기능성 소화불량증환자에서 Winstal® 투여에 관한 임상경험

이창형,김영탁,금민수,권중구,안병철,윤영미,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.3

목적 : 기능성 소화불량증은 소화, 흡수등 장관의 기능적인 이상과 관련되어 있을 것으로 생각되며 복합소화효소제(Winstal®)를 투여하여 그 임상효과를 평가하고자 본 연구를 실시하였다. 대상 및 방법 : 1994년 3월 부터 6월까지 경북대학교병원 내과를 방문한 기능성 소화불량증을 호소하는 환자 20명을 대상으로 Winstal®을 1회 1정씩, 1일 3회 식후 30분내에 경구로 2주간 투여하였다. 결과 : 소화불량증의 증상은 복부불쾌감, 복부팽만감, 식욕부진 및 오심, 복부동통, 공기연하증, 고창 및 구토순이었으며, 증상의 개선은 복부불쾌감이 76.4%(13/17)로 가장 높았으며, 그 다음으로 복부팽만감 및 공기연하증이 66.5%(10/15, 6/9)이었고, 오심 61.5%(8/13), 식욕부진 53.8%(7/13), 복부동통 41.6%(5/12), 고창 37.5%(3/8)이었다. 각 환자별 종합적인 증상의 개선도는 현저한 개선이 2예(10%), 중등도 개선이 3예(15%), 약간개선이 11예(55%), 불변이 4예(20%)이었으며 종합적인 유효율은 80%(16/20)이었다. 부작용은 한 예에서도 관찰되지 않았다. 결론 : 본 제제는 기능성 소화불량증 환자의 증상개선에 추천할 만한 유효한 약제로 생각된다. Dyspepsia is a common symptom in gastroenterologic practice and trigger for numerous consultations with physician. The treatment of chronic functional dyspesia is unsatisfactory. This study was performed to evaluate the efficacy of the digestive compound (Winstal®) on 20 functional dyspepsia patients. On open trial, all patients were given 6 tablets daily for 2 weeks and we evaluated the efficacy of this preparation according to the degree of the improvement. The improvement of symptoms was 76.4%(13/17) in abdominal discomfort, 66.5%(10/15, 6/9) in abdominal distension and aerophagia, 61.5%(8/13) in nausea, 53.8%(7/13) in abdominal pain, and 37.5% (5/12) in flatulence, respectively. Overall effectiveness of subjective symptoms was 80% (16/20) and there were no untoward effects of the preparations during this study. As a result, We think that this preparation is an effective one to relieve symptoms of functional dyspepsia.

투입-산출관계에 따른 연관산업 간 공간적 영향력 형성에 관한 연구 : 인천시 제조업의 주력업종을 중심으로 Focused on the leading categories of manufacturing and the related industries in Incheon city

탁영식,이동배 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

This is the second part of our study concerning reorganization of Industry locations in Incheon city The aim of this study is to extrapolate the spatial influence of the five leading categories of manufacturing and the related industries In connection with spatial distribution. Using regression equation based on Gravity Model, we tried to estimate Spatial Influence Index of leading categories, the result of which was analyzed to deduct the systematization tendency of the leading categories and their distribution in Incheon city. The Implications of the result to the policy-making can be summarized as follows 1) Designation of a certain industrial area as a target of relocation can possibly result in the weakening of the leading categories of manufacturing industries by letting them to lose their competitiveness Accordingly, the policy-making should be guided by careful consideration on the characteristics of industries examined by types and regions 2) Considering the fact that the four leading categories have reached a certain degree of formation of interrelationship among themselves, It is recommended to reorganize the industrial location m the course of strengthening the possibility of mutual influence with the rest of the related industries 3) If industries excluded from the leading categories are proved to be highly interrelated with them, the integration of such industries with the leading categories should be taken into consideration in the policy-making of the industrial reorganization

인터넷상에서의 실시간 주문형 비디오 설계 및 구현

탁영봉,이종철 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1998 自動化 및 컴퓨터應用技術 Vol.5 No.1

In implementing real time video on demand(VOD), the increase of user on internet causes a network traffic congestion. In this paper, we programmed a CGI able to login in VOD home for limiting the number of user in solving the problem, and also applied an adaptive multimedia synchronization technique for controlling video and audio data in a network. In addition, a real time multimedia player was designed and implemented in a personal computer operating at Window95/98/NT.

新技術 中小企業의 企業價値評價 硏究

이영탁 성균관대학교 한국산업연구소 2000 韓國經濟 Vol.27 No.--

The purpose of this study is to find out the factors that cause the difference between the market value and the intrinsic(fundamental) value, to develop a model that can explain the difference, and to propose a new method of valuating venture companies. Intrinsic value is calculated based on "the standard for deciding the underwriting price of publicly offered stocks," which is based on discounted cash flow analysis. the higher market value of venture companies over their intrinsic value has raised the argument that there is bubble in their stock prices. Since we used the data of only 64 venture companies, there are limitations to generalizing the results of the study, and further research is necessary. It is imperative to develop a method for valuating venture companies that incorporates quantitative value as well as qualitative value such as manpower value, business-model value, and technology value.

