Investigation on High Temperature Mechanical Behaviors of TiC-γ′ Reinforced Ni Composite

Wenqiang Hu,Zhenying Huang,Qun Yu,Yuanbo Wang,Yidan Jiao,Yang Zhou,Hongxiang Zhai 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.8

A duplex TiC and γ′-Ni3(Al,Ti) reinforced nickel composite was fabricated through hot-press sintering a 30 vol% Ti2AlC–Nimixtures followed by thermal treatment method. Detailed microstructural detection was performed by adopting the routeof high-resolution transmission electron microscopy. In situ generated submicron TiC particulate and nanosized L12-γ′were homogeneously distributed in a fcc γ-Ni matrix. The high temperature tensile and compression behaviors of the TiC-γ′/Ni composites were evaluated in the temperature range of 25–800 °C. The results indicated that ultimate tensile andcompression properties exhibited the dependence of temperatures. The tensile properties of the composite determined at600 °C was 945 MPa, decreasing by 28.1% and 23.0% for elongation, compared to those of measured at room temperature(UTS = 1305 MPa, elongation = 5.35%). However, the yield strength exhibited the temperature independent until to 600 °C. The yield strength of the TiC-γ′/Ni composite are comparable with conventional superalloy under 600 °C, proving that TiCand γ′ particles constitute efficient reinforcements for Ni matrix according to thermal expansion dislocations strengthening,load-transfer and coherent strengthening mechanisms. The monotonic temperature dependence of yield strength at600–800 °C indicates that plastic deformation of TiC-γ′/Ni composite follows the thermally activated mechanism. TheTiC-γ′/Ni composite exhibited superior mechanical properties both at room and high temperatures, which can be ascribedto the synergistic strengthening effect in term of dislocation density, Orowan, coherent and atomic ordering strengtheningmechanisms. The present work reveals the deformation behaviors of in situ TiC-γ′/Ni composite from room to high temperatures,which is critical to predict the failure and thereby optimize the microstructure to further enhance the high temperatureproperties of TiC-γ′/Ni composite.

Thermal Shock Behavior of a Novel TiCx–Ni3(Al,Ti)/Ni Functionally Graded Composite

Qun Yu,Zhenying Huang,Guangming Zheng,Wenqiang Hu,Cong Lei,Yuanbo Wang,Yidan Jiao,Hongxiang Zhai 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12

This paper focuses on the study of thermal shock behaviors of a novel TiCx–Ni3(Al,Ti)/Ni functionally graded material (FGM)fabricated from Ti3AlC2and Ni powders. Thermal shock resistance of resulted FGM was conducted by water quenching atdifferent temperatures, mechanical properties and microstructures after thermal shocks were correspondingly determined andcharacterized. The microstructure of the FGM after thermal shocks shows no cracks of instability failure between the transitionzones, and the reinforcement phases were closely combined with the matrix. Meanwhile, compared with the strengthof 1329 MPa without thermal shock, when the temperature of the thermal shock reached 800 °C and 1000 °C respectively,with 10 repeated heat-water quench cycles, the residual flexural strength of FGM decreased slightly, but it could still reach1100 MPa. Notably, the strength can still maintain at 843 MPa after 10 cycles of thermal shock at 1200 °C. Such excellentthermal shock performance may be the result of the good interfacial bonding and the special gradient structure, the oxidationlayer also plays a protective role.

A national survey on how to improve traditional Chinese medicine learning internationally: Perceptions from both teachers and students

Zhu Yu-Hang,Yan Wu,Hao Zhang,Yanfei Zhao,Yule Ren,Wei Hu,Pan Li,Huiyi Wang,Ying Wang,Boda Zhang,Yujie Wang,Hongwen Yuan,Jiping Zhang,Wenqiang Li,Yufang Zhao,Jie Zhao,Yedong Shi,Yanye Shu,Xiao Zhang,Ya 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.4

