Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis

Zhen Wang,Xueheng Xie,Mengchen Wang,Meng Ding,Shengliang Gu,Xiaoyan Xing,Xiaobo Sun 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.4

Sports Wireless Bluetooth Headset

Zhen xing Wang,Si Ming Dong 한국디자인학회 2021 한국디자인학회 국제초대전도록 Vol.2021 No.5

세계 SUV 브랜드 차량 디자인의 영향요인 분석

왕진흥(Wang, Zhen Xing),김원섭(Kim, Won Sup) 한국전시산업융합연구원 2015 한국과학예술융합학회 Vol.20 No.-

연구배경 21세기 들어서 세계 자동차 산업은 대규모의 합병으로 인한 대형 글로벌 기업의 탄생과 더불어 국제화되는 환경적 영향 속에서 커다란 진화를 맞이하고 있다. 이 진화의 주요 원인 중 하나는 소비자의 니즈를 만족시키기 위한 세계 자동차 시장의 치열한 경쟁의 결과라 할 수 있다. 최근에는 SUV가 자동차 판매량에서 다른 차종에 비해 지속적으로 가파른 증가세를 나타내고 있으며, 대형 자동차 제조사들에서도 이러한 추세를 반영하듯 SUV를 중요한 전략 상품으로 내세우고 있다. 반면, 차량 디자인 분야에 있어서 디자인 환경을 분석하고 소비자들의 니즈를 파악하기 위한 리서치가 타 소비재 산업 비해 부족하다. SUV 디자인 역시 다양한 관점에서 체계적으로 접근해 본 연구가 드물다. 따라서 자동차 디자이너들이 소비재에 영향을 미치는 다양한 외부 영향 요인들을 SUV 스타일링에 반영하는데도 미숙한 실정이다. 연구방법 본 논문은 세계 주요 자동차 시장인 북미, 유럽, 아시아 지역의 가장 대표적인 SUV 브랜드를 연구 대상으로 삼았고, 2차 세계대전을 전·후로 하여 현재까지 시대적 진화에 따라 사회적 요인, 기능적 요인, 기술적 요인이 SUV 사양과 디자인에 미친 영향을 분석하는 것을 연구 목표로 설정했다. 관련 자료는 학술 논문, 잡지, 저서와 인터넷 자료를 통해 수집되었다. 연구결과 본 연구에서는 Jeep, Land rover, 쌍용 브랜드에 대해 SUV 제작 초기부터 현재까지 사회적인 이슈를 중심으로 4~5개의 시대로 구분하고 각 시대별로 SUV 산업과 디자인에 영향을 미친 요인을 주로 사회성, 사용성, 기술성의 관점에서 정리?분석하였고 대표적인 모델의 기술적 사양과 형태를 분석하였다. 초기 SUV 디자인은 전쟁 상황에 적합한 기능적인 도구로 유연성과 기동성이 강한 운송 수단이었다. 이후 SUV는 전쟁 후 도시 재건과 농업 생산에 필요한 기능을 반영한 모델 위주로 개발되었다. 사회 안정과 함께 각 SUV 브랜드는 20세기 말까지 고유 스타일링을 개발해 왔다. 최근 전 세계적으로 기술의 융합과 공유가 이루어지고 자원 문제가 심각해지면서 SUV 디자인 또한 글로벌 기업들 간의 자원공유 개념을 통해 과학기술의 융합, 에너지 절약, 환경 보호 등을 지향하는 친환경적 디자인으로 진화해가고 있다. 오늘날의 SUV 디자인은 다른 자동차들과 마찬가지로 기술적 요인보다는 소비재 디자인에 필요한 사용성과 사회성 이라는 요소에 관심을 더욱 기울이고 있다. 결론 역사를 통해 세계적으로 대표적인 SUV 브랜드의 시장을 분석한 결과 서로 다른 지역적 환경 속에서도 전쟁과 오일쇼크라는 전 세계적인 사건 등으로 유사한 발전 과정을 보여주고 있다. 반면 시대와 지역에 따른 사회적, 기술적, 사용적 요인은 고유한 독자적인 브랜드 문화 형성에 영향을 미치고 있다. 향후 SUV 산업에서 기업들 간의 자원공유를 통한 글로벌 협력과 이에 따른 다양한 기술의 융합, 에너지절약과 환경보호, 개성화를 반영하는 현재의 디자인 추세는 당분간 지속될 것으로 예측된다. Background With the advent of the 21th century, the global automobile industry has become faced with great changes amid environmental effects of internationalization together with the birth of big global companies resulting from large scale mergers. One of causes for such change is fierce competition in the global automobile market to satisfy consumers" needs. Recently, sales amount of sport utility vehicles (SUVs) are steadily and rapidly on the rise compared to other types of cars and large automobile manufacturers are putting up SUVs as important strategic goods as if reflecting such trend. On the other