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한국어 중고급 쓰기에서의 피드백 제공자에 따른 수정 양상
우연희 ( Woo Yeonhee ),김영주 ( Kim Youngjoo ) 연세대학교 언어연구교육원 한국어학당 2022 외국어로서의 한국어교육 Vol.67 No.-
This study analyzed feedback acceptance patterns after providing self-feedback, peer feedback, and teacher feedback to intermediate and advanced learners in order to increase the utilization of Korean writing feedback. The post-group results and intra group acceptance patterns were analyzed. Direct and indirect feedback was provided based on the feedback classification system of Sheen & Ellis (2011), and the evaluation criteria table was reorganized and utilized in accordance with this study by referring to previous studies that prepared evaluation criteria through a fair selection process. The reliability of the evaluation was secured by verifying the significance by analyzing the results evaluated by one Ph.D. graduate in Korean language education and this researcher. According to the results of this study, the score after providing teacher feedback was the highest among the post-group results, followed by self-feedback and peer feedback. In the group acceptance pattern, there was a positive change when the teacher and peers provided feedback, whereas there was no difference in scores before and after self-feedback. As a result, this study identified an effective feedback provider for intermediate and advanced learners. (Kyunghee University)
Won, Gun Woo,Sung, Minji,Lee, YoungJoo,Lee, Yong Hee Academic Press 2019 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>The mammalian Ste20-like kinase (MST) pathway or Hippo pathway plays essential roles in cell proliferation, apoptosis, organ size control, and development. Runx2 is a key transcription factor in osteoblast differentiation. The objective of this study was to investigate whether the MST pathway could modulate Runx2 and osteoblast differentiation. First, we found that Runx2 interacted with MST2 and SAV1 via the WW domain of SAV1 and amino acid 292–445 of Runx2 containing a PY motif. Results of OSE luciferase reporter assay revealed that co-expression of MST2 and SAV1 inhibited the transcriptional activity of Runx2 whereas siRNA-mediated down-regulation of Mst1 and Mst2 increased its activity. MST2 and SAV1 significantly reduced mRNA levels of osteoblast differentiation marker genes such as alkaline phosphatase and osteocalcin in differentiating C2C12 cells. MST2 and SAV1 also hampered osteoblast differentiation of C2C12 cells induced by Runx2 as shown by alkaline phosphatase activity assay and Alizarin Red staining. Mass spectrometric analysis of immunoprecipitated Runx2 protein from HEK293 cells overexpressing MST2 and SAV1 revealed two novel phosphorylation sites at Ser-339 and Ser-370 residues of mouse Runx2 protein. Mutation of both serine residues to alanine interfered with the inhibitory effect of MST2 and SAV1 on the transcriptional activity of Runx2 and osteoblast differentiation induced by Runx2. Our results suggest that the MST kinase pathway can directly regulate osteoblast differentiation by modulating Runx2 activity through phosphorylation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MST pathway is a regulator of Runx2 activity. </LI> <LI> MST2 and SAV1 interacts with Runx2 </LI> <LI> MST2 and SAV1 inhibits the transcriptional activity of Runx2, the expression of osteoblast differentiation marker genes, and osteoblast differentiation of C2C12 cells. </LI> <LI> Two novel MST2 phosphorylation residues in the Runx2 protein were identified and shown to be critical for the regulation of Runx2 activity by MST2 during osteoblast differentiation. </LI> </UL> </P>
A thermal margin preservation scheme for interactive multimedia consumer electronics
Badano, Nicolas,Youngjoo Woo,Jeaho Hwang,Euiseong Seo Institute of Electrical and Electronics Engineers 2016 IEEE transactions on consumer electronics Vol.62 No.1
<P>The heterogeneous multicore architecture is considered a cogent solution to match the performance demand for processing the next-generation media formats such as ultra-high definition, 3D or holography. However, the performance cores in a heterogeneous multicore processor dissipate a huge amount of heat. To cope with the thermal risk, most modern embedded processors provide the dynamic thermal management (DTM) feature that forcefully reduces the clock speed of the processors. Although this simple approach can maintain the system temperature below the thermal trip point, the performance of prioritized multimedia or interactive applications can be significantly harmed by the reduced performance even when the thermal crisis is caused mostly by the non-prioritized applications. This paper proposes a novel DTM scheme called Thermal Margin Preservation (TMP). TMP differentiates the thermal trip point for the prioritized applications from that for the non-prioritized ones, and thus forms the thermal margin, which is the temperature gap between the two trip points. Under the proposed scheme, the prioritized applications can run without any disturbance in the thermal margin by sacrificing the performance only of the non-prioritized applications. The evaluation shows that the proposed scheme significantly reduces the quality-of-service degradation for video playback under high temperature conditions(1).</P>
