Comparative Analysis of Phenolic Contents and Antioxidant Potential of Aqueous and Methanolic Extracts from Tenebrio molitor larvae

Qin Cao,Sooyeong Seo,Yeeun Lee,Yizhe Cheng,Byung-Joon Kim,Jong-Su Lim 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.10

Flexural Behavior of Anchor Horizontal Boundary Element in Steel Plate Shear Wall

Ying Qin,JinYu Lu,Li-Cheng-Xi Huang,Shi Cao 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.3

Steel plate shear walls (SPSWs) have been increasingly used in lateral load resisting system since the post-buckling strength of web plates was realized and considered in practical design. Diagonal tension field is formed in the web plate to resist the lateral force induced by winds and earthquakes. The force is anchored by the surrounded horizontal boundary elements (HBEs) and vertical boundary elements (VBEs) and eventually transferred to the ground. Therefore, the response of HBEs, especially anchor HBEs, is essential to ensure that SPSWs could exhibit the required strength, ductility, and energy dissipation capacity. This paper presents the results of theoretical studies into the flexural behavior of the anchor HBEs of SPSWs and can be regarded as an extension to the previous work by Qu and Bruneau (2011) and Qin et al. (2017). The boundary effect was considered to reflect the actual stress state at the HBE-to-VBE connection, which assembled the method by Qin et al. (2017). Furthermore, more proper distributions of the vertical component of tension field for the positive and negative flexure cases, respectively, were proposed comparing to the work by Qu and Bruneau (2011). The hand calculation approach for the plastic flexural capacity of the anchor HBEs was given by the summation of the contributions from the flanges and the web. The developed equations are compared with previous data and good agreement was found between them. Meanwhile, comprehensively discussions are conducted to evaluate the influence of key parameters on the flexural behavior of anchor HBE. It was found that the plastic flexural capacity of anchor HBE decreases from unity to the minimum as a result of the increase in shear force, axial force and vertical stresses. Moreover, the flexural response of anchor HBE is most vulnerable to the change in shear force. This indicates that boundary effect is significantly important and cannot be ignored in the analysis. The research in this paper provides basis for the capacity design of anchor HBE.

응소(應?) 연보(年譜) 고증 -『후한서(后漢書)』 정오 3칙을 겸함

차오친 ( Cao Qin ) 중국사학회 2017 中國史硏究 Vol.109 No.-

본고는 후한말 인물로 『한관의(漢官儀)』, 『풍속통의(風俗通儀)』 등의 저술로 저명한 응소(應?)에 관하여 그의 연도별 생애, 관직 경력, 저술 활동 등의 내용을 연보 차원에서 정리 고증하였다. 그의 저술은 잘 알려져 있지만 『후한서(後漢書)』나 『삼국지(三國志)』 등에 그에 관한 기록이 소략하게 남아 있어서, 지금까지 그의 경력을 상세히 접근할 수 없었다. 본고는 응소에 관한 기록을 종합적으로 고증하였을 뿐만 아니라 특히 『후한서』에 기록된 그와 관련된 기록들을 『풍속통의(風俗通義)』ㆍ『삼국지』 등의 사료들과 대조 검토하였다. 이를 통해 응소와 관련된 『후한서』의 기록 중 서로 연대나 관직이 부합되지 않는 부분에 대한 고증을 통해 3군데 수정을 했다. 그리고, 『유관비음고리명(劉寬碑陰故吏名)』에 빠진 글자를 당시 응소의 관직이었던 “대위의조연(太尉議曹?)”으로 보충했으며, 또한 『한관의』의 일문(逸文)으로 “군주부질사백석(郡主簿秩四百石)”을 집록(輯錄)하였다.