hand, research to analyze design environment and figure out consumers" needs in the area of vehicle design is lacking compared to other commodity industries. Research which systematically approached SUV design from diverse perspectives is also rare. Therefore, car designers are poor in reflecting diverse external influential factors which affect commodities to SUV styling. Methods This paper involved most representative SUV brands in North America, Europe, and Asia, which are major car markets. This study aimed to analyze the effects of social, functional, and technological factors on SUV specifications and designs according to temporal changes from before and after the second world war to the present. Relevant data were collected through academic papers, magazines, books, and Internet data. Results This study divided the periods spanning from the early stage of SUV production to the present into four to five periods with Jeep, Land rover, and Ssangyong brand as the subjects and analyzed the factors which affected SUV industry and design by each era in terms of sociability, usability, and technology and analyzed technical dimensions and shapes of representative models. The SUV design in the early stage was a transport means with flexibility and mobility as a functional tool appropriate for a war situation. Thereafter, SUV reflected functions necessary for reconstruction and agricultural production. Together with social stability, each SUV brand had developed unique styling until the end of 20th century. Recently, as technological convergence and sharing are made globally and the problem of resource becomes serious, SUV design is evolving into eco-friendly design oriented toward convergence of scientific technologies, energy saving, and environmental protection. Today"s SUV design pays more attention to usability and sociability necessary for commodity design than technological factors. Conclusion According to analysis of global representative SUV brand markets throughout the history, they show similar developmental process due to the global events such as wars and oil shocks. On the other hand, social, technological, use factors are affecting unique, independent brand culture formation. In the future SUV industry, the current design trend reflecting global collaboration through resource sharing among companies and the resulting convergence of diverse technologies, energy saving, and environmental protection, and individuation is expected to continue for the time being.

