전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

당뇨병성 합병증을 가진 환자에서 혈증 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

임팩트시 테니스 라켓 재질의 차이에 따른 근전도 분석

윤양진,유국종,서국웅,정미라,강영택,이훈식,서국은 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this paper is to select 7 male athletes and female athletes of high school, and to compare their active potential differences of upper arm muscles according to characteristic of a racket. the results obtained are as follows: 1. According to the accumulative distribution rate of racket material, graphite and wood material show better efficiency in case of brachio radialis muscle of male athletes, but the racket material shows no constant efficiency in brachii radialis muscle of female athletes. In case of flexor carpi radialis muscle, wood material provides better efficiency only for male athletes. In case of triceps brachii muscle, wood material gives better efficiency to males athletes and steel material gives better efficiency to females athletes. Especially in case of biceps brachii muscle, neither male nor female athletes are influenced by racket materials at impact. 2. In the muscle load rate according to racket material, wood has the highest muscle active potential and graphite has the lowest active potential. Therefore, graphite is thoght to be better in the efficiency of muscle load rate.

개의 아토피 피부염에 대한 Leflunomide의 임상적 적용 1례

홍은지,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A Shih-tzu(8-year-old, castrated male) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of relapsing pruritus, recurrent dermatitis. On the physical examination, generalized erythema, otitis externa, alopecia and lichenification were observed. Using Favrot's criteria for diagnishing atopic dermatitis, 7 criteria were satisfied out of 8 criteria. After treatment for infection, intradermal skin test was performed(positive allergen : Df, Dp). And then immunotherapy was performed, but clinical signs were not getting better. Next treatment of glucocorticoid shown little improvement of clinical signs, and adverse effect(diarrhea) was shown after cyclosporine application. So application of leflunomide which is used for human atopic dermatitis treatment in some case was planned. After 6 months of application of leflunomide, clinical signs were decreased gradually.

컴퓨터 赤外線 全身體熱撮影과 FNT을 통해 살펴본 Bell's palsy에 대한 침치료의 臨床的 考察

尹敏永,趙恩嬉,許泰永,趙南根,文炯喆 한국전통의학연구소 2001 한국전통의학지 Vol.11 No.1

Object : This study is designed to evaluate the clinical therapy of acupuncture by the data of DITI(Digital Infrared Thermographic Imaging) and FNT(Facial Nerve stimulation Test) examination and the changes of clinical symptoms after the therapy of acupuncture in the patients with Bell's palsy. Contents : The conservative therapy with acupuncture was performed during 1-8weeks. The acupuncture points of S4, S6, G14, S2, BL2, SI18, TE23, LI4 and S36 were used. In the pre- and post therapy, DITI examinations was performed in patients who had Bell's palsy and were treated by acupuncture, and then tried to correlate the results of clinical symptoms with the difference of thermographic findings. And FNT examinations were performed in the same patients above, and then tried to correlate the results of clinical symptoms with the difference of nerve response findings. Setting : The standard routine thermographic examination with thermography (DITI) and nerve response with FNT(Facial Nerve Stimulation Test) were performed in the 16 patients with Bell's palsy at pre- and post acupuncture. Patients : Thermographic imaging of 16cases was analyzed. They had diagnosed Bell's palsy. They were treated by acupuncture and moxibustion therapy in Wonkwang Oriental Hospital from Jauary, 1999 to February, 2000. Results : 1) The results of treatment showes that 56.25% of patients achieved clinical excellent recovery and 31.25% achieved good recovery. After compairing the DITI results before and after treatment, we found 43.75% of patients achieved excellent recovery and 43.75% achieved good recovery. 2) After compairing the FNT results before and after treatment, we found 25% of patients achieved excellent recovery and 56.25% achieved good recovery. Conclusion : 1) Acupuncture showed good results over 87.5% in clinical evaluation and 87.5% in DITI. Thermographic examination showes terapeutic effect of acupuncture treatment. 2) Acupuncture showed good results over 87.5% in clinical evaluation and 81.25% in FNT. FNT showes nerve response recovery effect of acupuncture treatment.

HIV-1 역전사효소 억제제의 구조화 활성 사이의 정량적 상관관계 연구 : HEPT와 TIBO 유도체 HEPT and TIBO Derivatives

윤은진,조효영,윤창주 가톨릭대학교 자연과학연구소 2003 자연과학논문집 Vol.24 No.-

본 연구는 QSAR을 이용하여 HIV-1 RT의 한 종류인 TIBO와 HEPT의 구조와 활성간의 상관관계를 설명하였다. 좋은 QSAR 모델은 통계적인 수치와 예측 정도를 모두 만족시켜야 한다. 생성된 모델과 수식을 통해 HEPT 유도체는 소수성이 활성과 관련이 있는 반면, TIBO 유도체는 소수성과 비편재화, 물 굴절도가 활성도와 관련이 있음을 알 수 있었다. 이러한 결과는 TIBO와 HEPT 유도체의 구조적인 특징을 파악하는데 유용하며, HIV-1 RT 억제 과정의 이해를 돕는다. 따라서, 본 연구를 통해 좀 더 강력하고 새로운 HIV-1 RT inhibitor를 제안할 수 있다. Quantitative structure-activity relationship(QSAR) have been applied in order to explain the structure requirements of HIV-1 RT inhibitory activity of TIBO and HEPT derivatives. The best QSAR models are satisfactory in both statistical significance and predictive ability. The derived structural descriptors for HEPT indicate the importance of hydrophobic contributions toward the HIV-1 RT inhibition, but the descriptors for TIBO indicate the importance of hydrophobic, electronic and molar refractivity contribution toward the HIV-1 RT inhibition. These results can be useful in identifying the structural requirements of TIBO and HEPT derivatives and helpful for better understanding the HIV-1 RT inhibition. Eventually, they provide a beneficial basis to design new and more potent inhibitors of HIV-1 RT.

