건설 예정의 Coil Center 운영에 대한 Simulation 분석

성덕현,윤원영,옥영석 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.52 No.-

본 논문은 건설예정인 coil center의 처리능력과 물류를 평가하기위한 시뮬레이션모델을 개발하는 연구이다. 경험적인 추정에 의한 야드에서의 수량, 저장시간의 분포를 구하고 3가지 운영대안이 제안되어 SLAMII를 이용한 시뮬레이션을 실시하며 최종적인 대안은 설비(Slitter)의 추가가 추천되어 이 것에 대한 시뮬레이션 결과를 분석한다. 그 결과 Slitter와 저장야드의 병목현상이 나타나므로 향후 이부분에 대한 기술적인 고려가 필요한 것으로 나타났다. In this paper, the simulation model is developed to evaluate the capacity and the material flow of the planned coil center. By the empirical estimation, the distributions of the quantity and the elapse time in the yard are obtained, and three alternatives are proposed. Based on the primitive simulation using SLAMII, the final alternative is prepared which includes one more facility (slitter), and the simulation is also performed. The result shows that the slitter and the storage yard are the bottleneck points throughout the slitting process. And the problem should be solved technically in managerial decision making related to construct the new coil center.

쇄골하정맥을 통하여 중심정맥도관 삽입 실패 후 나타난 혈흉 1예

김대영,김대우,손희원,박상진,이덕희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Central venous catheterization via an internal jugular vein or subclavian vein has become a common procedure in monitonng CVP and managing severely ill patients. However, there have beennumerous reports of complications associated with central venous catheterization. These include vessel injury, pneumothorax, hemothorax, nerve injury, arrhythmias, artriovenous thrombosis, pulmonary embolism, and infection at the insertion site. We report a case of hemothorax after subclavian vein catheterization failure, along with successful treatment.

장기간 체중부하 운동훈련이 흰쥐 노화 심근에 미치는 영향

박원학,조현국,이영실,정형재,이용덕 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1998 Journal of biomedical laboratory sciences Vol.4 No.2

장기간 체중부하운동이 흰쥐의 심근에 미치는 효과를 규명하기 위하여 생후 3개월, 10개월 및 20개월된 흰쥐를 5개월간 운동 시킨 후 각각의 비운동군과 비교하여 심근의 조직학적 ·세포학적 변화를 관찰하고, 심근세포내 미세구조적 변화를 입체해석학적으로 비교 ·분석하였다. 운동 15개월군부터 노화색소의 양이 현저히 증가되었고 사립체의 변성, 공포화 현상 그리고 간질조직의 증식이 뚜렷하였으며, 25개월군에서는 윤반분리, 근원섬유의 소실 및 과수축대 출현빈도가 증가되었다. Glucose-6-phosphatase의 활성도는 15개월 운동군에서 감소하여 25개월 운동군에서는 활성도가 거의 나타나지 알았다. 입체해석학적 결과에서도 장기간 체중부하운동으로 인해 15개월, 25개월군에서 모두 사립체와 근원섬유의 체적밀도는 감소되었고, 간질조직의 체적밀도는 증가되었다. 본 연구의 결과로 볼 때 장기간 체중부하운동은 3개월군에 있어서 심장에 미치는 역효과가 없으나 10개월군과 20개월군에서는 심근 기능강화에 역효과를 초래 할 우려가 큰 것으로 판단된다. There is considerable interests in the effect of regular, vigorous exercise, in particular weight training as a possible measure in improving myocardial function. The present investigation aimed to examine possible effect of a long-term weight training program on the heart in aging rats. Male rats aged 3-, 10-, and 20-month-old were divided at random into a control (sedentary) and the exercise group. The training group was exercised for 5 days a week by 1 RM of ten times with weight training apparatus. This investigation examined the changes of the heart muscle relative to histological, ultrastructural, cytochemical, and stereological studies in rats. Quantity of lipofuscin pigments was clearly increased in the weight training group of 15-month-old rats, and mitochondrial degeneration, vacuolization, and interstitial proliferation were observed as well. In the weight training group of 25-month-old rats the frequency as separated intercalated discs, fraying myofibrils and hypercontraction band increased in number compared with the same 15-month-old group. From the experimental result of glucose-6-phosphatase activity, the enzyme activities decreased in the weight training group of 15-month-old rats, and more decreased in the same 25-month-old group. In stereological study, both 15- and 25-month-old training groups, mitochondrial and myofibrilar volume densities significantly decreased, whereas interstitial volume density significantly increased. From the experimental results obtained in the present study, it is suggested that long-term weight training exercise do not cause any significantly qualitative and quantitative ultrastructural change of the heart muscle in the young. On the contrary, long-term weight training exercise stress may actually induce degenerative changes in the heart muscle in the old age.

