IGCT Self-Protection Strategy for IGCT Converters

Hong Zeng,Xiulin Chen,Yongmin Chen,Xuejun Pan,Shunbiao Zhang,Fanglin Chen,Wenbin Zeng 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

The high-power semiconductor IGCT is widely used in two-level or three-level IGCT converters and for these converters a comprehensive system-protection strategy may be used to protect the IGCT. But there are still some problems resulted from signal transmission delays, such as incorrect timing, low response speeds, second breakdown and those problems can result in IGCT overload failure, bridge-arm shoot-through and other consequences. In this paper, the anode voltage and current parameters gained from the IGCT device are studied as protection reference in a new GCT gate drive unit. The gate drive unit can control and process the signal logic, and execute safe and reliable switching action. The signal is simultaneously feed back to the host computer in IGCT converters to perform the switching control of other devices. This new gate unit can effectively reduce device failure rates and improve the reliability of IGCT converters systems, while reducing operating costs.

基於本體研究和語料調查的"是"字句偏誤分析

Zeng Chang-hong 계명대학교 국제학연구소 2013 국제학논총 Vol.19 No.-

In this paper, we provide a comprehensive review on the research of “shi” and the sentence of “shi”, and forecast the possible biased errors. we also collect examples of biased errors about “shi” from the corpus and give them detailed description and systematic analysis, then counter-view the inadequacies of the research on ontologyan d application, and in this basis, we tryt o put forward a certain number of suggestions for pertinent data bank construction and for the teaching about the sentence of “shi” in TCSL(Teaching Chinese as second language).

8-60hIPP5^m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21^cip1/waf1 Pathways and Delayed Cyclin B1 Nuclear Translocation

Zeng, Qi-Yan,Zeng, Lin-Jie,Huang, Yu,Huang, Yong-Qi,Zhu, Qi-Fang,Liao, Zhi-Hong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression and cell cycle progression. The active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for PP1, has been shown to inhibit the growth of human cervix carcinoma cells (HeLa). In order to elucidate the underlying mechanisms, the present study assessed overexpression of $8-60hIPP5^m$ in HeLa cells. Flow cytometric and biochemical analyses showed that overexpression of $8-60hIPP5^m$ induced G2/M-phase arrest, which was accompanied by the upregulation of cyclin B1 and phosphorylation of G2/M-phase proteins ATM, p53, $p21^{cip1/waf1}$ and Cdc2, suggesting that $8-60hIPP5^m$ induces G2/M arrest through activation of the ATM/p53/$p21^{cip1/waf1}$/Cdc2/cyclin B1 pathways. We further showed that overexpression of $8-60hIPP5^m$ led to delayed nuclear translocation of cyclin B1. $8-60hIPP5^m$ also could translocate to the nucleus in G2/M phase and interact with $pp1{\alpha}$ and Cdc2 as demonstrated by co-precipitation assay. Taken together, our data demonstrate a novel role for $8-60hIPP5^m$ in regulation of cell cycle in HeLa cells, possibly contributing to the development of new therapeutic strategies for cervix carcinoma.

Effects of lycopene on number and function of human peripheral blood endothelial progenitor cells cultivated with high glucose

Yao-Chi Zeng,Gui-Ping Mu,Shu-Fen Huang,Xue-Hui Zeng,Hong Cheng,Zhong-Xin Li 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.4

BACKGROUND/OBJECTIVES: The objectives of this study were to investigate the effects of lycopene on the migration, adhesion, tube formation capacity, and p38 mitogen-activated protein kinase (p38 MAPK) activity of endothelial progenitor cells (EPCs) cultivated with high glucose (HG) and as well as explore the mechanism behind the protective effects of lycopene on peripheral blood EPCs. MATERIALS/METHODS: Mononuclear cells were isolated from human peripheral blood by Ficoll density gradient centrifugation. EPCs were identified after induction of cellular differentiation. Third generation EPCs were incubated with HG (33 mmol/L) or 10, 30, and 50 μg/mL of lycopene plus HG. MTT assay and flow cytometry were performed to assess proliferation and apoptosis of EPCs. EPC migration was assessed by MTT assay with a modified boyden chamber. Adhesion assay was performed by replating EPCs on fibronectin-coated dishes, after which adherent cells were counted. In vitro vasculogenesis activity was assayed by Madrigal network formation assay. Western blotting was performed to analyze protein expression of both phosphorylated and non-phosphorylated p38 MAPK. RESULTS: The proliferation, migration, adhesion, and in vitro vasculogenesis capacity of EPCs treated with 10, 30, and 50 μg/mL of lycopene plus HG were all significantly higher comapred to the HG group (P < 0.05). Rates of apoptosis were also significantly lower than that of the HG group. Moreover, lycopene blocked phosphorylation of p38 MAPK in EPCs (P < 0.05). To confirm the causal relationship between MAPK inhibition and the protective effects of lycopene against HG-induced cellular injury, we treated cells with SB203580, a phosphorylation inhibitor. The inhibitor significantly inhibited HG-induced EPC injury. CONCLUSIONS: Lycopene promotes proliferation, migration, adhesion, and in vitro vasculogenesis capacity as well as reduces apoptosis of EPCs. Further, the underlying molecular mechanism of the protective effects of lycopene against HG-induced EPC injury may involve the p38 MAPK signal transduction pathway. Specifically, lycopene was shown to inhibit HG-induced EPC injury by inhibiting p38 MAPKs.

