코로나19 집단 확산 방지를 위한 위기관리 대책

Yue Pu(Yue Pu) 충북대학교 국가위기관리연구소 2020 위기관리연구논총 Vol.4 No.2

Associations of ABCB1 and XPC Genetic Polymorphisms with Susceptibility to Colorectal Cancer and Therapeutic Prognosis in a Chinese Population

Yue, Ai-Min,Xie, Zhen-Bin,Zhao, Hong-Feng,Guo, Shu-Ping,Shen, Yu-Hou,Wang, Hai-Pu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Associations between ABCB1 and XPC genetic polymorphisms and risk of developing colorectal cancer (CRC) as well as clinical outcomes in CRCs with chemotherapy were investigated. A case-control study was performed on the ABCB1 C3435T, G2677T/A and XPC Lys939Gln polymorphisms in 428 CRC cases and 450 hospitalbased, age and sex frequency-matched controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. We observed that the ABCB1 3435CT or CC+CT variants were significantly linked with increasing risk of developing CRC (adjusted OR (95% CI): 1.814 (1.237-2.660), P=0.0022; adjusted OR (95% CI): 1.605 (1.117-2.306), P=0.0102, respectively). Moreover, the distribution frequency of XPC AC genotype or AC+CC genotypes also showed a tendency towards increasing the suscepbility for CRC (P=0.0759 and P=0.0903, respectively). Kaplan-Meier curves showed that the ABCB1 C3435T variant was associated with a tendency toward longer progression-free survival (PFS) (n=343, Log-rank test: P=0.063), and the G2677T/A variant genotypes (GT+TT+GA+AA) with a tendency for longer OS in postoperative oxaliplatin-based patients (n=343, Log-rank test: P=0.082). However, no correlation of the XPC Lys939Gln polymorphism was found with PFS and OS in patients with postoperative oxaliplatin-based chemotherapy (n=343). Our study indicated that ABCB1 polymorphisms might be candidate pharmacogenomic factors for the prediction of CRC susceptibility, but not for prognosis with oxaliplatin chemosensitivity in CRC patients.

Grouping-Sorting Optimized Model Predictive Control of Modular Multilevel Converter with Reduced Comp utational Load

L. Pu,W. Yue,C. Wulong,L. Wanjun 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

Modular Multilevel Converter (MMC) is a promising topology for high voltage/power AC/DC and DC/AC applications. Model Predictive Control (MPC) is an advanced and simple method for power converters control. However, its computational load becomes unacceptable when MMC voltage level increases. Although an optimized MPC proposed for the MMC decreased the number of the possible actuations of each phase from Cⁿ2N to N+1 for N+1 levels MMC, which is still difficult for application as the number of submodule for each arm reached hundreds. The Grouping-Sorting algorithm optimized MPC (GSOMPC) is proposed in the paper. The submodule capacitor voltages within the group and among groups are sorted according to the arm current polarity, the proposed GSOMPC decreased the number of the possible actuations of each phase from N+1 to 2X+M+3 (N=M×X) for N+1 levels MMC. The simulation and experimental results based on 25-level MMC verify the correctness and effectiveness of the GSOMPC strategy.

Emerging 3D bioprinting applications in plastic surgery

Yang Pu,Ju Yikun,Hu Yue,Xie Xiaoyan,Fang Bairong,Lei Lanjie 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Plastic surgery is a discipline that uses surgical methods or tissue transplantation to repair, reconstruct and beautify the defects and deformities of human tissues and organs. Three-dimensional (3D) bioprinting has gained widespread attention because it enables fine customization of the implants in the patient's surgical area preoperatively while avoiding some of the adverse reactions and complications of traditional surgical approaches. In this paper, we review the recent research advances in the application of 3D bioprinting in plastic surgery. We first introduce the printing process and basic principles of 3D bioprinting technology, revealing the advantages and disadvantages of different bioprinting technologies. Then, we describe the currently available bioprinting materials, and dissect the rationale for special dynamic 3D bioprinting (4D bioprinting) that is achieved by varying the combination strategy of bioprinting materials. Later, we focus on the viable clinical applications and effects of 3D bioprinting in plastic surgery. Finally, we summarize and discuss the challenges and prospects for the application of 3D bioprinting in plastic surgery. We believe that this review can contribute to further development of 3D bioprinting in plastic surgery and provide lessons for related research. Graphical Abstract