Telephone Traffic Forecasting Based on Grey Neural Network Optimized by Improved Particle Swarm Optimization Algorithm

Xiuting Yu,Xizhong Qin,Zhenhong Jia,Chuanling Cao,Chun Chang 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

Detection of the expression of a Bombyx mori Atypical Protein Kinase C in BmPLV-Infected Larval Midgut

Cao, Jian,He, Yuanqing,Li, Guohui,Chen, Keping,Kong, Jie,Wang, Fenghua,Shi, Jing,Yao, Qin Korean Society of Sericultural Science 2011 International Journal of Industrial Entomology Vol.22 No.2

Protein kinase C (PKC) is involved in many cellular signaling pathways, it participates in many physiological processes, such as cell cycle, growth, proliferation, differentiation and apoptosis. To investigate the effect of PKC on the silkworm midgut tissue infection of Bombyx mori parvo-like virus (BmPLV), a B. mori atypical protein kinase C (BmaPKC) gene was cloned from larval midgut tissue, expressed in E. coli and purified. Additionally, the BmPLV susceptible silkworm strain and resistant silkworm strain were used to test the effect of the B. mori infection on BmPLV. The result showed that BmaPKC encodes a predicted 586 amino acid protein, which contains a C-terminal kinase domain and an N-terminal regulatory domain. The maximum expression amount of the soluble (His)6-tagged fusion protein was detected after 0.8 mmol/L IPTG was added and cultured at $21^{\circ}C$. The (His) 6-tagged fusion protein revealed about 73 kDa molecular weight which confirmed by western blot and mass spectrography. Furthermore BmaPKC protein were detected at 0-72 h post-infection in BmPLVinfected larval midgut tissue, western blot showed that as time went on, the expression of BmaPKC increased gradually in susceptible strain, the expression quantity on 72 h is 5 times of 0 h. However, in resistant strain, the expression quantity is slightly lower than susceptible strain. But no significant change in resistant strain was observed as time went on. The available data suggest that BmaPKC may involve in the regulation of BmPLV proliferation.

pH-dependent release of platycodin mitigates its gastrointestinal mucosa irritation after oral administration in rats

Qin Chen,Wen-Wen Yang,Pan Shen,Qing-Ri Cao,Beom-Jin Lee,Jing-Hao Cui 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6

The present study aimed to evaluate the gastrointestinalmucosa irritation of three platycodin formulations. Platycodin-loaded core pellets were prepared viaextrusion–spheronization method and coated withEudragit L100-55 (L100) or Eudragit S100 (S100) forpH-dependent release. The release of platycodin D fromcoated pellets exhibited pH dependent release profiles. Thepharmacokinetic study in rats showed that Tmax of thecoated pellets were prolonged as compared to that of uncoatedpellets. The S100-coated pellets possess a lowerCmax and decreased AUC0–24h as compared to the L100-coated and uncoated pellets. Hematoxylin-eosin stainingand nuclear factor Kappa B (NF-jB) measurement werecarried out to observe the gastrointestinal mucosa irritations. The results revealed that the irritations of platycodinon the upper gastrointestinal mucosa are dose-dependent. However, no obvious irritation effect on the gastrointestinaltissues of rats was detected after oral administration ofthe coated pellets. In addition, the amount of NF-jB in thestomach of rats treated with the uncoated pellets was aboutfivefold higher as compared to that of the coated pellets. Insummary, the L100-coated platycodin pellets exhibitedhigher oral bioavailability and less gastrointestinal mucosairritations as compared to the other two formulations.

BRCA1 Gene Exon 11 Mutations in Uighur and Han Women with Early-onset Sporadic Breast Cancer in the Northwest Region of China

Cao, Yu-Wen,Fu, Xin-Ge,Wan, Guo-Xing,Yu, Shi-Ying,Cui, Xiao-Bin,Li, Li,Jiang, Jin-Fang,Zheng, Yu-Qin,Zhang, Wen-Jie,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

