THE INFLUENCE OF RELIGION ON PERCEPTIONS TOWARD THE REGULATION OF CONTROVERSIAL ADVERTISING

Zehua Wang,Sameer Deshpande,David S. Waller,B. Zafer Erdogan 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.3

Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer

Zehua Wang,Jianwen Gao,Jiabing Zhou,Haiou Liu,Congjian Xu 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2

Objective: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP inhibitor, has an anti-tumor effect on high grade serous ovarian cancer, but its effects on cellular senescence have not been reported. This study intends to explore the role of olaparib in the regulation of senescence in ovarian cancer cells. Methods: The effects of olaparib on the senescence of ovarian cancer cells were detected by using the senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated heterochromatin aggregation (SAHF). Quantitative real-time polymerase chain reaction was used to analyze the senescence-associated secretory phenotype (SASP). Cell cycle and apoptosis were detected by flow cytometry. The effect of olaparib on tumor growth was analyzed in a nude mouse xenograft transplantation model. Results: Long-term (6 days) treatment with olaparib (5 μM) significantly inhibited the growth of ovarian cancer cells, leading to arrest the cell cycle at G0/G1 phase, significant increase the number of positive SA-β-Gal stained cells and positive SAHF cells. The expression of P16 and retinoblastoma protein (p-RB) were significantly enhanced in SKOV3 cells under olaparib treated, meanwhile, the expression of P53 and p-RB were upregulated in A2780 cells. In OVCAR-3 cells, the expression of P53 was downregulated and p-RB was upregulated. Mice with SKOV3 xenograft transplantation was given olaparib (10 mg/kg/day) via abdominal cavity administration, the tumor volume was reduced (p<0.01). Conclusion: Continuous low dosage administration of olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer.

lncRNA Epigenetic Landscape Analysis Identifies <i>EPIC1</i> as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Wang, Zehua,Yang, Bo,Zhang, Min,Guo, Weiwei,Wu, Zhiyuan,Wang, Yue,Jia, Lin,Li, Song,Caesar-Johnson, Samantha J.,Demchok, John A.,Felau, Ina,Kasapi, Melpomeni,Ferguson, Martin L.,Hutter, Carolyn M.,Sof Cell Press 2018 Cancer Cell Vol. No.

<P><B>Summary</B></P> <P>We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including <I>EPIC1</I> (epigenetically-induced lncRNA1). Overexpression of <I>EPIC1</I> is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth <I>in vitro</I> and <I>in vivo.</I> Mechanistically, <I>EPIC1</I> promotes cell-cycle progression by interacting with MYC through <I>EPIC1</I>'s 129–283 nt region. <I>EPIC1</I> knockdown reduces the occupancy of MYC to its target genes (e.g., <I>CDKN1A</I>, <I>CCNA2</I>, <I>CDC20</I>, and <I>CDC45</I>). MYC depletion abolishes <I>EPIC1</I>'s regulation of MYC target and luminal breast cancer tumorigenesis <I>in vitro</I> and <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LncRNAs show a hypomethylation phenotype, in contrast to a CIMP phenotype in cancer </LI> <LI> <I>EPIC1</I> promotes breast tumorigenesis through regulating cancer cell-cycle progression </LI> <LI> <I>EPIC1</I> directly interacts with MYC protein through <I>EPIC1</I>'s 129–283 nt region </LI> <LI> <I>EPIC1</I> regulates MYC targets by enhancing MYC occupancy on its target promoters </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

THE INFLUENCE OF RELIGION ON PERCEPTIONS TOWARD THE REGULATION OF CONTROVERSIAL ADVERTISING

Zehua Wang,Sameer Deshpande,David S. Waller,B. Zafer Erdogan 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

