트리영상의 프랙탈 및 준프랙탈 해석

박용식,임장섭 木浦海洋大學校 1998 論文集 Vol.6 No.1

Fractal mathematics using image processing is being highlighted as a research method for classification of electrical tree. for image analysis of tree pattern, the fractal mathematics processing is actively studied as a experimental new technique of electrical tree.. But the application of Fractal dimension(FD) has been required the complicated calculation method because of its complex repetition progressing. In this paper, it has been developed the new approach method to express the Semi-Fractal Dimension(SFD) for high-speed calculation and on-line measurement system using special image processing algorithm. As a result after SFD testing, the recognized area of SFD has a good linear characteristics compared to FD.

사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구

박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성

박태원,홍영준,박임순,김형섭,최인미,배수영,윤경식,강대희 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : Catechol-O-Methyltransferase(COMT)는 카테콜아민 신경전달물질의 불활성화를 담당하는 효소로서, 정신분열병과 관련된 후보 유전자로서 알려져 왔다. 최근, 기능성 COMT유전자 다형성과 정신분열병의 관련성이 제기되었는데, 한국인 정신분열병에서도 이러한 관련성이 있는지를 살피기 위해 본 연구를 시행하였다. 방 법 : 정신분열병으로 진단된 환자군 103명과 성별 및 연령별로 1:1 짝짓기 대조군 사이에 유전자형과 대립유전자의 분포를 비교하였다. 또한, 환자군은 공격적 행동, 가족력, 아동기 발병 여부에 따라 두 군으로 나누어 비교하였다. DNA의 다형성 부의를 중합효소연쇄반응에 의해 증폭한 후 ,NlaⅢ제한효소법과 전기영동을 실시하여 유전자형을 판별하였다. 결 과 : 환자군 전체와 대조군 사이에 유전자형과 대립유전자 빈도의 차이가 없었다. 가족력이 있는 환자군을 대조군과 비교하였을 때는, 대립유전자 L을 포함하는 유전자형과 그렇지 않은 유전자형의 분포에 있어 유의한 차이를 보였다(p=0.02, OR=3.9, 95% Cl=1.1∼14.3). 결 론 : 한국인 정신분열병과 기능성 COMT 유전자 다형성 사이에 유의한 관련성이 없었다. 따라서, 기능성 COMT 유전자 다형성이 한국인 정신분열병의 발병에 영향을 주지 못한다. 그러나, 정신분열병 가족력과 기능성 COMT유전자 다형성의 관련성이 시시돠어, 향후 본 연구에서 나타난 방법론적인 문제점을 보완하고 추가 대상자를 확보한 연구가 필요하다. Objectives : Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine meurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls. Methods : One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaⅢ and electrophoresis. Results : No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4 fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 9.5% CI=1.10-14.33). Conclusion : Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

증편의 저장 중 조직 특성 변화

張奎燮,李貞植,崔錫鉉,朴榮德 충남대학교 농업과학연구소 1991 농업과학연구 Vol.18 No.2

This study was carried out to investigate the storage conditions and methods required for commercializaion of Jeung-Pyon. The storage characteristics of Jeung-Pyon were examined with Universal Testing Machine (UTM. Instron model 1000) for textural properties during storage of tinder the conditions such as sealing, nonsealing, and temperatures. The differences in storage characteristics on the different varieties and years of rices were not shown. When the Jeung-Pyon was lost it's quality as a commercial product, the measured value of UTM was increased as hardness 0.74㎏ to 1.0㎏, gumminess 0.23㎏ to 0.59㎏, chewiness 6㎏.mm to 18㎏.mm, but decreased in adhesiveness 0.65㎏.mm to 0.40㎏.mm, cohesiveness 0.61 to 0.34, springiness 41㎜ to 32㎜. The nonsealed Jeung-Pyon was lost it's quality for storing at room temperature because of the case-hardening after 2 days. In the case of sealed Jeung-Pyon, the case-hardening phenomena by the evaporation of moisture was not occured, therefore it was a significant factor for an extension in sealed Jeung-Pyon. The shelf-life of sealed Jeung-Pyon was 20 days and 5 days respectively during storage at -20℃ and 20℃ The sealed Jeung-Pyon stored at 5℃ was lost it's quality, in consideration of cold chain this temperature was suitable for retrogradation of starch. The Jeung-Pyon sealed with air and mosture proof packaging material stored at the accelerated condition as 92% R.H. and 35℃ lost it's quality within two or three days.