중국 고유 SUV 디자인 개발의 역사적 고찰

왕진흥(Wang, Zhen Xing),김원섭(Kim, Won Sup) 한국디자인문화학회 2015 한국디자인문화학회지 Vol.21 No.3

세계 자동차 산업의 변화에 따라 중국 자동차 시장은 자동차 소비 중심 대국에서 생산 및 판매 대국으로 변화하고 있다. 중국은 사회 역사 발전의 배경의 특수성으로 인해 해외 기업과의 합자형태와 자체 자본에 의한 형태인 두 가지 기업 유형이 등장하였다. 특히 2001년 중국이 WTO에 가입한 후 중국의 자동차 생산 판매량은 지속적으로 세계 제 1위의 자리를 유지하고 있다. 이 기간 동안 중국의 자동차 산업에서는 세계 시장 경제, 국가 정책에 의해 다양한 변화가 나타났는데, 내부의 요인과 더불어 세계 자동차 산업의 변화에 따른 외부적 영향도 있었다. 이와 같은 배경 하에 본 연구에서는 중국 고유의 SUV 모델 발전 역사에 대한 심도 있는 고찰을 통해 중국 고유 SUV 모델 발전에 있어 디자인의 영향 요소를 분석하고 이를 통해 중국 자체 개발 SUV 모델의 향후 발전에 대해 전망해보고자 하는데 그 목적이 있으며, 연구는 다음과 같은 방법으로 수행되었다. 첫째, 중국 고유 브랜드를 중심으로 기술적, 사회적 이슈 및 영향 요소를 파악하기 위해 관련 연구논문 및 현지기업 자료를 분석하여 자동차 산업의 역사적 발전, 기업 현황에 대해 조사하였다. 둘째, 단행본 및 보고서를 중심으로 한 문헌고찰을 통해 사회적 배경, 사용자의 니즈, 기술적인 요인을 분석하였다. 최종적으로 도출된 기술적, 사회적 영향 요소, 사용자의 니즈, 기술적인 요인의 연계성을 통해 중국 고유 SUV발전시킨 요소를 정리하고 파악하였다. 중국 대표 SUV 모델과 브랜드의 역사를 종합해 볼때, 중국 SUV 발전은 세계 자동차 시장의 강력한 영향 하에 국가 정책의 테두리 안에서 국외 기술의 지지를 받아 주로 공무용 개발된 발전 초기 및 성장 단계, 그리고 중저가 민간용 모델이 생산의 중심이 되어 융합적 기술의 관여로 고속 발전 단계에 들어선 현 시기로 이분할 수 있다. 역사적 고찰과 현황 분석으로부터 중국 대표 SUV 브랜드의 고유 모델은 국내⋅외 첨단 융합 기술을 기반으로 국제 자동차 시장 변화의 영향 아래 중저가 민간용 주력 모델 생산에서 점진적으로 고급 민간용 모델 생산 증가 추이를 보일 것으로 예측된다. China’s automotive landscape, in line with rapid changes seen in the global automotive industry, is deeply transforming its shape from consumption dominant market to manufacturing and sales centered market. As a result of distinct characteristics of China’s social and historical development, over the years two forms of automotive company have emerged in China: one being Chinese-multinational joint ventures and the other, local automakers that started with their own capital. After China’s entry into the World Trade Organization (WTO) in 2001, China’s automotive sales volume has maintained first place in the world for consecutive years. Over the years of this transformation, China’s automotive market has been influenced by both internal factors such as domestic policies as well as external elements concerned with significant changes of the global automobile industry. This study aims to provide a deeper insight to the growth of domestically developed SUV models in China. This paper extends the research focus to analyzing the design elements that influence the development of domestic SUV models. With the finding, this paper expects to prospect the potential growth and development of domestically produced SUV models in China (in the future to come). The method of research for study In the center of chinese domestic brands, The historical development of the autoative industry, business condition was investigated to identify the historical, social issues and the impact elements. Through Review of literature, analyze the social background, the user"s needs, technological factors. This study organize and figure out the impact elements to the growth of domestically developed SUV models in China from the linkage of derived technical, social impact factor, user"s needs, technical elements. Taking into account both research on the Chinese representative SUV model and the brand history, it can be said that the Chinese SUV growth experienced two stages of development: the first stage being the early and growth stage, where SUVs were developed for civil purposes with the support of foreign technology within the outline of national policies under the larger influence of the changes in the global automotive industry and the second stage, which is the current stage showing high-speed growth, where SUVs are mainly aimed at China’s masses at an affordableprice, which these SUVs include convergence technology. Studying historical background and current status of the SUV market in China, it is expected that there will be gradual increase in tailoring Chinese SUV models to affluent Chinese private drivers with advanced convergence technologies from China and the outside world.

