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STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer
Yujuan Chen,Xiaodong Wang,Xuejuan Liu,Hongjiang Li,Qing Lv,Jingqiang Zhu,Bing Wei,Ying Tang,JING WANG 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1
Purpose: The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer. Methods: We retrospectively analyzed the clinicopathologic characteristics and overall survival (OS) of 140 breast cancer patients after curative surgery, and detected STAT3 expression, phosphorylated STAT3 (pSTAT3) expression, Ki-67 expression, vascular endothelial growth factor (VEGF)-C and -D expression in breast cancer tissues, and adjacent nontumor tissues. Survival analysis and relationship analysis were adopted for demonstrated the important mechanism of STAT3 contribution to progression of breast cancer. Results: STAT3 expression, pSTAT3 expression, Ki-67 expression, VEGF-C expression, and VEGF-D expression in breast cancer tissues were significantly higher than those in adjacent nontumor tissues, respectively. With survival analysis, only number of lymph node metastasis (N stage) was identified as the independent predictors of the OS of breast cancer patients. Besides, we demonstrated there was the most prominent correlation between STAT3 expression and lymph node metastasis in breast cancer tissues by using the multinominal regression method. Conclusion: STAT3, a poor survival biomarker potential association with lymph node metastasis, was suitable for predication the OS of breast cancer patients after curative resection.
Yujuan He,Yu Cao,황현준,Sarath M. Vega Gutierrez,Shujie Li,Hsiou-Lien Chen,Seri C. Robinson,Chih Hung Chang,Rajiv Malhotra 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.3
Current methods of fabric dyeing have a significant negative effect on the environment via toxic effluent emissions, high water usage, and high energy consumption. We demonstrate, for the first time, low-energy inkjet printing of an ecofriendly and biodegradable pigment derived from widely available spalting fungi with synthesis by-products that are fully biodegradable. Vivid and stable coloration is achieved on polyester and cotton using benign acetone-based and ethanol-based biopigment inks, with no liquid effluent or runoff, and without any synthetic dyes or mordants. We investigate the influence of fabric type, solvent type, and the number of printing passes on the color type, intensity, and uniformity, pigment crystallization, and environmental stability. Greater spatial definition of the printed pigment in inkjet printing effects greater crystallization and more vivid and uniform coloration as compared to drop-casting, the primary method used till date to color fabrics with such fungal biopigments. pH-driven interactions between the fabric, solvent, and biopigment cause solvent-driven changes in color type (from bluish to reddish) and fabric-governed changes in color intensity. The impact of our findings on minimizing the environmental impact of fabric dyeing is discussed.
Kinoshita, Yoshihiro,Chen, Junwen,Rapee, Ronald M.,Bö,gels, Susan,Schneier, Franklin R.,Choy, Yujuan,Kwon, Jung-Hye,Liu, Xinghua,Schramm, Elisabeth,Chavira, Denise A.,Nakano, Yumi,Watanabe, Norio Lippincott Williams Wilkins, Inc. 2008 Journal of nervous and mental disease Vol.196 No.4
Conviction subtype Taijin-Kyofu (c-TK) is a subgroup of mental disorder characterized by conviction and strong fear of offending others in social situations. Although the concept of c-TK overlaps with that of social anxiety disorder (SAD), patients with c-TK often may not be diagnosed as such within the current Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria. We propose the Nagoya-Osaka criteria to amend this situation. This study examined the cross-cultural interrater reliability of the proposed criteria. Eighteen case vignettes of patients with a variety of complaints focused around social anxieties were collected from 6 different countries, and diagnosed by 13 independent raters from various nationalities according to the original DSM-IV and the expanded criteria. The average agreement ratio for the most frequent diagnostic category in each case was 61.5% with DSM-IV and 87.6% with the modified DSM-IV with Nagoya-Osaka criteria (p < 0.001). These findings indicate that the Nagoya-Osaka criteria for SAD can improve interrater reliability of SAD.
Xian Lin,Jinling Chen,Gengsheng Xiao,Yujuan Xu,Daobang Tang,Jijun Wu,Jing Wen,Weidong Chen 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.3
Ultrasonic-microwave synergistic extraction (UMSE) was optimized for the extraction of oligosaccharides from longan pulp (OLP). Box-Behnken design was used to evaluate the effects of temperature (35-55oC), ultrasonic time (5-25 min), and water to material ratio (10-30 mL/g) on the extraction efficiency of crude OLP. A regression model was developed and its validity was statistically demonstrated. Significant interaction between temperature and water to material ratio was observed. The following optimal conditions for the extraction yield of crude OLP were determined: extraction temperature 55oC, ultrasonic time 18.52 min, and water to material ratio 10 mL/g. The extracted OLP were purified for the determination of molecular weight distribution and antioxidant activity. Results of matrix-assisted laser desorption ionization time-of-flight mass spectrometry revealed that the molecular weight distribution of the purified OLP ranged from m/z 495.138 to 795.511. The purified OLP exhibited a dose-dependent behavior in 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.