前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰

박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.

A family with NKX2.5 gene mutations presenting as familial atrial septal defect and atrioventricular block: A case report

Youn Young Choi,Min Hyung Woo,Gi Beom Kim,Mi Kyoung Song,Sang Yoon Lee,Eun Jung Bae,Murim Choi,Young-Sook Kim 대한의학유전학회 2018 대한의학유전학회지 Vol.15 No.1

Point mutations in the human cardiac homeobox gene NKX2.5 are associated with familial atrial septal defect (ASD), atrioventricular (AV) conduction disturbance, as well as sudden cardiac death. To date, more than 60 NKX2.5 mutations have been documented, but there are no reports in Korea. We are reporting the first Korean family with ASD and AV block associated with a novel mutation in the NKX2.5 coding region. A 9-year-old boy presented with a slow and irregular pulse, and was diagnosed with secundum ASD and first degree AV block. The boy’s father, who had a history of ASD correction surgery, presented with second degree AV block and atrial fibrillation. The boy’s brother was also found to have secundum ASD and first degree AV block. There were two sudden deaths in the family. Genetic testing revealed a novel mutation of NKX2.5 in all affected members of the family.

Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis.

Bae, Gi-Sang,Kim, Min-Sun,Park, Kyoung-Chel,Koo, Bon Soon,Jo, Il-Joo,Choi, Sun Bok,Lee, Dong-Sung,Kim, Youn-Chul,Kim, Tae-Hyeon,Seo, Sang-Wan,Shin, Yong Kook,Song, Ho-Joon,Park, Sung-Joo WJG Press 2012 WORLD JOURNAL OF GASTROENTEROLOGY Vol.18 No.25

<P>To determine if the fraction of Nardostachys jatamansi (NJ) has the potential to ameliorate the severity of acute pancreatitis (AP).</P>

Carpinus turczaninowii extract modulates arterial inflammatory response: a potential therapeutic use for atherosclerosis

Youn Kyoung Son,Sora Yoon,Woo Young Bang,Chang Hwan Bae,Joo Hong Yeo,Rimkyo Yeo,Juhyun An,Juhyun Song,Oh Yoen Kim 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.4

BACKGOURND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects. However, no study has reported the regulatory effect of C. turczaninowii extract on the arterial inflammatory response. This study therefore investigated modulation of the arterial inflammatory response after exposure to C. turczaninowii extract, using human aortic vascular smooth muscle cells (HAoSMCs). MATERIALS/METHODS: Scavenging activity of free radicals, total phenolic content (TPC), cell viability, mRNA expressions, and secreted levels of cytokines were measured in LPS-stimulated (10 ng/mL) HAoSMCs treated with the C. turczaninowii extract. RESULTS: C. turczaninowii extract contains high amounts of TPC (225.6 ± 21.0 mg of gallic acid equivalents/g of the extract), as well as exerts time-and dose-dependent increases in strongly scavenged free radicals (average 14.8 ± 1.97 μg/mL IC50 at 40 min). Cell viabilities after exposure to the extracts (1 and 10 μg/mL) were similar to the viability of non-treated cells. Cytokine mRNA expressions were significantly suppressed by the extracts (1 and 10 μg/mL) at 6 hours (h) after exposure. Interleukin-6 secretion was dose-dependently suppressed 2 h after incubation with the extract, at 1-10 μg/mL in non-stimulated cells, and at 5 and 10 μg/mL in LPS-stimulated cells. Similar patterns were also observed at 24 h after incubation with the extract (at 1-10 μg/mL in non-stimulated cells, and at 10 μg/mL in the LPS-stimulated cells). Soluble intracellular vascular adhesion molecules (sICAM-1) secreted from non-stimulated cells and LPS-stimulated cells were similarly suppressed in a dose-dependent manner after 24 h exposure to the extracts, but not after 2 h. In addition, sICAM-1 concentration after 24 h treatment was positively related to IL-6 levels after 2 h and 24 h exposure (r = 0.418, P = 0.003, and r = 0.524, P < 0.001, respectively). CONCLUSIONS: This study demonstrates that C. turczaninowii modulates the arterial inflammatory response, and indicates the potential to be applied as a therapeutic use for atherosclerosis.