과민성방광의 비수술적 치료 : 방광의 저장용적을 증가시키는 치료법 Therapy to Increase Bladder Storage Capacity

송윤섭,문기혁,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Overactive bladder including frequency, nocturia, urgency ate common and Its cause is decreased bladder storage capacity. Non-pharmacologic therapy to facilitate bladder storage capacity are behavioral, bladder overdistention or electrical stimulation. For behavioral therapy, patient education about lower urinary tract function, information about lifestyle changes or dietary modification, bladder training which includes instituting intervals of timed voiding and gradually increasing these intervals, pelvic floor physiotherapy with or without biofeedback are necessary. For physically or mentally challenged individuals, schedulled toileting or prompted voiding is necessary, too. Bladder overdistention, electrical stimulation or neuromodulation are also used for the treatment of overactive bladder.

만성전립선염 환자에 있어서 항정자항체의 존재와 정자의 운동성 감소

송윤섭,김민의,박영호 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Chronic prostatitis may be related to the decrease of semen quality affecting fertility due to the existence of antisperm antibody. So we evaluated the characteristics of antisperm antibody in the control group and patients with chronic prostatitis. Statistical significance was noted in average path velocity(VAP), straight line velocity(VSL), curvilinear velocity(VCL), beat frequency(BCF), elongation of sperm motility parameters between the control group and patients with chronic prostatitis. Detection of antisperm antobody with direct and indirect immunobead test were 0%(0/11), 9.1%(1/11) in the control group and 6.3%(1/16), 37.5%(6/16) in the patients with chronic prostatitis. Titers of antisperm antibodies according to isotype (% binding, control group/ patients with chronic prostatitis) were 0/0.63±2.5(IgG), 0/0(IgA), 0.13±0.5/0(IgM) with direct immunobead test and 0.18±0.60/1.19±1.80(IgG), 0/0.06±0.25(IgG), 0/1.25±2.32(IgM) with indirect immunobead test. Statistical significance was noted in VAP, VCL, BCF between chronic prostatitis patients with and without antisperm antibody. The correlation between IgG and VAP, IgG and VCL existed. In conclusion, decreased sperm motility and the antispermantibody were found in chronic prostatitis. The antisperm antibody showed sharp contrast between the control group and the patients by indirect immunobead test, rather than by direct immunobead test. The existence of antisperm antibody correlated with sperm motility in chronic prostatitis.

왜소음경증과 남성 성기능에 관한 연구

송윤섭,김민의,이남규,박영호,전윤수,김응구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Micropenis is defined as a normally formed penis with a size greater than 2 standard deviations below the mean. Twenty three patients with micropenis were managed at Soonchunhyang University Hospital from January 1988 to December 1995 We interviewed and examined them with micropenis to investigate the cause of micropenis, concomitant diseases, the efficacy of treatment and their sexual activity in postpubertal men. The patients were divided into 2 groups: 16 prepubertal and 7 postpubertal men. 9 patients had cryptorchidism, 3 of them were bilateral and 5 patients had hypospadias. Etiology was determined by hormonal assay including HCG stimulation test ; 8 as hypogonadotrophic hypogonadism, 4 as primary testicular dysfunction and 5 as idiopathic. However etiology was undetermined in 6 patients. All patients had endocrine therapy using HCG or depot testosterone. All except 4 cases responded satisfactorily. All postpubertal patients(group 2) were below the 10th percentile. Puberty was delayed in 3 patients in the older group. All patients were heterosexual and they have had erections and orgasms. Five patients have had ejaculations, 3 of them were sexually active and they have experienced vaginal penetration, Nevertheless, their sexual partners have had complaints and the patients themselves have felt ashamed and dissatisfied. Fortunately, they were mentally healthy. None of these patients were married or had a child.

室內 音響 特性에 있어서 初期時間遲廷에 關한 硏究

任英彬,朴昌燮 釜山工業大學校 1990 論文集 Vol.32 No.-

Sabine's Reverberation time was for a long Time regarded as the principal objective quantity in the acoustical design of halls and auditorial. It is now generally accepted that it is not the sole design quantity as an acoustical criterion for halls. Sound reflection in a room naturally play a very important role in subjective evaluation of acoustic performance of the room and favourable reflections should be provided by the walls and ceilings. It is very important for listeners to receive early high-frequency reflections with 20millisconds of the arrival of the direct orchestral sound for them to experience optimum musical presence and definition. The difference in time between the arrival of direct sound and the first reflection is called the initial time delay gap(ITDG). The ITDG is related to the size and shape of a concert hall. This paper presents the value of ITDG by the experimental model. The Main hall of A Cultual center was used for the paper. The experimental method were used by geometrical and impulse response.