포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

골아세포 MC₃T₃-E₁의 증식과 기능에 Insulin Like Growth Factor Ⅰ, Ⅱ 및 부갑상선 호르몬이 미치는 영향

윤현구,정호연,양인명,김성운,김진우,김광원,김영설,최영길,서광식 대한내과학회 1992 대한내과학회지 Vol.42 No.1

MC₃T₃-E₁골아세포군을 이용하여 IGF-Ⅰ과 Ⅱ를 투여하고 DNA합성과 골아세포기능을 측정하기 위해 PTH에 대한 C-AMP반응정도, alkaline phosphatase 활성도를 측정하여 다음과 같은 결과를 얻었다. 1) IGF-Ⅰ과 Ⅱ는 모두 DNA합성이 어느 농도까지는 증식효과를 나타내지만 그 이후에는 억제되는 양상을 보였다. 2) PTH에 대한 골아세포의 C-AMP반응으로 증가되었지만 IGF-Ⅰ과 Ⅱ의 투여시 농도변화에 따른 의미있는 변화는 없었다. 3) 본 실험의 조건에서 alkaline phosphatase 활성도는 증가되지 않았다. 이상의 결과로 MC₃T₃-E₁ 골아세포에 IGF-Ⅰ과 Ⅱ는 세포의 증식을 자극하여 PTH는 C-AMP생성을 촉진하는 효과가 있었다. The effect of insulin-like growth factor (IGF) Ⅰ and Ⅱ on cloned MC₃T₃-E₁ cells that had osteoblastic activity was examined by [³H] thymidine incorporation into DNA, cyclic AMP responsiveness to parathyroid hormone (PTH), and alkaline phosphatase activity. IGF Ⅰ and Ⅱ stimulated the growth and proliferation of osteoblastic cells at 20ng/㎖ and 50ng/㎖, respectively. We next examined the effect of IGF-Ⅰ and Ⅱ on the expression of osteoblastic activity. Adenylate cyclase response of PTH to IGF-Ⅰ and Ⅱ-treated cells showed maximal stimulation at 10 and 50㎚PTH, respectively, but IGF Ⅰ and Ⅱ induced limited activity of osteoblastic function. In conclusion, IGF-Ⅰ and Ⅱ were potent stimulators to the growth of osteoblastic cells but did not have an immediate effect on expression of osteoblastic function in this experiment.

스포츠 참가자의 라이프스타일 특성과 서비스 만족의 관계

윤승원,정경회,이일재,박영표 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

The analysis of the customers' mind is crucial in the modern society where marketing strategy is very important for the satisfaction of the customers. the purpose of this study was investigating the relationship between lifestyle characteristics and service satisfaction of sports center customer. To achieve this purpose, the population of this study are the participants of the swimming pool, bowling center, fitness club and golf club among the commercial sports center in Jeonju, Jeollabugdo. They are chosen by the multi-stage stratified random sampling considering the events and region. The valid samples are 420 persons at last among 500 persons except the 80 persons whose validity are determined low. To analyze the data, frequency analysis, factor analysis, t-test, ANOVA, regression analysis and covariance structural analysis are used in this study. In this study, those following results are gathered by analysing the data through above approaches. First, According to the background variation of the sports participator; material service to income, personal service to educational level and occupation, systematic service to sex and educational level, there are significant service satisfactions. Second, Lifestyle characteristics of the sports participator influence on service satisfactions significantly; persuit of the trend, social contact, nervousness and individualism influence on personal service social contact, persuit of the trend, nervousness and sentimentalism on systematic service and the other variations on material service.

