결핵 환자에서의 뇨중 Neopterin의 측정

김선영,이경주 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

Assessment of disease activity in pulmonary tuberculosis is difficult when AFB is not demonstrated in smear or culture of specimen. To elucidate the usefulness of urinary neopterin as an activity index of pulmonary tuberculosis, urinary neopterin and creatinine ratio were measured in 24 normal healthy controls, 8 inactive pulmonary tuberculosis and 16 active pulmonary tuberculosis by high-performance liquid chromatograpy. Urinary neopterin creatnine ratio in normal healthy control and inactive pulmonary tuberculosis were 1.15±0.63nmol/㎎ of Cr AND 0.515±0.63nmol/㎎ of Cr, respectively. Urinary neopterin/creatinine ratio in total active pulmonary tuberculosis patient was 4.62±4.91nmol/㎎ of Cr. In minimal active pulmonary tuberculosis, the ratio was 5.49±6.56nmol/㎎ of Cr and in moderately advanced active pulmonary, the ratio was 3.35±3.08nmol/㎎ of Cr and in far advanced active pulmonary, the ratio was 5.12±4.47nmol/㎎ of Cr The difference of mean urinary neopterin levels between minimal, moderately difference of mean urinary neopterin levels between nomal controls and active pulmonary tuberculosis was statistically significant(P<0.005). It is suggested that urinary neopterin level could be an useful index of disease activity in pulmonary tuberculosis.

원예치료를 통한 여성재소자들의 사회성 및 대인관계 변화 연구

김미선,안경선,이진영,이상미,이시래,서정근 한국식물인간환경학회 2000 인간식물환경학회지 Vol.3 No.4

The purpose of this study was identify change for socialite and interpersonal relationship of female prisoner through horticultural therapy on 14 prisoners in ○○female prison located in Chung-Book. Measurement methods were used Scale of sociality, Scale of change for interpersonal relationship, Form for evaluation of horticultural therapy. The results were as follows; 1.After HTP, Sociality was increased on female prisoners. and there was statistically significant difference(p〈0.01). 2.According to low-ranking field of I-R, communication, sensitivity, openness were increased, satisfaction, confidence, a feeling of intimacy were decreased, understanding was the same after HTP. But the average was increased, and there was statistically significant difference(p〈0.01). 3.Form for evaluation of horticultural therapy showed a increase of participation, interest and assistance, verbal communication, interpersonal relationship. Through above result, horticultural therapy has positive effect far socialite and I-R on female prisoners.

발효 조건이 막걸리 술덧 유래 다당의 면역자극 활성에 미치는 효과

이영경(Young Kyoung Rhee),남소현(So-Hyun Nam),김혜련(Hye-Ryun Kim),조장원(Chang-Won Cho),이영철(Young-Chul Lee),김영찬(Young-Chan Kim),홍희도(Young-Chan Kim) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.12

본 연구에서는 가장 대중적인 한국의 전통주 막걸리의 제조과정이 기능성 분획에 미치는 영향을 확인하고자 하였다. Saccharomyces cerevisae 균주별, 발효온도별, 발효기간 별로 다르게 만든 막걸리로부터 ethanol 침전법을 이용해 crude polysaccharides(CP-M)를 분리하여 peritoneal macrophage 활성화 효과와 세포 배양액 중의 interleukin(IL)-6와 -12 농도에 미치는 영향을 조사하였다. S. cerevisae 89-1-1, 98-2, 268-3, 113-4의 4가지 효모 중 S. cerevisae 113-4로 발효한 CP-M을 peritoneal macrophage에 10 ㎍/mL 처리했을 때 세포 배양액 중 nitric oxide(NO) 농도 33.3 ㎛로 가장 높았으며, IL-6와 -12의 농도 역시 116.3 pg/mL와 59.8 pg/mL로 가장 높게 나타났다. S. cerevisae 113-4를 접종하여 온도별로 발효한 발효물에서 분리한 CP-M 중 25℃에서 발효 후 얻은 CP-M을 peritoneal macrophage 세포에 처리했을 때, NO 농도가 Control 대비 2.7∼3.3배, IL-6 농도는 5.7배까지 증가하였다. 그러나 15, 20, 30℃에서 발효하여 얻은 CP-M의 경우 peritoneal macrophage의 NO와 IL-6 생성량에는 Control(무처리구)과 비교하여 영향이 없었다. 발효기간별 영향을 관찰한 결과 5일째 술덧에서 분리한 CP-M에 의한 NO 생성량이 가장 높아 0일째 MCP에 비해 2.2배 증가하였다. 그러나 급격하게 IL-6와 -12의 농도가 감소한 10일째 MCP를 제외하고는 발효기간에 따른 IL-6와 -12의 유의적인 농도 차이는 없었다. 이상의 결과에서 가장 활성이 좋은 발효 조건은 S. cerevisae 113-4를 접종하여 25℃에서 5일간 발효시킨 술덧의 CP-M이었다. 이때 CP-M의 조성은 neutral sugar 함량 78.6%, acidic polysaccharide 11.6%, 단백질 9.8%였다. 특히 neutral sugar의 구성당 비율은 mannose 47.8 ㏖e%, glucose 29.6 ㏖e%, galactose 12.7 ㏖e%였다. 이상의 결과에서 면역증강 활성이 있는 기능성 조다당 CP- M은 mannose 함량이 높은 yeast 유래의 extracellular polysaccharide로 추정하였다. Various microorganisms are involved in the fermentation of Mageoli, Korean traditional liquor. Among them, the most predominant microorganism is yeast, including Saccharomyces cerevisae. This study investigated the effects of crude polysaccharides separated from Mageoli mash (CP-M) on activation of peritoneal macrophages in cell culture medium. Four types of yeasts, S. cerevisae 89-1-1, 98-2, 268-3, and 113-4, were used. When peritoneal macrophages were treated with 10 ㎍/mL of CP-M fermented with S. cerevisae 113-4, the concentration of nitric oxide (NO) in the medium was highest (33.3 ㎛). The concentrations of IL-6 and -12 were also highest at 116.3 pg/mL and 59.8 pg/mL, respectively. In the case of CP-M cultured at 15, 20, and 30℃ after inoculation with S. cerevisae 113-4 and fermented at different temperatures, production of NO and IL-6 by peritoneal macrophages did not change compared to the control. For CP-M obtained after fermentation at 25℃, however, NO concentration increased 2.7~3.3 fold and IL-6 concentration by 5.7 fold compared to the control. Furthermore, the effect of fermentation period on expression of CP-M functionality was examined. NO production by CP-M of the 5th day mash was highest, increasing 2.2 fold compared to 0-day CP-M. However, there were no significant differences in concentration of IL-6 or -12 according to different fermentation periods, although CP-M showed a large decrease after 10 days. The results show that fermentation conditions with the highest activity were observed in CP-M inoculated with S. cerevisae 113-4 and fermented at 25ºC for 5 days. CP-M consisted of 78.6% neutral sugar, 11.6% acidic polysaccharide, and 9.8% protein. In particular, the sugar composition of neutral sugar consisted of mannose (47.8%), glucose (29.6%), and galactose (12.7%). Based on the results, CP-M is assumed to be an extracellular polysaccharide originating in yeast with high mannose content.