전로제강 슬래그(BOF-Slag)를 이용한 고온탈황에 관한 연구

오광중,정덕영,최성원,조상원,손병현 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.51 No.-

고온 석탄연료가스의 탈황에 BOF-Slag의 이용가능성을 실험해 보았다. BOR-Slag의 온도, 유량, 탈황제의 특성등이 H₂S 제거효율에 미치는 영향을 조사해 본 결과, 최적의 H₂S 제거효율은 700℃에서 이루어졌고 입자크기가 작을수록 황포집능은 향상되었으나 0.214-0.631mm에서는 큰 영향이 발견되지 않았다. 조업온도 800℃이상에서는 탈황제의 응집으로 내부물질전달저항이 증가하여 탈황제의 반응성이 저하되었다. Experiments have been made to test the practical feasibility of using BOF-Slag to desulfurize hot coal-derived fuel gas. In this study, the effects of particle size, temperature, flow rate and sorbent characteristics on the H₂S removal efficiency of BOF-Slag were investigated. Experimental results showed that the removal efficiency of H₂S was optimum when the temperature was about 700℃ and the smaller sample size, the better sorbent capacity had and the sample size in the range of 0.214∼0.631mm didn't influence. When the temperature was above 800℃, the reactivity of sorbent has lowered because agglomeration of sorbent increased intraparticle transport resistance.

강릉시 5세 아동의 "조기 유아기 우식증" 관련 추정요인의 기술 역학적 연구

박진아,마득상,박덕영,박호원,이광수 大韓小兒齒科學會 2002 大韓小兒齒科學會誌 Vol.29 No.2

본 연구에서는 조기 유아기 우식증의 위험 인자를 규명하고 일치된 조기 유아기 우식증의 정의를 수립하는데 기초연구로서 층화집락추출법으로 선출된 강릉시 만 5세 유치원 아동들의 보호자 364명을 대상으로 이들 아동들의 조기 유아기 우식증과 관련된 형식·식이요인, 태아기나 출생기의 상태에 대한 설문조사연구를 시행한 결과 다음과 같은 결론을 얻었다. 1. 조사대상의 4분의 3이상(76.1%)의 아동이 생후 12개월 이후까지 연장된 수유를 하였으나 수면과 연관된 부적절한 수유의 빈도는 21.3%로 낮게 나타났다. 2. 대부분 보호자들(91.3%)이 이가 날 때부터 이를 닦아 주어야 한다는 사실을 알고있었음에도 불구하고, 맹출 직후 이를 닦기 시작한 경우는 35.1%에 지나지 않고 특히 2세 이후에야 이닦기를 시작하는 경우가 약 40%이상으로 조사되었다. 3. 현재 하루 칫솔질 회수가 1회 이상이 90%이상으로 매우 높게 나타났으나 5명 중 3명의 아동(61.4%)이 보호자의 도움없이 혼자 이를 닦는 것으로 나타났으며, 간식섭취 빈도는 하루 1-3회가 약 60%, 수시로 섭취하는 대상이 약 40%를 차지하여 비교적 높은 것으로 밝혀졌다(x^2-test, p<.05 or Fisher's exact test, p>.05). 4. 대부분(87%)의 첫 치과방문시기가 3세 이상인 경우로 나타나, 조기 유아기 우식증 예방에 대한 관심이 필요할 것으로 생각되었으나, 5세 아동의 예방적 치과방문 경험이 비교적 높을 것(40.2%)으로 보아 강릉지역 보호자의 구강건강에 대한 높은 의식수준을 반영한다고 볼 수 있다. 5. 보호자의 구강환경관리상태와 아동의 일일 평균 칫솔질 회수, 예방적 치과방문, 최초 치과 방문 시기와의 상관관계 및 지역별, 공사립 유치원별 및 남녀별 차이는 통계학적으로 유의하지 않았다(x^2-test, p>.05 or Fisher's exact test, p>.05). The purpose of this study was to get descriptive statistics of the contributing factors for early childhood caries and to predict the relationship of dietary, behavior factors and health status factors of the mother and child at pregnancy and after birth. 411 first caregivers of 5-year-old children in 12 kindergartens in Kangnung city were selected by stratified random cluster sampling. They were asked to fill out questionnaires and 364 of them responded The obtained results were as follow: 1. Over the three-Fourth of children used nursing bottle of had breast feeding habit beyond the age of 1 year. 2. 8.7% of respondents didn't recognize the necessity of the preventive measures immediate after eruption of primary tooth, and only 35.1% replied that they had begun tooth cleaning. 3. Over 90% of children brush the teeth more than once per day. But over half (61.4%) of them brush their teeth without parents instruction. Sixty percent of children eat between the meals as often as 1-3 time(s) a day and the remainder at any times. 4. The first time of dental visit was for most children (87%) at over 3 years, recommending the earlier dental visit. Notwithstanding the rate of routine dental visit experience was relatively high(40.2%), implicating positive parents' attitude about oral health at Kangnung area. 5. The relationships between oral health state of the parents and the variables such as the timing of the first tooth cleaning the frequency of brushing, the time of first dental visit, and the reason of first dental visit were not statistically significant. Together, there was no statistically significant difference between rural and urban area, private and public kindergarten, and boy and girl(x^2-test, p>.05 or Fisher's exact test, p>.05).