CA 125치가 증가된 난소종괴 환자에서 악성 감별을 위한 CA 15-3과 TAG 72의 효용성

이수미,김영탁,정동근,남주현,목정은 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

The purpose of our study was to evaluate whether the combined use of serum tumor markers, CA 15-3 and TAG 72 could improve the efficacy for discriminating malignant from benign ovarian masses in patients with elevated serum CA 125 levels. Serum CA 15-3 and TAG 72 were preoperatively measured by immunoradiometric assay in 78 patients with pelvic masses who had elevated serum CA 125 levels above 35 U/ml. In 32 patients with epithelial ovarian cancers, serum CA 125 levels were elevated above 65 U/ml in 97% and serum CA 15-3(>30U/ml) and TAG 72(>10 u/ml) levels were elevated in 59% and 50%, respectively, suggesting relatively low sensitivity of CA 15-3 and TAG 72. However, in 41 patients with benign ovarian tumors, elevations of these two markers were detected only in 7% and 5%, respectively, and particularly, both markers were not elevated among all the aptients over 50 years of age. Coordinate elevations of CA 125(>35U/ml) and CA 15-3(>30U/ml) or TAG 72(>10 U/ml) could discriminate epithelial ovarian cancers from benign masses with a sensitivity of 72% and specificity of 90%. Among patients over 50 years of age, sensitivity and specificity were increased to 79% and 100%, respectively. It is concluded that the combined use of CA 15-3 and TAG 72 with CA 125 could obtain an improved efficacy for discrimination of epithelial ovarian cancer, especially among patients over 50 years of age.

제조업의 주력업종 선정에 관한 연구 : 인천시 제조업의 생산액을 중심으로 Based on the production output of the manufacturing industry in Incheon City

탁영식,이동배 대한건축학회 2004 대한건축학회논문집 Vol.20 No.9

The City of Incheon has the necessity of reorganizing the actual industrial structure for her continuous growth In the future. This study is aiming at the selection of the main categories of industry that can play leading role for the regional economic growth of Incheon City For this purpose we analyzed time series data of output industrial classification from four different angles of Location Quohent, Impact on the Gross Regional Domestic Product by gross output, Concentration Ratio and Output Rate of industry held Especially, for the most effective clarification of the conjuncture, we adopted the factor analysis and regression analysis with use of SPSS 100 The result led us to choose five leading categories m the manufacturing industry of Ineheon as Food & Beverage product, Manufacture of basie metals, Assembling metal-products, and Machinery and Transport equipment. Food and beverage product has the high growth potential under the favorable condition of the large-scale market m capital region Other four categories have strong opportunity with the possibility of enhanced technological cooperation among themselves with the major role of Machinery and Transport Equipment category. The implication of the result to the policy-making can be summarized as follow. 1) The proportion of Food and Beverage product, Manufacture of basic metals and Transport equipment has been decreasing Therefore, It IS necessary to support for the strengthening of the market competitiveness 2) For the industries with high concentration ratio challenged by the big enterprises should be encouraged m order to keep them m Incheon 3) The minor manufacturing industries having huge effect In connection with the main category of manufacturing industry are also needed to bring up