중고생의 미용인식에 대한 연구 : 헤어 미용을 중심으로

윤은영,김성남 한국패션뷰티학회 2008 한국패션뷰티학회지 Vol.6 No.1

The purpose of the study is to look at the middle and high school student's recognition of beauty Arts. The collected data were analyzed by frequency analysis, factor analysis, reliability test, t-test, correlations analysis, from which the result is as follows. Firstly, the lower levels of beauty art are comprehensive interest, personal interest professional interest, effort type, management type and consumption type. Secondly, Beauty art interest and attitude by gender and school levels showed meaningful difference. Thirdly, there is meaningful correlations between beauty art interest and beauty art attitude.

Leukocyte adhesion deficiency type I 환자의 치험례

윤은영,이난영,이상호 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

Leukocyte adhesion deficiency type I(LAD I)은 혈관 내피 세포에 백혈구가 부착하는 과정에 결함이 발생하여 혈관에서 감염부위로의 백혈구의 이주가 방해되어 발생하는 질환으로, 재발성 감염증과 백혈구 증가증을 보이는 희귀 질환이다. 피부와 점막의 괴사성 감염, 장내 패혈증, 제대염, 중이염, 뇌수막염 등의 임상 증상을 보이며, 이러한 환자들의 주요한 구강 내 증상은 심각한 치주 질환과 치조골 소실, 치주낭 형성, 유치열과 영구치열의 부분적 또는 전체적 조기 상실을 보인다. 본 증례는 심한 사춘기전 치주염 소견을 보이는 LAD type I환자로 국소적, 전신적 감염을 예방하기 위해 정기적인 치과 내원으로 치면 세균막 관리를 시행하였다. 감염 시 항생제 투여 및 세균 도말 검사를 시행하였다. Leukocyte adhesion deficiency is rare inherited defect on phagocytic function resulting lack of leukocyte cell surface expression of β2 integrin molecule that are essential for leukocyte adhesion to endothelial cells and chemotaxis. Clinical features of patients with leukocyte adhesion deficiency type I include recurrent necrotic infection of the skin mucous membranes, and intestinal tract with septicemia, and omphalitis arising from delayed umbilical cord separation. Oral manifestations are severe progressive periodontitis with alveolar bone loss, periodontal pockets, and partial and total premature loss of the deciduous and permanent dentitions. We report a case of leukocyte adhesion deficiency type I in a 5-year-old child with severe periodontitis. In order to prevent local and systemic infection, we controlled periodontal disease with periodic oral prophylaxis. Oral swabs and blood cultures were perfomed for suspected infection, so that optimal measures were taken through the use of appropriate antibiotics.

인터넷을 이용한 영양교육 프로그램 개발

윤은영,김윤정 대전대학교 생활과학연구소 1999 생활과학연구 Vol.5 No.-

The purpose of this study was to develop nutrition education program via internet and evaluate the response of this nutrition education program. For this study, nutrition education media via internet was developed with CGI program. And also to evaluate this program, a survey was conducted with 127 students who lived in Taejon. This survey carried out in May, 1999. This nutrition education program : Step 1 shows one's physical status. Step 2 shows good food habits. Step 3 shows requirement of calorie for weight control, high calorie foods, low calorie foods, recipes to reduce calorie and calorie of fast foods. Step 4 shows methods of exercise for health. Step 5 help to maintain normal weight. Step 6 provides internet site related with obesity. The result of this survey is summarized as follow; Most of the subjects answered this program was very useful(35.4%) or useful(50.4%). By using this information, they could increase their knowledge of nutrition(96.1%), change their food attitude(87.2%) and increase the practice capability of meal management(76.2%). Therefore, internet nutrition education program should be developed much more.

천연자원의 간기능 보호 효과에 관한 연구 : Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 강활의 효과 The Effect of Angelica koreana on Benzo(a)pyrene Induced Hepatotoxicity

윤수홍,이송애,박은주,이주영 효성여자대학교 부설 한국환경위생연구소 1992 환경위생연구 Vol.2 No.1

민간에서 주로 사용되는 약용식물들 중 간독성의 발현 저해 및 간기능 보호 효과가 우수한약물을 찾아 임상적인 약효를 밝혀보고자 하는 실험과정으로 탄소화물의 불완전 연소 및열분해에 의해 생성되는 간장해 물질인 benzo(a)pyrene으로 유도한 rats의 간독성 발현에미치는 강활 수침액의 예방 및 치료 효과를 실험하여 다음과 같은 결과를 얻었다. 1. 강활 수침액의 투여는 B(a)P투여로 현저하게 증가된 혈청 및 간장의 AST, ALT, LDH,ALP 활성의 유의성 있게 감소시켰다. 2. B(a)P투여로 증가한 혈청 total cholesterol 및 phospholipid 함량은 강활 수침액의 투여로감소시킬 수 있었다. 3. 강활의 투여는B(a)P에 의한 간독성 발현을 유의성 있게 감소시켰으며 그 효과는 전처리가후처리에 비해 우수하였다. The present study was undertaken to compare the pharmacologicalactivities of crude Angelica koreana reported with the clinical uses in the orientalmedicine. Crude angelica. used for the treatment of common cold, headache, neu-ralgia and arthralgia. Therefore we tested the effects of Angelica water extract on the liver-protec-live activities in the rats. The results obtained from liver microsomal enzymeassay, measurement of serum and liver alanine' aspartate aminotransferase andlipid accumulation indicated that angelica extract showed significant liver-protec-tive activities against benzo(a)pyrene poisoning.