장기간 체중부하 운동훈련이 흰쥐 노화 심근에 미치는 영향

조현국(Hyung Gug Cho),이영실(Young Sil Lee),정형재(Hyeung Jae Chung),이용덕(Yong Deok Lee),박원학(Won-Hark Park) 대한의생명과학회 1998 Biomedical Science Letters Vol.4 No.2

장기간 체중부하운동아 흰쥐의 심근에 미치는 효과를 규명하기 위하여 생후 3개월, 10개월 및 20개월된 흰쥐를 5개월간 운동 시킨 후 각각의 비운동군과 비교하여 심근의 조직학적ㆍ세포학적 변화를 관찰하고, 심근세포내 미세구조적 변화를 입체해석학적으로 비교ㆍ분석하였다. 운동 15개월군부터 노화색소의 양이 현저히 증가되었고 사립체의 변성, 공포화 현상 그리고 간질조직의 증식이 뚜렷하였으며, 25개월군에서는 윤반분리, 근원섬유의 소실 및 과수축대 출현빈도가 증가되었다. Glucose-6-phosphatase의 활성도는 15개월 운동군에서 감소하여 25개월 운동군에서는 활성도가 거의 나타나지 않았다. 업체해석학적 결과에서도 장기간 체중부하운동으로 인해 15개윌, 25개월군에서 모두 사립체와 근원섬유의 체적밀도는 감소되었고, 간질조직의 체적밀도는 증가되었다. 본 연구의 결과로 볼 때 장기간 체중부하운동은 3개월군에 있어서 심장에 미치는 역효과가 없으나 10개월군과 20개월군에서는 심근 기능강화에 역효과를 초래할 우려가 큰 것으로 판단된다. There is considerable interests in the effect of regular, vigorous exercise, in particular weight training as a possible measure in improving myocardial function. The present investigation aimed to examine possible effect of a long-term weight training program on the heart in aging rats. Male rats aged 3-, 10-, and 20-month-old were divided at random into a control (sedentary) and the exercise group. The training group was exercised for 5 days a week by 1 RM of ten times with weight training apparatus. This investigation examined the changes of the heart muscle relative to histological, ultrastructural, cytochemical, and stereo logical studies in rats. Quantity of lipofuscin pigments was clearly increased in the weight training group of 15-month-old rats, and mitochondrial degeneration, vacuolization, and interstitial proliferation were observed as well. In the weight training group of 25-month-old rats the frequency as separated intercalated discs, fraying myofibrils and hypercontraction band increased in number compared with the same 15-month-old group. From the experimental result of glucose-6-phosphatase activity, the enzyme activities decreased in the weight training group of 15-month-old rats, and more decreased in the same 25-month-old group. In stereological study, both 15-and 25-month-old training groups, mitochondrial and myofibrilar volume densities significantly decreased, whereas interstitial volume density significantly increased. From the experimental results obtained in the present study, it is suggested that long-term weight training exercise do not cause any significantly qualitative and quantitative ultrastructural change of the heart muscle in the young. On the contrary, long-term weight training exercise stress may actually induce degenerative changes in the heart muscle in the old age.

거푸집 일체형 외단열 갱폼시스템의 전단내력실험

김호수,정희범,김소연,박영석,원종덕 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

The shear capacity is evaluated for the structural safety security of integrated gang form system for outer insulation. Therefore, this study presents the composition types of outer insulation system and evaluates the shear capacity for the several design cases. Through the results, we find out the influencing factors that affect the shear capacity.