CC Chemokine CKβ8의 발현 조절 물질 탐색 및 저해활성 물질 분석

김탁용,이태훈,백남인,정대균,김지영 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

CKβ8은 CC 케모카인의 부류에 속하는 사이토카인의 일종으로, 단핵구, 호염구, 호산구, T 림프구, 자연살해세포, 수지상세포 등의 화학주성물질로 작용하는 것으로 알려져 있다. CKβ8은 염증반응 및 혈관신생 등과 같은 여러 가지 생체 반응에 역할을 하는 것으로 알려져 있다. 본 논문에서는 사람 CKβ8 유전자의 전사저해 물질을 선별하기 위하여 CKβ8/Luc 유전자를 발현하는 세포주를 확립하였다. CKβ8 유전자의 전사시작점에서 -299 부터 +10 프로모터 부위를 PCR에 의해 얻은 다음 포유세포 발현 플라스미드에 클로닝하였다. CKβ8/Lvc 유전자는 U937 세포내에서 PMA에 의해 10배 이상 발현이 증가한다. CKβ8/Luc 발현 U937 세포주는 식물 추출물에서 전사 저해제를 탐색하는데 이용되었다. 46 개의 식물 추출물 중에서 6개가 90% 이상 CKβ8/Luc의 전사를 저해하였다. 이들 물질에 대해 세포 독성 실험을 수행한 결과 그 중 한 개만이 세포 독성이 거의 없는 것으로 나타났다. 이 추출물은 붉나무에서 얻은 추출물이며 이 식물 추출물은 염증관련 질환에 대한 가능성이 있는 치료제로 이용될 수도 있을 것으로 추측된다. Ckβ8 belongs to a family of CC chemokines, which is known to act as a chemoattractant for monocytes, basophils, eosinophils, T lymphocytes, NK cells, and dendritic cells. CKβ8 is known to play roles in various biological processes such as inflammation and angiogenesis. In the present study, we developed U937 cell line expressing CKβ8/Luciferase fusion gene for screening of transcriptional inhibitors for human CKβ8 gene. Genomic sequences that contain CKβ8 promoter region from 299 to+10 nucleotide from the transcription start site was amplified by PCR and cloned into mammalian episomal plasmid. The CKβ8/Luc fusion plasmid was introduced into human promonocytic U937 cells and selected for stable U937 cells expressing the fused reporter gene. The expression of the fusion gene was induced by more than 10 folds upon treatment of phorbol myristate acetate. The stable U937 transfectant cells were used for searching transcriptional inhibitors for human CKβ8 gene from plant extracts. Among 46 plant extracts tested, six extracts exerted more than 90% inhibition of PMA-induced CKβ8 transcription. Cytotoxic tests demonstrated that one of extracts, which was extracted from Rhus chinensis Mill, had little cytotoxic effect. The extract may be used for developing a potential therapeutic agent for inflammatory diseases.

지능기법을 이용한 가공시스템의 설계 및 모니터링에 관한 연구

金永卓,文熙根,金秀貞,金寬衡,李尙培 한국해양대학교 산업기술연구소 2003 연구논문집 Vol.20 No.-

본 논문은 지능 기법과 영상처리기법을 이용하여 특정 대상물의 절단위치를 검색하는 방법을 제시한 것으로서, 최근에는 기존의 아날로그 센서를 대신한 CCD(Charge-Couple Decive)카메라로 얻어진 화상 데이타(data)를 이용하여 물체의 정보를 추출하는 방법이 많이 응용되고 있다. 최근에 영상의 형태학, 신경망, 지식기반의 영상 해석 시스템에 대한 관심이 높아지면서, 거의 모든 분야에 화상처리기법들이 사용되어지고 있다. 따라서 본 논문에서는 실시간 그레이 레벨의 입력 화상에 대하여 영상처리기법을 이용하여 특정 물체의 특정위치검출 방법을 제안하고, 실제의 시스템에 적용한 예를 제시하려고 한다. In this paper proposed detecting specific position of the object using intelligent method and image processing. Recently instead of classifying the object by shade using existing analog sensor, app.y a theory to detect of the object information by using image data from CCD camera. It takes interest in the morphology of image, neural networks and image analysis system on knowledge base. and now days, image processing method was used in the most part of field. So, In this paper proposed detecting method on specific position of specific object about real time gray level input image using image processing method and application case in real system.

5-FU 투여후 백서 가슴샘에서 일어나는 형태학적 및 생화학적 변화

손영탁,김선,정옥,한승로,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Thymus is a lymphoid organ forming T-cells from hematogenous stem cells. Apoptosis of thymocytes in the cortex of thymus is so rapid that cannot find easily with routine histological techniques. In this experiment, TUNEL immunohistochemistry and TEM were used to detect apoptotic changes after 5-fluorouracil treatment in the thymus of the rat. In addition, SDS-PAGE was carried to reveal protein changes along the apoptotic changes. The results were as follows ; 1. Thymocytes in the cortex were decreased markedly and many apoptotic cells were found in the cortex on DAT 3. 2. Relatively small-sized apoptotic bodies induced by 5-FU were detected on DAT 3 at the cortex, and clustered in partly. 3. On DAT 6, new germinal centers formed in the peripheral cortex, and many apoptotic bodies of various size and shapes were detected in the germinal center. 4. In SDS-PAGE, a protein with molecular weight of 123kDa was increased on DAT 6. According to the above results, it could be concluded that 5-FU acted directly on the thymocytes and induced apoptotic changes on DAT 3. But, on DAT 6, the period of recovery, new germinal centers were formed in the cortex, in which active B cell production to compensate the loss of thymocytes was noticed. To make new T-cells from B-cells and to eliminate unnecessary B-cells, vigorous apoptosis in the germinal centers should occur, and 123kDa proteins which considered as integrins should act as transmembrane signaling molecules in this process.

원가 진단을 위한 자원소비변화 지표

홍영탁,유정호,이현수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In order to prevent cost overrun, it is required to check the cost overrun factors periodically. The purpose of this study is to suggest three indexes that can help diagnosing construction cost. Total construction cost can be decomposed into individual cost items according to resource consumption. Therefore, it is necessary to control resources that may cause cost variance. The three indexes suggested in this paper are variance of total resource input, variance of individual resource input, and variance of resource balance, where the resource input and resource balance are measured as cost.