Background With the increasing popularity of traditional Chinese medicine (TCM) by the global community, how to teach basic knowledge of TCM to international students and improve the teaching quality are important issues for teachers of TCM. The present study was to analyze the perceptions from both students and teachers on how to improve TCM learning internationally. Methods A cross-sectional national survey was conducted at 23 universities/colleges across China. A structured, self-reported on-line questionnaire was administered to 34 Chinese teachers who taught TCM course in English and to 1016 international undergraduates who were enrolled in the TCM course in China between 2017 and 2021. Results Thirty-three (97.1%) teachers and 900 (88.6%) undergraduates agreed Chinese culture should be fully integrated into TCM courses. All teachers and 944 (92.9%) undergraduates thought that TCM had important significance in the clinical practice. All teachers and 995 (97.9%) undergraduates agreed that modern research of TCM is valuable. Thirty-three (97.1%) teachers and 959 (94.4%) undergraduates thought comparing traditional medicine in different countries with TCM can help the students better understand TCM. Thirty-two (94.1%) teachers and 962 (94.7%) undergraduates agreed on the use of practical teaching method with case reports. From the perceptions of the undergraduates, the top three beneficial learning styles were practice (34.3%), teacher's lectures (32.5%), case studies (10.4%). The first choice of learning mode was attending to face-to-face teaching (82.3%). The top three interesting contents were acupuncture (75.5%), Chinese herbal medicine (63.8%), and massage (55.0%). Conclusion To improve TCM learning among international undergraduates majoring in conventional medicine, integration of Chinese culture into TCM course, comparison of traditional medicine in different countries with TCM, application of the teaching method with case reports, and emphasization of clinical practice as well as modern research on TCM should be fully considered.

Analysis and optimization research on latch life of control rod drive mechanism based on approximate model

Sitong Ling,Wenqiang Li,Tianda Yu,Qiang Deng,Guozhong Fu 한국원자력학회 2021 Nuclear Engineering and Technology Vol.53 No.12

The Control Rod Drive Mechanism (CRDM) is an essential part of the reactor, which realizes the start-stopand power adjustment of the reactor by lifting and lowering the control rod assembly. As a moving partin CRDM, the latch directly contacts with the control rod assembly, and the life of latch is closely relatedto the service life of the reactor. In this paper, the relationship between the life of the latch and the stepstress, friction stress, and impact stress in the process of movement is analyzed, and the optimizationmethodology and process of latch life based on the approximate model are proposed. The design variables that affect the life of the latch are studied through the experimental design, and the optimizationobjective of design variables based on the latch life is established. Based on this, an approximate model ofthe life of the latch is built, and the multi-objective optimization of the life of the latch is optimizedthrough the NSGA-II algorithm.

Microstructural and Mechanical Properties of TiCX–Ni3(Al,Ti)/Ni Functionally Graded Composites Fabricated from Ti3AlC2 and Ni Powders

Guangming Zheng,Zhenying Huang,Qun Yu,Wenqiang Hu,Xingyang Qiu,A. Lixia,Yuanbo Wang,Yidan Jiao,Yang Zhou,Hongxiang Zhai 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.6

In this paper, a novel type of functionally graded material (FGM) was successfully fabricated from pure Ni and Ti3AlC2powder mixtures by hot-press sintering route at 1200 °C and 17 MPa. In each layer, Ti3AlC2particles transformed into TiCxphase, while the additional Al–Ti atoms decomposed from Ti3AlC2diffused into the Ni matrix, giving rise to the formationof γ′-Ni3(Al,Ti). Part of the submicron TiCxand Ni3(Al,Ti) particles were uniformly distributed in the Ni matrix, whilesome of the TiCxmaintained the original Ti3AlC2plate-like morphology. Both TiCxand Ni3(Al,Ti) content decreased from60Ti3AlC2/Ni layer to 10Ti3AlC2/Ni layer in a stepwise manner was fabricated. The microstructural analysis indicatesthat no cracks, delamination and step-type abrupt changes occured in the graded layer of the manufactured FGM. Flexuralstrength and Vickers hardness enhanced with the increasing Ti3AlC2content except for fracture strain and toughness. Theoverall fracture toughness and the flexural strength of FGM can reach 21.76 MPa m1/2 and 1329 ± 34 MPa, respectively. Theprepared FGM, herein, with a hard ceramic surface on one side to resist local plastic deformation, and a ductile metallicsurface on the other side to provide toughness.