문헌에 나타난 열무김치 및 열무물김치 제조 방법의 표준화

공창숙(Chang-Suk Kong),김도경(Do-Kyoung Kim),이숙희(Sook-Hee Rhee),노치웅(Chi-Woong Rho),황해준(Hae-Jun Hwang),최경락(Keyng-Lag Choi),박건영(Kun-Young Park) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.1

조리서 및 문헌을 통해 열무김치 및 열무물김치의 재료배합비 및 제조방법을 표준화하였다. 열무김치의 표준화과정에서 열무 이외에 사용빈도수가 50%이상인 부재료는 파와 홍고추였으며, 양념류로는 고춧가루, 마늘, 생강, 젓갈이 이에 속했다. 또한 재료 및 양념의 배합비는 절인 열무 100 g에 대해 파 8.0±3.8, 마늘 2.9±1.3, 생강 1.6±0.7, 홍고추 7.0±1.7, 고춧가루 4.2±1.2, 젓갈 3.7±0.5로 나타났다. 열무물김치의 표준화과정의 경우, 사용빈도수가 50%이상인 부재료로는 풋고추, 홍고추, 파가, 양념류로는 마늘, 생강, 전분이 이에 속했으며, 열무물김치의 재료배합비의 표준화는 첨가된 물의 양을 기준으로 하였다. 즉, 물 100 mL에 대해 절인 열무 50.6±10.8, 파 3.3±1.3, 풋고추 3.3±1.9, 홍고추 2.4±1.3, 마늘 3.0±0.7, 생강 1.5±0, 전분 1.5±0.6의 비율로 나타났다. Manufacturing method and ingredient ratio for young radish kimchi (yulmoo kimchi) and young radish watery kimchi (yulmoo mool-kimchi) were standardized from literatures. Ingredients having frequency of use greater than 50% were only used in the standardization process. Green onion, red pepper, red pepper powder, garlic, ginger, and anchovy juice were included in young radish kimchi. Green pepper, red pepper, garlic, ginger, and starch were included in young radish watery kimchi. The standardized ingredients ratio of young radish kimchi (yulmoo kimchi) on young radish 100 g was as follows: green onion 8.0±3.8, crushed garlic 2.9±1.3, crushed ginger 1.6±0.7, red pepper 7.0±1.7, red pepper powder 4.2±1.2, and anchovy juice 3.7±0.5. The standardized ingredients ratio of young radish watery kimchi (yulmoo mool-kimchi) on added water 100 mL was as follows: young radish 50.6±10.8, crushed garlic 3.0±0.7, crushed ginger 1.5±0, green onion 3.3±1.3, green pepper 3.3±1.9, red pepper 2.4±1.3, and starch 1.5±0.6.