The prevalence of BRCA1 gene mutations in breast cancer differs between diverse ethnic groups. Relatively little information is known about patterns of BRCA1 mutations in early-onset breast cancer in women of Uighur or Han descent, the major ethnic populations of the Xinjiang region in China. The aim of this study was to identify BRCA1 mutations in Uighur and Han patients with early-onset (age <35 years), and sporadic breast cancer for genetic predisposition to breast cancer. For detection of BRCA1 mutations, we used a polymerase chain reaction single-stranded conformation polymorphism approach, followed by direct DNA sequencing in 22 Uighur and 13 Han women with early-onset sporadic breast cancer, and 32 women with benign breast diseases. The prevalence of BRCA1 mutations in this population was 22.9% (8/35) among early-onset sporadic breast cancer cases. Of these, 31.8% (7/22) of Uighur patients and 7.69% (1/13) of Han patients were found to have BRCA1 mutations. In 7 Uighur patients with BRCA1 mutations, there were 11 unique sequence alterations in the BRCA1 gene, including 4 clearly disease-associated mutations on exon 11 and 3 variants of uncertain clinical significance on exon 11, meanwhile 4 neutral variants on intron 20 or 2. None of the 11 BRCA1 mutations identified have been previously reported in the Breast Cancer Information Core database. These findings reflect the prevalence of BRCA1 mutations in Uighur women with early-onset and sporadic breast cancer, which will allow for provision of appropriate genetic counseling and treatment for Uighur patients in the Xinjiang region.

Homogenized cross-section generation for pebble-bed type high-temperature gas-cooled reactor using NECP-MCX

Qin Shuai,Li Yunzhao,He Qingming,Cao Liangzhi,Wang Yongping,Wu Yuxuan,Wu Hongchun 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

In the two-step analysis of Pebble-Bed type High-Temperature Gas-Cooled Reactor (PB-HTGR), the lattice physics calculation for the generation of homogenized cross-sections is based on the fuel pebble. However, the randomly-dispersed fuel particles in the fuel pebble introduce double heterogeneity and randomness. Compared to the deterministic method, the Monte Carlo method which is flexible in geometry modeling provides a high-fidelity treatment. Therefore, the Monte Carlo code NECP-MCX is extended in this study to perform the lattice physics calculation of the PB-HTGR. Firstly, the capability for the simulation of randomly-dispersed media, using the explicit modeling approach, is developed in NECP-MCX. Secondly, the capability for the generation of the homogenized cross-section is also developed in NECP-MCX. Finally, simplified PB-HTGR problems are calculated by a two-step neutronics analysis tool based on Monte Carlo homogenization. For the pebble beds mixed by fuel pebble and graphite pebble, the bias is less than 100 pcm when compared to the high-fidelity model, and the bias is increased to 269 pcm for pebble bed mixed by depleted fuel pebble. Numerical results show that the Monte Carlo lattice physics calculation for the two-step analysis of PB-HTGR is feasible.

Efficiency Optimization Control of an IPMSM Drive System for Electric Vehicles (EVs)

Qin-Mu Wu,Yu Zhan,Mei Zhang,Xiang-Ping Chen,Wen-Ping Cao 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.8

Electric vehicles are a key technology to decarbonize the transport sector where interior permanent magnet synchronous motors (IPMSMs) are the best performer at the heart of the electrical drive system. In order to optimize their operational efficiency, the model-based method associated with parameter identification is widely adopted. However, efficiency optimization and parameter identification in the existing methods are implemented independently by different strategies in a sequential execution manner, which does not produce an optimized systemlevel solution. In this paper, the two methods are combined to deal with a constrained optimization problem in an IPMSM drive. Firstly, the problem is converted into a variational problem based on the variational principle and projection dynamic theory. Then, a unified projection dynamic equation (UPDE) is used to estimate the parameters and determine the solution of optimal current (OC) of the IPMSM. Further, a recursive neural network (RNN)corresponding to the UPDE is developed to implement the developed fast efficiency optimization of the IPMSM drive. The results of simulation experiments show the proposed method is effective to identify motor parameters and determine the OC of the drive system rapidly and accurately. Thus, it can rapidly realize efficiency optimization of an IPMSM drive-system. Because the designed RNN can be easily implemented in the hardware, such as a field-programmable gate array (FPGA) or dedicated neural network chip, the method can achieve instantaneousefficiency optimization of the IPMSM drive system and therefore improve the widespread application of IPMSMs in EVs.

Tuning adsorption and electronic states of polar molecules

Zhihui QIN,Jian CHEN,Shuangzan LU,Min HUANG,Gengyu CAO 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8