고요산동물에서의 익지인의 요산저하 효과

이영실,김지연,김승형,김동선,Lee, Young-Sil,Kim, Jiyoun,Kim, Seung-Hyung,Kim, Dong-Seon 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6

Objective : Hyperuricemia is a metabolic disease characterized by elevated blood uric acid levels, and its prevalence is rapidly increasing worldwide. Alpiniae Oxyphyllae Fructus (AO) belonging to Zingiberaceae is one of well-known traditional medicines in China and Korea, and has been used to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis traditionally. However, the effect of AO has not been studied. In this study we investigated the anti-hyperuricemic effect of AO, and the mechanisms underlying the effect in potassium oxonate (PO)-induced hyperuricemic rats. Methods : To examine the anti-hyperuricemic effects of the AO extract, serum uric acid levels were analyzed in normal and PO-induced hyperuricemic rats. The mechanism underlying the effects of the AO extract on uric acid levels was studied through xanthine oxidase (XOD) activity test and uric acid uptake assay in vitro. The chemical finger printing of the AO extract was analyzed using HPLC-DAD. Results : The AO extract significantly reduced serum uric acid levels in normal as well as PO-induced hyperuricemic rats. It also significantly inhibited the uptake of uric acid in oocytyes and human embryonic kidney cells (HEK293) expressing urate transporter (URAT)1, but not XOD activity in vitro. The chemical finger printing analysis of the AO extract showed nootkatone as a main component. Conclusion : The AO extract exhibits anti-hyperuricemic effects, and these effect were accompanied by increasing excretion of uric acid in kidney. Therefore, the AO extract could be used for prevention or treatment of hyperuicemia and gout.

퇴원한 정신분열병 환자의 재활을 위한 가족교육프로그램의 지침서

이영실 한국 정신보건 사회사업학회 1997 정신보건과 사회사업 Vol.4 No.-

정신분열병을 앓고 있는 퇴원한 환자의 대부분은 가정환경이 지지적이지 못하다. 가족은 심한 죄책감과 수치심에 사로잡혀 있으며 지나친 과잉간섭, 비판 혹은 분노 등의 잘못된 태도를 표현함으로써 상황을 더욱 악화시킨다. 또한 가족은 환자가 앓고 있는 병에 대해 체계적인 교육을 받지 못했기 때문에 잘못된 태도를 가질 수 밖에 없다. 본 연구는 퇴원한 정신분열병 환자의 가족에게 병에 대한 지식과 올바른 태도를 가르쳐 가족의 부담 및 고통을 덜어주고 환자의 재활치료에 도움이되는 환경을 조정하도록 만들기 위해 이에 대한 가족교육 지침서를 만들었다. 이것을 위해 전반적인 가족교육의 요소들과 내용들을 살펴보았다. 본 연구자가 고안한 가족교육 프로그램의 지침서는 실제 이 프로그램을 실시할 때 도움이 되도록 결과목표, 하위목표, 프로그램 내용 및 수행방법, 프로그램 매개체, 정신보건사회복지사 역할 및 과업, 환자의 역할 및 과업, 그리고 프로그램과정평가 즉, 평가지표, 측정도구, 평가방법을 제시했으며, 나아가 실제 가족교육프로그램을 효과적으로 수행하기 위한 당면과제를 제안했다. This guideline for a family education program was based on the synthetic studies on the rehavilitation of the discharged schizophrenics. The purpose of this article was to provide a practical model for mental health social workers to use on sites. Chapter 1 presented the importance of the family education as a part of the rehabilitation process and the overall objective of this study. In Chapter 2 and 3, a thorough review of relative literatures which played an essential role in this study was offered. Chapter 2 introduced the basic factors for an effective family education program and its diverse styles. Chapter 3 dealt with the preparatory work for the family education, total education of the schizophrenics, proper attitudes of the family, and any crucial skills in coping with the difficult situations. The conclusion of this article included the expected outcome, sub-goals, contents, intermedium and execution methods of the family education program, and the role and task of mental health social workers, and the schizophrenics. This section also contained the assessment process of the program: an assessment of a directing post, measurement instruments, and the assessment methods. The writer suggested to verify continuously the efficiency of this guideline for a family education program. She also shared other various opinions on family education programs for the discharged schizophrenics.

