전착된 폴리이미드 박막의 고온영역에서의 절연파괴 특성에 관한 연구

유영복,김종석 大田産業大學校 1997 한밭대학교 논문집 Vol.14 No.1

This study deals with the breakdown characteristics of the polyimide film fabricated by electrophoretic method. We fabricated the film on to glass substrate with controlling the electrophoretic time and voltage, after that, dried and annealed the film at elevated temperature of 300℃ then evaluated the film with breakdown test at over the temperature of 100℃. The breakdown strength of the film at 130℃ are still high as 380KV/mm, and the strength is decreased with increasing the temperature. We can know that central part of the path of breakdown on polyimide film is decomposed by arcing heat. but there left some backbone structure around the path.

^(7)Li, ^(87)Rb과 ^(27)Al NMR을 이용한 (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6)와 K_(2)SnCl_(6):Al^(3+)의 상전이 근처에서의 결정 동력학 연구

김복수,김영훈,강재필,백아영,차유정,김민경,서용문,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

K_(2)SnCl_(6)는 antifluoride계에 속하는 결정으로서 K_(2)SnCl_(6)에 Li^(+)를 첨가하여 ^(7)Li 핵자기공명(NMR)을 측정하여 동형(isomorphic) 혼합결정(K_(1-x)Rb_(x))_(2)SnCl_(6)와 비동형(nonisomorphic) 혼합결정 K_(2)SnCl_(6):Al^(3+)에서의 핵자기공명(NMR), ^(87)Rb NMR과 ^(27)Al NMR의 측정값과 비교하였다. Rb^(+) 이온은 K_(2)SnCl_(6)의 K^(+)이온을 대신해 동형 결정을 이루며, Al^(3+)이온은 Sn^(4+)이온을 대치하면서 비동형 결정을 이루는데 Li^(+)이온 또한 K^(+)이온을 대신하는 동형 혼합결정과 유사한 결과 값을 얻을 수 있었다. 이 연구 결과는 종래의 Cl-NQR 연구 결과와 비교함으로서 K_(2)SnCl_(6)의 동력학적 특성과 구조 상전이 근처에서의 임계현상을 새로운 관점에서 볼 수 있는 가능성을 보여주었다. ^(7)Li, ^(87)Rb and ^(27)Al NMR have been investigated in the isomorphic and nonisomorphic impurity doped crystals (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6) and K_(2)SnCl_(6):Al^(3+) as a supplementary to the previous Cl NQR studies in these crystals. The results yielded that the features of NMR spectra for both types of crystals are roughly in line with the systematic trends shown in the Cl NQR in these crystals, though the outstanding characteristics exhibited in the Cl NQR become in the case of the NMR of the doped impurities in crystals somewhat weakend. This is due to the degradation of the role of the local field from the main hamiltonian in NQR to the subsidiary in NMR. Each NMR result of the iso/nonisomorphic crystals has been analyzed in terms of the 'impurity induced dynamic lattice defects' for K_(2)SnCl_(6):Al^(3+) and the 'static primary impurity effects' for (K_(1-x)Rb_(x))_(2)SnCl_(6) and (K_(1-x)Li_(x))_(2)SnCl_(6) respectlvely.

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.

Polaron Hopping in the K_(2)O · B_(2)O_(3) · V_(2)O_(5) Glasses

차유정,강재필,홍성덕,김복수,김영훈,서용문,송승기 명지대학교 자연과학연구소 2005 자연과학논문집 Vol.24 No.-

K_(2)O · B_(2)O_(3) · V_(2)O_(5) 계 유리의 조성비에 따른 밀도, 굴절율, 전이온도, 천이금속이온비율 등과 직류 전기 성질을 100~450K 온도영역에서 연구하였다. 실험결과를 비정질 반도체에 관한 전기전도에 대한 이론 모델을 이용하여 분석하였다. 고온 영역에서는 직류전도도의 온도 의존성을 Mott의 포논-도움껑충뛰기 전도모델로 분석할 수 있었다. 활성화에너지는 0.28~0.33 eV로 시료내 V_(2)O_(5) 의 양이 증가할수록 감소하는 경향을 보인다. 저온 영역에서 직류 전기전도도는 Mott의 가변거리 껑충뛰기(variable-range hopping)전기전도도와 잘 일치하며, N(E_(F))값은 국지화 상태에서와 같다. The dc conductivity of K_(2)O-B_(2)O_(3)-V_(2)O_(5) glasses has been investigated in the temperature range 100~450K and physical parameters such as density, refractive indices, glass transition temperature and fraction of reduced transition-metal ion, were observed for various compositions. The experimental results are analyzed with reference to theoretical models proposed for electrical conduction in amorphous semiconductors. The analysis shows that at high temperature region the temperature dependence of the dc conductivity is consistent with Mott's model of phonon-assisted hopping of small polarons. The values of activation energy are 0.28~0.33 eV and decrease with increasing V_(2)O_(5) content in the sample. The lowtemperature dc conductivity data can be well fitted to Mott's variable-range hopping conductivity and the values of N(E_(F)) are also reasonable for localized states.

