Comparison of two recycle dilated banyan network with output buffers

Ming Zhou,Zeng Ji Liu 한국통신학회 1998 한국통신학회 기타 간행물 Vol.- No.-

HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid Leukemia cells

( Ming Yi Zhao ),( Ming Hua Yang ),( Liang Chun Yang ),( Yan Yu ),( Min Xie ),( Shan Zhu ),( Rui Kang ),( Dao Lin Tang ),( Zhi Gang Jiang ),( Wu Zhou Yuan ),( Xiu Shan Wu ),( Li Zhi Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9

HMGB1 is associated with human cancers and is an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels of HMGB1 are high in leukemia cells and it is involved in the progression of childhood chronic myeloid leukemia (CML). HMGB1 decreases the sensitivity of human myeloid leukemia cells K562 to anti-cancer drug induced death through up-regulating the autophagy pathway, which is confirmed by the observation with an increase in fusion of autophagosomes and autophagolysosomes. When overexpressing HMGB1, both mRNA levels of Beclin-1, VSP34 and UVRAG which are key genes involved in mammalian autophagy and protein levels of p-Bcl-2 and LC3-II are increased. Luciferase assays document that over-expression of HMGB1 increases the transcriptional activity of JNK and ERK, which may be silenced by siRNA. The results suggest that HMGB1 regulates JNK and ERK required for autophagy, which provides a potential drug target for therapeutic interventions in childhood CML. [BMB reports 2011; 44(9): 601-606]

Pulse-enhanced electrokinetic remediation of fluorine-contaminated soil

Ming Zhou,Shufa Zhu,Fang Liu,Dongfang Zhou 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.11

The presence of abundant fluorides in soil can pose potential threats to environment and human health. We investigated the effects of pulsed electric field on electrokinetic remediation of fluorine-contaminated soil by varyingthe pulse interval. Although the remediation time was increased, experimental results indicated pulse-enhanced electroki-netic remediation could improve the removal efficiency of fluorine better than the conventional electrokinetic remedia-tion in the same intensity of electric field. The fluorine removal efficiency of the former (30 min, pulse interval) was80.93% and that of normal electrokinetic remediation was 72.40%, because pulsed electric field could reduce the con-centration polarization and increase the electrical current, electroosmotic flow and the electrical voltage part in soilcell. Therefore, in the later phase of electrokinetic remediation, when electrical current and the fluorine removal efficiencydecreased obviously, at this time the pulse-enhanced method would be a considerable choice to eliminate fluorine incontaminated soils.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

P008 Inhibition of collagen synthesis by a small molecule tankyrase inhibitor IWR in fibroblasts

( Ming-wei Zhou ),( Cho-ah Lim ),( Hae-eul Lee ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Keloid is a benign tumor that is characterized by the hyperproliferation of dermal fibroblasts and excessive deposition of extracellular matrix (ECM) especially the collagen. Aberrant activation of Wnt/β-catenin signaling is implicated in the pathogenesis of keloid. Objectives: We investigated the effects of IWR-1, a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase, on production of collagen and matrix metalloproteinase (MMP) in dermal fibroblasts. Methods: We cultured human normal skin- and keloid-derived fibroblasts, then treated with IWR-1. The effects of IWR-1 on collagen and MMP production were determined by Western blot, ELISA and zymography. Results: IWR-1 significantly suppressed the proliferation and migration of both the normal and keloid fibroblasts. IWR-1 also inhibited the production and secretion of type I collagen from the fibroblasts. In addition, IWR-1 significantly increased the expression of MMPs, such as MMP-1, MMP-3 and MMP-13, along with the increase of gelatinase activity. These results suggest that inhibitory effect of IWR-1 on collagen production may be related with the increased MMP activity. Conclusion: These results provide evidence that IWR-1 can be a possible candidate to be developed as a therapeutics for keloid.

Finite-time H∞ Adaptive Fault-Tolerant Control for Wing Flutter of Reentry Vehicle Subject to Input Saturation

Ming-Zhou Gao,Guo-Ping Cai 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1

In current study for wing flutter of reentry vehicle, the effect of input saturation to wing flutter is rarelyconsidered and few of the fault-tolerant control problem is taken into account. In this paper, we use the radial basisfunction neural network and the finite-time adaptive fault-tolerant control technique to deal with the wing flutterproblem, which is subject to input saturation, parameter uncertainties and external disturbances. Sensor and actuatorfaults are both considered in the control design. Firstly, an optimal flight trajectory of reentry vehicle is designedusing the conjugate gradient method, so as to decrease the aerodynamic heating rate and temperature on the surfaceof the reentry vehicle. Then based on the trajectory optimization, we ignore the effect of temperature, and buildup the motion equation of wing flutter. Finally, a finite-time H¥ adaptive fault-tolerant controller is introduced. Simulation results indicate that, the optimized trajectory designed may decrease the aerodynamic heating rate ofthe reentry vehicle; the designed fault-tolerant controller can effectively deal with the faults in the system and canpromptly suppress the wing flutter as well.

