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Mao-pu Xia,Hai-bo Li,Nan Jiang,Jun-lin Chen,Jia-wen Zhou 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1
Rockfall is a major geological disaster that frequently occurs on rock slopes in alpine and gorge regions and poses a significant threat to life and property in areas exposed to rockfall hazards. In this study, a methodology is presented for comprehensive rockfall hazard analysis, including data acquisition, source identification, numerical simulation, quantitative assessment and mitigation evaluation. A high-precision and high-resolution digital terrain model (DTM) is generated based on the point cloud data obtained by terrestrial laser scanning (TLS) and is utilized for rockfall simulation and automatic identification of structural planes. The model parameters are calibrated by three-dimensional (3D) back analysis, and the rockfall motion is simulated based on a probabilistic model and an energy dissipation model. Rockfall mitigation under passive protection is evaluated according to the rockfall interception ratio (RIR), hazard reduction rate (HRR) and statistics of the rockfall characteristics and hazards within the rockfall threat area. Under the influence of construction excavation, the diversion tunnel inlet slope of Jinchuan Hydropower Station has suffered from a series of rockfall events and potential overall instability, which has become a great threat to the construction personnel, equipment and vehicles below the slope. Thus, the presented methodology is applied to thoroughly study the example case of the rockfall events at the inlet slope of the diversion tunnel of Jinchuan Hydropower Station. The advantages, limitations and notes of each link of the presented methodology are discussed, and the suggestion of strengthening the cracked area with integral active support is proposed.
Xia-Wa Mao,Jia-Quan Xiao,Zhong-Yi Li,Yi-Chun Zheng,Nan Zhang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
This study investigated the effects of microRNA-135a (miR-135a) targeting of glycogen synthase kinase 3β (GSK3β) on the epithelial–mesenchymal transition (EMT), migration and invasion of bladder cancer (BC) cells by mediating the Wnt/β-catenin signaling pathway. BC and adjacent normal tissues were collected from 165 BC patients. Western blotting and quantitative realtime PCR were used to detect the expression of GSK3β, β-catenin, cyclinD1, E-cadherin, vimentin and miR-135a in BC tissues and cells. Cells were assigned to blank, negative control (NC), miR-135a mimics, miR-135a inhibitors, small interfering RNA (siRNA)-GSK3β or miR-135a inhibitors+siRNA-GSK3β groups. miR-135a, β-catenin, cyclinD1 and vimentin expression increased, while GSK3β and E-cadherin expression decreased in BC tissues compared with adjacent normal tissues. Compared with the blank and NC groups, the expression of miR-135a, β-catenin, cyclinD1 and vimentin was higher, and cell proliferation, migration, invasion and tumor growth were increased in the miR-135a mimics and siRNA-GSK3β groups. These groups showed an opposite trend in GSK3β and E-cadherin expression and cell apoptosis. The miR-135a inhibitors group was inversely correlated with the blank and NC groups. It was concluded that miR-135a accelerates the EMT, invasion and migration of BC cells by activating the Wnt/β-catenin signaling pathway through the downregulation of GSK3β expression.
Localization and Privacy Preservation in Cognitive Radio Networks
Xu Zhang,Xia Ying,Hongrui Mao,Hae Young Bae 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1
Cognitive Radio Networks (CRNs) has been considered as a key technology for future wireless communications and mobile computing. Localization of primary user is crucial in enabling several key capabilities in CRNs. In this paper, we present a survey of representative methods dealing with user localization and location privacy preservation issues and propose a taxonomy that summarizes the state-of-the-art. The objective is to provide a comprehensive analysis and guide of existing efforts around localization and location privacy preservation in cognitive radio network. This survey is intended to help researchers in quickly understanding existing works and challenges, and possible improvements to bring.
Xia Qian,Zhan Gaofeng,Mao Meng,Zhao Yin,Li Xing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Excessive and unresolved neuroinflammation is a key component of the pathological cascade in brain injuries such as ischemic stroke. Tripartite motif-containing 45 (TRIM45) is a ubiquitin E3 ligase involved in various critical biological processes. However, the role of TRIM45 in cerebral ischemia remains unknown. Here, we found that the TRIM45 protein was highly expressed in the peri-infarct areas of mice subjected to cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion. This study systemically evaluated the putative role of TRIM45 in the regulation of neuroinflammation during ischemic injury and the potential underlying mechanisms. We found that TRIM45 knockdown significantly decreased proinflammatory cytokine and chemokine production in primary cultured microglia challenged with oxygen-glucose deprivation and reoxygenation (OGD/R) treatment. Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1–TAK1–TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-κB) signaling pathway. In an in vitro coculture Transwell system, downregulation of TRIM45 expression also inhibited the OGD/R-induced activation of microglia and alleviated neuronal apoptosis. More importantly, microglia-specific knockdown of TRIM45 in mice significantly reduced the infarct size, mitigated neurological deficit scores, and improved cognitive function after ischemic stroke. Taken together, our study reveals that the TRIM45–TAB2 axis is a crucial checkpoint that controls NF-κB signaling in microglia during cerebral ischemia and reperfusion injury. Therefore, targeting TRIM45 may be an attractive therapeutic strategy.