In the past, particular advertisements have offended people for being controversial products or executions, and, globally, religion plays a significant role in influencing attitudes toward controversial advertising. In light of advertising controversy and the impact of social values on government regulations, this study explores how religion (Christianity, Islam, Buddhism/Taoism, Hinduism, and non-believers) influences consumers’ perceptions of government regulations on controversial advertising. Controversial advertising is defined as “advertising that, by the type of product or execution, can elicit reactions of embarrassment, distaste, disgust, offence, or outrage from a segment of the population when presented” (Waller, 2006, p. 7). Typical controversial products include gender/sex related products, addictive products, social/political groups and health and care products (Fam, Waller, & Erdogan, 2004). Controversial executions usually refer to antisocial behaviour, indecency, fear, racism, and sexuality (Wilson & West, 1981). Several examples in recent decades show that marketing communications which involve controversial products or executions can cause a large-scale boycott of a brand. Studies have found that religion becomes a crucial indicator in influencing consumers’ perceptions of marketing activities and shopping behaviours (Al-Hyari et al., 2012). When the advertised content violates the religious beliefs of the audiences, brand damage can follow. While controversial advertising offends consumers, its insufficient regulation hurts too (Christy, 2006); thus leading to calls for more attention from government regulatory bodies (Boddewyn, 1991). According to previous studies, “many general spiritual principles and actual rituals in religion are related to ethical positions” (p. 533). Consumers’ religious beliefs could affect how they expect regulatory bodies to behave as social agents (Cornwell et al., 2005). Therefore, this study extends the literature by examining how consumers affiliated with different religions evaluate the current government regulation of the advertising of controversial products and executions, and whether they perceive that the regulations have effectively restricted the advertising offense based on their religious beliefs. Based on research data collected from 1,402 university students in 11 countries from across North America, Europe, Asia, and Australia (namely, (Canada, Italy, Australia, Germany, England, China, India, Turkey, Mexico, Korea, and Malaysia), the findings confirm the existing literature that different religions are identified as having different levels of tolerance toward the advertising of controversial goods and executions (Fam, Waller, & Erdogan, 2004; Morphitou & Gibbs, 2000). Also, the restrictions required by some religious groups are inadequately addressed by regulatory bodies. See Tables 1 and 2. Islamic followers are more easily offended by controversial advertising. At the same time, they perceive relatively weak government regulations on controversial advertising. This is particularly true for the advertising of addictive products, personal themes, and risky/avoidable executions. Although in some Muslim countries (e.g., Malaysia) where numerous government regulations are already instituted to protect the Islamic values and their cultural identity (Waller & Fam, 2000), the force of the regulations is still perceived as weak, thus demanding more restrictions. Buddhists/Taoists and non-believers who are moderately offended by the controversial advertisements, more frequently indicate that the government restrictions on advertising are stronger than those indicated by Muslims, Hindus, and Christians. Perceptions of Buddhists are likely influenced by their philosophical teachings, which includes teachings of “Wisdom (right view, right intention), Ethical conduct (right speech, right action, right livelihood), and Concentration (right effort, right mindfulness and right concentration)” (“Buddhism,” 2013). Although Non-believers do not officially commit to a religion, the 73.37% of non-believers in this study reside in China and South Korea, both societies that practice Confucian cultures (Gao & Kim, 2009). Confucianism is concerned with “morality, propriety, modesty, social harmony and human relationships” (Ching, 1997; Wilhelm, 1931 in Gao & Kim, 2009). As such, Buddhists/Taoists and non-believers perceive that the regulations strongly protect their cultural values and the harmony of the society from inappropriate commercials, but are less restrictive of freedom of choice, free speech and marketers’ creativity. Hindus are found to be less offended by the advertisements of the majority of controversial product and execution groups; at the same time they believe that the advertisements are less regulated compared to other religions. However, their negative attitudes toward the advertising of addictive products call for special attention of marketers and regulatory bodies. Compared to the other four religious groups, Hindus indicate that the regulations are weakly planned in restricting the advertising of addictive products and the advertising offense still occurs. This finding confirms Hindus’ desire to prohibit such advertising in media in order to protect health and well-being of their young population (Shastri, 2012) and control overall crime in the Hindu society (Schneider, 2013). Christians perceive the regulatory restrictiveness as being significantly lower than Buddhists/Taoists and non-believers, but not different from Muslims and Hindus. Christians indicate an overall lower extent of offensiveness on all eight groups of products and executions than the other four religions, and they also report the regulations to be acceptable. These findings validate Morphitou and Gibbs’s (2008) argument that Christians have more tolerance toward self-interest and acceptance of the diversity in marketing communications. Christians’ opinions on the restrictive effects of the regulations on hindering free speech, freedom of choice, and creativity of marketing communications are salient. This finding would remind the regulatory bodies to be cautious about not being overly restrictive in Christian-dominated countries when planning regulations. The study findings have practical value for advertisers and policy makers. The advertising practitioners need to be aware of elements in their advertising that conflict with consumers’ religious beliefs, especially when operating in international markets, and prevent advertising offense. Direct marketing strategy is strongly recommended when promoting controversial products in a highly sensitive mass media environment, especially for marketing in pluralistic societies which have multiple religions. Advertisers need to exercise special caution when promoting gender/sex-related products and social/political groups in Muslim-dominated markets (Michell & Al-Mossawi, 1999; Fam, Waller, & Erdogan, 2004; De Run et al., 2010). Advertising of those two product groups to non-believers who conform to the ethical codes of Confucianism can also be offensive (Gao & Kim, 2009). Marketers should be aware that the advertising of alcohol and cigarettes is highly offensive to Hindus and Muslims. Their promotion in mass media may evoke negative responses. Additionally, using controversial executions in advertising should be avoided, especially when targeting Muslims and Confucian consumers. These findings may also help advertising regulation planners (self-regulating advertising bodies and policy makers) to gain understanding about how different religions view the current regulations of controversial advertising. When targeting Buddhists/Taoists and non-believers, advertising regulators should consider keeping the current level of restrictions of controversial advertising. We recommend similar approach when targeting Hindus except for imposing more regulations in relation to advertising of addictive products. In Islamic societies, more restrictions or more awareness of what are the current restrictions may be necessary, in order to comply with Muslims’ sensitivities, while an easing of the restrictions on the advertising in Christian-dominated markets would be desired.