A battery lifetime guarantee scheme for selective applications in smart mobile devices
Jungwook Cho,Youngjoo Woo,Suntae Kim,Euiseong Seo IEEE 2014 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.60 No.1
<P>Unpredictable battery lifetime arising from multitasking can have a significant negative effect on availability for mobile devices. In practice, some applications are prioritized and required to remain in operation for certain duration. This paper suggests a battery lifetime guaranteeing scheme for prioritized applications in multitasking mobile systems. The proposed approach profiles and analyzes the battery usage pattern of each task dynamically, and preserves the energy budget for operation of prioritized tasks for a guaranteed time. In addition, this paper proposes an energyconstrained scheduler that limits the energy consumption of tasks while preserving scheduling patterns, which translates to the QoS. The suggested scheme is implemented in a commercial smartphone and evaluated. The evaluation showed that the proposed scheme successfully provides guaranteed operation time for prioritized tasks.</P>
Facile Docking and Scoring Studies of Carborane Ligands with Estrogen Receptor
Ok, Kiwon,Jung, Yong Woo,Jee, Jun-Goo,Byun, Youngjoo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4
Closo-carborane has been considered as an efficient boron-carrier for boron neutron capture therapy (BNCT) and an attractive surrogate of lipophilic phenyl or cyclohexyl ring in drug design. Despite a great number of carborane-containing ligands have been synthesized and evaluated, molecular modeling studies of carborane ligands with macromolecules have been rarely reported. We herein describe a facile docking and scoring-function strategy of 16 carborane ligands with an estrogen receptor by using the commercial Gaussian, Chem3D Pro and Discovery Studio (DS) computational programs. Docked poses of the carborane ligands in silico exhibited similar binding modes to that of the crystal ligand in the active site of estrogen receptor. Score analysis of the best docked pose for each ligand indicated that the Ligscore1 and the Dockscore have a moderate correlation with in vitro biological activity. This is the first report on the scoring-correlation studies of carborane ligands with macromolecules. The integrated Gaussian-DS approach has a potential application for virtual screening, De novo design, and optimization of carborane ligands in medicinal chemistry.
( Daulat Bikram Khadka ),( Hyunjung Woo ),( Su Hui Yang ),( Chao Zhao ),( Yifeng Jin ),( Thanh Nguyen ),( Youngjoo Kwon ),( Won-jea Cho ) 전남대학교 약품개발연구소 2015 약품개발연구지 Vol.24 No.-
Inspired by the initial success of the monoarylisoquinolines and the quest to identify more potent and selective anticancer agents with topoisomerase (topo) inhibitory activity, series of diarylisoquinolines (3,4-diarylisoquinolones and 3,4-diarylisoquinolinamines) were designed and synthesized. Synthesis of these compounds primarily involved Iithiated toluamide-benzonitrile cycloaddition, Suzuki coupling, and nucleophilic aromatic substitution reactions. Eight of the derivatives were selectively toxic against human ductal breast epithelial tumor cells (T47D), human prostate cancer cells (DU145), and human colorectal adenocarcinoma cells (HCT-15), but had no effect on normal human breast epithelial cells (MCF10A)T. he topo inhibitory activities of the diarylisoquinoline compounds were relatively dependent upon their chemical structure. 3,4-Diarylisoquinolones generally did not inhibit topo I and only showed moderate inhibition of topo II. In contrast, several 3,4-diarylisoquinolinamines showed superior topo I inhibitory activity. Isoquinolinamine derivatives had greater affinity for topo I than for topo II. Topo inhibition by 3,4-diarylisoquinolines was further supported by docking models showing intercalative and/or H-bond interactions between these compounds and the DNA/topo(s). An analysis of the correlation between the cytotoxicity and topo inhibition of these compounds indicated that the primary biological target of derivatives with potent cytotoxicity was topo, which in turn establishes diarylsubstituted isoquinolines as a novel class of potential anticancer drugs.