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- 저자 : Zheyu Liu (검색결과 2 건)
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Yiqiang Li,Xin Chen,Zheyu Liu,Ruina Liu,Wentao Liu,Han Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
Polymeric surfactant can simultaneously thicken aquous phase and reduce water–oil interfacial tension(IFT), which makes it present a great application prospect in the oilfield taword enhanced oil recovery(EOR). There are two kinds of polymeric surfactant with different molecular structures are commonlyused to realize the salt resistance, thermal endurance and shear resistance. However, the influence ofthe molecular structure of polymeric surfactant on their properties related on EOR are not well understood. In the work, we synthesized two kinds of polymeric surfactants with different molecular structurewhich respectively named intermolecular association molecule (IAM) and rigid chain molecule (RCM). Their physico-chemical properties, porous media transportation and EOR are compared with a series ofexperiments. It is found that the hydrodynamic characteristic sizes and retention of IAM are higher thanthose of RCM via the membrane filtration test and nuclear magnetic resonance (NMR) scan. These featuresmake IAM have a larger resistance factor and residual resistance factor than RCM and hydrolyzedpolyacrylamide (HPAM) in the same viscosity. Compare to HPAM with shear thinning, RCM presents aNewtonian fluid region and IAM presents a shear thickening region when the shear rate is lower than1 s 1. The spatial structure of IAM can pack oil drop into its network, which make it easy to form oilin-water-in-oil (O/W/O) emulsions. Moreover, the concentration and water–oil ratio (WOR) rarely affectthe stability of IAM emulsions once the intermolecular association generated. The increamental oil recoveryfactor of IAM is 17.5% after water flooding in the three-layer core flooding experiments with the permeabilityof 500 mD, 1500 mD and 3000 mD at 55℃, which is higher than that of 14.5% for RCM and11.4% for HPAM.
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Chen Liang,Liu Yuting,Wang Zheyu,Zhang Leiyang,Xu Yi,Li Yinan,Zhang Lan,Wang Guiming,Yang Shuofei,Xue Guanhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Neutrophil extracellular traps (NETs) play an important role in abdominal aortic aneurysm (AAA) formation; however, the underlying molecular mechanisms remain unclear. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) may exert therapeutic effects on AAA through their immunomodulatory and regenerative abilities. This study aimed to examine the role and mechanism of MSC-EVs in regulating the development of NET-mediated AAA. Excessive release of NETs was observed in patients with AAA, and the levels of NET components were associated with the clinical outcomes of the patients. Datasets from the Gene Expression Omnibus database were analyzed and revealed that the PI3K/AKT pathway and ferroptosis were strongly associated with NETosis during AAA formation. Further experiments verified that NETs promoted AAA formation by inducing ferroptosis in smooth muscle cells (SMCs) by inhibiting the PI3K/AKT pathway. The PI3K agonist 740 Y-P, the ferroptosis inhibitor ferrostatin-1, and Padi4 deficiency significantly prevented AAA formation. MSC-EVs attenuated AAA formation by reducing NET release in an angiotensin II-induced AAA mouse model. In vitro experiments revealed that MSC-EVs reduced the release of NETs by shifting NETosis to apoptosis. Our study indicates an important role for NET-induced SMC ferroptosis in AAA formation and provides several potential targets for AAA treatment
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