Robust Adaptive Fault-Tolerant H∞ Control of Reentry Vehicle Considering Actuator and Sensor Faults Based on Trajectory Optimization

Ming-Zhou Gao,Guo-Ping Cai,Ying Nan 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1

Based on the trajectory optimization, this article proposes an adaptive fault-tolerant H∞ compensationcontrol approach for a reentry vehicle with external disturbance and parameter uncertainty. The sensor and actuatorfaults are both considered to including loss of effectiveness, stuck and outage of actuator, and loss of effectivenessof sensor. Firstly, we set up the reentry model for the reentry vehicle and use computational fluid dynamics (CFD)to calculating the heating rate on the surface of the vehicle. Then we divide the vehicle into several isothermalregions appropriately according to the heating rate, and establish the corresponding database for the aerodynamiccharacteristics. When the database accomplished, more accurate control variables and flight path can be achievedby using the conjugate gradient method. And the aerodynamic heating rate on the surface of the reentry vehicle willbe improved considerably. Afterwards, an adaptive fault-tolerant H∞ compensation control method is introduced todeal with the external disturbance and parameter uncertainty of the reentry vehicle system based on the trajectoryoptimization. The Lyapunov functional is adopted to guarantee the stability of the system. The effectiveness ofsuch adaptive fault-tolerant H∞ compensation control method has been identified by numerous simulation results.

Intraperitoneal Incubation of Bladder Acellular Matrix Grafts Improves Bladder Smooth Muscle Regeneration via Neovascularization

Zhou Zhe,Zhang Ming,Xu Mingxi,Zhang Ke,Zhao Yang,Zhou Juan,Zhu Yingjian,Wang Zhong,Lu Mujun 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.3

The objective of this study was to investigate whether intraperitoneal incubation improves the regenerative capacity of bladder acellular matrix grafts (BAMGs) in a rat model of bladder augmentation. After 2 weeks of incubation in the peritoneum of male rats, BAMG flaps with vascular pedicles were harvested for autologous bladder augmentation. As the control, BAMGs were directly used for bladder augmentation without intraperitoneal incubation. Histological analyses of the incubated BAMGs demonstrated extensive cell growth and vasculature in homogeneous collagen bundles. The cells were positive for vimentin and negative for α-smooth muscle actin and pan-cytokeratin AE1/AE3. Cystography revealed smoother contours of the augmented bladders in the incubated group at 4 and 12 weeks postoperatively. However, the bladder capacity was not significantly different between the two groups. In both groups, the entire urothelium regenerated well without obvious differences. At both time points, compared with the control group, increased numbers of smooth muscle cells (SMCs) and blood vessels were found in the incubated group. At 12 weeks, the SMCs in the incubated group were more similar to those in the native smooth muscle fiber bundles of the bladder. Taken together, our results demonstrated that BAMGs preincubated in the peritoneum promote the regeneration of bladder smooth muscle via neovascularization in a rat bladder augmentation model.

Preparation and property evaluation of a temperature-resistant Zr-crosslinked fracturing fluid

Ming Zhou,Jinfeng Zhang,Zhonghua Zuo,Mao Liao,Peng’ao Peng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.96 No.-

Compared with the traditional water-based fracturingfluid thickener guanidine gum, the price ofsynthetic polymer is relatively low, and the temperature resistance, shear resistance and viscoelasticityof the formed fracturingfluid are better. Therefore, the fracturingfluid formed by the crosslinking ofHPAM and organic metal crosslinker will become one of the hot spots in the research of water-basedfracturingfluid. In this paper, zirconium oxychloride, acetic acid and triethanolamine were used as rawmaterials to prepare organic Zr-crosslinked agent. The polymer gel was formed by crosslinking theorganic Zr-crosslinked agent with the acrylamide copolymer KY-5S solution, and the viscosity of the gelwith different concentrations was investigated. The performance of the fracturingfluid was evaluatedthrough laboratory experiments. The results showed that the viscosity of the fracturingfluid remainedabove 100 mPa s at the shear rate of 170 s 1 and after 2 h of shear at 140 C. When the temperature was20 C, the shear stress was 0.1 Pa, and the frequency f varied from 0.1 to 10 Hz, the elastic modulus offracturingfluid was at least 11.6 Pa, and the viscous modulus was at least 8.54 Pa. At the temperature of90 C, when the addition of glue breaker was 0.01 wt%, the longest breaking time was 3 h, and themaximum viscosity of breaking liquid was 4.05 mPa s. The damage rate of core permeability of gluebreaker was about 13%. When the temperature was 25 C and the shear rate was 0–170 s-1, the viscosity offracturingfluid remained above 200 mPa s.

A Power Allocation Algorithm Based on Variational Inequality Problem for Cognitive Radio Networks

( Ming-yue Zhou ),( Xiao-hui Zhao ) 한국정보처리학회 2017 Journal of information processing systems Vol.13 No.2

Power allocation is an important factor for cognitive radio networks to achieve higher communication capacity and faster equilibrium. This paper considers power allocation problem to each cognitive user to maximize capacity of the cognitive systems subject to the constraints on the total power of each cognitive user and the interference levels of the primary user. Since this power control problem can be formulated as a mixed-integer nonlinear programming (NP) equivalent to variational inequality (VI) problem in convex polyhedron which can be transformed into complementary problem (CP), we utilize modified projection method to solve this CP problem instead of finding NP solution and give a power control allocation algorithm with a subcarrier allocation scheme. Simulation results show that the proposed algorithm performs well and effectively reduces the system power consumption with almost maximum capacity while achieve Nash equilibrium.