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전영남,송형운,김정열,유경석 조선대학교 환경공해연구소 2004 環境公害硏究 Vol.18 No.-
This paper presents numerical simulation of the flow and combustion process in a pulverized coal fired utility boiler of 350MWe with 24 swirl burners installed at the boiler front wall. The numerical model is applied to an Eulerian-Eulerian model of coal combusiton and NOx formation, It uses Eulerian, time averaged, conservation equations for all the dependent variables. Especial attention is paid to the accuracy of the representation of the several physical submodels of the coal particle, such as particle drying, volatilization or heterogenous combustion. In this systematic investigation, burning characteristics of pulverized coal were calcuated temperature, NOx, unburned carbon content of char and exhaust gas composition in utility boiler. Parametric screening studies have been achieved for the suggestion of improvement operating conditions for reducing NOx and unburned carbon content.
Water jet 플라즈마를 이용한 프로판 개질에 따른 수소 생산 연구
전영남,김성천,유경석 조선대학교 환경공해연구소 2006 環境公害硏究 Vol.19 No.1
The purpose of this paper is to development water jet plasma reactor and investigate the optimal condition of the SynGas production by reforming of hydrocarbon fuel. Fuel was used propane and plasma was generated by arc discharge on water jet surface. Discharge slipping over the water surface has a number of advantages such as a source of short-wave, UV radiation and it can be used for biological and chemical purification of water. The effects of power, water jet flow rate. electrode gap as well as treatment time were studied. When the variations of power (0.18~0.74 ㎾), water jet flow rate (38.4~65.6 ㎖/min), electrode gap (5~15 mm) and treatment time (2~20 min) were 0.4 ㎾, 53.9 ㎖/min, 10 mm and 20 min respectively, under the condition mentioned above result of maximum H_(2) concentration was 61.6 %, intermediates concentration were 6.1 % and propane conversion rate was 99.8 %.
수술후 경막외강에 주입한 ketamine의 진통효과에 관한 연구
정기호,조남수,임경준,유병식,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Author divided 60 patients who got lower abdomen or lower extremity surgical operation into three groups. Each group consisted of 20 patients. We injected ketamine 10㎎, 20㎎, and 30㎎ respectively into the epidural space when the patient complained of pain postoperatively and observed the postoperative analgesic effect of ketamine. Finally, we concluded the following : 1) The onset time of analgesic effect. : The analgesic effect appeared within 10 minutes in 3 groups and the significant difference among them was not seen. 2) The duration of analgesic effect : The duration of analgesia was relatively short with less than 1 hour on an average in all 3 groups and was not constant. 3) Cardiopulmonary system. : The significant change of blood pressure, pulse and respiratory rate was not seen in all three groups and and the difference among them also was not seen. 4) Side effects. : Sedative action(16%), nausea(10%), dizziness(5%), headache(3.3%) From above results, the epidural administration of ketamine is not suitable for postoperative pain management because of a lot of side effects as well as short and inconstant duration of analgesic effeet.
녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험
장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3
목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.
( Nam Kyung Roh ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Hyung Jin Hahn ),( Hyun Jung Park ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: The level of serum inflammatory cytokines and LL-37 is known to be elevated in patients with psoriasis compared to healthy controls. However, researches of level of serum inflammatory cytokines and LL-37 according to phenotypic heterogeneity in psoriasis have been scarcely reported. We demonstrate that interleukin(IL)-1 receptor antagonist and IL-17A were more increased in the eruptive inflammatory state when compared with the chronic stable state in the previous study. Objectives: We aimed to clarify difference of the circulating Th1, Th17 cytokines and LL-37 between guttate and plaque psoriasis and correlation between disease severity and serum level of inflammatory cytokines. Methods: A total of 74 patients with psoriasis(32 guttate psoriasis, 42 plaque psoriasis) were evaluated and serum samples were obtained. Multiple cytokine assay was used to measure Th1 and Th17 derived cytokines. Data were analyzed using the SPSS 17.0 for Windows program (SPSS, Chicago, IL, USA) Results: We observed no difference of the level of serum inflammatory cytokines and LL-37 according to clinical phenotype in patients with psoriasis. Psoriasis Area and Severity Index(PASI) is significantly correlated with serum cytokine level in patients with plaque psoriasis but not in patients with guttate psoriasis. Conclusion: There is no difference of the level of serum inflammatory cytokine and LL-37 according to clinical phenotype. Clinical severity was correlated with serum inflammatory cytokines but not LL-37
P232 : Clinical and pathological study of seborrheic keratosis in Korean patients
( Nam Kyung Roh ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin that may occur singly or more often in multitude. Histologically, SK is divided into six major variants; acanthotic, hyperkeratotic, adenoid, irritated, clonal, and melanoacanthoma. However, investigation of histopathological subtypes and sites of the SKs to detect any possible correlations have been rarely documented. Objectives: To analyze the clinical and histopathological features of a large number of cases of SK diagnosed in Korean patients. Methods: Total of 271 pathology slides of clinically diagnosedSK and 206 cases of biopsy-proven SK were analyzed. Cases of biopsy-proven SK were assessed for histopathologicalsub-classification. Results: The most frequent histopathological subtype was the acanthotic type, followed by hyperkeratotic, melanoacanthoma, clonal, irritated type, and adenoid types. Of them, adenoid type was more common in sun-exposed site than sun-protected site. Overall, premalignant and malignant entities together represented 24.2% of the clinic-pathological mismatch cases. The frequency of a mismatch for the sun-exposed area was significantly higher than that of the non-sun exposed area (p=0.043). Conclusion: Adenoid type was more common in sun-exposed area. High frequency of mismatch is associated with SKs situated on sun-exposed area. We should take a biopsy particularly in lesions situated on sun-exposed area to exclude either premalignant or malignant diseases.
Nam, Kyung‐,Wan,Bak, Seong‐,Min,Hu, Enyuan,Yu, Xiqian,Zhou, Youngning,Wang, Xiaojian,Wu, Lijun,Zhu, Yimei,Chung, Kyung‐,Yoon,Yang, Xiao‐,Qing WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.8
<P><B>Abstract</B></P><P>The thermal instability of the cathode materials in lithium‐ion batteries is an important safety issue, requiring the incorporation of several approaches to prevent thermal runaway and combustion. Systematic studies, using combined well‐defined in situ techniques, are crucial to obtaining in‐depth understanding of the structural origin of this thermal instability in overcharged cathode materials. Here time‐resolved X‐ray diffraction, X‐ray absorption, mass spectroscopy, and high‐resolution transmission electron microscopy during heating are combined to detail the structural changes in overcharged Li<SUB><I>x</I></SUB>Ni<SUB>0.8</SUB>Co<SUB>0.15</SUB>Al<SUB>0.05</SUB>O<SUB>2</SUB> and Li<SUB><I>x</I></SUB>Ni<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>O<SUB>2</SUB> cathode materials. By employing these several techniques in concert, various aspects of the structural changes are investigated in these two materials at an overcharged state; these include differences in phase‐distribution after overcharge, phase nucleation and propagation during heating, the preferred atomic sites and migration paths of Ni, Co, and Mn, and their individual contributions to thermal stability, together with measuring the oxygen release that accompanies these structural changes. These results provide valuable guidance for developing new cathode materials with improved safety characteristics.</P>
P613 : Exfoliative/Erythrodermic psoriasis after discontinuation of ustekinumab: a case report
( Nam Kyung Roh ),( Min Jung Kim ),( Hae Jeong Youn ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1