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Xing-Chun Wu,Chang-Xun Fang,Jin-Yang Chen,Qing-Shui Wang,Ting Chen,Wen-Xiong Lin,Zhong-Liang Huang 한국식물학회 2011 Journal of Plant Biology Vol.54 No.4
To determine the proteomic response to UV irradiation, two cultivars, i.e., Lemont (UV tolerant) and Dular (UV sensitive), were exposed to natural and enhanced ultraviolet-B (UV-B) irradiation for 1, 7, and 14 days, and two-dimensional gel electrophoresis in combination with mass spectrometry (MS) and bioinformatics were used to compare the different proteomic responses in the leaves of the two cultivars. Thirty-nine proteins were up- or downregulated following the UV-B treatments. Among them, 30 increased or decreased more than 1.5-fold in abundance. They were further tested by using matrix-assisted laser desorption/ionization time of flight MS and performed a database search. Twentyfour proteins were thus identified. These identified proteins were mostly upregulated in Lemont, whereas only 14 of them upregulated in Dular. Nine proteins involved in glycometabolism and fatty acid metabolisms, signal transduction, and protein synthesis and folding in Dular were not changed. These results suggest that there was a complex regulative mechanism on the proteomes in rice leaves upon UV-B exposure.
Experimental Study on Stratigraphic Subsidence Induced by Sand Leakage in Tunnel Lining Cracks
Zhong-Chang Wang,Guodong Li 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.8
In order to study the problem of strata subsidence caused by sand leakage in tunnel lining cracks in sandy soil, a set of sand (water) leakage visualization test system for underground engineering which could change the size of circular leakage opening was designed. The sand flow pattern under different working conditions was obtained. It was shown that the sand inrush process could be divided into four stages: initial stage, induced stage, diffusion stage and stable stage. The influence of the diameter of the leakage opening and the thickness of soil layer on the sand inrush and the sandy soil subsidence was studied. When the diameter of the sand leakage opening was same, the influence range of the subsidence increased with the increase of the thickness of soil layer. When the thickness-to-span ratio reached 21.4, the sand layer only subsided. No sand inrush occurred. When the thickness-to-span ratio continued to increase to 25.7, the sand layer did not subside. When the thickness of the sand layer was same, the diameter of the columnar region in the vertical subsidence zone increased with the increase of the diameter of the sand leakage opening. The subsidence range induced by the circular sand leakage opening was rounded on the top plane, and the quadratic surface was approximated on the section. The subsidence range of the soil was related to the shape failure angle of the collapsed surface. The shape failure angle of the collapsed surface was about 13° larger than the natural angle of repose of the soil. This provided a reference for the prevention and control of stratigraphic subsidence caused by the sand leakage of tunnel lining cracks in sandy soil layers.
Huan Wang,Yu Zou,Zhong Zhang,Kai-Yuan Wang,Huan An,Chang-Yong Zhan,Jun Wang,Jian-Chun Wu 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.8
The migration properties of uranium vacancies and interstitials in zirconium-doped uranium dioxide are studied by using density functional theory (DFT) and the climbing-image nudge elastic band (CI-NEB) method. The strong correlations among uranium $5f$ electrons were described by using a spherically averaged Hubbard parameter. In the model, the zirconium atoms are introduced by replacing the uranium atoms at the nearest and the next nearest neighbor sites along the diffusion path of uranium defects. The doping with zirconium obviously reduces the migration barriers for defects in uranium dioxide. The effect of doping with zirconium on the diffusion of uranium defects decreases with increasing distance between the zirconium dopant and the uranium defects. Further, we investigated the lattice distortion and the electron transfer associated with the migration of uranium defects, and we analyzed the physical origin of the reduction in the migration barriers caused by zirconium doping.
Chang-Feng Chi,Bin Wang,Zhong-Rui Li,Hong-Yu Luo,Guo-Fang Ding 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4
Acid-soluble collagen from the cartilages of scalloped hammerhead (Sphyrna lewini, ASC-S), red stingray (Dasyatis akajei, ASC-D), and skate (Raja porosa,ASC-R) were isolated with yields of 5.64±0.41, 8.72±0.31,and 6.74±0.28% on the basis of wet weight, respectively. ASC-S, ASC-D, and ASC-R had glycine as the major amino acid with contents of 220, 231, and 228 residues/1,000 residues, respectively, and contained imino acid of 174, 155, and 142 residues/1,000 residues, respectively. Three kinds of collagens more likely were comprised of 2types of collagen (type I and II) and had some differences in primary structures. The denaturation temperatures (Tds)of the ASC-S, ASC-D, and ASC-R were 23.8, 15.1, and 12.1oC, respectively. Maximum solubility of the 3 ASCs in 0.5 M acetic acid was observed at pH 2, and a sharp decrease in solubility above 2%(w/v) was observed in the presence of NaCl. The 3 lyophilized collagens displayed loose, fibrous, and porous structures.