Molecular and Kinetic Properties of Two Acetylcholinesterases from the Western Honey Bee, Apis mellifera

Young Ho Kim,Deok Jea Cha,Je Won Jung,Hyung Wook Kown,Si Hyeock Lee 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.10

We investigated the molecular and kinetic properties of two acetylcholinesterases (AmAChE1 and AmAChE2) from the Western honey bee, Apis mellifera. Western blot analysis revealed that AmAChE2 has most of catalytic activity rather than AmAChE1, further suggesting that AmAChE2 is responsible for synaptic transmission in A. mellifera, in contrast to most other insects. AmAChE2 was predominately expressed in the ganglia and head containing the central nervous system (CNS), while AmAChE1 was abundantly observed not only in the CNS but also in the peripheral nervous system/non-neuronal tissues. Both AmAChEs exist as homodimers; the monomers are covalently connected via a disulfide bond under native conditions. However, AmAChE2 was associated with the cell membrane via the glycophosphatidylinositol anchor, while AmAChE1 was present as a soluble form. The two AmAChEs were functionally expressed with a baculovirus system. Kinetic analysis revealed that AmAChE2 has approximately 2,500-fold greater catalytic efficiency toward acetylthiocholine and butyrylthiocholine than AmAChE1, supporting the synaptic function of AmAChE2. In addition, AmAChE2 likely serves as the main target of the organophosphate (OP) and carbamate (CB) insecticides as judged by the lower IC50 values against AmAChE2 than against AmAChE1. When OP and CB insecticides were pre-incubated with a mixture of AmAChE1 and AmAChE2, asignificant reduction in the inhibition of AmAChE2 was observed, suggesting a protective role of AmAChE1 against xenobiotics. Taken together, based on their tissue distribution pattern, molecular and kinetic properties, AmAChE2 plays a major role in synaptic transmission, while AmAChE1 has non-neuronal functions, including chemical defense.

The Influence of Acyclic Nucleotide Analogues on Renal Function in Patients with Chronic Hepatitis B

Won Young Park,Jae Young Jang,Yong Hun Kim,Soung Won Jeong,Dong Joon Oh,Eui Ju Park,Sae Hwan Lee,Sang Gyune Kim,Sang-Woo Cha,Young Seok Kim,Young Deok Cho,Hong Soo Kim,Boo Sung Kim,Ji Sung Lee 한국간담췌외과학회 2014 한국간담췌외과학회 학술대회지 Vol.2014 No.4

HCV, Alcoholic : O-023 ; Novel inhibitory effect of ginsenoside Rg3 in HCV replication and apoptosis

( Jae Young Jang ),( Eun Kyung Cho ),( Soung Won Jeong ),( Jin Woo Choo ),( Jin Nyoung Kim ),( Soon Ha Kwon ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background/Aim: Pegylated Interferon and ribavirin are standard therapy of chronic hepatitis C. There is an increasing need to identify more optimal strategies for treating this disease, especially viable treatment options for patients who are intolerable to interferon. We investigated the anti-HCV (Hepatitis C Virus) effect of ginsenoside using a HCV cell culture model. Methods: We used ginsenosides (Ro, Re, Rg1, Rg2, Rg3, Rh1, Rh2) with different concentrations (10, 25, 50, 100μM) for the treatment of JFH-1 (HCV) infected Huh 7.5.1 cells. MTT assay was performed for cytotoxicity of ginsenoside. JFH-1 mRNA, HCV core and cleaved PARP antibody were used for HCV replication and apoptosis, respectively. We compared HCV replication and apoptosis between ginsenoside-treated and interferon-treated JFH-1 infected Huh 7.5.1 cells. Activation of transcriptional factor was evaluated by NFκB. Results: 1) Cytotoxicity was minimal in ginsenoside-treated JFH-1 infected Huh 7.5.1 cells except 100 μM of Rh2. 2) Prominent decreased JFH-1 mRNA level and HCV core were found in Rg3 treated JFH-1 infected Huh 7.5.1 cells compared to other ginsenoside treated JFH-1 infected Huh 7.5.1 cells by Real-time PCR and western blot, respectively. 3) Marked decreased cleaved PARP was shown in Rg3 treated JFH-1 infected Huh 7.5.1 cells compared to other ginsenoside treated JFH-1 infected Huh 7.5.1 cells. 4) The degree of anti-HCV and anti-apoptosis after treating Rg3 was dose dependent manner. 5) The anti-viral and anti-apoptotic effect of Rg3 was very similar with interferon treated JFH-1 infected Huh 7.5.1 cells in a dose dependent manner. 6) Phosphorylation of NFκB was increased in Rg3 treated JFH-1 infected Huh 7.5.1 cells compared to other cell lines (p<0.001). Conclusion: Ginsenoside Rg3 has a marked anti-HCV effect without cell toxicity in JFH-1 infected Huh 7.5.1 cells in a dose dependent manner and this effect is mediated by induction of NFκB (Korean Patent Application No.:10-2012-0001800).