카바메이트 중독에 의한 급성췌장염 1례 : 증례보고 A case report

이영실,강승완 동국대학교 경주대학 1998 東國論集 Vol.17 No.2

카바메이트계 살충제는 임상적 작용은 유기인계와 비슷하지만 독성은 상대적으로 약하다. 카바메이트 중독에 의한 급성췌장염은 증상이 대개 경하나 드물게 심한 합병증을 초래할 수 있다. 이러한 합병증은 아트로핀의 조기 사용에 의해 피할 수 있다. 따라서 카바메이트 약물 중독환자에서 췌장 효소 측정 및 주기적 방사선학적 검사가 필요하며, 이를 통해 급성 췌장염을 빨리 인지함으로써 치료 및 예후를 향상시킬 수 있다. 저자들은 카바메이트 약물 중독으로 인한 급성췌장염을 경험하고 조기에 아트로핀을 투여하여 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carbamate insecticides produce a clinical picture of cholinergic excess similar to that of organophosphate toxicity. Pancreatitis secondary to carbamate insecticide toxicity is extremely rare but pancreatitis to organophosphate is relatively common and a few cases are previously reported. Poisoning by anticholinesterase insecticide was suspected by the observation of pinpoint pupils, the increased salivation, muscle fasciculations and mental confusion. We encountered a case of acute pancreatitis related to carbamate toxicity. A 34-year-old man was admitted to the Dongguk University Pohang Hospital for attempted suicide by ingestion of a carbamate insecticide (Huradan^ⓡ). There were no gallstone, alcohol intake history, drug ingestion influenced in pancreas except carbamate ingestion. Lipase was increased to 735 U/L, amylase to 939 U/L, ACCR 4%. Pancreatic CT findings were grade A of acute pancreatitis. Carbamate pesticides share the same risk of pancreatitis as organophosphorus pesticides and should be monitored similarly. We suggest that carbamate intoxication patients are monitored carefully by determination of pancreatic enzyme serum levels and serial ultrasonographic studies. Early recognition of acute pancreatitis in these patients may improve management and outcome.

해결중심 단기가족치료이론을 적용한 아내 구타 사례연구

이영실 한국임상사회사업학회 2006 임상사회사업연구 Vol.3 No.3

중복장애자녀의 부모교육을 통한 임파워먼트 향상에 관한 연구-지적 및 자폐성장애와 정신장애의 중복장애를 중심으로-

이영실,강윤경 한국임상사회사업학회 2009 임상사회사업연구 Vol.6 No.2

최근 장애인의 인구는 계속적으로 증가추세이다. 특히, 여러 유형의 장애 중 지적장애, 자폐성장애의 경우 성장하는 과정 중 비장애인과 여러 가지 측면에서 격차가 많이 발생하며 때로 뜻하지 않게 일시적이거나 영구적으로 정신장애라는 중복된 장애를 겪으며 살아야한다. 따라서 이들은 평생을 통해 지속적인 보호가 필요하며, 이러한 장애인을 돌보는 부모에게는 큰 부담으로 느껴진다. 본 연구는 중복장애자녀를 둔 부모들의 부담을 덜고 중복장애자녀의 지역사회통합화를 위하여 부모들의 임파워먼트가 중요하다고 보았다. 그리하여 지역복지관을 이용한 부모교육을 통하여 임파워먼트 향상에 대한 효과성을 알고자 본 연구를 하게 되었다. 결과로는 부모교육을 통하여 중복장애자녀의 미래준비에 대해 만족을 얻었으며 모든 프로그램을 통하여 심리적 안정을 통한 가족유대감을 형성하였음으로 전체적인 만족감을 표현하였다. 또한 대상자들이 자조모임을 형성함으로 하여 교육을 받은 부모들이 임파워먼트향상을 도모하였으며 앞으로 중복장애자녀를 양육하는데 있어 방향성을 제시하는데 도움이 되었다. Recently, disabled population has been continuously increased. Especially, for the intellectual disability / autism among many kinds of disability, children who suffer from such disabilities show big differences in various areas when they are growing, compared to ordinary children. Sometimes, they have to live with multiple disabilities caused by unexpected temporary and permanent mental disorder. Therefore, they must be given continual protections during their entire life and their parents who provide cares for them would have big burden. As this study recognized reducing such burden of parents and empowerment to parents for integration into the local society as important elements, it was carried out to find effects of education of parents pro-vided by a local welfare center on increase of empowerment. In findings, participants expressed overall satisfaction about the programs because they satisfied the preparation for the future of children with multi-ple disabilities by educating parents and formed family relationship with psychological stability by partic-ipating in all the programs. Also, it is shown that participants planned to increase empowerment to edu-cated parents through forming a self supporting group and the programs helped to show direction for bringing up their children who have multiple disability.

