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Feasibility of implementing a surgical student internship program in South Korea
HyeRin Roh,Ku Sang Kim,Kee Hwan Kim,In Seok Choi,Kyu Eun Lee,Hyun-Young Kim,Nam-Joon Yi,Sun-Whe Kim,Min Gyu Kim 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.4
Purpose: Despite recommendations for introducing student internships (SI) in undergraduate medical education in Korea, the feasibility of surgical SIs has not been demonstrated in the Korean context. We thus identified tasks that could be performed by surgical student interns in a Korean education hospital. Methods: The opinions of surgery clerkship directors of medical schools nationwide, regarding the tasks, symptoms and signs, disease entities, and procedures that student interns could perform in their hospitals, were subjected to descriptive analysis. Results: Out of the 41 medical schools in Korea, 32 responded. Five implemented an optimal-quality SI program. Two schools considered third-year clerkship as SI. The respondents replied that student interns could be involved in basic nonspecific tasks such as history taking, physical examination, medial recording, reporting patients’ status, and assisting during surgery. However, more surgery-specific tasks such as perioperative management or caring for a patient with acute abdominal pain were considered difficult for student interns to encounter in the Korean context. Conclusion: Surgical educators should determine a specific role for student interns and encourage them to perform surgery-specific tasks. We recommend societal and system support, and curriculum renovation to establish an SI program in Korea.
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Topical eupatilin as a PPARα activator is effective for atopic dermatitis
( Hyerin Jeon ),( Bo Kyung Kim ),( Dong Hye Kim ),( Eunjung Kim ),( Youn Hwa Nho ),( Su Nam Kim ),( Eung Ho Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: We observed that eupatilin, an active flavone derived from Artemisia plant species, functions as a PPAR メ activator through in vitro study. Objectives: We evaluated whether sequential application of topical eupatilin after topical glucocorticoid (GC) could be more effective than GC alone for AD lesion in AD murine model. Also, we conducted clinical trials to assess the efficacy and safety of Artemisia argyi extracts containing eupatilin for AD patients. Methods: In animal experiment, GC was applied on inflamed skin of hairless mice only in the first day of the experiment, with 3 subsequent consecutive days of treatment with eupatilin as well as bezafibrate as a positive control, or vehicle as a negative control. The efficacy of eupatilin was evaluated by gross feature and skin barrier function. For clinical study, thirty subjects were recruited and randomly applied with active cream (treated site) or vehicle cream (control site) to the left or right side of the whole body twice a day for 4 weeks. Treatment outcomes were assessed by EASI score, itch score and skin barrier function. Results: In the animal study, topical eupatilin improved eczema lesion and skin barrier function. In the clinical study, a significant decrease in the EASI and itch scores (p<0.05) was observed in the treated sites. The skin barrier function was also improved. Any remarkable side effects related with the active cream were not found. Conclusion: Topical application of eupatilin could improve AD lesions.
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MRPrimerV: a database of PCR primers for RNA virus detection
Kim, Hyerin,Kang, NaNa,An, KyuHyeon,Kim, Doyun,Koo, JaeHyung,Kim, Min-Soo Oxford University Press 2017 Nucleic acids research Vol.45 No.d1
<P>Many infectious diseases are caused by viral infections, and in particular by RNA viruses such as MERS, Ebola and Zika. To understand viral disease, detection and identification of these viruses are essential. Although PCR is widely used for rapid virus identification due to its low cost and high sensitivity and specificity, very few online database resources have compiled PCR primers for RNA viruses. To effectively detect viruses, the MRPrimerV database (http://MRPrimerV.com) contains 152 380 247 PCR primer pairs for detection of 1818 viruses, covering 7144 coding sequences (CDSs), representing 100% of the RNA viruses in the most up-to-date NCBI RefSeq database. Due to rigorous similarity testing against all human and viral sequences, every primer in MRPrimerV is highly target-specific. Because MRPrimerV ranks CDSs by the penalty scores of their best primer, users need only use the first primer pair for a single-phase PCR or the first two primer pairs for two-phase PCR. Moreover, MRPrimerV provides the list of genome neighbors that can be detected using each primer pair, covering 22 192 variants of 532 RefSeq RNA viruses. We believe that the public availability of MRPrimerV will facilitate viral metagenomics studies aimed at evaluating the variability of viruses, as well as other scientific tasks.</P>
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Lee, Jaecheol,Kim, Youngkyun,Yi, Hyoju,Diecke, Sebastian,Kim, Juryun,Jung, Hyerin,Rim, Yeri Alice,Jung, Seung Min,Kim, Myungshin,Kim, Yong Goo,Park, Sung-Hwan,Kim, Ho-Youn,Ju, Ji Hyeon BioMed Central 2014 ARTHRITIS RESEARCH AND THERAPY Vol.16 No.1
<P><B>Introduction</B></P><P>Since the concept of reprogramming mature somatic cells to generate induced pluripotent stem cells (iPSCs) was demonstrated in 2006, iPSCs have become a potential substitute for embryonic stem cells (ESCs) given their pluripotency and “stemness” characteristics, which resemble those of ESCs. We investigated to reprogram fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) to generate iPSCs using a 4-in-1 lentiviral vector system.</P><P><B>Methods</B></P><P>A 4-in-1 lentiviral vector containing Oct4, Sox2, Klf4, and c-Myc was transduced into RA and OA FLSs isolated from the synovia of two RA patients and two OA patients. Immunohistochemical staining and real-time PCR studies were performed to demonstrate the pluripotency of iPSCs. Chromosomal abnormalities were determined based on the karyotype. SCID-beige mice were injected with iPSCs and sacrificed to test for teratoma formation.</P><P><B>Results</B></P><P>After 14 days of transduction using the 4-in-1 lentiviral vector, RA FLSs and OA FLSs were transformed into spherical shapes that resembled embryonic stem cell colonies. Colonies were picked and cultivated on matrigel plates to produce iPSC lines. Real-time PCR of RA and OA iPSCs detected positive markers of pluripotency. Immunohistochemical staining tests with Nanog, Oct4, Sox2, Tra-1-80, Tra-1-60, and SSEA-4 were also positive. Teratomas that comprised three compartments of ectoderm, mesoderm, and endoderm were formed at the injection sites of iPSCs. Established iPSCs were shown to be compatible by karyotyping. Finally, we confirmed that the patient-derived iPSCs were able to differentiate into osteoblast, which was shown by an osteoimage mineralization assay.</P><P><B>Conclusion</B></P><P>FLSs derived from RA and OA could be cell resources for iPSC reprogramming. Disease- and patient-specific iPSCs have the potential to be applied in clinical settings as source materials for molecular diagnosis and regenerative therapy.</P>