CSI-based human sensing using model-based approaches: a survey

Zhengjie Wang,Zehua Huang,Chengming Zhang,Wenwen Dou,Yinjing Guo,Da Chen 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.2

Currently, human sensing draws much attention in the field of ubiquitous computing, and human sensing based on WiFi CSI (channel state information) becomes a hot research topic due to the easy deployment and availability of WiFi devices. Although various human sensing applications based on the CSI signal model are emerging, the model-based approach has not been studied thoroughly. This paper provides a comprehensive survey of the latest model-based human sensing methods and their applications. First, the CSI signal and framework of model-based human sensing methods are introduced. Then, related models and fundamental signal preprocessing techniques are described. Next, typical human sensing applications are investigated, and the crucial characteristics are summarized. Finally, the advantages, limitations, and future research trends of model-based human sensing methods are concluded in this paper.

A three-region movable-boundary helical coil once-through steam generator model for dynamic simulation and controller design

Wu Shifa,Li Zehua,Wang Pengfei,Su G.H.,Wan Jiashuang 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.2

A simple but accurate mathematical model is crucial for dynamic simulations and controller design of helical coil once-through steam generator (OTSG). This paper presents a three-region movable boundary dynamic model of the helical coil OTSG. Based on the secondary side fluid conditions, the OTSG is divided into subcooled region (two control volumes), two-phase region (two control volumes) and superheated region (three control volumes) with movable boiling boundaries between each region. The nonlinear dynamic model is derived based on mass, energy and momentum conservation equations. And the linear model is obtained by using the transfer function and state space transformation, which is a 37-order model of five input and three output. Validations are made under full-power steady-state condition and four transient conditions. Results show good agreements among the nonlinear model, linear model and the RELAP5 model, with acceptable errors. This model can be applied to dynamic simulations and controller design of helical coil OTSG with constant primary-side flow rate.

Effects of chlorantraniliprole on detoxification enzymes activities in Locusta migratoria L.

Guangchun Cao,Miao Jia,Xia Zhao,Lei Wang,Xiongbing Tu,Guangjun Wang,Xiangqun Nong,Zehua Zhang 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.3