Two Cases of Syncope As The Initial Presentation of Pulmonary Embolism

Rhee, Sang Jae,Kim, Nam Ho,Choi, Young Won,Cho, Eun Young,Kweon, Kyoung Hee,Choi, Eun Kyoung,Kim, Hak Ryul,Oh, Seok Kyu,Yang, Sei Hoon,Jeong, Eun Taik,Jeong, Jin-Won,Park, Ock Kyu 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

Pulmonary embolism presenting as an isolated syncopal spell can be a difficult clinical correlation to make. However, physicians must be vigilant with patients who have syncope, because this symptom may be the “forgotten sign” of life-threatening pulmonary embolism. The need for prompt diagnosis is clear, because with appropriate treatment the majority of patients may survive. We report two cases of pulmonary embolism-induced syncope and review the pathopuysiology of pulmonary embolism.

Case Reports : Tachycardiomyopathy Induced by Ventricular Premature Complexes: Complete Recovery after Radiofrequency Catheter Ablation

Kyoung Hoon Rhee,Ju Young Jung,Kyoung Suk Rhee,Hyun Sook Kim,Jei Keon Chae,Won Ho Kim,Jae Ki Ko 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.3

Ventricular premature complexes (VPCs) are known to be one of the most benign cardiac arrhythmias when they occur in structurally normal hearts. We experienced a 32-year old man who presented with dyspnea, palpitations and very frequent VPCs (31% of the total heart beats). Echocardiography revealed a dilated left ventricle (LV 66 mm at end-diastole and 57 mm at end-systole) and a decreased ejection fraction (34%). Very frequent VPCs had been detected 10 years previously and he underwent a failed radiofrequency catheter ablation (RFCA) procedure at that time. The patient had been treated with heart failure medications including betablockers, ACE inhibitors and spironolactone for the two most recent years. Six months after we eliminated these VPCs with a second RFCA procedure, the heart returned to normal function and size. Long standing and very frequent VPCs could be the cause of left ventricular dysfunction in a subset of patients who suffer with dilated cardiomyopathy, and RFCA should be the choice of therapy for these patients.

논문 : 열무김치 및 열무물김치의 발효특성과 in vitro 항암효과

공창숙 ( Chang Suk Kong ),김도경 ( Do Kyoung Kim ),이숙희 ( Sook Hee Rhee ),노치웅 ( Chi Woong Rho ),황해준 ( Hae Jun Hwang ),최경락 ( Keyng Lag Choi ),박건영 ( Kun Young Park ) 부산대학교 김치연구소 2005 김치의 과학과 기술 Vol.11 No.-

Does a small biopsied gastric specimen limit the usage of two directional transnasal esophagogastroduodenoscopy?

Rhee, Kyoung Hoon,Han, Hye Seung,Lee, Sun-Young,Seo, Tae Ho,Ko, Soon-Young,Kim, Byung Kook,Sung, In-Kyung,Jin, Choon-Jo,Min, Young Il Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.2

<P>Abstract</P><P>Background and Aims: </P><P>It is difficult to approach certain gastric regions due to the limited bending ability of transnasal esophagogastroduodenoscopy (TN-EGD). We analyzed the TN-EGD biopsied specimens according to where they were obtained inside the stomach.</P><P>Methods: </P><P>Two hundred and eighty-nine gastric biopsy specimens were obtained during diagnostic TN-EGD. The gastric biopsied specimens were quantified according to their diameter and depth in micrometers, and depth in layers (superficial mucosa, deep mucosa, muscularis mucosa and submucosa). The quality was measured by the degrees of anatomical orientation (good, intermediate and poor), presence of crush artifact (none to minimal, mild and moderate) and overall diagnostic adequacy (adequate, suboptimal and inadequate).</P><P>Results: </P><P>Poor orientation, presence of crush and overall diagnostic inadequacy were present in 33 (11.4%), 26 (9.0%) and 37 (12.8%) of the 289 specimens, respectively. Deep mucosa was present in 211 specimens (73.0%), while muscularis mucosa was present in only 75 specimens (26.0%). Specimens taken from the posterior aspect of the cardia exhibited the shallowest depth (<I>P</I> = 0.011), poorest orientation (<I>P</I> < 0.001) and poorest diagnostic adequacy (<I>P</I> < 0.001). Fluoroscopic findings demonstrated that the posterior aspect of the cardia was difficult to approach closely and perpendicularly because of the anatomical configuration of the stomach in nature.</P><P>Conclusion: </P><P>TN-EGD biopsied specimens obtained from the posterior aspect of the cardia exhibit limitations in both quality and quantity. When performing a biopsy using two directional TN-EGD, special attention should be paid to gastric lesions located on the posterior aspect of the cardia.</P>

The change of saponin profile in ginseng fermented by Ganoderma Lucidum

Young Chul Lee,Young Chan Kim,Sang Yoon Choi,Young Kyoung Rhee,Hee Do Hong,Chang Won Cho,Jeong Hac Rho 한국육종학회 2007 한국육종학회 학술발표회 발표요지 Vol.2007 No.6

The Immunomodulating Effects of Lactobacillus sakei K040706 and Nutritional Factors Affecting Its Cell Surface

Young Kyoung Rhee 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8