Ginsenosides Conversion and Anti-oxidant Activities in Puffed Cultured Roots of Mountain Ginseng

Muhammad Awais,Jian Yu Pu,Zelika Mega Ramadhania,Yue Huo,Dong Wook Lee(이동욱),Feng Jiao Xu,Yaxi Han,Deok Chun Yang(양덕춘) 한국약용작물학회 2022 한국약용작물학회 학술대회논문집 Vol.2022 No.1

Bidirectional two-sample mendelian randomization analysis identifies causal associations between age at menarche and sarcopenia-related traits

Fan Wei,Gu Peng,Pu Bin,Yue Dan,Xin Qiao,Zheng XiaoHui,Zeng ZhanPeng,Fan Shaoyong 한국유전학회 2023 Genes & Genomics Vol.45 No.8

Background Observational studies have shown that the age of menarche is associated with sarcopenia, but confounding factors make the causal relationship difficult to infer. Objective Therefore, we conducted a bidirectional two-sample Mendelian randomized (MR) analysis to evaluate the potential causal relationship between age at menarche and sarcopenia-related traits (hand grip strength, lean mass, walking pace). Methods We obtained the latest aggregate statistics from the Genome-wide association studies (GWAS) database on the age of menarche of 182,416 participants from ReproGen, the appendicular lean mass of 244,730 participants from EMBL’s European Bioinformatics Institute, the left-hand grip strength of 401,026 participants, the right-hand grip strength of 461,089 participants and the usual walking pace of 459,915 participants from the UK Biobank. The inverse variance weighting (IVW) method and other MR methods were used to evaluate the bidirectional causal relationship between the age of menarche and sarcopenia. Results The forward MR results showed that the age of menarche predicted by the gene was positively correlated with left-hand grip strength (IVWβ=0.041, P = 2.00 × 10−10), right-hand grip strength (IVWβ=0.053, P = 1.97 × 10−18), appendicular lean mass (IVWβ=0.012, P = 4.38 × 10−13) and usual walking pace (IVWβ=0.033, P = 1.62 × 10−8).In the reverse MR analysis, we also found that the usual walking pace was positively correlated with the age of menarche predicted by genes (IVWβ=0.532, P = 1.65 × 10−4). Still, there was no causal relationship between grip strength and appendicular lean mass and the age at menarche. Conclusion Our results show that earlier menarche will increase the risk of sarcopenia. In addition, people with higher muscle function tend to have menarche later. These findings may provide a reference for prevention strategies and interventions for menarche in advance and sarcopenia.

Multifunctional, Hydrophobic and Flame-retarded Cotton Fabrics Modified with Liner Piperzine/Phosphorous/Polysiloxane Copolymer

Zhaohua Chen,Chaohong Dong,Qun Li,Yue Pu,Zhou Lu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.4

α,ω-di[(4-butoxy-piperazin-1-yl)-phosphinic acid methyl ether]-terminated linear polysiloxane (PNPDMS) was synthesized and utilized as the flame retardant and hydrophobing agent. The flame retardance and thermal decomposition behaviors of cotton fabrics were systematically estimated by limiting oxygen index (LOI), thermogravimetric analysis and vertical burning test, respectively. It was found that the LOI of cotton fabric treated with PNPDMS enhanced to 29.82 % compared with cotton fabric without treatment, whose LOI was only 18.00 %. The treated cotton fabric showed a shorter char length, a shorter After-flame time, and no After-glow time as revealed in vertical burning test. The mechanical property in treated cotton fabric was slightly decrease. Furthermore, the grade of water repellency of treated cotton fabric reached to 90 and water contact angle (WCA) increased to 141.90 o compared with cotton fabric without treatment whose WCA was 62.80 o. The result showed that the cotton fabric treated with PNPDMS exhibited excellent flame retardance and hydrophobic properties.