경관 Simulation을 통한 수영강 연접지역의 건축물 고도규제 방안

윤시운,이광국,황영우 東亞大學校 建設技術硏究所 1999 硏究論文集 Vol.23 No.1

This study analyzes the future landscape assesment of Suyoung-River and adjacent areas. Computer Simulation method is used for these purposes. It is expected that the high buildings and high density in Suyoung Information Site might cover the Jang-Mountain view. Therefore this study analyzes the expectations by the experiment of the change of the heights of buildings and the view-point so that Suyoung Information Site can secure the feelings of openness and can be harmonious with natural landscape and skyline. If the high dense buildings are going to be constructed, the optimum condition of development should be between 1.5 and 2.0 of evaluation indicator. The minimum indicator 1.5 would be appropriate as the standard of regulation. The results show that the buildings along the riverside road in the west need to be regulated under the height of 30m(about 10 stories) and the buildings along the Chungryul-Street in the east under the height of 90m(about 30 stories). 하천은 산과 구릉지 등과 함께 도시의 아름다운 경관을 형성하는 중요한 경관요소이다. 도시내 하천변에 나타나는 경관문제는 대부분 대규모 건축물에 의한 경관 훼손에서 비롯된다. 부산의 대부분 하천은 시가지를 통하여 바다로 유입되고 있으나 대부분 복개되었거나 주변지역의 고층건물 입지로 인해 하천 자체가 시민에게 주는 정 (正)의 경관적 요소는 점점 감소하고 있다. 본 연구의 대상지인 수영강은 현재 시가지내를 흐르고 있어 시민에게 주요한 openspace로 기능하고 있다. 주변지역은 지금까지 수영 비행장이라는 기능으로 연해 개발이 유보되어 오다 최근 수영정보단지의 개발계획 등으로 인해 개발압력을 강하게 받고 있다. 향후개발이 진행된다면 수영강변에서 조망할 수있는 주변 자연경관과 시가지 경관은 차폐될 뿐만 아니라, 그 자체의 규모가 크고 형태도 단조로와 위압적이고 획일적인 경관이 형성되게 될 것이다. 현재에도 수영강변의 구릉지에는 아파트 가 입지하여 조망을 차폐하고 있을 뿐 아니라 녹지를 잠식하고 있다. 이러한 현상은 향후 개발압력에 빌려 수영강변의 어느 지역 에서나 발생하는 공통적인 현상이 될 것이다. 이러한 조망차폐, 획일성, 위압감의 조성, 지형의 훼손 및 잠식 등으로 대표되는 수영강의 경관문제는 현행법상 건축심의 시 받는 경관심의로 해결하기에는 한계가 있다. 따라서 본 연구는 수영강과 연접지역, 그리고 배경녹지축인 주변산을 공간적 범위로 하여 첫째, 수영강 연접지역의 범위를 설정하고 연접지역을 몇 개의 경관구역으로 나누어 각 경관구역별 경관의 문제점과 특성을 살펴본다. 둘째, 경관분석을 위하여 Computer를 이용한 수영강변 주요 조망점 에서 사람의 눈에 보이는 대로 주변 경관을 연출해 낼 수 있는 가상의 경관 Simulation을 실시한다. 셋째,이를 바탕으로 수영강 연접지역의 건축물 고도규제 를 위한 기준설정과 고도규제 방안을 제안하는데 목적이 있다.

사회과에서 학습자의 메타인지 수준이 학업성취도에 미치는 효과

윤주영,강운선 대구대학교 사범대학 부설 교육연구소 2007 敎育硏究 Vol.3 No.1

This study had an object to inspect the effect of meta cognition level come up to on learner’s learning attainment in social studies class. The general idea of Meta cognition for Knowing about one’s comprehension while one’s studying. Then examined this for better classwork. Meta cognition includes all of these processes. It’s based on constructivism. And it is a notion that is helping an active study. And comprehension level is a common goal as education reform plan. Because that would make an excellent addition which makes for the competition power security in the future. Therefore, if you analyze a Meta cognition level and a comprehension level, you can develop your abilities (self control ability in complicated situation, recognize by self control develop study efficiency). All of these processes show these are important things in social education text books. In this study, investigated thoroughly about the Meta cognition and social affairs division looked out a recent result before took this survey. It was surveyed about Meta cognition level in natural lesson situation. Then, we proved relation between their comprehensions (which was taken by each of their mid-term tests results) and their Meta cognitions through a statistical program, SPSS win 12.0. I choose 100 students in each school, then randomly selected except people who were not fitness of the test. We hypothesized dependent variable is a record of social studies, independent variable is Meta-cognition level, and variable of control is their characteristics This survey was taken from June, 2006 to July, 2006. First, the researcher explained the survey’s purpose and tenors to the schools, then got their agreements to do the Meta cognition test. We used mid-term test’s result in social studies education. As a result of this study, Meta cognition level affect learning attainment. 본 연구의 목적은 고등학생을 대상으로 메타인지 수준이 학업성취도에 미치는 효과를 밝히는 것으로서, 연구목적에 따라 "학습자의 메타인지 수준이 높을수록 학업성취도가 높을 것이다"라는 연구가설을 설정하였다. 연구가설을 검증하기 위하여 2006년 6월~7월까지 약 두달간 자료를 수집하였으며, 고등학교 2학년 학생 100명을 임의로 선정하여 교사의 지도아래 설문조사를 실시하였다. 가설을 검증하기 위하여 종속변인은 학업성취도(사회과 성적), 독립변인은 메타인지 수준, 그리고 통제변인(학습자 특성)으로 성별, 부모의 소득수준과 학력으로 이루어진 분석모형을 구성하고, 회귀분석을 실시한 결과 메타인지 수준이 학업성취도에 통계적으로 유의미한 영향을 미치는 것으로 나타나 가설은 채택되었다. 입시라는 현실적 여건에서 학생 자신은 물론이거니와 교사와 학부모 모두 학습자의 학업성취도에 대하여 민감한 상황에서 메타인지 전략을 통한 교육적인 처방을 통하여 학업성취도가 높아질 수 있는 가능성을 확인하는 계끼를 마련했다는 점에서 본 연구의 의의를 찾을 수 있다.

