Active Earth Pressure against Cantilever Retaining Walls with a Long Relief Shelf in Rotation about the Top

Yun Que,Xue-feng Gui,Fu-Quan Chen 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.6

A cantilever retaining wall with a long relief shelf (CRW-LRS) is a particular type of retaining wall, but no studies have yet reported on rotation about the top of this type of retaining wall. This work studied failure mechanisms in semi-infinite non-cohesive soils in rotation about the top using the finite element elastoplastic analysis method (FEEA). By considering the influence of both the relief shelf and rotational stress from the soil, a formula for calculating the active earth pressure (Ea) was developed using the horizontal differential layer limit analysis method. Four different parameters were studied, i.e., unloading plate’s geometric conditions, heel length and the internal friction angle of the backfill, in terms of their influence on the Eadistribution, resultant force etc. The lowest Ea was found when the relief shelf’ relative position m = 0.4.

Seismic Active Earth Pressure of Infinite Width Backfilled Soil on Cantilever Retaining Wall with Long Relief Shelf under Translational Mode

Yun Que,Cheng-cheng Long,Fu-Quan Chen 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8

In the area of high seismic intensity, there were few methods for calculating active earth pressure (Ea). Especially for the cantilever retaining wall with long relief shelf (CRW-LRS), the theoretical method lags behind the practical engineering. The seismic active earth pressure (Es) of the CRW-LRS subject to translational mode was researched. By finite element method (FEM), the failure mode of the active limit state under seismic load was evaluated. The results show that the backfill behind the wall generates the first sliding surface at the wall heel bottom, the second at the wall heel top, and the third at the relief shelf top. The calculation formula of Es under long relief shelf failure mode was proposed using the limit analysis method of a horizontal differential layer. The calculation results were compared with the FEM results to prove the rationality and reliability of the theoretical solution. The effects of relief shelf relative length (l) and position (m), wall heel length (n), internal frictional angle of the backfill (ϕ), seismic horizontal acceleration (ah), and seismic vertical acceleration (av) on Es were studied.

중뇌동맥 경색증 환자에서 감압개두술의 적응증

박석규,윤일규,김범태,도재원,배학근,이경석,최순관,변박장 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.11

A new six-port receiver architecture using polyphase networks

Lee, Sang-Yun,Kim, Dong-Zo,Lee, Moon-Que,Yu, Jong-Won Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.3

<P>In this article, a novel six-port receiver architecture is proposed and experimentally verified. The six-port receiver circuit is realized by using power dividers/combiners and polyphase networks for the first time. A prototype operating in 2.4-GHz ISM band has been fabricated and experimentally verified, to show its performance as demodulator. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 499–502, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24962</P>

Morphological Characteristics of the Thalamoperforating Arteries

Park, Sukh-Que,Bae, Hack-Gun,Yoon, Seok-Mann,Shim, Jai-Joon,Yun, Il-Gyu,Choi, Soon-Kwan The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.47 No.1

Objective: The aim of this study was to investigate the morphological characteristics of the thalamoperforating arteries that arise from the P1 segment of the posterior cerebral artery. Methods: Thalamoperforating arteries located in the interpeduncular fossa were dissected in 26 formalin-fixed human cadaver brains. We investigated the origin site of thalamoperforating arteries from the P1 segment, number and diameter. and variations in their origin. Results: Thalamoperforating arteries arose from the superior, posterior or posterosuperior surfaces of the P1 segment at the mean 1.93 mm (range, 0.41-4.71 mm) distance from the basilar apex and entered the brain through the posterior perforated substance. The average number was 3.6 (range 1-8) and mean diameter was 0.70 mm (range 0.24-1.18 mm). Thalamoperforating arteries could be classified into five different types according to their origin at the P1 segment: Type I (bilateral multiple), 38.5%; Type II (unilateral single, unilateral multiple), 26.9%; Type III (bilateral single), 19.2%; Type IV (unilateral single), 11.5%; Type V (unilateral multiple), 3.8%. In 15.4% of all specimens. thalamoperforating arteries arose from the only one side of P1 segment and were not noted in the other side. In such cases, the branches arising from the one side of P1 segment supplied the opposite side. Conclusion: Variations in the origin of the thalamoperforating arteries should be keep in mind to perform the surgical clipping, endovascular treatment or operation involving the interpeduncular fossa. In particular, unilateral single branch seems to be very risky and significant for surgical technique or endovascular treatment.

MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma

You, Yu,Que, Keting,Zhou, Yun,Zhang, Zhen,Zhao, Xiaoping,Gong, Jianpin,Liu, Zuojin Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.9

Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear ${\beta}-catenin$ level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear ${\beta}-catenin$ level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the ${\beta}-catenin-TCF4$ interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.

MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma

Yu You,Keting Que,Yun Zhou,Zhen Zhang,Xiaoping Zhao,Jianpin Gong,Zuojin Liu 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.9

Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR-766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear β-catenin level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear β-catenin level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the β-catenin-TCF4 interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.

복합재를 활용한 버스루프 경량화에 관한 연구

유승원(Seungwon Yoo),박종찬(Jongchan Park),이윤규(Yun Que Lee),이상규(SangKyu Lee) 한국자동차공학회 2010 한국자동차공학회 부문종합 학술대회 Vol.2010 No.5

The transportation industry vehicles made of steel often have common problems which it can be feasible to solve using other materials or byimproving the design, depending on the nature of the problem. In this study, material properties for roof structure using composite material are obtained by test and optimization for roof structure and joint structure is performed using DFSS method. With the optimized roof structure design, new composite roof structure is made with composite materials. By comparing the simulation results and test results, we get the reliable results. By using composite materials we get lighter roof structure and this technique will be applied to other components