http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Li-Hua Zhu,Gang Li,Zhi-Qian Dong 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.2
The structural damage or collapse caused by weak-story failure mechanisms poses a great threat to the safety of human life and property under strong earthquakes. Many researchers have attempted to transform this unexpected failure mechanism into the desired overall failure mechanism by installing various energy dissipation devices on unsafe structures. This paper introduced a lattice-shaped friction device (LSFD), which is a friction device with hardening postyielding stiffness, into a steel frame with a weak-story failure mechanism. Then, shaking table tests of a three types of two-story steel frames—a frame with LSFDs, a frame with traditional friction brace dampers (FBDs), and a bare frame—were carried out. The seismic responses of the hardening postyielding stiffness of the LSFD on the weak-story failure mechanism of the frame were emphatically studied. The results showed that there was little difference in the seismic responses between the two damped structures under moderate and weak earthquakes. The distribution of maximum story drift for the structure with LSFDs was more uniform, which effectively suppressed the weak-story failure under strong earthquakes, whereas the structure with FBDs had serious deformation concentrations. The numerical simulation results of the structure with LSFDs in the shaking table test showed that the simplified model results were basically consistent with the experimental results. Hence, this model could be used to analyze the seismic performance of damped structures with LSFDs.
Innovative Design and Practice in Horizontal Skyscraper-ChongQing Raffles
Li-Gang, Zhu Council on Tall Building and Urban Habitat Korea 2022 International journal of high-rise buildings Vol.11 No.3
One of important design challenges in Chongqing Raffles City Plaza project is Sky Bridge structural design and its connection scheme in high level. This article systematically describes the structural system and its design and analysis methodology, with discussing the impacts on structural performance due to different connection approaches. The seismic isolation scheme in high level is innovatively adopted to the final design. Under the conditions of various load cases, the different models and assumptions are implemented. A full assessment on Sky Bridge's structural performance, seismic isolation, and its connection is conducted in terms of seismic performance based design. By co-operating with architecture, MEP and other disciplines, the structural economy index is fulfilled.
Causes, Features, and Outcomes of Drug-Induced Liver Injury in 69 Children from China
( Yun Zhu ),( Yong Gang Li ),( Jia Bo Wang ),( Shu Hong Liu ),( Li Fu Wang ),( Yan Ling Zhao ),( Yun Feng Bai ),( Zhong Xia Wang ),( Jian Yu Li ),( Xiao He Xiao ) 대한소화기학회 2015 Gut and Liver Vol.9 No.4
Background/Aims: Drug-induced liver injury (DILI) is a frequent cause of pediatric liver disease; however, the data on DILI are remarkably limited. Methods: All 69 children hospitalized with DILI between January 2009 and December 2011 were retrospectively studied. Results: A total of 37.7% of the children had medical histories of respiratory infection. The clinical injury patterns were as follows: hepatocellular 89.9%, cholestatic 2.9%, and mixed 7.2%. Liver biopsies from 55 children most frequently demonstrated chronic (47.3%) and acute (27.3%) hepatitis. Hypersensitivity features, namely, fever (31.9%), rash (21.7%), and eosinophilia (1.4%), were found. Twenty-four children (34.8%) developed chronic DILI. Antibiotics (26.1%) were the most common Western medicines (WMs) causing DILI, and the major implicated herbs were Ephedra sinica and Polygonum multiflorum. Compared with WM, the children whose injuries were caused by Chinese herbal medicine (CHM) showed a higher level of total bilirubin (1.4 mg/dL vs 16.6 mg/dL, p=0.004) and a longer prothrombin time (11.8 seconds vs 17.3 seconds, p=0.012), but they exhibited less chronic DILI (2/15 vs 18/39, p=0.031). Conclusions: Most cases of DILI in children are caused by antibiotics or CHM used to treat respiratory infection and present with hepatocellular injury. Compared with WM, CHM is more likely to cause severe liver injury, but liver injury caused by CHM is curable. (Gut Liver 2015;9:525-533)
Chen, Peng,Wang, Xiu-Li,Ma, Zhong-Sen,Xu, Zhong,Jia, Bo,Ren, Jin,Hu, Yu-Xin,Zhang, Qing-Hua,Ma, Tian-Gang,Yan, Bing-Di,Yan, Qing-Zhu,Li, Yan-Lei,Li, Zhen,Yu, Jin-Yan,Gao, Rong,Fan, Na,Li, Bo,Yang, Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.
Influence of hexapod robot foot shape on sinking considering multibody dynamics
Gang He,Zhaoyuan Cao,Qian Li,Denglin Zhu,Ji Aimin 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.9
Hexapod robots have attracted attention for their excellent terrain adaptabilities. When a robot walks on soft soil, dynamic subsidence and slippage greatly reduce its walking performance. The influence of foot’s shape is usually ignored or simply studied without considering the multibody dynamics of the robot. This study is focused on the influence of the foot shape on the walking performance of a robot by coupling the sinkage with multibody dynamics. A composite contact model based on the Bekker, spring-damping, and Janosi– Hanamoto models was used to model the interaction of the robot and soft soil. Non-uniform rational B-spline (NURBS) surface and mesh were used to describe the geometries of foot and soft soil, respectively. The influences of three foot shapes on the sinkage and walking stability of the robot were analyzed by comparsion. The improved X-shaped foot reduced the robot’s sinkage and improved its walking stability.
Li-Fei Yang,Jun-Yi Gai,Yue-Lin Zhu,Gang Chen,Guo-Ping Wei,Cong Wang,Qian-Qian Liu 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.1
The objectives of this paper were to construct a full-length cDNA library and identify genes encoding high quality proteins in developing seeds of vegetable soybean [Glycine max (L.) Merr.]. The construction of full-length cDNA library was essential for screening and cloning of novel genes. Using vegetable soybean variety ‘NN99-10’ as an experimental material, a full-length cDNA library from the developing seeds was constructed by switching mechanism at 5’-end of RNA transcript (SMART) approach. Total RNA from different developmental stages of seeds was purified. Double strand cDNA was synthesized by SMART method and the cDNA fragments were ligated to the pBluescript II SK vector. The recombinant plasmids were transformed into E. coli by electroporation and a cDNA library of developing seeds was successfully constructed. By counting the number of colonies, the titer of the primary cDNA library was 7.6×10? cfuㆍ㎖<SUP>-1</SUP>, and that of the amplified library was 2.4×10<SUP>12</SUP> cfuㆍ㎖<SUP>-1</SUP>. Electrophoresis gel results indicated that most of the cDNA inserts were ranged from 0.40 to 2.0 kb, with an average size of larger than 800 bp. Randomly picked clones showed that the recombination rate was above 99%. These evidences showed that the cDNA library constructed was a full-length library with high quality, and could be used to screen the genes encoding high quality proteins. A total of 206 randomly selected positive clones were successfully sequenced, and 73% of them contained full-length coding regions. Based on bioinformatics analysis of the sequences, we obtained 192 expressed sequence tags (ESTs) from 206 cDNA positive clones. Eight important genes which might be involved in seed quality were identified, and two of their genes were identified to be related to the allergenicity of seed proteins. The full-length cDNA library constructed in this research has laid the foundation for the further cloning of novel genes and the revealed EST sequences have enriched our knowledge of the function genes of vegetable soybean seeds.