High level of LncRNA MAPKAPK5-AS1 predicts poor prognosis and contributes to the malignant proliferation and EMT of non-small cell lung cancer via sponging miR-490-3p from HMGB2

Miao Jidong,Gao Yang,Guan Wenqiang,Yu Xiaolin,Wang Yong,Jiang Ping,Yang Lili,Xu Lun,You Wei 한국유전학회 2023 Genes & Genomics Vol.45 No.5

Background Patients with non-small cell lung cancer (NSCLC) show a low survival rate, owing to the lack of early diagnostic method and high invasiveness. Long non-coding RNA MAPKAPK5-AS1 that regulates tumor genesis and progression through multiple signals, is upregulated and involved in the growth and apoptosis in lung adenocarcinoma (LUAD). Objective To investigate whether MAPKAPK5-AS1 affected the malignant progression of NSCLC. Methods The levels of MAPKAPK5-AS1, miR-490-3p and HMGB2 in lung cancer were first analyzed through StarBase website, and confirmed by a quantitative reverse transcriptase-PCR (qRT-PCR) assay. The biological functions of NSCLC cells were examined by CCK-8, 5-ethynyl-2ʹ-deoxyuridine (EdU) and flow cytometry assays. The potential binding sequences lncRNA-miRNA and miRNA-mRNA were predicted by StarBase software and verified via dual luciferase reporter experiment. The effects of MAPKAPK5-AS1 on tumor growth were evaluated in a xenografted mice model. Results The expression of MAPKAPK5-AS1 was upregulated in tumor tissues from NSCLC patients. Patients with high expression of MAPKAPK5-AS1 had higher tumor size, advanced TNM stage, higher incidence of lymph node and distant metastasis, and shorter overall survival. Knockdown of MAPKAPK5-AS1 inhibited the proliferation, induced apoptosis and blocked epithelial mesenchymal transformation (EMT) of NSCLC cells. Mechanically, MAPKAPK5-AS1 could upregulate the HMGB2 level in NSCLC cells through competitively binding to miR-490-3p. MiR-490-3p inhibitor reversed the roles of MAPKAPK5-AS1 knockdown on tumor cell proliferation, apoptosis and EMT. Also, HMGB2 knockdown suppressed tumor cell malignant phenotypes. Furthermore, interference of MAPKAPK5-AS1 slowed NSCLC tumor growth in vivo. Conclusion Knockdown of MAPKAPK5-AS1 inhibited the aggressive tumor phenotypes through miR-490-3p/HMGB2 axis in NSCLC. MAPKAPK5-AS1/miR-490-3p/HMGB2 might be potential biomarkers or therapeutic targets for NSCLC.

Development and Application of Three-Dimensional Bioprinting Scaffold in the Repair of Spinal Cord Injury

Lu Dezhi,Yang Yang,Zhang Pingping,Ma Zhenjiang,Li Wentao,Song Yan,Feng Haiyang,Yu Wenqiang,Ren Fuchao,Li Tao,Zeng Hong,Wang Jinwu 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6

Spinal cord injury (SCI) is a disabling and destructive central nervous system injury that has not yet been successfully treated at this stage. Three-dimensional (3D) bioprinting has become a promising method to produce more biologically complex microstructures, which fabricate living neural constructs with anatomically accurate complex geometries and spatial distributions of neural stem cells, and this is critical in the treatment of SCI. With the development of 3D printing technology and the deepening of research, neural tissue engineering research using different printing methods, bio-inks, and cells to repair SCI has achieved certain results. Although satisfactory results have not yet been achieved, they have provided novel ideas for the clinical treatment of SCI. Considering the potential impact of 3D bioprinting technology on neural studies, this review focuses on 3D bioprinting methods widely used in SCI neural tissue engineering, and the latest technological applications of bioprinting of nerve tissues for the repair of SCI are discussed. In addition to introducing the recent progress, this work also describes the existing limitations and highlights emerging possibilities and future prospects in this field.