scale) at admission. And initial GCS score, location of hematoma, volume of hematoma, quadrigeminal cistern obliteration grade, intraventricular hemorrhage and hydrocephalus, rebleeding, treatment modality, age were correlated to outcome. So I conclude that decreased GCS score at admission, large volume of hematoma, severe quadrigeminal cistern obliteration, presence of intraventricular hemorrhage and hydrocephalus could be considered as surgical indications and contributing factors for poor prognosis in the patients with spontaneous intracerebellar hemorrhage.

뇌동맥류 수술시 일시적 동맥 차단술이 예후에 미치는 영향에 대한 임상 분석

고현송 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

The author analysed the postoperative results of 120 patients who underwent temporary clipping during cerebral aneurysm surgery from January, 1995 to December, 1997. We excluded multiple aneurysms in this study. The purpose of this study was to analyse and evaluate the safety and efficiency of temporary clipping during cerebral aneurysm surgery. The patients were divided into four groups according to the site of the temporary clip application. 1. The overall outcome was as follows : good-58.3%, fair-26.7%, poor-7.5%, dead-7.5%. These results were similar to those of the patients who did not recieve temporary clipping. Ischemic complication did not increase in the temporary clipping group. 2. In the patients with a high GCS(Glasgow coma scale) score the outcome was more favorable. 3. There was no relation between the number and frequency of temporary clipping with the outcome of the patients. 4. The safe durations of temporary clipping were as follows : 1) anterior cerebral artery clipping group, about eight minutes for Hunt-Hess grade Ⅰ &Ⅱ patients and three minutes for Hunt-Hess grade Ⅲ & Ⅳ patients ; 2) middle cerebral artery clipping group, about ten minutes for Hunt-Hess grade Ⅰ & Ⅱ patients and three minutes for Hunt-Hess grade Ⅲ & IⅣ patients ; 3) internal carotid artery clipping group, about six minutes for Hunt-Hess grade Ⅰ & Ⅱ patients and three minutes for Hunt-Hess grade Ⅲ & Ⅳ patients ; 4) basilar artery clipping group showed favorable outcome in all three cases within ten minutes of temporary clipping. So we concluded that general safe time of temporary clipping is within ten minutes and five minutes in Hunt-Hess grade Ⅰ , Ⅱ and Ⅲ, Ⅳ patients, respectively. The results of this analysis suggest that the temporary clipping would be a very useful method to dissect the aneurysmal neck safely and to prevent and control premature rupture of the cerebral aneurysm during surgery without influencing the outcome.

일부 농촌지역 주민의 모발중 금속 농도 분포

고현송,심운택,조영채 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

In order to know the concentration of some metals in human hairs from residents living in rural area, the 88 hair samples were taken from Kunbuk-Myon residents during the period from August through October, 1990. The 4 elements(Pb, Cd, Mn, and Zn) in human hair were determined by atomic absorption spectrophotomer with flame and grapite furnace atomizer systems using wet ashing procedure. The results were as follows: 1. The mean concentrations of metals in human hair of the total 88 samples were: Pb was 3.14±1.63㎍/g, Cd was 0.81±0.71㎍/g, Mn was 4.02±3.86㎍/g, Zn was 199.11± 80.33㎍/g, and in the males: Pb was 3.51±1.54㎍/g, Cd was 0.84±0.63㎍/g, Mn was 3.95±4.78㎍/g, Zn was 215.88±76.76㎍/g, and in the females: Pb was 3.34±1.69㎍/g, Cd was 0.79±0.77㎍/g, Mn was 4.08±2.95㎍/g, Zn was 186.36±82.90㎍/g 2. There were no significant differences among 4 elements (Pb, Cd, Mn, Zn) by Age groups, by exposed to pesticides and by exposed years to pesticides. 3. In males, there were negative correlation between age and Cd level(r=-0.2860, P<0.05), between Cd and Zn(r=-0.3760, P<0.01), and significant positive correlations between Pb and Zn(r=0.2881, P<0.05). In females, there was significant positive correlations between Pb and Zn(r=0.3096, P<0.01).3 4. There were positive correlations between Pb and Cd(r=0.1835, P<0.05) and between Zn and Pb(r=0.3049, P<0.01), but there was negative correlation between Mn and Cd(r=-0.1817, P<0.05).