국내 원자력발전소의 사용후핵연료 선원항 평가에 관한 연구

윤인식,정운관,김성영,염유선,심재학 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.2

우리나라에서도 원자력발전이 상용화된지 이십여년을 넘어서면서 원자력발전을 하고 있는 다른 나라와 마찬가지로 사용후핵연료 관리가 국가적인 문제로 심각히 대두되고 있다. 중간저장 시설은 1997년부터 운영예정이었으나 현재 그의 부지가 아직 확보되지 못한 상태에서 그 운전개시 시점이 불확실하다. 그리고 중간저장 이후의 사용후핵연료 정기관리 전략이 아직 마련되어 있지 못한 실정이다. 그러므로 발전소에서 발생되는 사용후핵연료 양과 그에 따른 선원항 평가는 반드시 선행되어야 할 것이다. 이제 본 연구에서는 국내 사용후핵연료 형태중 17×17에 대해서 농축도와 연소도 그리고 냉각시간별로 선원항 평가를 하였다. 사용후핵연료 선원항 평가를 위해 미국 Nuclear Regulatory Commission(NRC)의 인·허가 코드인 SCALE 코드를 이용하였다. 선원항 평가는 SCALE 코드의 모듈을 이용하였다. 선원항 평가 결과 농축도와 3.5 w/o와 연소도 35 GWD/MTU 일때 Cooling Time 0.3년은 7.5651E+16, 1년 2.8954E+16, 3년 9.8242E+15, 5년 5.4000E+15, 10년 3.0945E+15으로 계산되었으며, Cooling Time이 0.3년일때와 10년일때의 Source Term이 크게 차이가 남을 알 수 있었다. 방사선량율은 10 ㎝부터 500 ㎝ 까지 거리에 따라 선량율에 대하여 10 ㎝ 4.8365E+03(㏉/hr)에서 500 ㎝ 7.8456E+01으로 감소함을 알 수 있었다. 현재 국내 사용후핵연료에 대한 선원항 평가가 이루어지지 않았으며, Data Base 구축이 기초단계 이므로 이러한 기초자료는 추후 저장조가 건설되면 사용후핵연료 안전성과 관련하여 사용할 수 있는 것이고 기초 Data Base구축하는데 이용할 수 있을 것이다 As nuclear power has been used in our country over 20 years, spent fuel management is raised seriously as one of the national`s problems, which lies in similar situation to other countries having nuclear power plants. An interim storage facility has been planned to operate in 1997, it is highly uncertain whether this facility will start to operate by the time because the site has not been decided yet. After the intermediate storage, the spent fuel periodical management strategy has not prepared yet. Therefore it has to be preceded that the spent fuel quantity which is happening at the power station and the following source term. Now the main have evaluated the source term according to enrichment, burn-up, and cooling time for 17×17 of spent fuel form. I used the SCALE code which were certified by Nuclear Regulatory Commission(NRC) for the source term calculations of Spent Fuel. The source term was calculated, which reflected the feature of target nuclear fuel using ORIGEN-S, a module of the SCALE Code, and the exposure dose rates were calculated by using the QADS modules, considering the geometry. When the enrichment in the evaluated result of source term is 3.5 w/o and the burn-up is 35 GWD/MTU, the cooling time 0.3year is 7.561E+16(photon/second), 1year 2.8954E+16, 3year 9.8242E+15, 5year 5.400E+15, 10year 3.0945E+15 and found that the big difference in Photon Spectrum of cooling time 0.3year and 10year. I have found that radiation dose rate is decreased in 10㎝ 4.8365E+03(㏉/hr) into 500 ㎝ 7.8456E+01 for dose rate according to distance from 10 ㎝ to 500 ㎝. It is not made the source term evaluation on the domestic spent fuel, and since the data base construction is basic level, some time later, if the storage place is constructed, in connection with the safety, these basic data can be used and we can construct these basic data base.