스포츠 지도자 멘탈코칭 프로그램 개발을 위한 교육요구분석

이영실,이경화 숭실대학교 영재교육연구소 2019 Global Creative Leader Vol.9 No.2

The purpose of this study is to analyze the educational need for mental coaching program development for sports leaders. Based on the previous research, the questionnaire for the educational needs analysis was prepared. The content validity was verified by one professor of pedagogy and two coaching experts, and 150 sports leaders were surveyed. The collected data was analyzed with t-test, Borich need assessment model and the Locus for Focus Model. The findings of this study showed that sports leaders recognized almost the importance and educational necessity of five sub-factors of mental control, self-regulation, coaching leadership, coaching skill and communication. According to the Borich’s educational need analysis, the ranked order was listening, emotion control, alternative search, concentration, and anxiety control. The results of the Locus for Focus Model were derived from the six components of concentration, behavior planning, listening, feedback, empathy, and understanding of others in the HH segment. Based on the results of this study, some implications were suggested. 본 연구는 스포츠 지도자를 위한 멘탈코칭 프로그램이 필요하다는 측면에서 교육요구분석을 통하여 스포츠지도자 멘탈코칭 프로그램에 포함되어야 할 멘탈코칭의 중요도와 교육 필요도 항목의 우선 순위를 규명하는 데에 목적이 있다. 선행연구를 분석하여 요구분석 설문지를 작성한 후, 교육학 교수 1명과 코칭 전문가 2명에게 내용타당도를 검증받았으며, 스포츠지도자 150명 대상으로 조사를 실시하였다. 수집된 자료는 SPSS 22.0 프로그램을 이용하여 t-test, 우선순위를 산출하기 위하여 Borich 요구도 분석, The Locus for Focus Model의 방법으로 분석하였다. 연구결과에서 스포츠지도자들은 멘탈조절, 자기조절, 코칭리더십, 코칭스킬, 의사소통으로 구성된 다섯가지 하위요인에 대해서 거의 대부분 중요성과 교육필요성을 인식하고 있었다. Borich 요구도 분석에 의하면, 산출된 순위는 경청, 정서조절, 대안탐색, 집중력, 불안조절 순서로 나타났다. The Locus for Focus Model로 분석한 결과는 HH분면에서 집중력, 행동계획, 경청, 피드백, 공감능력, 타인이해의 여섯 개 구성요인이 도출되었다. 본 연구결과를 바탕으로 몇 가지 함의가 제안되었다.

사회사업 교육에 있어서의 인간관계 이론에 관한 연구

이영실 한국 정신보건 사회사업학회 1994 정신보건과 사회사업 Vol.1 No.-

This study attempts to reflect on the theory of the human relationships in the following methods : Chapter one represents the issues raised, the objective and research method of the study. In chapter two, review of relative literature and study which played an essential role in this study are described. These contents describe four subjects as follows : 1. The Importance and The Necessity of Human Relationships 2. The Development Process of Humun Relationships 3. Johari's Self-Awareness Model 4. Communication and Human Relationships In chapter three, the researcher recommands a synthetic conclusion of the following three related to the theory of human relationships. First, clinical social workers or practitioners who consult on problems of clients, they should be trained on the theory of human relationships. Second, professors and practitioners who teach the theory of human relationships should be accumulated on the professional knowledge and training. Third, the researcher suggests the activation of the study for developing the theoritical knowledge and the training of the human relationships. This, therefore, should be kept on going, centering around "Korean Academy of Psychiatric Social Work."

Effect of Physical Composition, Molecular Weight of the Polymer, and Processing Condition on Control of Phase Morphology and Physical Properties for Polycarbonate-Poly(Butylene Terephthalate) Blends

이영실 한국고분자학회 2023 폴리머 Vol.47 No.3

In this study, the phase morphology of polycarbonate/poly(butylene terephthalate) (PC/PBT) blends was examined and the impact of chemical composition, molecular weight, and processing conditions on the phase morphology was determined. Through precise control of these variables, the researchers were able to create PC/PBT nano-blends with exceptional material properties and processing stability. The nano-blend showed remarkable fatigue and impact resistance, making it a strong candidate for use in mobile devices that are exposed to repeated stress and impact. The study also revealed that the PC/PBT morphology can be tailored from micro-scale to nano-scale by using the appropriate processing protocol, allowing for the desired properties to be achieved. The physical properties of the PC/PBT blends were explained in terms of their phase structures, thermodynamics, and kinematic principles.

코로나 19 범유행 후 재난적 의료비 현황

이영실 한국보건행정학회 2022 한국보건행정학회 학술대회 논문집 Vol.2022 No.2

Honokiol, Magnolol, and a Combination of Both Compounds Improve Glucose Metabolism in High-fat Diet-induced Obese Mice

이영실,최선실,Takayuki Yonezawa,우제태,김효정,차병윤,Toshiaki Teruya 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.4

Honokiol and magnolol are neolignans contained in the Chinese medicinal herb Magnolia officinalis that exert anti-tumor and anti-inflammatory effects. Both compounds have been reported to enhance glucose uptake. Little is known about effects when used in combination. The effects of honokiol, magnolol, and a combination of both compounds on lipid and glucose metabolism in highfat diet-induced obese mice were investigated, and underlying mechanisms were examined. All 3 treatments significantly (p<0.05) reduced plasma total cholesterol and glucose levels, and improved glucose tolerance, compared with controls. In addition, treatments increased mRNA expression of the peroxisome proliferator-activated receptor (PPAR)-γ, glucose transporter (GLUT)-4, and adiponectin genes in white adipose tissue (WAT). Both compounds individually and in combination significantly (p<0.05) increased Akt phosphorylation and GLUT4 protein expression in WAT compared to the control group. Honokiol and magnolol improve dyslipidemia and hyperglycemia and act synergistically when used in combination.