자발성 뇌실질내 출혈 환자에서 정위적 혈종 흡인술 및 유로키나제 세척술에 대한 임상 분석

고현송 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

There are many methods in the management of spontaneous intracerebral hemorrhage. Among them, stereotactic surgery can minimize can minimize the brain damage and can performed safely and accurately under local anesthesia. A series of 23 patients who underwent stereotactic evacuation of spontaneous intracerebral hemorrhage from June 1996 through 1997 November were analysed. The purpose of this study was to analyse and evaluate the therapeutic result of stereotactic aspiration of hematoma and urokinase irrigation. The results of this analysis suggest that stereotactic hematoma aspiration and urokinase irrigation is safe and efficient in treating spontaneous intracerebral hemorrhage with similar outcome but lower mortalith compared with traditional craniotomy. So I recommend stereotactic aspiration of hematoma and urokinase irrigation as safe and effective method in the management of spontaneous intracerebral hemorrhage.

Experimental Study on the Effect of Temporary Clipping on the Histological Changes of the Arterial Walls of Rats

고현송,권오유 대한의생명과학회 2007 Biomedical Science Letters Vol.13 No.2

뇌실질내출혈 환자에서 유로키나제 세척술을 겸한 지속적 뇌실외 배액술의 효과에 대한 임상적 분석

고현송,송시헌,김성호,김관태,김윤 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.5

The mortality and morbidity of the intraventricular hemorrhage(IVH) has been decreased since the introduction of external ventricular drainage(EVD) and direct intraventricular infusion of urokinase as an effective therapeutic method. In 1989, we already reported a series of 54 cases of IVH treated with simple EVD or EVD with urokinase irrigation in a few cases. Authors analyzed again a series of 50 cases of IVH treated by EVD with direct intraventricular urokinase irrigation after the previous report. The mortality rate was 55.5% in former occasion, however 18% in this study and the complications were considerably low. We experienced again that the EVD with urokinase irrigation is an effective method and convenient, simple technique in the management of IVH even though there is no ICP monitoring. So we prefer EVD with urokinase irrigation therapy in managing the IVH even if the patient in moribund state.

뇌동맥류 파열에 의한 지주막하 출혈 후 수두증 발생의 위험 인자에 대한 임상 연구

최정재,고현송,조준희,김선환,염진영,송시헌,김윤,Choi, Jeong-Jae,Koh, Hyeon-Song,Cho, Jun-Hee,Kim, Seon-Hwan,Youm, Jin-Young,Song, Shi-Hun,Kim, Youn 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.12

Objective : The authors analyzed the incidence, the cause and the prognosis of hydrocephalus following aneurysmal subarachnoid hemorrhage to evaluate the risk factors of hydrocephalus and to provide the proper treatment method for hydrocephalus following aneurysmal subarachnoid hemorrhage. Methods : The 505 cases of subarachnoid hemorrhage followed by aneurysmal surgery from January 1990 to May 1999, were divided into shunt group and shunt-free group and we were reviewed for the clinical status, Fisher's grade, brain CT findings and prognosis. Results : The incidence of acute hydrocephalus was 37.2% of patients and 18.9% to developed chronic hydrocephalus. Shunt surgery due to chronic hydrocephalus was required in 6.5% of patients. We found following variables were significantly related to shunt-dependent hydrocephalus : high Hunt-Hess and Fisher grade, initial CT findings of intraventricular hemorrahge, posterior circulation aneurysm, preoperative rebleeding, delayed ischemic deficits, and initial high ventricular size index. There were no statistically significant relationships between shunt-dependent hydrocephalus and patient age or sex, timing of operation. The previous hypertension was not related to shunt dependent hydrocephalus. Prognosis in shunt group showed poor result. Conclusion : The risk factors of hydrocephalus following aneurysmal subarachnoid hemorrhage are high Hunt-Hess grade, high Fisher's grade, aneurysms of posterior circulations, preoperative aneurysmal rebleeding, delayed ischemic deficits, initial CT findings of intraventricular hemorrahge and initially increased ventricular size. The patients with these factors should the carefully observed and managed accordingly due to poor prognosis related to hydrocephalus requiring shunt operation.