외화면 공간과 인지심리에 관한 연구

왕진홍(Wang Zhen Xing),김동현(Kim Dong Hyun) 한국멀티미디어학회 2010 멀티미디어학회논문지 Vol.13 No.2

Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes : Dynamin 2 in mouse oocytes

Wang, Qiao-Chu,Liu, Jun,Wang, Zhen-Bo,Zhang, Yu,Duan, Xing,Cui, Xiang-Shun,Kim, Nam-Hyung,Sun, Shao-Chen Wiley Blackwell (Blackwell Publishing) 2014 Biology of the cell Vol.106 No.6

Upregulation and biological function of transmembrane protein 119 in osteosarcoma

Zhen-Huan Jiang,Jun Peng,Hui-Lin Yang,Xing-Li Fu,Jin-Zhi Wang,Lei Liu,Jian-Nong Jiang,Yong-Fei Tan,Zhi-Jun Ge 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development. However, the level of TMEM119 expression and its roles in osteosarcoma have not yet been elucidated. In the present study, TMEM119 mRNA and protein expression was found to be up-regulated in osteosarcoma compared with normal bone cyst tissues. The level of TMEM119 protein expression was strongly associated with tumor size, clinical stage, distant metastasis and overall survival time. Moreover, gene set enrichment analysis (GSEA) of the Gene Expression Omnibus (GEO) GSE42352 dataset revealed TMEM119 expression in osteosarcoma tissues to be positively correlated with cell cycle, apoptosis, metastasis and TGF-β signaling. We then knocked down TMEM119 expression in U2OS and MG63 cells using small interfering RNA, which revealed that downregulation of TMEM119 could inhibit the proliferation of osteosarcoma cells by inducing cell cycle arrest in G0/G1 phase and apoptosis. We also found that TMEM119 knockdown significantly inhibited cell migration and invasion, and decreased the expression of TGF-β pathway-related factors (BMP2, BMP7 and TGF-β). TGF-β application rescued the inhibitory effects of TMEM119 knockdown on osteosarcoma cell migration and invasion. Further in vitro experiments with a TGF-β inhibitor (SB431542) or BMP inhibitor (dorsomorphin) suggested that TMEM119 significantly promotes cell migration and invasion, partly through TGF-β/BMP signaling. In conclusion, our data support the notion that TMEM119 contributes to the proliferation, migration and invasion of osteosarcoma cells, and functions as an oncogene in osteosarcoma.

Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro

Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8

Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.

Nanotwinned Microstructure Engineering of Electroplated Copper for Enhanced Anti-corrosion in Alkaline Medium

Xing‑Quan Liu,Zhe Li,Zhen‑Jia Peng,Rui‑Xun Wang,Zhi‑Quan Liu 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.1

Electroplated copper is a key electronic interconnect material in integrated circuits and printed circuits and inevitablyexposed to corrosive media in manufacturing processes. The present work reports, for the first time, that corrosion resistanceof electroplated copper in 4 wt% NaOH is enhanced via nanotwinned microstructure engineering. Nucleation and growthof oxide/hydroxide on nanotwinned copper are inhibited, attributed to existence of highly (111)-preferred grain orientationand high-density parallelly-aligned coherent twin boundaries at surface. This study unveils a novel anti-corrosion strategyof nantowinned microstructure engineering against alkaline etchant, and exhibits great application values in industrial electroplatingof copper, silver, or their alloys.

Metabolic Engineering of Saccharomyces cerevisiae to Improve Glucan Biosynthesis

( Xing Zhou ),( Jing He ),( Lingling Wang ),( Yang Wang ),( Guocheng Du ),( Zhen Kang ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.5

β-Glucan is a chief structural polymer in the cell wall of yeast. β-Glucan has attracted intensive attention because of its wide applications in health protection and cosmetic areas. In the present study, the β-glucan biosynthesis pathway in S. Cerevisiae was engineered to enhance β-glucan accumulation. A newly identified bacterial β-1, 6-glucan synthase GsmA from Mycoplasma agalactiae was expressed, and increased β-glucan content by 43%. In addition, other pathway enzymes were investigated to direct more metabolic flux towards the building of β-glucan chains. We found that overexpression of Pgm2 (phosphoglucomutase) and Rho1 (a GTPase for activating glucan synthesis) significantly increased β-glucan accumulation. After further optimization of culture conditions, the β-glucan content was increased by 53.1%. This study provides a new approach to enhance β-glucan biosynthesis in Saccharomyces cerevisiae.