골프기능 수행과 몰입경험에 관한 연구

윤기운,조영권 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

This study examined the flow experience and golf performance. 230 golfers completed the flow questionnaire. That is to assess flow experience in golf performance. Results of this study showed as follows ; The First, there were difference in flow experience of golfer as a function of ability level. participant period, and practice time. And, there was more flow experience of man golfer than that of woman golfer. Second, participant period of golfer have positive effect on flow experience. In Conclusions, Continuance period of golf participant is very important on flow experience in golf performance.

정상과 갑상선 종양조직에서 사람 IGF-I 유전자의 발현

김성운,장현하,박상미,김덕윤,우정택,양인명,김진우,김영설,김광원,고석환,홍성화,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

Many of the growth-promoting properties of growth hormone(GH) are mediated by insulin-like growth factor-I(IGF-I), a highly conserved circulating 70-amino acid peptide. Recent studies have shown that multiple mechanisms influence IGF-I gene expression, including transcription from two promoters, alternative RNA splicing, and variable polyadenylation. In thyroid tissue, thyroid stimulating hormone(TSH) and IGF-I are the most possible candidates for follicular cell proliferation and hypertrophy. Actually IGF-I had autocrine and paracrine effect for tissue growing. We prepared thyroid tumor tissue mRNAs using single step method for detecting IGF-I levels according to different tissues, i.e., thyroid adenoma or papillary thyroid carcinoma. We used Northern blot analysis for IGF-I mRNA and RNase protection assay (RPA) for IGF-I transcription start sites. For Northern blot, we used whole human IGF-I cDNA as a DNA probe and for RPA, we used IGF-I exon 1 containing noncoding promoter 1 as a riboprobe. We got good RNA bands from Northern blot analysis around 1 kb (IGF-IA) and 7.5 kb (IGF-IB) region. To clarify the amount of both IGF-IA and IB mRNAs, we measured autoradiographied signal of IGF-I mRNAs bands using densitometer. In IGF-IA signals, there's no change among liver and thyroid tissues, but in case of IGF-IB mRNA bands, the signal was markedly increased in thyroid carcinoma tissues than that of normal thyroid tissue (85% vs 14%). In the study of RPA, all thyroid tissues used the same transcription start sites as those of liver's. We concluded that that this different regulation of IGF-I mRNA was originated from tissue specificity. That meant some tissue specific transcription factor/s were related to tissue IGF-I expression.

자연 친화적 골프장 건설을 위한 방안

조영권,윤기운 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

Golf has been attracting sensational popularity as public sports in the countries such as Europe and Japan as well as the United States which can be said an advanced country of sports. Furthermore, in recent years, the population who enjoys golf is rapidly growing to the extent that it can take large share in the national economic part so that terms of 'golf industry' and 'golf tour' may appear. Differently from the worldwide trends, golf in our country cannot remove the recognition that golf is 'luxurious amusement' or 'the principal offender of environmental pollution' so that it has resulted in various social or environmental conflicts. The conflict between the golf and the environment is an original conflictive problem in terms of 'exploitation and preservation.' The researcher is going to suggest a method to minimize ecological conflict which is generated in construction and operation of golf course from the viewpoint of development of environment rather than complete settlement. Therefore, this dissertation was trying to suggest co-existence plans of the natural environment factors and construction of golf course through the results from analyzing related precedent research, conclusions were obtained. First, a systematic plan for improvement should be searched so that the System of Evaluation for Environmental Influence which is currently executed could be operated more efficiently in order to minimize the environmental problems which appear when golf course is constructed. Second, as for a plan to push forward constructing a golf course for effective use of land, the current construction manner of golf course which has disproportionately been constructed in particular districts should be controlled, instead, the disperse construction in city or province should be induced. Furthermore, a plan to construct golf course which is environmentally affinitive so that it can make the most of natural spectacle, considering the characteristic of configuration of the ground should be contrived. Especially, the systematic plan for improvement should be worked out to relieve the locational conditions so that some small scaled golf courses (6 hole, 9 hole) can be constructed by means of composing green zone in green belt district, waste reclamation field, or abandoned mine district to secure rest area for citizens. Third, re-utilization of purified water of golf course and installation of artificial reservoir should be completely made as a duty in order to settle conflict against regional residents because of phenomenon of insufficient underwater and agricultural water upon managing the golf course. Fourth, as for a problem of spreading agricultural chemicals which is the most negative conflictive factor according to the result of consciousness of investigation of golf and environment, the rather rational synthetic controlling system against damage by noxious insects should be established and practiced effectively. Fifth, a method to make the most of regional residents actively should be investigated when weeds are removed and agricultural chemicals for golf course are spreaded in order to solve the negative view of regional residents about spreading agricultural chemicals over golf course.