서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

입원 환자 영양검색 전산 프로그램 개발

안수미,윤기영,신연명,최경현,임근승,장문경,송윤미,공은희 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : About 30% of patients in the hospital are under nourishment. A large portion of people are undernourished when they are admitted to the hospital and in the majority of these, undernutrition develops further while in hospital. Patient-Generated subjective global assessment(PG-SGA), a method of nutritional assessment based on clinical judgment, has been widely used to assess the nutritional status of adults for both clinical and research purposes. Modified PG-SGA can be used as a nutrition screening tool, and a comprehensive nutrition assessment is desirable for those who are malnourished. The purpose of this study is to develop a simple, reliable and valid nutrition screening program(NSP). Methods : We applied the nutrition screening program(NSP) to adult inpatients who are at risk of malnutrition using the Modified Patient-Generated subjective global assessment(PG-SGA) and objective assessment(electrical medical record data). Results : Therefore simple and beneficial NSP is developed for patients with severe malnutrition. Using NSP. nutritional information of the severe malnutrition patient should be shared with the physicians and they should be taken care of by clinical dietitians to improve their nutritional status. Conclusion : The Modified PG-SGA and nutrition screening tool are simple, reliable and valid nutrition screening program(NSP).

중첩현상과 제약상충

안수영,서정민 東新大學校 2003 論文集 Vol.13 No.-

This paper investigates the application styles in reduplication within the framework of Correspondence Theory(McCarthy & Prince, 1995a); normal application, overapplication, underapplication, and the emergence of the unmarked. In this paper, we argue that the application styles are results from the conflict of faithfulness constraints and well-formedness constraints. To explain reduplication, Generative Phonology(Chomsky & Halle, 1968) has assumed a mapping from underlying to surface forms. This idea of the grammar allows us to determine a single form from which it is possible to derive all shapes. In Correspondence Theory, which is based on Optimality Theory(McCarthy & Prince, 1993), however, the input-output mapping is determined by the interaction of faithfulness constraints and well-formedness constraints. This paper is organized as follows: In Section 1, we provide an introductory remark about this paper. In Section 2, we introduce Correspondence Theory(McCarthy & Prince, 1995a), and then argue that the application styles are results from the conflict of faithfulness constraints and well-formedness constraints. Section 3 is a concluding summary of this paper.

고출력 CW Nd:YAG 레이저를 이용한 CSP 1N 박판재 절단시 공정변수의 절단표면특성에 미치는 영향

안동규,김민수,이상훈,유영태,박형준 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The objective of this research work is to investigate the influence of process parameters, such as power of laser, travel speed of laser and material thickness, on roughness and striation of the cut surface for the case of cutting of CSP IN sheet using high power Nd:YAG laser with continuous wave (CW). In order to find the practical cutting region and the relationship between process parameters on the roughness and the striation, several laser cutting experiments are carried out. From the results of experiments, the allowable cutting region and an optimal cutting speed for each cutting condition have been obtained to improve the quality of the cut surface. In addition, it has been shown that the surface roughness is related to the number of striation and depth of valley of the cut surface.

Single Nucleotide Primer Extension 기법을 이용한 SNP 연구

안영욱,예성수,박영홍 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Single nucleotide polymorphisms(SNPs) are the most frequent type of DNA sequence variation of individuals. They are defined by the presence of two alternative bases at a particular position in a DNA sequence and occur about one per 500-1000bp in the human genome. The recent completion of the first reference sequence of the human genome has provided a basis for comprehensive analysis of sequence variation in man. The identification and dense mapping of SNPs is of considerable significance for association studies of complex diseases, pharmacogenetics, population genetics and physical mapping. Their use as genetic markers is favored by their high abundance, low mutation rate and the easy automation of typing. With the development of ABI Prism 3100 or 3700 system, single nucleotide primer extension, we car get a straightforward and large-scale method for validation of or comparative genotyping of known SNPs and point mutations. In the mini sequencing primer extension reaction, a DNA polymerase is used specifically to extend a primer that anneals immediately adjacent to the nucleotide position to be analyzed with a single labeled nucleoside triphosphate complementary to the nucleotide at the variant site. The reactor allows highly specific detection of point mutations and single nucleotide polymorphisms(SNPs) without direct sequencing. Because all SNPs can be analyzed with high specificity at the same reaction conditions, mini sequencing is a promising reaction principle for multiplex high-throughput genotyping assays. It is also a useful tool for accurate quantitative PCR-based analysis. This review discusses the advanced biotechnique.