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Kim Hyerin,Shin Kyung-Hwa,Kim Hyung-Hoi,Lee Hyun-Ji 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.2
Background: With increasing number of migrants in Korea, there is an increasing need for blood products with rare blood antigens. Accordingly, the role of blood donors among migrants has been acknowledged. We investigated migrants’ experiences and perceptions of blood donation along with their sociodemographic status and identified the effects on selfreported blood donation status. Methods: A cross-sectional survey using a self-developed, structured questionnaire was conducted on 479 migrants. The questionnaire included items about experiences, knowledge, and perceptions on blood donation and sociodemographic factors of respondents. Results: Most migrants in this study were from Southeast Asia (54.7%) or China (39.9%). Among them, 28.6% (N=137) had donated blood previously, and 2.7% (N=13) had previously donated blood in Korea. All previous blood donors were volunteers, and the two major deterrents of blood donation for non-donors were the fear of pain and lack of knowledge about blood donation. In multivariable logistic regression analysis, the country of birth (odds ratio [OR]=2.65, P <0.001 [China]; OR=4.85, P =0.001 [countries other than China and Southeast Asian countries]) and employment status (OR=2.80, P =0.034) were independently associated with blood donation. Conclusions: This is the first Korean study to analyze migrants’ experiences and perceptions of blood donation in relation to their sociodemographic status. Our findings can help establish blood donation policies for migrants, devise campaigns to enhance blood donation awareness, and ultimately create a pool of rare blood resources in a multicultural society.
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Comparative study of nanolithography based on extraordinary and diffracted optical transmissions
Kim, Taeyeon,Ahn, Heesang,Song, Hyerin,Kim, Kyujung,Choi, Jong-ryul Elsevier 2019 OPTICS AND LASER TECHNOLOGY Vol.119 No.-
<P><B>Abstract</B></P> <P>Extraordinary optical transmission (EOT) has been actively applied to optical lithography for nanoscale structures, and optical Talbot lithography with adjustable external gap spacing offers the possibility to fabricate nanostructures of various shapes. In this research, we conducted a comparative study of optical lithography based on EOT and diffracted light exposures to confirm the feasibility of EOT in optical lithography for nanoaperture fabrication. Additionally, we identified the possibility of Talbot nanolithography by applying external gap spacings through simulation and actual fabrication results to improve the degree of freedom in nanostructure fabrication. Compared with the results of the simulation, we confirmed that the actual nanostructures were slightly larger and that the conditions for the mask and nanostructure fabrication processes should be established considering this phenomenon. The parameters and processes from this comparative study can be employed for the fabrication of high-resolution nanostructures of various shapes using EOT and Talbot lithography with external gap spacings. Additionally, the techniques in the study suggest a way to establish well-designed nanostructures to cover a large area, complementing lithographic systems and the relationship between simulations and practical fabrication results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We explored optical lithography using EOT and Talbot nanolithography. </LI> <LI> Optical lithography using EOT and diffracted light were compared. </LI> <LI> Talbot nanolithography with gap spacings was applied to fabricate nanostructures. </LI> <LI> EOT-based Talbot nanolithography can be employed for advanced optical lithography. </LI> </UL> </P>
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( Hyerin Jeon ),( Donghye Kim ),( Jong Kyung Youm ),( Soo Nam Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: We found that extracts of natural herbs such as Kochia Scoparia and Rosa multiflora have PPAR α/γ dual agonistic effect. Objectives: We investigate whether and how they have anti-aging effect on photo-aging skin. Methods: Hairless mice were irradiated with UVA and UVB three times a week for 8 weeks. Natural herb extracts with PPAR α/γ dual agonistic effect were topically applied on photo-aging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, were applied as a positive control and vehicle as a negative control. Epidermal effects including barrier function and dermal effects were measured respectively and compared. Results: Compared to UV exposed photoaging skin, the natural herb extracts with PPAR α/γ dual agonistic effect enhanced skin barrier function by normalizing basal TEWL and increasing SC integrity. They also increased the epidermal differentiation but decreased epidermal IL-1α expression. In the dermis, they increased dermal thickness, collagen density, and procollagen type 1 expression as well as TGF-β. Conclusion: The extracts of natural herbs such as Kochia Scoparia and Rosa multiflora with PPAR α/γ dual agonistic effect could prevent the epidermal processes of photo-aging by recovering the barrier function through correcting the epidermal differentiation, and the dermal process by increasing dermal thickness and collagen density through procollagen type 1 production induced by TGF-β
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