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Stabilization of Proteins Inside Cells by Immobilization on Plasmid
Yunjeong PARK,Jonghyeok SHIN,Chakhee KIM,Hooyeon KIM,Emine SEYDAMETOVA,Dae-Hyuk KWEON,Choongjin BAN,Joon-Bum PARK,Myungseo PARK,Younghun JUNG,Seokoh MOON,Seok-Hyeon YU,Sora CHO,Hye Rin KIM,Hyun Seok O 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.10
Park, Yunjeong,Sim, Mikyung,Chang, Tong-Shin,Ryu, Jae-Sang The Royal Society of Chemistry 2016 Organic & Biomolecular Chemistry Vol.14 No.3
<P>We have developed a straightforward and auxiliary-free synthetic route towards tBu-tubuphenylalanine (tBu-Tup) and tBu-epi-tubuphenylalanine (tBu-epi-Tup), which are the key components of tubulysins and their analogs. A Lewis acid-mediated diastereoselective Mukaiyama aldol reaction using silyl ketene acetal and N-Boc-L-phenylalaninal provided gamma-amino-beta-hydroxyl-alpha-methyl esters, which were deoxygenated to gamma-amino-alpha-methyl esters under Barton-McCombie deoxygenation conditions. Notably, the desired tBu-Tup and tBu-epi-Tup were obtained in good overall yields in four steps.</P>
Bionanoelectronic platform with a lipid bilayer/CVD-grown MoS<sub>2</sub> hybrid
Park, Yunjeong,Kang, Byunggil,Ahn, Cheol Hyoun,Cho, Hyung Koun,Kwon, Hyukjoon,Park, Sungsu,Kwon, Junhwan,Choi, Myunghwan,Lee, Changgu,Kim, Kyunghoon Elsevier 2019 Biosensors & bioelectronics Vol.142 No.-
<P><B>Abstract</B></P> <P>We demonstrate a bionanoelectronic platform for a supported lipid bilayer formed on an MoS<SUB>2</SUB> film for biosensing, biomolecule recognition, and bioelectronic applications. A large-area MoS<SUB>2</SUB> film was synthesized on a sapphire substrate and treated with O<SUB>2</SUB> plasma or Al<SUB>2</SUB>O<SUB>3</SUB> deposition to change the surface from hydrophobic to hydrophilic. Measurements of fluorescence and fluorescence recovery after photobleaching confirmed the physical properties of the lipid bilayer on the treated surfaces. We fabricated an electronic device using the treated MoS<SUB>2</SUB> film and characterized the influence of the lipid bilayer on its electrical properties. Furthermore, transmembrane ion channels peptide (gramicidin A) were incorporated into the lipid bilayer and modulations of the electrical properties of the device under various pH conditions and calcium ion were observed. This sensitive and stable platform has strong potential for housing artificial channels and transmembrane ion channels for advanced bioapplications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2D bionanoelectronics based on lipid/MoS<SUB>2</SUB> hybrid was designed to monitor ion channel activity. </LI> <LI> Integration of lipid bilayer on a MoS<SUB>2</SUB> field effect transistor opens up potential utility of 2D nanomaterials for biosensing applications. </LI> <LI> Hybrid structure of MoS<SUB>2</SUB>/lipid bilayer with membrane peptides can provide a platform for designing interface between biology and electronics. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>