Quantitative Detection of Corroded Reinforced Concrete of Different Sizes Based on SMFL
Mao Yang,Jianting Zhou,Qingyuan Zhao,Qianwen Xia,Hong Zhang,Lifeng Wang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1
In order to solve the problem of quantitative detection of corroded reinforced concrete of different sizes, the quantitative detection experiment based on spontaneous magnetic flux leakage (SMFL) was carried out in batches. Electrochemical corrosion of 27 reinforced concrete specimens was carried out, and the SMFL signals of reinforcement were obtained by magnetic detection equipment. Four-dimensional magnetic indicators M1-M4 that can characterize the corrosion degree of the specimens were defined. The influence of different sizes on the magnetic indicators were analyzed. It is concluded that the thicknesses of the concrete covers affect the magnetic indicators by affecting the lift-off heights z. The influence of diameter of the rebars on the quantitative detection can be eliminated by describing the corrosion degree with the average cross-section loss rate α. The influence of length of the rebars on quantitative detection is not clear yet. Finally, Support Vector Machine (SVM) was introduced to establish a classification model of corrosion classes and magnetic indicators. Using the model to predict the corrosion classes of the specimens can achieve a high classification accuracy. The research provides a new method for the quantitative detection of steel corrosion.
Xia Yu,Conggui Chen,Kezhou Cai,Cunliu Zhou,Daorong Mao,Gaojun Sun 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.4
The effects of blood plasma (BP, 0-2.5%), agar (0-1.0%), and microbial transglutaminase (MTG, 0-0.5%)on water-binding capacity, color (L*, a*, and b* values)and textural properties of pork muscle gels (PMG) were investigated with response surface methodology. The potential interaction among these ingredients was evaluated by DSC, SEM, and FT-IR. The results shown that the addition of BP into PMG could result in decreased cooking loss (CL) and L* (p<0.01), as well as increased a*, springiness,and chewiness of the gels (p<0.05), while the treatment with MTG led to increased CL (p<0.01). Agar could obviously improve CL of PMG, but lead to inferior springiness and cohesiveness (p<0.05). Moreover, the synergism among muscle proteins, BP, MTG, and agar implied that there were some kinds of interactions among these ingredients, thus influencing the properties of PMG.
Mao, Huiling,Xia, Yuefeng,Tu, Yan,Wang, Chong,Diao, Qiyu Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.11
Objective: This study was conducted to investigate the effects of weaning times on the growth performance, rumen fermentation and microbial communities of yellow cattle calves. Methods: Eighteen calves were assigned to a conventional management group that was normally weaned (NW, n = 3) or to early weaned (EW) group where calves were weaned when the feed intake of solid feed (starter) reached 500 g ($EW_{500}$, n = 5), 750 g ($EW_{750}$, n = 5), or 1,000 g ($EW_{1,000}$, n = 5). Results: Compared with NW, the EW treatments increased average daily gain (p<0.05). The calves in $EW_{750}$ had a higher (p<0.05) starter intake than those in $EW_{1,000}$ from wk 9 to the end of the trial. The concentrations of total volatile fatty acids in $EW_{750}$ were greater than in NW and $EW_{1,000}$ (p<0.05). The EW treatments decreased the percentage of acetate (p<0.05). The endogenous enzyme activities of the rumen were increased by EW (p<0.05). EW had no effect on the number of total bacteria (p>0.05), but changes in bacterial composition were found. Conclusion: From the present study, it is inferred that EW is beneficial for rumen fermentation, and weaning when the feed intake of the starter reached 750 g showed much better results.
Ruin probabilities in the risk model with two compound Binomial processes
Mao-Jun Zhang,Jiang-Xia Nan,Sen Wang 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.1
In this paper, we consider an insurance risk model governed by a compound Binomial arrival claim process and by a compound Binomial arrival premium process. Some formulas for the probabilities of ruin and the distribution of ruin time are given, we also prove the integral equation of the ultimate ruin probability and obtain the Lundberg inequality by the discrete martingale approach.
( Xia Gao ),( Xu Ping Fu ),( Tao Li ),( Jian Zi ),( Yao Luo ),( Qing Wei ),( Er Liang Zeng ),( Yi Xie ),( Yao Li ),( Yu Min Mao ) 생화학분자생물학회 2003 BMB Reports Vol.36 No.6
In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.