Effects of boundary layer and liquid viscosity and compressible air on sloshing characteristics
Chang-Fang Zou,De-Yu Wang,Zhong-Hua Cai 대한조선학회 2015 International Journal of Naval Architecture and Oc Vol.7 No.4
In this paper, numerical investigations for tank sloshing, based on commercial CFD package FLUENT, are performed to study effects of boundary layer grid, liquid viscosity and compressible air on sloshing pressure, wave height and rising time of impact pressure. Also, sloshing experiments for liquids of different viscosity are carried out to validate the numerical results. Through comparison of numerical and experimental results, a computational model including boundary layer grid can predict the sloshing pressure more accurately. Energy dissipation due to viscous friction leads to reduction of sloshing pressure and wave elevation. Sloshing pressure is also reduced because of cushion effect of compressible air. Due to high viscosity damping effect and compressible air effect, the rising time of impact pressure becomes longer. It is also found that liquid viscosity and compressible air influence distribution of dynamic pressure along the vertical tank wall.
Once-weekly Subcutaneous Administration of Bortezomib in Patients with Multiple Myeloma
Wang, Liang,Wang, Ke-Feng,Chang, Bo-Yang,Chen, Xiao-Qin,Xia, Zhong-Jun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.
( Zhong Wen Chen ),( Yin Bing Zhang ),( Xaing Jun Chen ),( Xiao Liu ),( Zhen Wang ),( Xi Kun Zhou ),( Ji Qiu ),( Nan Nan Zhang ),( Xiu Teng ),( Yong Qiu Mao ),( Chang Yong Liu ),( Yu Quan Wei ),( Jion 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1- dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfoxide can increase the efficiency of gene transfection in the topical transdermal delivery system. Objective: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14- VEGF) factor transgenic mice. Methods: After pretreatment with RA, plasmid pIL-4 in 10% dimethylsulfoxide was applied to the ear skin by topical transdermal penetration. Hematoxylin- eosin staining and immunohistochemistry were performed with ear samples to evaluate anti-psoriasis efficiency in mice. Results: The psoriasis pathological features were relieved and psoriasis-associated factors were significantly reduced. Conclusion: Our results reveal that topical application of pIL-4 in dimethylsulfoxide by transdermal delivery with RA pretreatment can improve psoriasis significantly. (Ann Dermatol 27(2) 121∼127, 2015)
( Zhong Wen Chen ),( Yin Bing Zhang ),( Xaing Jun Chen ),( Xiao Liu ),( Zhen Wang ),( Xi Kun Zhou ),( Ji Qiu ),( Nan Nan Zhang ),( Xiu Teng ),( Yong Qiu Mao ),( Chang Yong Liu ),( Yu Quan Wei ),( Jion 대한피부과학회 2015 Annals of Dermatology Vol.27 No.2
Background: Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1- dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfoxide can increase the efficiency of gene transfection in the topical transdermal delivery system. Objective: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14- VEGF) factor transgenic mice. Methods: After pretreatment with RA, plasmid pIL-4 in 10% dimethylsulfoxide was applied to the ear skin by topical transdermal penetration. Hematoxylin- eosin staining and immunohistochemistry were performed with ear samples to evaluate anti-psoriasis efficiency in mice. Results: The psoriasis pathological features were relieved and psoriasis-associated factors were significantly reduced. Conclusion: Our results reveal that topical application of pIL-4 in dimethylsulfoxide by transdermal delivery with RA pretreatment can improve psoriasis significantly.(Ann Dermatol 27(2) 121∼127, 2015)
Bus-Based Content Offloading for Vehicular Networks
Zhe Wang,Zhangdui Zhong,Minming Ni,Miao Hu,Chih-Yung Chang 한국통신학회 2017 Journal of communications and networks Vol.19 No.3
Vehicular ad hoc networks (VANETs) represent the promising technologies for comfort driving and infotainment applications which rely heavily on the content offloading. Due to the rapid change of network topology and intermittent connection, it is a big challenge to satisfy the content requests from multi-sedans at the same time. This paper proposes a bus-based content offloading (BBCO) algorithm which aims to maximize the volume of offloaded content from bus to sedans while the offloading opportunity fairness of each sedan is also taken into consideration. By predicting the number of buses which the sedan would encounter in its future path and estimating the transmission rate, the BBCO algorithm schedules the content offloading service for sedans slot by slot to maximize the offloaded content volume and guarantee the offloading opportunity fairness. The effectiveness of the proposed algorithm is evaluated by extensive simulations.