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Won Gil Chung,Hong Joo Kim,Young Gil Choe,Hyo Sun Seok,Chang Wook Chon,Yong Kyun Cho,Byung Ik Kim,Young Yool Koh 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.2
Background/Aims: The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients. Methods: The medical records of 88 treatment-naïve patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identifi cation Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment. Results: A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not diff er signifi cantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was signifi cantly lower among hazardous alcohol users (91.5% vs. 70.6%; P =0.033). Conclusions: Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was signifi cantly lower among the hazardous alcohol users. (Clin Mol Hepatol 2012;18:195-202) Background/Aims: The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients. Methods: The medical records of 88 treatment-naïve patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identifi cation Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment. Results: A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not diff er signifi cantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was signifi cantly lower among hazardous alcohol users (91.5% vs. 70.6%; P =0.033). Conclusions: Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was signifi cantly lower among the hazardous alcohol users. (Clin Mol Hepatol 2012;18:195-202)
( Won Gil Chung ),( Hong Joo Kim ),( Young Gil Choe ),( Hyo Sun Seok ),( Chang Wook Chon ),( Yong Kyun Cho ),( Byung Ik Kim ),( Young Yool Koh ) 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.2
Background/Aims: The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients. Methods: The medical records of 88 treatment-naive patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identifi cation Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment. Results: A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not diff er signifi cantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was signifi cantly lower among hazardous alcohol users (91.5% vs. 70.6%; P=0.033). Conclusions: Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was signifi cantly lower among the hazardous alcohol users. (Clin Mol Hepatol 2012;18:195-202)
Gil, Ji-Hye,Hong, Jong-Ki,Choe, Joong-Chul,Kim, Young-Hwan Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.8
The structures of molecular species of galactolipids, such as monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG), isolated from wheat flour have been investigated using negative-ion electrospray ionization (ESI) mass spectrometry interfaced with high performance liquid chromatography (HPLC). According to the result of HPLC analysis, MGDG and DGDG were found to consist of mixtures of five and four molecular species, respectively. The galactolipids have been also analyzed to determine their fatty acid compositions, using HPLC/ESI-MS combined with in-source (or cone voltage) fragmentation. HPLC/ ESI-MS is very useful for one-step analysis of mixtures of galactolipids with a small sample quantity. Especially, the carboxylate anions produced in in-source fragmentations of the negative-ion of each component separated by HPLC provide valuable information on the composition of its fatty acyl chains.
김지영,노현모,최준호,최성일,곽혜련 한국유전학회 1993 Genes & Genomics Vol.15 No.1
A rat liver cDNA library was screened for a prothrombin cDNA using a cDNA fragment coding human prothrombin as a probe. Among about 50,000 plaques, 30 positive plaques were obtained by hybridization with ^(32)P-labelled probe. The cDNA insert from two of the positive λ DNA were selected for further analysis of the prothrombin cDNA. The DNA sequence of the cDNA coding a rat prothrombin has been determined. It consists of 1950 nucleotides and encodes an ORF of 1851 nucleotides, 22 bp noncoding regions at 5' end and 97 bp noncoding regions at 3' end. It does not have poly A tail and poly A addition signal, AATAAA. Our cloned prothrombin cDNA differs by 6 nucleotides from already cloned rat prothrombin cDNA. It shows 80% homology with human prothrombin. Comparative analysis of region having considerable sequence homology between human and rat prothrombin suggests that the functional and structural domains and post translational modification sites in rat prothrombin cDNA can be mapped. The signal peptide, the cleavage sites, γ-carboxylated region, glycosylation attachment sites and the cleavage sites by Factor Xa in rat prothrombin can be presumed by comparative analysis. The rat prothrombin cDNA was expressed in E. coli as a fusion protein using glutathione S-transferase vector system.
Jeong, Sehee,Choe, Minhyeok,Kang, Jang-Won,Kim, Min Woo,Jung, Wan Gil,Leem, Young-Chul,Chun, Jaeyi,Kim, Bong-Joong,Park, Seong-Ju American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.9
<P>We report the electrical and optical properties of ZnO/ZnS core/shell nanowire (NW) devices. The spatial separation of charge carriers due to their type II band structure together with passivation effect on ZnO/ZnS core/shell NWs not only enhanced their charge carrier transport characteristics by confining the electrons and reducing surface states in the ZnO channel but also increased the photocurrent under ultraviolet (UV) illumination by reducing the recombination probability of the photogenerated charge carriers. Here the efficacy of the type-II band structure and the passivation effect are demonstrated by showing the enhanced subthreshold swing (150 mV/decade) and mobility (17.2 cm<SUP>2</SUP>/(V s)) of the electrical properties, as well as the high responsivity (4.4 × 10<SUP>6</SUP> A/W) in the optical properties of the ZnO/ZnS core/shell NWs, compared with the subthreshold swing (464 mV/decade), mobility (8.9 cm<SUP>2</SUP>/(V s)) and responsivity (2.5 × 10<SUP>6</SUP> A/W) of ZnO NWs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-9/am500731n/production/images/medium/am-2014-00731n_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am500731n'>ACS Electronic Supporting Info</A></P>
Effects of Boronic Acid on the Fluoride-selective Chemosignaling Behavior of a Merocyanine Dye
Cha, Sun-Young,Jeon, Hye-Lim,Choi, Myung-Gil,Choe, Jong-In,Chang, Suk-Kyu Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.5
The effects of boronic acid on the fluoride-selective chemosignaling behavior of a merocyanine dye were investigated. In the presence of phenylboronic acid (PBA), N-methylquinolinium-based merocyanine dye displayed fluoride-selective chromogenic signaling behavior over other commonly coexisting anions in the micromolar concentration range. Signaling is produced by a fluoride-induced displacement of the dye from its complex with PBA, resulting in a significant chromogenic signal for the fluoride ion. This signaling was successfully analyzed using a ratiometric analysis of the UV-vis absorption in response to changes in fluoride ion concentration. A PBA substituted with an electron withdrawing group was found to exhibit a more pronounced signal. Polymer-bound PBA also exhibited useful fluoride-selective signaling behavior.
최호섭(Ho-Seop Choe),옥철영(Cheol-Young Ock),장문수(Moon-Soo Chang),장명길(Myung-Gil Jang) 한국정보과학회 2002 한국정보과학회 학술발표논문집 Vol.29 No.1B
시소러스, 의미망, 온톨로지 등과 같은 지식베이스는 자연언어처리와 관련된 여러 분야에서 중요한 언어자원의 역할을 담당하고 있다. 하지만 정보검색, 기계번역과 같은 특정 분야마다 다르게 구축되어 이러한 지식베이스는 실질적인 한국어 처리에는 크게 효과를 보지 못하고 있는 실정이다. 본 논문은 한국어를 대상으로 한 시소러스, 의미망 등의 구축 방법론적 문제를 지적하고, 말뭉치를 중심으로 한 텍스트 언어처리에 필요한 의미망의 구축 방법과 포괄적인 활용 방안을 모색한다. 의미망 구축의 기반이 되는 지식은 각종 사전(dictionary)를 이용했으며, 구축하고 있는 의미망의 활용 가능성을 평가하기 위하여 ETRI의 ‘의미기반 정보검색’과 언어처리의 큰 문제 중 하나인 단어 중의성 해소(WSD)에서 어떻게 활용되는지를 살핀다. 그리하여 언어자원의 처리 방안 중의 하나인 의미망을 구축함으로써 언어를 효과적으로 처리하기 위한 기본적이면서 중요한 어휘 데이터베이스 마련과 동시에 언어자원 구축의 한 방향을 제시하고자 한다.