A Real-Time Vibration Frequency Measurement System of Bridge Pier

Yao-Ming Hong,Jian-Rong Zeng,Yao-Chiang Kan,Hsueh-Chun Lin 보안공학연구지원센터 2014 International Journal of Hybrid Information Techno Vol.7 No.6

This study developed a real-time remote monitoring system (RTRMS) to receive the vibration frequency of bridge pier. The system included a front station and a middle station. A multi-hop wireless routing is employed to transmit the data from the front to the middle station. The front station includes a receiver equipped to receive the vibration frequency, and a wireless sensor network to transmit the data. The middle station is designed by an embedded system for storing the data. The pressure test shows that the loss rate of received data is less than 0.6%. The consuming power of one day is 3 ampere hours in the front station and 30 ampere hours in the middle station if the 12 voltage battery is used.

Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism: A Prospective Study

Chai Hui-hui,Zhao Yu,Zeng Zeng,Ye Rui-zhong,Hu Qiao-hong,He Hong-feng,Baek Jung Hwan,Peng Cheng-zhong 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5

Objective: To assess the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) in patients with primary hyperparathyroidism (PHPT). Materials and Methods: This prospective study enrolled 39 participants (14 male, 25 female; mean age, 59.5 ± 15.3 [range, 18–87] years) between September 1, 2018, and January 31, 2021. All participants had parathyroid lesions causing PHPT, proven biochemically and through imaging. The imaging features of the PHPT nodules, including the shape, margin, size, composition, and location, were evaluated before treatment. Serum intact parathyroid hormone, calcium, and phosphorus levels; parathyroid nodule volume; and PHPT-related symptoms were recorded before and after treatment. We calculated the technical success, biochemical cure, and clinical cure rates for these patients. Complications were evaluated during and after the ablation. Results: Complete ablation was achieved in 38 of the 39 nodules in the 39 enrolled participants. All the patients were treated in one session. The technical success rate was 97.4% (38/39). The mean follow-up duration was 13.2 ± 4.6 (range, 6.0–24.9) months. At 6 and 12 months post-RFA, the biochemical cure rates were 82.1% (32/39) and 84.4% (27/32), respectively, and the clinical cure rates were 100% (39/39) and 96.9% (31/32), respectively. Only 2.6% (1/39) of the patients had recurrent PHPT. At 1, 3, 6, and 12 months after technically successful RFA, 44.7% (17/38), 34.3% (12/35), 15.8% (6/38), and 12.5% (4/32) of participants, respectively, had elevated eucalcemic parathyroid hormone levels. Recurrent laryngeal nerve paralysis occurred in 5.1% (2/39) of the patients, who recovered spontaneously within 1–3 months. Conclusion: US-guided RFA was effective and safe for PHPT patients. RFA may be an alternative treatment tool for patients who cannot tolerate or refuse to undergo surgery.

Biocatalysis and Fermentation Technology : Purification and Characterization of a Thermostable Xylanase from Paenibacillus sp. NF1 and its Application in Xylooligosaccharides Production

( Hong Chen Zheng ),( Ming Zhe Sun ),( Ling Cai Meng ),( Hai Sheng Pei ),( Xiu Qing Zhang ),( Zheng Yan ),( Wen Hui Zeng ),( Jing Sheng Zhang ),( Jin Rong Hu ),( Fu Ping Lu ),( Jun She Sun ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.4

High levels of extracellular xylanase activity (211.79 IU/mg) produced by Paenibacillus sp. NF1 were detected when it was submerged-cultured. After three consecutive purification steps using Octyl-Sepharose, Sephadex G75, and Q-Sepharose columns, a thermostable xylanase (XynNF) was purified to homogeneity and showed a molecular mass of 37 kDa according to SDS-PAGE. The specific activity of the purified XynNF was up to 3,081.05 IU/mg with a 14.55-fold purification. The activity of XynNF was stimulated by Ca2+, Ba2+, DTT, and β-mercaptoethanol, but was inhibited by Fe3+, Zn2+, Fe2+, Cu2+, SDS, and EDTA. The purified XynNF displayed a greater affinity for oat spelt xylan with the maximal enzymatic activity at 60°C and pH 6.0. XynNF, which was shown to be cellulose-free, with high stability at high temperature (70°C-80°C) and low pH range (pH 4.0-7.0), is potentially valuable for various industrial applications. The enzyme hydrolyzed oat spelt xylan to yield mainly xylooligosaccharides (95.8%) of 2-4 degree of polymerization (DP2-4). Moreover, the majority of the xylooligosacharides (DP2- 4) products was xylobiose (61.5%). The thermostable xylanase (XynNF) thus seems potentially usefull in the production of xylooligosaccharides.