연천 지역사회를 대상으로 하는 당뇨병 환자에서의 사망률 조사

배강우,안윤진,박용수,박경수,양병국,이홍규 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:1993년에 경기도 연천 지역에서 당뇨병의 유별률과 발생률을 산출하고자 시행된 한 단면연구의 대상자들을 추적 조사하고, 그 대상자들의 사망자료를 분석하여 당뇨병 환자의 사망률과 당뇨병 환자에서 흡연, 고혈압, 비만 등 여러 위험요인이 사망에 미치는 영향을 조사하고자 하였다. 대상 및 방법:1993년도에 수행되었던 제1차 당뇨병 유병율 조사 참여하였던 2,520명을 대상으로 하여 1993년 3월부터 1998년 12월까지 통계청의 사망자료를 확보하고 코호트 자료에 사망자료를 연계 결합함으로써 코호트 내에서의 사망례와 사망일을 확인하였다. 2,520명중 생화확적 검사 미실시, 설문조사 미실시, 주미등록번호 기재의 오류 등으로 2,305명만이 연구대상에 포함되었으며 사고와 중독으로 사망한 8명은 자료 분석 시 제외되어 2,297명이 최종적으로 분석 대상에 포함되었다. 결과:1. 코호트 구성원 2,297중 사망자는 6년 동안 남자 56명(5.5%), 여자 31명(2.4%)로 총 87(3.7%)이었다. 2. 비당뇨군 대 당뇨군의 전체 사망률에 대한 상대 위험도는 여러 위험요인들(연령, 성별, 수축기 혈압, 혈중 총 콜레스테롤, 흡연, 그리고 BMI)을 보정한 후 2.03이었다. 3. 비 당뇨군 대 당뇨군의 상대위험도는 남자에서는 40∼49세 사이에서, 여자에서는 60∼69세 사이에서 가장 크게 나타났으며, 나이가 증가함에 따라 감소하는 양상을 보여 주었다. 4. 흡연, 혈중 총 콜레스테롤, 수축기 혈압 및 BMI에 대하여 여러 군으로 나누어 당뇨군과 비당뇨군에서 사망률의 차이를 보면 당뇨군에서는 흡연, 혈중 총 콜레스테롤은 위험요인이 증가할수록 사망률도 증가하였다(p value<0.05). 그러나 수축기 혈압 및 BMI는 뚜렷한 연관성을 보이지 않았다. 5. 고혈압, 고지혈증, 비만 흡연 등의 위험요인이 증가함에 따른 사망률의 증가가 비당뇨군에 비해 당뇨군에서 더욱 크게 나타났다. 결론:이전의 대부분의 연구들이 당뇨의 유병률과 당뇨의 발생위험요인에 대한 단면적인 연구들이었으나 이 연구는 2.297명을 대상으로 6년 동안 추적 관찰하여 전향적으로 진행된 코호트 연구로서 우리나라에서 당뇨병 환자의 사망률을 조사한 최초의 연구이다. 다만 연구 대상자의 수가 적고 추적기간이 짧아 여러 위험요인이 사망률에 미치는 효과를 파악하기에는 부족하여 향후 추가적인 추적조사가 필요할 것으로 생각된다. Background : This study is designed to estimate the mortality rate and to assess the relation between other risk factors for mortality and death in adults with diabetes by analysis of death certificates in Yonchon cohort population. Methods : A population-based cross-sectional study was conducted in 1993 in Yonchon country to estimate the prevalence and risk factors of diabetes. This study population consists of respondents (2,463 persons) from Yonchon study and followed for 6 years from 1993 to 1998. Status of death and causes of death were determined from death certificates from National Statistical Office. Results : During the 6 year follow-up, 18 deaths (10%) occurred in the 184 persons with diabetes and 69 deaths (3.3%) occurred in the 2,113 persons without diabetes. After adjustment for multiple variable (age, sex, total cholesterol, systolic blood pressure, smoking and body mass index (BMI), mortality rate was significantly higher for diabetic adults than non-diabetic adults (RR, 2.03). The proportional hazard analysis for all-cause mortality in the 190 persons with diabetes showed that smoking, high total cholesterol, and high LDL-cholesterol were significantly associated with increased risk for mortality (p value < 0.05), but BMI, HDL-cholesterol, and high systolic blood pressure were not significantly associated with increased risk for mortality. Conclusions : This study was a prospective cohort study that followed 2,463 persons of Yonchon cohort for 6 years and showed that diabetic adults had higher mortality than non-diabetic adults. The strength of the association between risk factors and mortality was less clear because follow-up period was short and study population size was small, therefore further follow-up study are needed (J Kor Diabetes Asso 25:384~398, 2001).