The broad insecticide chlorantraniliprole causes death by activating the ryanodine receptor, and its effects on detoxification enzymes limit its proper rotation and mixed use with other pesticides. Therefore, we studied the changes in detoxification enzymes activities of Locusta migratoria L. nymphs induced by chlorantraniliprole. When nymphs of locust were treated with chlorantraniliprole only on the first day, the LC50 was 4.8 μg mL−1, and the activities of esterases (ESTs) and glutathione S-transferases (GSTs) increased, but the activity of multifunction oxidases (MFOs) increased only at 3 day after treatment, although the activities fluctuated over 7 days after treatment. When the nymphs of locust were treated for 7 days, the LC50 was 2.3–3.1 μg mL−1, and similarly the activities of ESTs and GSTs increased while that of MFOs decreased significantly in a concentrationdependent manner. Synergism of triphenylphosphate, piperonyl butoxide, and diethyl maleate with chlorantraniliprole toxicity confirmed the correlation between chlorantraniliprole and changes in ESTs, GSTs, and MFOs activities. Herein, we improved the knowledge about the effects of chlorantraniliprole on these detoxification enzymes of L. migratória. These results clarified the effects of chlorantraniliprole on the activities of ESTs, GSTs, and MFOs in L. migratoria, and will provide insight into its proper rotation and mixed use with other pesticides.

A semi-analytical method of time-varying mesh stiffness in concentric face gear split-torque transmission system

Jianxiong Dong,Jin-Yuan Tang,Zehua Hu,Yi Wang 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.2

Concentric face gear split-torque transmission system (CFGSTTS) has great applied value in the field of aeronautical transmission due to the characteristic of high integration. Mesh stiffness, as one of the most primary sources of vibration, is vitally important for the dynamic performances of gear transmission system. The existing finite element method (FEM) and analytical method (AM) are not suitable for tackling the mesh stiffness calculation of closed-loop multi-branch system such as CFGSTTS. Thus, a semi-analytical method (SAM) is presented and verified, which combines the high precision of FEM with the high efficiency of AM. Additionally, the differences between the mesh stiffness of independent face gear drive and that of the same gear pair in CFGSTTS under accordant load is researched by applying SAM. The influence rules of distribution angle and load condition on the mesh stiffness of gear pairs considering system structure are also studied. Results demonstrate that the mesh stiffness of gear pairs in CFGSTTS is time-varying and tends to be consistent with each other by adjusting load parameters.

ARD1/NAA10 acetylation in prostate cancer

Katherine J. Kuhns,Guanyi Zhang,Zehua Wang,Wanguo Liu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Prostate cancer (PCa) is the second most common cancer in men. Androgen receptor (AR) signaling pathway plays a crucial role in prostate development and homeostasis. Dysregulation of this pathway activates AR leading to PCa pathogenesis and progression. AR binds testosterone and other male hormones, which then undergoes posttranslational modification for AR nuclear translocation and transcriptional activation. AR activation by post-translational modification is thus imperative for PCa cell growth and survival. Identification and understanding of the pathological and mechanistic roles of AR modifications may increase our understanding of AR activation in PCa and provide new therapeutic options. Recently, AR acetylation has been described as an important step for AR activation. Upregulation of several acetyltransferases has been reported to be associated with PCa progression. Herein, we provide a general understanding of AR acetylation, with a special emphasis on ARD1, and potential therapies that may be exploited against the ARD1–AR axis for PCa treatment.

Low beta superconducting cavity system design for HIAF iLinac

Mengxin Xu,Yuan He,Shengxue Zhang,Lubei Liu,Tiancai Jiang,Zehua Liang,Tong Liu,Yue Tao,Chunlong Li,Qitong Huang,Fengfeng Wang,Hao Guo,Feng Bai,Xianbo Xu,Shichun Huang,Xiaoli Li,Zhijun Wang,Shenghu Zha Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

A superconducting ion-Linac (iLinac), which is supposed to work as the injector in the High Intensity heavy-ion Accelerator Facility project, is under development at the Institute of Modern Physics (IMP), Chinese Academy of Sciences. The iLinac is a superconducting heavy ion linear accelerator approximately 100 meters long and contains 96 superconducting cavities in two types of 17 cyromodules. Two types of superconducting resonators (quarter-wave resonators with a frequency of 81.25 MHz and an optimal beta β = v/c = 0.07 called QWR007 and half-wave resonators with a frequency of 162.5 MHz and an optimal beta β = 0.15 called HWR015) have been investigated. The cavity design included extensive multi-parameter electromagnetic simulations and mechanical analysis, and its results are described in details. The fundamental power coupler and cavity dynamic tuner designs are also presented in this article. The prototypes are under manufacturing and expected to be ready in 2023.