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RISS 인기검색어
- 검색키워드
- 저자 : Zhang Yanqiong (검색결과 6 건)
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Mechanism of a Torrential Rainstorm That Occurred to the West of a Mei-yu Frontal Low
Yun Zhang,Lifeng Zhang,Chunming Wang,Yanqiong Xie,Jie Xiang 한국기상학회 2014 Asia-Pacific Journal of Atmospheric Sciences Vol.50 No.4
Heavy rainfall usually occurs to the southeast of a Mei-yu frontal low. The rainstorms appeared to the west of Mei-yu frontal lows are difficult to forecast because their formation mechanisms are not well understood. An extreme rainfall event occurred to the west of a Mei-yu frontal low in Anqing City, Anhui Province, China, on 13 July 2010, which was not well predicted. Based on observation data, NCEP/NCAR reanalysis data and high-resolution numerical simulation output, the mechanisms of this severe rainstorm are analyzed in this paper. The results indicate that the eastward moving meso-α-scale low was a key synoptic system that resulted in the formation of the mesoscale convective system causing the rainstorm. As the low moved eastward and strengthened, the increasing northerly flow and the southerly warm/moist flow formed an eastwest elongated convergence line (frontal zone) at the west part of the low. While the low moved to the coastal region, its intensity was enhanced and its moving speed was reduced. As a result, the convergence line and the frontal zone remained quasi-stationary near Anqing. Furthermore, Anqing is located in a valley between the Dabie and Wannan Mountains; the northerly winds flowed around Dabie Mountains and entered the valley, leading to an intense local convergence and frontogenesis near Anqing. Under the unstable environments with sufficient water vapor, the local intense frontogenesis along with intense convergence triggered and maintained the quasi-stationary mesoscale convective system that resulted in the record-breaking rainfall in Anqing.
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Zheng Yanqiong,Peng Junbiao,Tang Jie,Li Weiguang,Chen Juncong,Wang Chao,Zhang Jianhua,Wei Bin,Li Xifeng 한국물리학회 2021 Current Applied Physics Vol.22 No.-
The mixed cohosts of electron transport host (E-host): 4,40-bis(carbazol-9-yl)biphenyl (CBP) have been comparatively investigated for an efficient green fluorescent organic light emitting diode (OLED) doped with a thermally activated delayed fluorescence (TADF) emitter (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN). The E-host:CBP systems significantly enhance the electroluminescent (EL) properties. After doping Ehost, the lifetime of the emissive layer decreases and the surface becomes smoother, together with the impedance decreases for one magnitude and the hole-injection depresses. The charge balance and improved interface both contribute to the EL performance enhancement. Here we develop a universal mixed host system suitable to most of emitters.
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Han Zhang,Liangshan Hu,Wei Xiao,Yanqiong Su,Donglin Cao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Melanoma is a highly aggressive form of skin cancer with increasing incidence and mortality rates. Chemotherapy, the primary treatment for melanoma, is limited by hypoxia-induced drug resistance and suppressed immune response at the tumor site. Modulating the tumor microenvironment (TME) to alleviate hypoxia and enhance immune response has shown promise in improving chemotherapy outcomes. Methods In this study, a novel injectable and in situ forming hydrogel named MD@SA was developed using manganese dioxide (MnO2) nanosheets pre-loaded with the chemotherapy drug doxorubicin (DOX) and mixed with sodium alginate (SA). The sustainable drug delivery, oxygen generation ability, and photothermal property of MD@SA hydrogel were characterized. The therapeutic efficacy of hydrogel was studied in B16F10 in vitro and B16F10 tumorbearing mice in vivo. The immune effects on macrophages were analyzed by flow cytometry, real-time quantitative reverse transcription PCR, and immunofluorescence analyses. Results The MD@SA hydrogel catalyzed the tumoral hydrogen peroxide (H2O2) into oxygen, reducing the hypoxic TME, down-regulating hypoxia-inducible factor-1 alpha (HIF-1α) and drug efflux pump P-glycoprotein (P-gp). The improved TME conditions enhanced the uptake of DOX by melanoma cells, enhancing its efficacy and facilitating the release of tumor antigens. Upon NIR irradiation, the photothermal effect of the hydrogel induced tumor apoptosis to expose more tumor antigens, thus re-educating the M2 type macrophage into the M1 phenotype. Consequently, the MD@SA hydrogel proposes an ability to constantly reverse the hypoxic and immune-inhibited TME, which eventually restrains cancer proliferation. Conclusion The injectable and in situ forming MD@SA hydrogel represents a promising strategy for reshaping the TME in melanoma treatment. By elevating oxygen levels and activating the immune response, this hydrogel offers a synergistic approach for TME regulation nanomedicine.
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Provably Secure Forward Secure Certificateless Proxy Signature Scheme
( Jiguo Li ),( Yanqiong Li ),( Yichen Zhang ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.8
In order to deal with key exposure problem, we introduce forward secure technique into certificateless proxy signature scheme, and propose the formal definition and security model of the forward secure certificateless proxy signature. Our security model takes into account the super adversary in certificateless signature. Furthermore, we present a construction of forward secure certificateless proxy signature scheme with bilinear maps. Based on the difficulty of computational Diffie-Hellman problem, we prove the scheme is secure against chosen message attack in the random oracle model. Finally, we analyze efficiency of the proposed scheme.
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Chen Wenjia,Ma Zhaochen,Yu Lingxiang,MAO Xia,Ma Nan,Guo Xiaodong,Yin Xiaoli,Jiang Funeng,Wang Qian,Wang Jigang,Fang Mingliang,Lin Na,Zhang Yanqiong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART regulates autophagic flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of GBA was significantly associated with aggressive progression and short overall survival times in HCC. Subsequent experiments revealed an association between autophagic activity and GBA expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC and an orthotopic mouse model, and human HCC cell lines. Interestingly, probe labeling identified GBA as an ART target, which was further verified by both a glutathione-S-transferase pulldown assay and surface plasmon resonance analysis. The elevated protein expression of LC3B, the increased numbers of GFP-LC3B puncta and double-membrane vacuoles, and the enhanced expression of SQSTM1/p62 indicated that the degradation of autophagosomes in HCC cells was inhibited by ART treatment. Both the in vitro and in vivo data revealed that autophagosome accumulation through targeting of GBA was responsible for the anti-HCC effects of ART. In summary, this preclinical study identified GBA as one of the direct targets of ART, which may have promising potential to inhibit lysosomal autophagy for HCC therapy.
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