A Proteomics Platform Combining Depletion, Multi-lectin Affinity Chromatography (M-LAC), and Isoelectric Focusing to Study the Breast Cancer Proteome

Zeng, Zhi,Hincapie, Marina,Pitteri, Sharon J.,Hanash, Samir,Schalkwijk, Joost,Hogan, Jason M.,Wang, Hong,Hancock, William S. American Chemical Society 2011 ANALYTICAL CHEMISTRY - Vol.83 No.12

<P>The discovery of breast cancer associated plasma/serum biomarkers is important for early diagnosis, disease mechanism elucidation, and determination of treatment strategy for the disease. In this study of serum samples, a multidimensional fractionation platform combined with mass spectrometric analysis were used to achieve the identification of medium to lower abundance proteins, as well as to simultaneously detect glycan and abundance changes. Immuno-affinity depletion and multi-lectin chromatography (M-LAC) were integrated into an automated HPLC platform to remove high abundance protein and fractionate glycoproteins. The collected glycoproteomes were then subjected to isoelectric focusing (IEF) separation by a digital ProteomeChip (dPC), followed by in-gel digestion and LC–MS analysis using an Orbitrap mass spectrometer. As a result, the total number of identified proteins increased significantly when the IEF fractionation step was included as part of the platform. Relevant proteins with biological and disease significance were observed and the dynamic range of the serum proteome measurement was extended. In addition, potential glycan changes were indicated by comparing proteins in control and cancer samples in terms of their affinity to the multi-lectin column (M-LAC) and the p<I>I</I> profiles in IEF separation. In conclusion, a proteomics platform including high abundance protein depletion, lectin affinity fractionation, IEF separation, and LC–MS analysis has been applied to discover breast cancer-associated proteins. The following candidates, thrombospondin-1 and 5, alpha-1B-glycoprotein, serum amyloid P-component, and tenascin-X, were selected as promising examples of the use of this platform. They show potential abundance and glycan changes and will be further investigated in future studies.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2011/ancham.2011.83.issue-12/ac2002802/production/images/medium/ac-2011-002802_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac2002802'>ACS Electronic Supporting Info</A></P>

NUMERICAL SIMULATION AND PREDICTION OF NEGATIVE STORM SURGE IN THE YANGTZE RIVER ESTUARY

Zeng Hao Qin,Yi Hong Duan,De Bao Hu,Mao Xing Gong 한국해안해양공학회 1999 학술강연회 발표논문초록집 Vol.1 No.1

An attempt is made by using both statistical model and multi-layer simplified ECOM-Si model with temperature and salinity effects neglected to investigate numerically the negative storm surge (SS) in the Yangtze River estuary. An operational system for predicting the negative SS are constructed in conjunction of ECOM-Si model with the operational limited-area fine-mesh numerical weather prediction (NWP) model developed by the Shanghai Typhoon Institute(STI).To test the reliability of ECOM-Si model and to understand the computational feature of the model in simulating sea surface elevation, both semi-diurnal tide computation at the river mouth tidal station and numerical SS simulations under the action of idealized easterly and westerly winds are completed. Based on these experiments, a series of negative SS simulations induced by the cold wave, tropical and extratropical cyclones are carried out respectively, in which the objective analysis data of atmospheric forcings on the sea surface are offered by STI NWP model. Case experiments show that the predicted peak negative SS are coincident with the real ones and the phase differences between them are within a acceptable limit. The system is hopeful in operational use for predicting negative SS in the Yangtze River estuary.

Cytotoxic lignans from Viburnum foetidum

Hong Li,Yuanguo Luo,Yan Ma,Jun Zeng,Xu Zhang,Dong Wang,Chunlin Hu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10

Two new lignans, 3,4,40-trihydroxy-30,9-dimethoxy-9,90-epoxylignan (1), 3,40-dihydroxy-30,4, 9-trimethoxy-9,90-epoxylignan (2), together with one known compound,4,40-dihydroxy-3,30,9-trimethoxy-9,90-epoxylignan(3), were isolated from the 95 % EtOH extract of Viburnumfoetidum. The structures of the two new compounds wereelucidated on the basis of 1D, 2D-NMR, and mass spectralanalysis. All the lignans were in vitro evaluated for theircytotoxic activities against four tumor cell lines (A549, SKOV-3, SKMEL-2 and HCT15).