急速凝固한 高純度 Fe―C―Si合金중의 Carbide共晶의 過冷却凝固 시뮬레이션

김영직,서수정,안현모 成均館大學校 科學技術硏究所 1991 論文集 Vol.42 No.1

This paper decribes a study of the solidification simulation with supercooling of levitation melted and rapidly solidified high purity Fe--C-Si alloys with emphasis on carbide eutectic. Newly designed growth model of carbide eutectic is proposed. From the simulation model, calculated cooling curves are derived by means of a personal computer, and compared with experimental data. The results calculated are influenced remarkably by coefficient of heat tranfer(h), latent heat of solidification(L), growth rate constant(n) and range of temperature of mushy zone. After suitable choice of h, L, n and especially temperature range of mushy zone as 100K, experimental cooling curves are duplicated by calculated. As the cooling rate exceed about l0^3K/s, graphite crystal is not formed in the high purity Fe -C-Si melts.

기저세포암 및 편평세포암에서 미세혈관밀도와 p53 단백 발현에 관한 연구

어수락,조규성,안호범,김대영,이삼용,조백현 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Basal cell carcinoma(BCC) and squamous cell carcinoma (SCC) are very prevalent neoplasms of the human skin. Ultraviolet radiation in sunlight is a well-established mutagen of the p53 gene and is one of basal cell carcinoma and squamous cell carcinoma. The newly-formed vascular network is important for neoplasms to grow beyond a size of about 1 ㎣. Recent reports have suggested the hypothesis that a mutant p53 protein is closely related with capillary density. Immumohistochemistry for p53 protein and CD34 was performed in 20 cases of BCCs and 14 SCCs to evaluated the relationship between p53 protein and capillary density. The results were as follows:1. The microvessels stained by CD34 were mainly located in the interface of tumor cells and stroma. 2. There was no difference in the microvessel density according to the histologic types and age of the patients, but a higher microvessel density was noted in male patients. 3. The aggressive BCCs and the less-differentiated SCCs showed higher p53 immunostaining. 4. The mean microvessel density of cases showing strong positive immunostaining of the p53 gene(54.73±17.75) was higher than that of others(39.75±18.30). These results suggested that p53 protein expression and microvessel density are not related to the histologic types and age of the patients, but that differentiation and biologic behavior such as the infiltrating property of tumors and the microvessel density are closely related to p53 protein expression.

쿠퍼씨 방법을 이용한 상악 전방부 골절단술

김소영,김수관,이상호,김수응,정태영,안태훈 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.5

Anterior segmental osteotomy were performed in 8 patients with Angle's II malocclusion or anterior maxillary protrusion. Cupar's method was used for operation. The period of follow up for patients were 15months by average. This study discussed the postoperative complications and soft tissue change after anterior segmental maxillary osteotomy. There are not specific major complications.

양극성 장애에서 표피성장인자의 유전적 다형성에 대한 연합연구

김수경,이규영,주은정,강웅구,안용민,김용식 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Epidermal growth factor (EGF) is a neurotrophic factor which regulates the intracellular signaling molecules. These molecules are also affected by mood stabilizers such as lithium and valproate. In addition, epidermal growth factor enhances neuronal survival, maturation and differentiation especially in midbrain dopaminergic neurons of which dysfimction may play a role in pathophysiology of bipolar disorders. Bipolar disorder has some genetic commonalities with schizophrenia, and several association studies of EGF have been done with schizophrenia. In this study, we tried to investigate the geneticassociation between EGF A61G polymorphism and bipolar disorder. Methods : Total of 189 patients and 347 nonnal control were included. All patients satisfied the diagnostic criteria of DSM-IV for bipolar disorder type I (BPDI, N= 146) and bipolar disorder type II (BPDII, N=43). Genomic DNA was extracted from the peripheral blood, and genotyping was performed by TaqMan™ method. Genotype and allele frequency of EGF A61G polymorphism between the patients and the control were compared by contingency chi-square test or the Fisher's exact test. Results : No association was found between EGF A61G polymorphism and susceptibility of BPDI, BPDII and bipolar disorder (all patients). Female patients with BPDII showed overexpression of AG genotype compared to that ofcontrol group (p=0.03). However, this association was not significant after correction of multiple testing. Conclusion : In conclusion, EGF A61G polymorphism has no association with susceptibility of bipolar disorder. However, the disease modifying role of EGF gene polymorphism for bipolar disorder remains to be elucidated in respect to factors such as gender difference or diagnostic subtype.