아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성

조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.

심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

Combination therapy using a fractional Micro-Plasma Radio-Frequency treatment followed by a drug delivery system with a sonotrode : A pilot study

( Young Bok Lee ),( Jun Young Lee ),( Hye Rim Ko ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3

Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model

( Young Bok Lee ),( Jun Young Lee ),( Hye Jin Lee ),( Seong Taek Yun ),( Jong Tae Lee ),( Hong Jig Kim ),( Dong Soo Yu ),( So Youn Woo ),( Jin Wou Kim ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2

Background: Balneotherapy, although not a well-established dermatological treatment, is thought to have therapeutic properties for psoriasis and is used as an alternative treatment modality throughout the world. Objective: To evaluate the mechanism underlying the therapeutic immunologic effects of thermomineral water. Methods: A murine model of imiquimod-induced psoriasis-like skin inflammation was used for evaluating the therapeutic effects of balneotherapy with Hae-Un-Dae hot spring mineral water. The clinical improvements were evaluated by a dermatologist. Lesional cytokines, including interleukin (IL)-17A, IL-23, and IL-22, were quantitatively measured by real-time reverse transcriptase polymerase chain reaction. Serum levels of interferon- γ, IL-4, IL-5, and IL-17A were measured by enzyme- linked immunosorbent assay. T cell proportions in the spleen were evaluated by flow cytometry, and histopathological evaluation of the skin was also performed. Results: The mineral water balneotherapy group showed faster improvement in skin erythema and scales than the distilled water bathing group. A substantial reduction was observed in the lesional mRNA levels of IL-17A and IL-23 in the mineral water group. Serum levels of IL-4 and IL-5 were significantly decreased in the mineral water group but not in the distilled water group. Normalized T cell proportions were observed after bathing. Conclusion: Balneotherapy showed immunomodulatory effects in a psoriasis-like murine model. Balneotherapy suppressed lesional IL-23 and IL-17A, which are important cytokines in the pathogenesis of psoriasis. These results suggest that balneotherapy can be used as an effective and safe treatment for psoriasis.

Seed Vigor and Properties of Imported Peanut Compared with Domestic Peanuts

Yu Young Lee,Suk Bok Pae,Kang Bo Shim,Chan Sik Jung,Myoung Hee Lee,Young Sup Ahn,Duck Yong Suh 한국육종학회 2005 한국육종학회 학술발표회 발표요지 Vol.37 No.1

P096 : A study of the results of patch test: the 5-year experience of 2009-2014

( Young Bok Lee ),( Hyun Jee Kim ),( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Allergic contact dermatitis is a hypersensitivity reaction to a sensitized allergen. The first step in diagnosing allergic contact dermatitis would be a careful history taking, but to identify the cause of allergic contact dermatitis, patch test is an essential method. However, there has been no recent study regarding the results of patch test in Korea. Objectives: The purpose of this study was to analyze the type, frequency of the common contact allergens in Korea. Methods: From June, 2009 to June, 2014, 330 patients with suspected contact dermatitis who visited our clinic were tested with 25 different allergens. Patient’s demographic findings and patch test results were evaluated. Patch test reading was performed after 48 hours. Results: A total of 330 patch tested cases were analyzed. The highest age distribution was 3rd decade in males and 5th decade in females. The most common affected sites were hands(31%), trunk(24%), and arms(22%) in male, but in female, the face, including eye, ear and lip, was the most frequently affected site comprising 51.7%. The next common sites in female were trunk(19.6%) and hands(17.4%), in order of frequency. In patients with strong or extreme positive reactions, the highest sensitization rates were found with: nickel sulfate(27.9%), cobalt chloride(14.2%), 4-phenylenediamine(9.2%), respectively. Conclusion: These results provide the basis for the presumption of the route of allergen exposure and prevention of contact dermatitis in Korea.