The Beneficial Effects of Nardostachys jatamansi Extract on Diet-Induced Severe Acute Pancreatitis

Bae, Gi-Sang,Park, Kyoung-Chel,Koo, Bon Soon,Jo, Il-Joo,Choi, Sun Bok,Lee, Dong-Sung,Kim, Youn-Chul,Kim, Jong-Jin,Shin, Yong Kook,Hong, Seung-Heon,Kim, Tae-Hyeon,Song, Ho-Joon,Park, Sung-Joo Lippincott Williams Wilkins, Inc. 2013 Pancreas Vol.42 No.2

The prevalence of feline parasites in Suwon, Korea

Youn, Heejeong,Cho, Myung-Rae,Lim, Yong-Suk,Kim, Kyoung Hee,Bae, Bo-Kyung,Shin, Namsik,Nam, Ho-Woo The Korean Society of Veterinary Science 2012 大韓獸醫學會誌 Vol.52 No.2

Feline parasites were investigated in the area of Suwon in Korea from September to October, 2003. Wild cat had spread to zoonotic parasites, these parasites could cause infection with a person. People have a lot of interest in parasite infection of wild cat. This article reviews rate of infection of a parasites and kind of a parasite of wild cats. We will report the critical characteristic features of parasites to a better understanding of the disease. The incidence rates of Toxocara cati, Trichuris felis, Ancylostoma braziliense and Capillaria sp were 37.0, 4.3, 1.1 and 1.1% in nematodes. Those of Taenia taeniaformis and Opisthorchis sp were 2.2 and 1.1% in cestode and trematode. Those of Isospora felis, Toxoplasma gondii, and Sarcocystis sp were 8.7, 9.8, and 2.2% in protozoa. Almost of these were zoonotic parasites without Isospora felis.

[P8-10] Metabolic Activity of Desalted Underground Seawater of Jeju

Bo-Youn Kim,Zhi-Gang Cui,Hee-Kyoung Kang,Young-Ki Lee,Deok-Bae Park 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

Age-specific effects of ozone on pneumonia in Korean children and adolescents: A nationwide time-series study

Kim Kyoung-Nam,Lim Youn-Hee,Bae Sanghyuk,Song In Gyu,김순태,홍윤철 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: The aim of this study was to estimate the age-specific effects of 8-hour maximum ozone levels on pneumonia in children and adolescents. METHODS: We performed quasi-Poisson regression analyses for individuals of 0-4 years, 5-9 years, 10-14 years, and 15-19 years of age using nationwide time-series data from the Korea (2011-2015). We constructed distributed lag linear models employing a generalized difference-in-differences method and controlling for other air pollutants. RESULTS: A 10.0-parts per billion increase in 8-hour maximum ozone levels was associated with a higher risk of hospital admissions due to pneumonia at 0-4 (relative risk [RR], 1.02; 95% confidence interval [CI], 1.01 to 1.03) and 5-9 years of age (RR, 1.06; 95% CI, 1.04 to 1.08), but not at 10-14 (RR, 1.01; 95% CI, 0.98 to 1.04) or 15-19 years of age (RR, 1.01; 95% CI, 0.97 to 1.06). The association between ozone and hospital admissions due to pneumonia was stronger in cool seasons (from November to April) than in warm seasons (from May to October), but was similar between boys and girls. CONCLUSIONS: Short-term exposure to ozone was associated with a higher risk of pneumonia at 0-4 years and 5-9 years of age, but not at 10-14 years or 15-19 years of age. Our findings can help identify vulnerable periods, determine the target populations for public health interventions, and establish air pollution standards.